lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	10188
Symbol	TNK2
Synonymous	ACK\|ACK-1\|ACK1\|p21cdc42Hs
Full name	tyrosine kinase, non-receptor, 2
Gene description	activated CDC42 kinase 1\|activated Cdc42-associated kinase 1\|activated p21cdc42Hs kinase\|tyrosine kinase non-receptor protein 2
Cytoband	3q29
Gene type	protein-coding
Synonymous	MIM:606994; HGNC:HGNC:19297; Ensembl:ENSG00000061938; HPRD:06104; Vega:OTTHUMG00000155737

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.2926C>T; p.Q976*; 3:195867225-195867225	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.3010C>T; p.R1004W; 3:195866989-195866989	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.824G>A; p.R275Q; 3:195882114-195882114	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1227G>A; p.M409I; 3:195878282-195878282	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1227G>A; p.M409I; 3:195878282-195878282	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1227G>A; p.M409I; 3:195878282-195878282	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.100C>T; p.R34C; 3:195888489-195888489	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1055G>A; p.R352Q; 3:195878552-195878552	ovary	other; neoplasm	Substitution - Missense
c.3087C>T; p.G1029G; 3:195866912-195866912	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1165C>A; p.Q389K; 3:195878344-195878344	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1732G>T; p.V578L; 3:195868521-195868521	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2251C>G; p.R751G; 3:195868002-195868002	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2759A>G; p.K920R; 3:195867494-195867494	skin	malignant_melanoma	Substitution - Missense
c.571C>T; p.R191C; 3:195883195-195883195	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2772C>A; p.S924S; 3:195867481-195867481	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.375C>T; p.D125D; 3:195884893-195884893	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.751C>T; p.R251C; 3:195882187-195882187	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.224G>A; p.W75*; 3:195886987-195886987	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.1418G>A; p.R473H; 3:195872309-195872309	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.250C>T; p.R84*; 3:195885018-195885018	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.131A>G; p.E44G; 3:195888458-195888458	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1986G>T; p.G662G; 3:195868267-195868267	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1551C>T; p.T517T; 3:195868702-195868702	pancreas	carcinoma	Substitution - coding silent
c.219G>T; p.K73N; 3:195886992-195886992	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2810C>T; p.P937L; 3:195867443-195867443	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.74G>A; p.R25Q; 3:195888515-195888515	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.2367G>T; p.S789S; 3:195867886-195867886	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.675C>T; p.L225L; 3:195882263-195882263	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.810C>G; p.D270E; 3:195882128-195882128	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2894C>G; p.A965G; 3:195867257-195867257	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1844C>T; p.P615L; 3:195868409-195868409	skin	malignant_melanoma	Substitution - Missense
c.852C>T; p.Y284Y; 3:195882086-195882086	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2645C>T; p.P882L; 3:195867608-195867608	thyroid	other; neoplasm	Substitution - Missense
c.527G>A; p.R176Q; 3:195883239-195883239	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.898G>A; p.E300K; 3:195879165-195879165	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.898G>A; p.E300K; 3:195879165-195879165	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.898G>A; p.E300K; 3:195879165-195879165	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2646C>T; p.P882P; 3:195867607-195867607	thyroid	other; neoplasm	Substitution - coding silent
c.457-8C>G; p.?; 3:195883317-195883317	eye; uveal_tract	malignant_melanoma; spindle	Unknown
c.511A>T; p.M171L; 3:195883255-195883255	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1046G>A; p.R349Q; 3:195878561-195878561	prostate	carcinoma	Substitution - Missense
c.1349C>T; p.S450L; 3:195872378-195872378	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.1349C>T; p.S450L; 3:195872378-195872378	skin	malignant_melanoma	Substitution - Missense
c.1349C>T; p.S450L; 3:195872378-195872378	skin; leg	malignant_melanoma	Substitution - Missense
c.1349C>T; p.S450L; 3:195872378-195872378	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1836G>T; p.L612L; 3:195868417-195868417	skin	malignant_melanoma	Substitution - coding silent
c.1318C>T; p.R440C; 3:195872409-195872409	prostate	carcinoma	Substitution - Missense
c.2798G>A; p.R933Q; 3:195867455-195867455	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2598A>G; p.P866P; 3:195867655-195867655	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.157C>T; p.R53W; 3:195888432-195888432	skin	malignant_melanoma	Substitution - Missense
c.2423C>G; p.S808*; 3:195867830-195867830	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.439G>A; p.A147T; 3:195884829-195884829	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.457-2A>G; p.?; 3:195883311-195883311	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.296G>A; p.R99Q; 3:195884972-195884972	ovary	carcinoma; mucinous_carcinoma	Substitution - Missense
c.296G>A; p.R99Q; 3:195884972-195884972	ovary	carcinoma; mucinous_carcinoma	Substitution - Missense
c.1164C>T; p.A388A; 3:195878345-195878345	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3042G>A; p.E1014E; 3:195866957-195866957	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2236_2237CC>TT; p.P746F; 3:195868016-195868017	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1984G>A; p.G662R; 3:195868269-195868269	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2683C>T; p.P895S; 3:195867570-195867570	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2908G>A; p.V970M; 3:195867243-195867243	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1859C>A; p.P620H; 3:195868394-195868394	pancreas	carcinoma	Substitution - Missense
c.295C>T; p.R99W; 3:195884973-195884973	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1859C>A; p.P620H; 3:195868394-195868394	pancreas	carcinoma	Substitution - Missense
c.2625C>T; p.F875F; 3:195867628-195867628	skin	malignant_melanoma	Substitution - coding silent
c.1144C>G; p.R382G; 3:195878463-195878463	ovary	other; neoplasm	Substitution - Missense
c.1611G>A; p.L537L; 3:195868642-195868642	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.635C>T; p.S212L; 3:195882303-195882303	skin	malignant_melanoma	Substitution - Missense
c.2338_2339CC>TT; p.P780L; 3:195867914-195867915	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1544-1_1544insAACC; p.Y518fs*3; 3:195868709-195868710	large_intestine; colon	carcinoma	Unknown
c.635C>T; p.S212L; 3:195882303-195882303	skin; scalp	malignant_melanoma	Substitution - Missense
c.101G>T; p.R34L; 3:195888488-195888488	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.252A>G; p.R84R; 3:195885016-195885016	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.101G>T; p.R34L; 3:195888488-195888488	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.101G>T; p.R34L; 3:195888488-195888488	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.252A>G; p.R84R; 3:195885016-195885016	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1482_1483insC; p.D495fs*25; 3:195870174-195870175	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.2101G>T; p.A701S; 3:195868152-195868152	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1482_1483insC; p.D495fs*25; 3:195870174-195870175	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1022A>T; p.H341L; 3:195878585-195878585	liver	carcinoma	Substitution - Missense
c.1022A>T; p.H341L; 3:195878585-195878585	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.120C>T; p.Y40Y; 3:195888469-195888469	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.360C>G; p.L120L; 3:195884908-195884908	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.144G>A; p.K48K; 3:195888445-195888445	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2819C>A; p.T940N; 3:195867434-195867434	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1085A>G; p.N362S; 3:195878522-195878522	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2252G>A; p.R751H; 3:195868001-195868001	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1493G>C; p.S498T; 3:195870164-195870164	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.158G>A; p.R53Q; 3:195888431-195888431	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1667C>T; p.P556L; 3:195868586-195868586	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.570C>T; p.I190I; 3:195883196-195883196	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1895_1896insC; p.P633fs*4; 3:195868357-195868358	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.296G>T; p.R99L; 3:195884972-195884972	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2225G>T; p.R742L; 3:195868028-195868028	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2225G>T; p.R742L; 3:195868028-195868028	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2702C>T; p.A901V; 3:195867551-195867551	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2146A>G; p.R716G; 3:195868107-195868107	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.294C>T; p.F98F; 3:195884974-195884974	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.652C>A; p.R218S; 3:195882286-195882286	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1786G>A; p.A596T; 3:195868467-195868467	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.295C>A; p.R99R; 3:195884973-195884973	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.463G>T; p.V155L; 3:195883303-195883303	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.171G>A; p.R57R; 3:195887040-195887040	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.303C>A; p.T101T; 3:195884965-195884965	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2070G>A; p.P690P; 3:195868183-195868183	breast	carcinoma	Substitution - coding silent
c.2576A>C; p.Y859S; 3:195867677-195867677	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2070G>A; p.P690P; 3:195868183-195868183	thyroid	other; neoplasm	Substitution - coding silent
c.12G>A; p.E4E; 3:195888577-195888577	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1417C>G; p.R473G; 3:195872310-195872310	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2100C>T; p.S700S; 3:195868153-195868153	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.400G>C; p.D134H; 3:195884868-195884868	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2674C>T; p.L892L; 3:195867579-195867579	skin	malignant_melanoma	Substitution - coding silent
c.297G>A; p.R99R; 3:195884971-195884971	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.2037G>A; p.P679P; 3:195868216-195868216	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.94G>A; p.V32I; 3:195888495-195888495	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.987G>A; p.E329E; 3:195879076-195879076	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1301G>A; p.C434Y; 3:195872426-195872426	liver	carcinoma	Substitution - Missense
c.1419C>T; p.R473R; 3:195872308-195872308	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.69C>T; p.F23F; 3:195888520-195888520	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.790G>A; p.D264N; 3:195882148-195882148	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.287G>T; p.S96I; 3:195884981-195884981	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.579C>T; p.Y193Y; 3:195883187-195883187	bone; fibula	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1178T>C; p.M393T; 3:195878331-195878331	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.599C>T; p.P200L; 3:195883167-195883167	skin	malignant_melanoma	Substitution - Missense
c.2266C>A; p.L756M; 3:195867987-195867987	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2997C>T; p.F999F; 3:195867002-195867002	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.73C>T; p.R25W; 3:195888516-195888516	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.873G>T; p.K291N; 3:195882065-195882065	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1291C>T; p.R431W; 3:195872436-195872436	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.126G>A; p.K42K; 3:195888463-195888463	skin	malignant_melanoma	Substitution - coding silent
c.126G>A; p.K42K; 3:195888463-195888463	skin	malignant_melanoma	Substitution - coding silent
c.92A>G; p.N31S; 3:195888497-195888497	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.975C>T; p.T325T; 3:195879088-195879088	skin	malignant_melanoma	Substitution - coding silent
c.1395_1396delAG; p.G466fs*5; 3:195872331-195872332	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.1036G>A; p.E346K; 3:195878571-195878571	ovary	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1036G>A; p.E346K; 3:195878571-195878571	ovary	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1334C>T; p.S445F; 3:195872393-195872393	skin	malignant_melanoma	Substitution - Missense
c.2355C>T; p.S785S; 3:195867898-195867898	skin	malignant_melanoma	Substitution - coding silent
c.1522delC; p.Q508fs*3; 3:195870135-195870135	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1482delC; p.D495fs*3; 3:195870175-195870175	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2177C>T; p.A726V; 3:195868076-195868076	skin	malignant_melanoma	Substitution - Missense
c.1482delC; p.D495fs*3; 3:195870175-195870175	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2266C>T; p.L756L; 3:195867987-195867987	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1522delC; p.Q508fs*3; 3:195870135-195870135	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1482delC; p.D495fs*3; 3:195870175-195870175	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2246C>T; p.P749L; 3:195868007-195868007	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2311G>T; p.G771*; 3:195867942-195867942	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1876G>T; p.A626S; 3:195868377-195868377	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.978C>T; p.Y326Y; 3:195879085-195879085	skin	malignant_melanoma	Substitution - coding silent
c.978C>T; p.Y326Y; 3:195879085-195879085	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1156C>T; p.L386L; 3:195878451-195878451	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.380G>A; p.R127H; 3:195884888-195884888	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2282delC; p.P761fs*72; 3:195867971-195867971	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2081G>A; p.G694E; 3:195868172-195868172	breast	carcinoma	Substitution - Missense
c.222G>A; p.S74S; 3:195886989-195886989	prostate	carcinoma	Substitution - coding silent
c.2081G>A; p.G694E; 3:195868172-195868172	breast	carcinoma	Substitution - Missense
c.1798C>A; p.L600M; 3:195868455-195868455	liver	carcinoma	Substitution - Missense
c.2629C>T; p.R877C; 3:195867624-195867624	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1798C>A; p.L600M; 3:195868455-195868455	liver	carcinoma	Substitution - Missense
c.1522_1523insC; p.Q508fs*12; 3:195870134-195870135	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1895delC; p.P632fs*84; 3:195868358-195868358	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1895delC; p.P632fs*84; 3:195868358-195868358	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.259G>T; p.A87S; 3:195885009-195885009	ovary	other; neoplasm	Substitution - Missense
c.835C>T; p.Q279*; 3:195882103-195882103	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1970C>T; p.A657V; 3:195868283-195868283	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.801G>T; p.K267N; 3:195882137-195882137	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.293T>A; p.F98Y; 3:195884975-195884975	ovary	other; neoplasm	Substitution - Missense
c.1769C>T; p.A590V; 3:195868484-195868484	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1085delA; p.N362fs*48; 3:195878522-195878522	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1719C>T; p.F573F; 3:195868534-195868534	thyroid	other; neoplasm	Substitution - coding silent
c.957A>G; p.T319T; 3:195879106-195879106	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1769C>T; p.A590V; 3:195868484-195868484	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1108C>T; p.H370Y; 3:195878499-195878499	skin	malignant_melanoma	Substitution - Missense
c.1719C>T; p.F573F; 3:195868534-195868534	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.672C>T; p.F224F; 3:195882266-195882266	skin	malignant_melanoma	Substitution - coding silent
c.792C>T; p.D264D; 3:195882146-195882146	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.940T>A; p.W314R; 3:195879123-195879123	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1798C>T; p.L600L; 3:195868455-195868455	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1387A>G; p.I463V; 3:195872340-195872340	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.124A>G; p.K42E; 3:195888465-195888465	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2319T>C; p.A773A; 3:195867934-195867934	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2319T>C; p.A773A; 3:195867934-195867934	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2319T>C; p.A773A; 3:195867934-195867934	breast	carcinoma	Substitution - coding silent
c.333G>C; p.E111D; 3:195884935-195884935	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2491delC; p.Q831fs*2; 3:195867762-195867762	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2491delC; p.Q831fs*2; 3:195867762-195867762	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2491delC; p.Q831fs*2; 3:195867762-195867762	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.486C>T; p.P162P; 3:195883280-195883280	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3068C>A; p.A1023D; 3:195866931-195866931	liver	carcinoma	Substitution - Missense
c.3068C>A; p.A1023D; 3:195866931-195866931	liver	carcinoma	Substitution - Missense
c.1124G>A; p.R375K; 3:195878483-195878483	skin	malignant_melanoma	Substitution - Missense
c.1577A>G; p.D526G; 3:195868676-195868676	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.683C>T; p.T228I; 3:195882255-195882255	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1719C>G; p.F573L; 3:195868534-195868534	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.914G>A; p.R305H; 3:195879149-195879149	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.326C>T; p.A109V; 3:195884942-195884942	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.416T>C; p.V139A; 3:195884852-195884852	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2113G>A; p.E705K; 3:195868140-195868140	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation