Cancer metastasis database

Annotation category 5

Gene information

Gene ID 10512
Symbol

SEMA3C

Synonymous

SEMAE|SemE

Full name

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C

Gene description

sema E|semaphorin E|semaphorin-3C|semaphorin-E

Cytoband

7q21-q31

Gene type

protein-coding

Synonymous

MIM:602645; HGNC:HGNC:10725; Ensembl:ENSG00000075223; HPRD:04034; Vega:OTTHUMG00000023447

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1751A>G; p.K584R; 7:80748989-80748989

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.330C>T; p.H110H; 7:80818416-80818416

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.547C>T; p.L183F; 7:80805750-80805750

upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1564G>A; p.A522T; 7:80758410-80758410

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1564G>A; p.A522T; 7:80758410-80758410

large_intestine; coloncarcinomaSubstitution - Missense

c.1564G>A; p.A522T; 7:80758410-80758410

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.683T>C; p.V228A; 7:80804224-80804224

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1094C>T; p.S365F; 7:80798129-80798129

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1046T>G; p.F349C; 7:80798177-80798177

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1347C>A; p.L449L; 7:80789313-80789313

lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1521C>T; p.S507S; 7:80758453-80758453

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1265G>A; p.R422H; 7:80789395-80789395

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1588C>T; p.P530S; 7:80758386-80758386

skin; upper_legmalignant_melanomaSubstitution - Missense

c.335G>T; p.C112F; 7:80818411-80818411

lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1049A>T; p.N350I; 7:80798174-80798174

lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.325A>C; p.T109P; 7:80827427-80827427

central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1126G>T; p.G376*; 7:80798097-80798097

lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Nonsense

c.471C>G; p.S157S; 7:80810678-80810678

lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.821G>C; p.R274P; 7:80802760-80802760

prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1630C>A; p.P544T; 7:80758344-80758344

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.2137C>G; p.R713G; 7:80745013-80745013

NSmalignant_melanomaSubstitution - Missense

c.2179G>T; p.G727W; 7:80744971-80744971

livercarcinomaSubstitution - Missense

c.1603G>A; p.D535N; 7:80758371-80758371

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1287T>C; p.Y429Y; 7:80789373-80789373

thyroidother; neoplasmSubstitution - coding silent

c.658+1G>A; p.?; 7:80805638-80805638

adrenal_gland; adrenal_glandadrenal_cortical_carcinoma; non_functioningUnknown

c.1930A>T; p.I644F; 7:80745220-80745220

lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1106G>C; p.R369T; 7:80798117-80798117

large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.965A>G; p.Y322C; 7:80800778-80800778

oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1913A>T; p.Q638L; 7:80745237-80745237

ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.109C>T; p.R37*; 7:80828740-80828740

skin; scalpcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.451C>G; p.Q151E; 7:80810698-80810698

skinmalignant_melanomaSubstitution - Missense

c.599G>A; p.R200Q; 7:80805698-80805698

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.599G>A; p.R200Q; 7:80805698-80805698

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1251G>A; p.R417R; 7:80789409-80789409

stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.730T>C; p.F244L; 7:80804177-80804177

central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.730T>C; p.F244L; 7:80804177-80804177

central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1110T>A; p.I370I; 7:80798113-80798113

skinmalignant_melanomaSubstitution - coding silent

c.174A>G; p.L58L; 7:80828675-80828675

NSmalignant_melanomaSubstitution - coding silent

c.1673G>A; p.G558E; 7:80751307-80751307

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1673G>A; p.G558E; 7:80751307-80751307

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.174A>G; p.L58L; 7:80828675-80828675

NSmalignant_melanomaSubstitution - coding silent

c.1582C>T; p.R528W; 7:80758392-80758392

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1582C>T; p.R528W; 7:80758392-80758392

central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1582C>T; p.R528W; 7:80758392-80758392

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.819G>A; p.L273L; 7:80802762-80802762

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1582C>T; p.R528W; 7:80758392-80758392

central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.2245C>A; p.P749T; 7:80744905-80744905

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.958C>A; p.L320I; 7:80800785-80800785

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.466G>A; p.D156N; 7:80810683-80810683

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1216C>T; p.L406F; 7:80789444-80789444

skinmalignant_melanomaSubstitution - Missense

c.389G>T; p.C130F; 7:80818357-80818357

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.2239C>T; p.Q747*; 7:80744911-80744911

stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1958C>T; p.T653I; 7:80745192-80745192

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1117C>T; p.P373S; 7:80798106-80798106

upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1665G>T; p.V555V; 7:80751315-80751315

upper_aerodigestive_tract; larynxcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.645C>A; p.S215S; 7:80805652-80805652

livercarcinomaSubstitution - coding silent

c.645C>A; p.S215S; 7:80805652-80805652

livercarcinomaSubstitution - coding silent

c.1323T>C; p.D441D; 7:80789337-80789337

stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.872C>T; p.S291L; 7:80802709-80802709

large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1348G>A; p.G450R; 7:80789312-80789312

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.545A>T; p.E182V; 7:80805752-80805752

livercarcinomaSubstitution - Missense

c.545A>T; p.E182V; 7:80805752-80805752

livercarcinomaSubstitution - Missense

c.1008C>T; p.A336A; 7:80798215-80798215

breastcarcinomaSubstitution - coding silent

c.1087C>T; p.L363L; 7:80798136-80798136

pancreascarcinomaSubstitution - coding silent

c.1095C>T; p.S365S; 7:80798128-80798128

skinmalignant_melanomaSubstitution - coding silent

c.801+1G>C; p.?; 7:80804105-80804105

central_nervous_system; brainglioma; astrocytoma_Grade_IVUnknown

c.847T>G; p.F283V; 7:80802734-80802734

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1056T>A; p.P352P; 7:80798167-80798167

large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1233C>G; p.I411M; 7:80789427-80789427

urinary_tract; bladdercarcinomaSubstitution - Missense

c.1567G>A; p.D523N; 7:80758407-80758407

lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1492T>A; p.L498M; 7:80758482-80758482

haematopoietic_and_lymphoid_tissue; soft_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.1643+1G>A; p.?; 7:80758330-80758330

lungcarcinoma; squamous_cell_carcinomaUnknown

c.1315G>A; p.A439T; 7:80789345-80789345

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.495C>T; p.R165R; 7:80810654-80810654

upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1665G>C; p.V555V; 7:80751315-80751315

pancreascarcinomaSubstitution - coding silent

c.1665G>C; p.V555V; 7:80751315-80751315

lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1576C>G; p.L526V; 7:80758398-80758398

central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1576C>G; p.L526V; 7:80758398-80758398

central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.2180G>C; p.G727A; 7:80744970-80744970

lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2180G>C; p.G727A; 7:80744970-80744970

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.401C>T; p.A134V; 7:80818345-80818345

breastcarcinomaSubstitution - Missense

c.1802T>C; p.I601T; 7:80748938-80748938

central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1802T>C; p.I601T; 7:80748938-80748938

central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.265-3C>A; p.?; 7:80827490-80827490

adrenal_gland; adrenal_glandadrenal_cortical_carcinoma; functioningUnknown

c.2034C>T; p.T678T; 7:80745116-80745116

lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.554C>T; p.S185F; 7:80805743-80805743

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1602G>T; p.W534C; 7:80758372-80758372

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1343T>A; p.F448Y; 7:80789317-80789317

skinmalignant_melanomaSubstitution - Missense

c.74C>A; p.P25H; 7:80916708-80916708

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1174G>T; p.E392*; 7:80789486-80789486

breastcarcinomaSubstitution - Nonsense

c.1144G>A; p.A382T; 7:80789516-80789516

kidneyother; neoplasmSubstitution - Missense

c.620C>T; p.A207V; 7:80805677-80805677

central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1424A>T; p.E475V; 7:80765174-80765174

ovaryother; neoplasmSubstitution - Missense

c.620C>T; p.A207V; 7:80805677-80805677

breastcarcinomaSubstitution - Missense

c.1719delA; p.N574fs*10; 7:80749021-80749021

lungcarcinoma; large_cell_carcinomaDeletion - Frameshift

c.448-10T>C; p.?; 7:80810711-80810711

livercarcinomaUnknown

c.1111C>T; p.P371S; 7:80798112-80798112

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1992A>T; p.S664S; 7:80745158-80745158

kidneyother; neoplasmSubstitution - coding silent

c.1478C>A; p.S493Y; 7:80761623-80761623

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1727C>T; p.A576V; 7:80749013-80749013

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.778T>G; p.S260A; 7:80804129-80804129

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1112C>T; p.P371L; 7:80798111-80798111

NSmalignant_melanomaSubstitution - Missense

c.1112C>T; p.P371L; 7:80798111-80798111

skinmalignant_melanomaSubstitution - Missense

c.522G>A; p.T174T; 7:80810627-80810627

endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.2087C>A; p.A696E; 7:80745063-80745063

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1485G>T; p.K495N; 7:80761616-80761616

central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.371G>A; p.R124H; 7:80818375-80818375

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1420C>T; p.L474L; 7:80765178-80765178

breastcarcinomaSubstitution - coding silent

c.1892G>T; p.R631L; 7:80745258-80745258

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.2012C>T; p.T671M; 7:80745138-80745138

central_nervous_system; braingliomaSubstitution - Missense

c.1585G>A; p.D529N; 7:80758389-80758389

pancreascarcinoma; acinar_carcinomaSubstitution - Missense

c.644C>A; p.S215Y; 7:80805653-80805653

livercarcinomaSubstitution - Missense

c.644C>A; p.S215Y; 7:80805653-80805653

livercarcinomaSubstitution - Missense

c.819G>C; p.L273L; 7:80802762-80802762

ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.968G>A; p.G323D; 7:80800775-80800775

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1351A>G; p.T451A; 7:80789309-80789309

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1139G>A; p.G380E; 7:80789521-80789521

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1332C>A; p.Y444*; 7:80789328-80789328

oesophaguscarcinoma; adenocarcinomaSubstitution - Nonsense

c.1351A>G; p.T451A; 7:80789309-80789309

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2025C>T; p.S675S; 7:80745125-80745125

skinmalignant_melanomaSubstitution - coding silent

c.1361G>T; p.G454V; 7:80765237-80765237

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.658G>A; p.E220K; 7:80805639-80805639

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.658G>A; p.E220K; 7:80805639-80805639

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.1411G>A; p.E471K; 7:80765187-80765187

livercarcinomaSubstitution - Missense

c.1411G>A; p.E471K; 7:80765187-80765187

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1749A>G; p.V583V; 7:80748991-80748991

lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.144C>T; p.S48S; 7:80828705-80828705

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.292G>T; p.V98F; 7:80827460-80827460

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2137C>T; p.R713W; 7:80745013-80745013

urinary_tract; bladdercarcinomaSubstitution - Missense

c.2053G>A; p.A685T; 7:80745097-80745097

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.400G>A; p.A134T; 7:80818346-80818346

breastcarcinomaSubstitution - Missense

c.862C>T; p.L288L; 7:80802719-80802719

upper_aerodigestive_tract; larynxcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1206G>T; p.R402R; 7:80789454-80789454

skinmalignant_melanomaSubstitution - coding silent

c.1607G>A; p.G536D; 7:80758367-80758367

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.735A>T; p.K245N; 7:80804172-80804172

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1357C>T; p.R453W; 7:80765241-80765241

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1357C>T; p.R453W; 7:80765241-80765241

large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1357C>T; p.R453W; 7:80765241-80765241

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.54T>C; p.C18C; 7:80916728-80916728

lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1316C>A; p.A439D; 7:80789344-80789344

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1820A>C; p.K607T; 7:80748920-80748920

kidneyother; neoplasmSubstitution - Missense

c.845C>T; p.T282I; 7:80802736-80802736

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.764C>T; p.T255M; 7:80804143-80804143

kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.332G>A; p.G111D; 7:80818414-80818414

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.857C>T; p.A286V; 7:80802724-80802724

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.659-1G>T; p.?; 7:80804249-80804249

large_intestine; coloncarcinoma; adenocarcinomaUnknown

c.2138G>A; p.R713Q; 7:80745012-80745012

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2013G>A; p.T671T; 7:80745137-80745137

stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.743T>C; p.L248P; 7:80804164-80804164

livercarcinomaSubstitution - Missense

c.1826A>G; p.K609R; 7:80748914-80748914

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1111C>G; p.P371A; 7:80798112-80798112

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.20G>T; p.C7F; 7:80916762-80916762

central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.360_367delGACTTTCA; p.T121fs*33; 7:80818379-80818386

oesophaguscarcinoma; adenocarcinomaDeletion - Frameshift

c.2242T>C; p.L748L; 7:80744908-80744908

central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.1842+3G>A; p.?; 7:80748895-80748895

livercarcinomaUnknown

c.1842+3G>A; p.?; 7:80748895-80748895

livercarcinomaUnknown

c.1042G>T; p.V348L; 7:80798181-80798181

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.923T>A; p.V308E; 7:80800820-80800820

central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.527C>T; p.S176F; 7:80810622-80810622

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1167C>T; p.T389T; 7:80789493-80789493

lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.659-2A>G; p.?; 7:80804250-80804250

lung; right_lower_lobecarcinoma; adenocarcinomaUnknown

c.543G>A; p.E181E; 7:80805754-80805754

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.2222G>A; p.S741N; 7:80744928-80744928

skinmalignant_melanomaSubstitution - Missense

c.1142_1144delGAG; p.G381delG; 7:80789516-80789518

breastcarcinomaDeletion - In frame

c.962T>C; p.V321A; 7:80800781-80800781

livercarcinomaSubstitution - Missense

c.962T>C; p.V321A; 7:80800781-80800781

livercarcinomaSubstitution - Missense

c.1198T>G; p.F400V; 7:80789462-80789462

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.128A>C; p.E43A; 7:80828721-80828721

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1832G>T; p.R611M; 7:80748908-80748908

lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.534G>A; p.M178I; 7:80810615-80810615

breastcarcinomaSubstitution - Missense

c.1017_1018delGT; p.Y340fs*4; 7:80798205-80798206

large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.1017_1018delGT; p.Y340fs*4; 7:80798205-80798206

endometriumcarcinoma; endometrioid_carcinomaDeletion - Frameshift

c.1017_1018delGT; p.Y340fs*4; 7:80798205-80798206

endometriumcarcinoma; endometrioid_carcinomaDeletion - Frameshift

c.1555A>G; p.T519A; 7:80758419-80758419

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1678C>T; p.P560S; 7:80751302-80751302

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2156G>A; p.G719E; 7:80744994-80744994

breastcarcinomaSubstitution - Missense

c.1408G>T; p.G470C; 7:80765190-80765190

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.354A>C; p.V118V; 7:80818392-80818392

haematopoietic_and_lymphoid_tissuelymphoid_neoplasmSubstitution - coding silent

c.1586A>G; p.D529G; 7:80758388-80758388

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense