lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	10539
Symbol	GLRX3
Synonymous	GLRX4\|GRX3\|GRX4\|PICOT\|TXNL2\|TXNL3
Full name	glutaredoxin 3
Gene description	PKC-interacting cousin of thioredoxin\|PKC-theta-interacting protein\|PKCq-interacting protein\|glutaredoxin 4\|glutaredoxin-3\|thioredoxin-like protein 2
Cytoband	10q26
Gene type	protein-coding
Synonymous	MIM:612754; HGNC:HGNC:15987; Ensembl:ENSG00000108010; HPRD:10153; Vega:OTTHUMG00000019267

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.127G>C; p.A43P; 10:130145245-130145245	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.550G>A; p.D184N; 10:130166578-130166578	urinary_tract; bladder	carcinoma	Substitution - Missense
c.777A>G; p.A259A; 10:130171589-130171589	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.672A>G; p.E224E; 10:130166939-130166939	ovary	other; neoplasm	Substitution - coding silent
c.420G>A; p.L140L; 10:130160939-130160939	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.63G>C; p.Q21H; 10:130136483-130136483	breast	carcinoma	Substitution - Missense
c.63G>C; p.Q21H; 10:130136483-130136483	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.63G>C; p.Q21H; 10:130136483-130136483	thyroid	other; neoplasm	Substitution - Missense
c.63G>C; p.Q21H; 10:130136483-130136483	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.868C>T; p.R290W; 10:130175000-130175000	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.515A>G; p.H172R; 10:130166543-130166543	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.868C>T; p.R290W; 10:130175000-130175000	skin	malignant_melanoma	Substitution - Missense
c.567G>T; p.Q189H; 10:130166595-130166595	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.815A>G; p.N272S; 10:130171627-130171627	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.431delC; p.C146fs*5; 10:130160950-130160950	oesophagus	carcinoma; adenocarcinoma	Deletion - Frameshift
c.100C>A; p.L34I; 10:130145218-130145218	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.530G>T; p.S177I; 10:130166558-130166558	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.341G>A; p.R114Q; 10:130160860-130160860	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.455G>A; p.G152E; 10:130160974-130160974	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.670G>T; p.E224*; 10:130166937-130166937	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.17_18insGGGGGCGGC; p.A6_E7insGAA; 10:130136437-130136438	lung	carcinoma; adenocarcinoma	Insertion - In frame
c.997G>A; p.G333R; 10:130179381-130179381	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.802C>G; p.L268V; 10:130171614-130171614	urinary_tract; bladder	carcinoma	Substitution - Missense
c.186A>G; p.Q62Q; 10:130145304-130145304	thyroid	carcinoma	Substitution - coding silent
c.844G>A; p.D282N; 10:130174886-130174886	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.611A>G; p.Y204C; 10:130166639-130166639	breast	carcinoma	Substitution - Missense
c.830A>G; p.E277G; 10:130174872-130174872	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.356G>A; p.G119D; 10:130160875-130160875	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1000G>T; p.E334*; 10:130179384-130179384	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.825-2A>T; p.?; 10:130174865-130174865	lung; right_upper_lobe	carcinoma; adenocarcinoma	Unknown
c.771G>A; p.Q257Q; 10:130169490-130169490	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.94T>G; p.S32A; 10:130145212-130145212	pancreas	carcinoma	Substitution - Missense
c.217G>T; p.V73F; 10:130160010-130160010	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.859G>T; p.E287*; 10:130174901-130174901	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.663A>G; p.A221A; 10:130166930-130166930	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.825-1G>A; p.?; 10:130174866-130174866	liver	carcinoma	Unknown
c.163G>C; p.E55Q; 10:130145281-130145281	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.367C>T; p.P123S; 10:130160886-130160886	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.367C>T; p.P123S; 10:130160886-130160886	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.469C>G; p.P157A; 10:130160988-130160988	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.802C>A; p.L268M; 10:130171614-130171614	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.829G>A; p.E277K; 10:130174871-130174871	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.531C>T; p.S177S; 10:130166559-130166559	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.531C>T; p.S177S; 10:130166559-130166559	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.87A>C; p.K29N; 10:130136507-130136507	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.276+1G>T; p.?; 10:130160070-130160070	lung	carcinoma; adenocarcinoma	Unknown
c.93-2A>C; p.?; 10:130145209-130145209	pancreas	carcinoma	Unknown
c.844G>T; p.D282Y; 10:130174886-130174886	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.844G>T; p.D282Y; 10:130174886-130174886	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.367C>A; p.P123T; 10:130160886-130160886	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.475T>C; p.C159R; 10:130160994-130160994	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.175G>T; p.E59*; 10:130145293-130145293	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.175G>T; p.E59*; 10:130145293-130145293	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.175G>T; p.E59*; 10:130145293-130145293	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.240T>A; p.Y80*; 10:130160033-130160033	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.483C>A; p.F161L; 10:130166511-130166511	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.520_521insT; p.Q175fs*3; 10:130166548-130166549	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.211G>A; p.E71K; 10:130160004-130160004	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.328delA; p.V112fs*26; 10:130160847-130160847	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Deletion - Frameshift
c.573C>T; p.L191L; 10:130166601-130166601	liver	carcinoma	Substitution - coding silent
c.151G>A; p.E51K; 10:130145269-130145269	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.202-1G>T; p.?; 10:130159994-130159994	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Unknown
c.897G>A; p.W299*; 10:130175029-130175029	ovary	other; neoplasm	Substitution - Nonsense
c.747G>T; p.M249I; 10:130169466-130169466	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.291C>T; p.I97I; 10:130160810-130160810	skin	malignant_melanoma	Substitution - coding silent
c.839C>T; p.T280I; 10:130174881-130174881	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.822T>C; p.T274T; 10:130171634-130171634	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.256C>T; p.P86S; 10:130160049-130160049	skin	malignant_melanoma	Substitution - Missense
c.967G>T; p.E323*; 10:130179351-130179351	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.454G>T; p.G152*; 10:130160973-130160973	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.525G>A; p.Q175Q; 10:130166553-130166553	pancreas	carcinoma	Substitution - coding silent
c.717C>T; p.L239L; 10:130169436-130169436	breast	carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation