lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	10498
Symbol	CARM1
Synonymous	PRMT4
Full name	coactivator-associated arginine methyltransferase 1
Gene description	histone-arginine methyltransferase CARM1\|protein arginine N-methyltransferase 4
Cytoband	19p13.2
Gene type	protein-coding
Synonymous	MIM:603934; HGNC:HGNC:23393; Ensembl:ENSG00000142453; HPRD:09158; Vega:OTTHUMG00000180699

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1517G>C; p.S506T; 19:10920926-10920926	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; follicular_lymphoma	Substitution - Missense
c.420G>A; p.R140R; 19:10908112-10908112	skin	malignant_melanoma	Substitution - coding silent
c.1021G>A; p.D341N; 19:10919595-10919595	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.574G>T; p.G192C; 19:10912199-10912199	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1449C>G; p.P483P; 19:10920858-10920858	liver	carcinoma	Substitution - coding silent
c.1449C>G; p.P483P; 19:10920858-10920858	liver	carcinoma	Substitution - coding silent
c.603T>A; p.F201L; 19:10912228-10912228	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1560G>C; p.L520F; 19:10921072-10921072	breast	carcinoma	Substitution - Missense
c.701G>C; p.R234P; 19:10913908-10913908	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1775C>A; p.S592Y; 19:10921705-10921705	urinary_tract; bladder	carcinoma	Substitution - Missense
c.531G>A; p.L177L; 19:10909180-10909180	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1106+1G>A; p.?; 19:10919681-10919681	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Unknown
c.333C>T; p.F111F; 19:10905063-10905063	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.333C>T; p.F111F; 19:10905063-10905063	breast	carcinoma	Substitution - coding silent
c.1800G>A; p.P600P; 19:10921730-10921730	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.333C>T; p.F111F; 19:10905063-10905063	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.921C>A; p.F307L; 19:10916480-10916480	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.524C>A; p.A175D; 19:10909173-10909173	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.305T>C; p.L102P; 19:10905035-10905035	liver	carcinoma	Substitution - Missense
c.305T>C; p.L102P; 19:10905035-10905035	liver	carcinoma	Substitution - Missense
c.305T>C; p.L102P; 19:10905035-10905035	liver	carcinoma	Substitution - Missense
c.1521C>T; p.S507S; 19:10920930-10920930	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.450C>T; p.F150F; 19:10908142-10908142	skin	malignant_melanoma	Substitution - coding silent
c.1452A>C; p.P484P; 19:10920861-10920861	breast	carcinoma	Substitution - coding silent
c.1530C>T; p.A510A; 19:10920939-10920939	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1088_1090delAAG; p.E364delE; 19:10919662-10919664	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.1304C>T; p.S435L; 19:10920543-10920543	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1350C>T; p.I450I; 19:10920674-10920674	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.978C>G; p.L326L; 19:10916735-10916735	kidney	other; neoplasm	Substitution - coding silent
c.695C>T; p.T232M; 19:10913902-10913902	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.978C>G; p.L326L; 19:10916735-10916735	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.561C>T; p.I187I; 19:10912186-10912186	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.216C>G; p.Y72*; 19:10871918-10871918	pancreas	carcinoma	Substitution - Nonsense
c.228_229insTG; p.V77fs*49; 19:10904958-10904959	stomach	adenocarcinoma	Insertion - Frameshift
c.257G>A; p.R86Q; 19:10904987-10904987	pancreas	carcinoma	Substitution - Missense
c.1802C>T; p.T601I; 19:10921732-10921732	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.608C>T; p.A203V; 19:10912233-10912233	breast	carcinoma	Substitution - Missense
c.1583C>G; p.S528C; 19:10921095-10921095	urinary_tract; bladder	carcinoma	Substitution - Missense
c.778G>T; p.G260C; 19:10913985-10913985	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.873C>T; p.D291D; 19:10916432-10916432	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.661C>T; p.H221Y; 19:10912286-10912286	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.796G>A; p.E266K; 19:10914003-10914003	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.254C>T; p.S85F; 19:10904984-10904984	ovary	carcinoma	Substitution - Missense
c.1117C>T; p.P373S; 19:10919887-10919887	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1515C>T; p.L505L; 19:10920924-10920924	breast	carcinoma	Substitution - coding silent
c.454delT; p.Y153fs*10; 19:10909103-10909103	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.762C>T; p.I254I; 19:10913969-10913969	skin	malignant_melanoma	Substitution - coding silent
c.767C>T; p.S256L; 19:10913974-10913974	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1623G>A; p.T541T; 19:10921382-10921382	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.823G>T; p.A275S; 19:10914030-10914030	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.823G>T; p.A275S; 19:10914030-10914030	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1721C>T; p.T574M; 19:10921651-10921651	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.499G>A; p.V167M; 19:10909148-10909148	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.499G>A; p.V167M; 19:10909148-10909148	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1203C>T; p.T401T; 19:10920442-10920442	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.396G>A; p.L132L; 19:10908088-10908088	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.404C>T; p.S135F; 19:10908096-10908096	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1692C>T; p.S564S; 19:10921622-10921622	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.227A>T; p.D76V; 19:10904957-10904957	skin	malignant_melanoma	Substitution - Missense
c.568G>C; p.D190H; 19:10912193-10912193	oesophagus	carcinoma	Substitution - Missense
c.1424+1G>A; p.?; 19:10920749-10920749	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.1281C>T; p.F427F; 19:10920520-10920520	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1581C>T; p.G527G; 19:10921093-10921093	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.692T>C; p.L231P; 19:10913899-10913899	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1675_1676insTTGTC; p.Q561fs*>50; 19:10921434-10921435	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1819G>A; p.G607R; 19:10921749-10921749	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1430C>T; p.T477M; 19:10920839-10920839	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.623G>A; p.R208Q; 19:10912248-10912248	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1478C>T; p.S493L; 19:10920887-10920887	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1020G>T; p.V340V; 19:10916777-10916777	liver	carcinoma	Substitution - coding silent
c.1439C>T; p.T480M; 19:10920848-10920848	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.559A>G; p.I187V; 19:10912184-10912184	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.346G>A; p.D116N; 19:10905076-10905076	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1707T>C; p.S569S; 19:10921637-10921637	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.383G>A; p.R128Q; 19:10908075-10908075	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.607G>C; p.A203P; 19:10912232-10912232	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.419G>A; p.R140Q; 19:10908111-10908111	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.630C>G; p.I210M; 19:10912255-10912255	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1327delA; p.N443fs*27; 19:10920566-10920566	liver	carcinoma	Deletion - Frameshift
c.424G>A; p.E142K; 19:10908116-10908116	urinary_tract; bladder	carcinoma	Substitution - Missense
c.605C>T; p.A202V; 19:10912230-10912230	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.605C>T; p.A202V; 19:10912230-10912230	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.605C>T; p.A202V; 19:10912230-10912230	skin	malignant_melanoma	Substitution - Missense
c.605C>T; p.A202V; 19:10912230-10912230	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.605C>T; p.A202V; 19:10912230-10912230	skin	malignant_melanoma	Substitution - Missense
c.257G>C; p.R86P; 19:10904987-10904987	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.726delG; p.E243fs*37; 19:10913933-10913933	breast	carcinoma	Deletion - Frameshift
c.1355T>C; p.I452T; 19:10920679-10920679	central_nervous_system; spinal_cord	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.853A>G; p.M285V; 19:10916412-10916412	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.950C>T; p.S317F; 19:10916707-10916707	breast	carcinoma	Substitution - Missense
c.609C>T; p.A203A; 19:10912234-10912234	skin	malignant_melanoma	Substitution - coding silent
c.636G>A; p.A212A; 19:10912261-10912261	breast	carcinoma	Substitution - coding silent
c.44C>T; p.A15V; 19:10871746-10871746	thyroid	other; neoplasm	Substitution - Missense
c.913G>A; p.E305K; 19:10916472-10916472	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1675A>G; p.I559V; 19:10921434-10921434	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1408delA; p.N471fs*50; 19:10920732-10920732	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1462C>A; p.H488N; 19:10920871-10920871	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1665G>C; p.M555I; 19:10921424-10921424	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1549G>A; p.A517T; 19:10921061-10921061	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1549G>A; p.A517T; 19:10921061-10921061	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1343A>G; p.Y448C; 19:10920667-10920667	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1388C>T; p.S463F; 19:10920712-10920712	skin	malignant_melanoma	Substitution - Missense
c.1382C>T; p.S461F; 19:10920706-10920706	skin	malignant_melanoma	Substitution - Missense
c.1742A>T; p.N581I; 19:10921672-10921672	thyroid	other; neoplasm	Substitution - Missense
c.1529C>A; p.A510D; 19:10920938-10920938	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1156G>A; p.G386S; 19:10919926-10919926	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1825T>C; p.*609Q; 19:10921755-10921755	endometrium	carcinoma; endometrioid_carcinoma	Nonstop extension
c.1067C>T; p.T356M; 19:10919641-10919641	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation