lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	10181
Symbol	RBM5
Synonymous	G15\|H37\|LUCA15\|RMB5
Full name	RNA binding motif protein 5
Gene description	RNA-binding protein 5\|putative tumor suppressor LUCA15\|renal carcinoma antigen NY-REN-9
Cytoband	3p21.3
Gene type	protein-coding
Synonymous	MIM:606884; HGNC:HGNC:9902; Ensembl:ENSG00000003756; HPRD:06052; Vega:OTTHUMG00000156785

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.2038C>T; p.R680*; 3:50115924-50115924	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1962C>T; p.R654R; 3:50115550-50115550	skin	malignant_melanoma	Substitution - coding silent
c.2388C>T; p.A796A; 3:50118396-50118396	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1912G>T; p.E638*; 3:50115500-50115500	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Nonsense
c.1912G>T; p.E638*; 3:50115500-50115500	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1704G>C; p.L568F; 3:50114036-50114036	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1237C>T; p.P413S; 3:50109647-50109647	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.191G>A; p.R64H; 3:50093727-50093727	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.888T>C; p.S296S; 3:50106799-50106799	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1445C>T; p.P482L; 3:50110760-50110760	skin	malignant_melanoma	Substitution - Missense
c.764C>T; p.A255V; 3:50105618-50105618	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.356A>C; p.E119A; 3:50099998-50099998	pancreas	carcinoma	Substitution - Missense
c.1554C>T; p.G518G; 3:50113481-50113481	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.848C>G; p.S283C; 3:50105702-50105702	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1365A>G; p.A455A; 3:50110680-50110680	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1365A>G; p.A455A; 3:50110680-50110680	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.382G>C; p.D128H; 3:50100024-50100024	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.217G>A; p.E73K; 3:50093753-50093753	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.217G>A; p.E73K; 3:50093753-50093753	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1366G>C; p.V456L; 3:50110681-50110681	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1760A>G; p.E587G; 3:50114092-50114092	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.432_433CG>GT; p.F144>?; 3:50100554-50100555	lung	carcinoma; adenocarcinoma	Complex
c.1675A>G; p.K559E; 3:50114007-50114007	skin	malignant_melanoma	Substitution - Missense
c.726_727delTG; p.V243fs*18; 3:50105580-50105581	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.308G>A; p.R103H; 3:50093844-50093844	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1293G>A; p.Q431Q; 3:50110393-50110393	stomach	adenocarcinoma	Substitution - coding silent
c.418C>A; p.R140S; 3:50100540-50100540	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2412G>A; p.R804R; 3:50118420-50118420	skin	malignant_melanoma	Substitution - coding silent
c.2447_2448delGA; p.*816fs?; 3:50118455-50118456	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.2447_2448delGA; p.*816fs?; 3:50118455-50118456	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2447_2448delGA; p.*816fs?; 3:50118455-50118456	stomach	carcinoma; diffuse_adenocarcinoma	Deletion - Frameshift
c.2447_2448delGA; p.*816fs?; 3:50118455-50118456	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.486A>C; p.K162N; 3:50103085-50103085	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2447_2448delGA; p.*816fs?; 3:50118455-50118456	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2447_2448delGA; p.*816fs?; 3:50118455-50118456	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2447_2448delGA; p.*816fs?; 3:50118455-50118456	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2447_2448delGA; p.*816fs?; 3:50118455-50118456	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2110C>T; p.R704*; 3:50117089-50117089	breast	carcinoma	Substitution - Nonsense
c.2447_2448delGA; p.*816fs?; 3:50118455-50118456	breast	carcinoma	Deletion - Frameshift
c.2447_2448delGA; p.*816fs?; 3:50118455-50118456	skin	malignant_melanoma	Deletion - Frameshift
c.2447_2448delGA; p.*816fs?; 3:50118455-50118456	NS	malignant_melanoma	Deletion - Frameshift
c.2447_2448delGA; p.*816fs?; 3:50118455-50118456	skin	malignant_melanoma	Deletion - Frameshift
c.2447_2448delGA; p.*816fs?; 3:50118455-50118456	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2447_2448delGA; p.*816fs?; 3:50118455-50118456	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2447_2448delGA; p.*816fs?; 3:50118455-50118456	liver	carcinoma	Deletion - Frameshift
c.2447_2448delGA; p.*816fs?; 3:50118455-50118456	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1717A>G; p.R573G; 3:50114049-50114049	liver	carcinoma	Substitution - Missense
c.82C>T; p.R28C; 3:50092107-50092107	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1717A>G; p.R573G; 3:50114049-50114049	liver	carcinoma	Substitution - Missense
c.2342G>C; p.G781A; 3:50118350-50118350	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1684delT; p.Q563fs*6; 3:50114016-50114016	breast	carcinoma	Deletion - Frameshift
c.2006C>T; p.S669L; 3:50115594-50115594	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.536G>C; p.R179T; 3:50103135-50103135	liver	carcinoma	Substitution - Missense
c.536G>C; p.R179T; 3:50103135-50103135	liver	carcinoma	Substitution - Missense
c.335G>A; p.S112N; 3:50093871-50093871	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.898C>T; p.P300S; 3:50106809-50106809	skin	malignant_melanoma	Substitution - Missense
c.2071G>C; p.A691P; 3:50115957-50115957	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1666G>T; p.E556*; 3:50113998-50113998	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2052G>C; p.L684L; 3:50115938-50115938	liver	carcinoma	Substitution - coding silent
c.2052G>C; p.L684L; 3:50115938-50115938	liver	carcinoma	Substitution - coding silent
c.954-3C>G; p.?; 3:50107479-50107479	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.2092G>A; p.E698K; 3:50115978-50115978	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.986G>A; p.S329N; 3:50107514-50107514	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.990T>C; p.A330A; 3:50107518-50107518	thyroid	other; neoplasm	Substitution - coding silent
c.83G>A; p.R28H; 3:50092108-50092108	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1369C>T; p.P457S; 3:50110684-50110684	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1553G>A; p.G518D; 3:50113480-50113480	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2276G>T; p.G759V; 3:50117333-50117333	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.795A>T; p.I265I; 3:50105649-50105649	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2104C>T; p.R702*; 3:50117083-50117083	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Nonsense
c.161A>G; p.Y54C; 3:50092186-50092186	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1961G>T; p.R654L; 3:50115549-50115549	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1727C>T; p.S576F; 3:50114059-50114059	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1727C>T; p.S576F; 3:50114059-50114059	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.307C>T; p.R103C; 3:50093843-50093843	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.255C>T; p.H85H; 3:50093791-50093791	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1335T>C; p.P445P; 3:50110435-50110435	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.503G>C; p.G168A; 3:50103102-50103102	liver	carcinoma	Substitution - Missense
c.503G>C; p.G168A; 3:50103102-50103102	liver	carcinoma	Substitution - Missense
c.1502delA; p.E503fs*49; 3:50113429-50113429	skin; mucosal	malignant_melanoma	Deletion - Frameshift
c.2373T>A; p.Y791*; 3:50118381-50118381	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Nonsense
c.1A>T; p.M1L; 3:50090435-50090435	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1A>T; p.M1L; 3:50090435-50090435	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1636C>T; p.R546C; 3:50113968-50113968	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1740C>T; p.D580D; 3:50114072-50114072	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1740C>T; p.D580D; 3:50114072-50114072	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.495G>A; p.V165V; 3:50103094-50103094	liver	carcinoma	Substitution - coding silent
c.495G>A; p.V165V; 3:50103094-50103094	liver	carcinoma	Substitution - coding silent
c.398_399AG>TC; p.K133I; 3:50100040-50100041	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2368G>A; p.A790T; 3:50118376-50118376	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.35G>A; p.R12H; 3:50092060-50092060	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.164G>A; p.R55Q; 3:50092189-50092189	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1070A>G; p.D357G; 3:50108098-50108098	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1810C>T; p.R604*; 3:50114222-50114222	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1439A>G; p.Y480C; 3:50110754-50110754	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.606C>T; p.F202F; 3:50104286-50104286	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1455A>G; p.Q485Q; 3:50110770-50110770	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1278G>A; p.P426P; 3:50109688-50109688	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.137G>A; p.R46Q; 3:50092162-50092162	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2410C>T; p.R804W; 3:50118418-50118418	skin	malignant_melanoma	Substitution - Missense
c.344G>C; p.R115P; 3:50099986-50099986	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1057G>C; p.G353R; 3:50108085-50108085	prostate	adenoma	Substitution - Missense
c.1515C>T; p.Y505Y; 3:50113442-50113442	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.105G>T; p.R35S; 3:50092130-50092130	skin	malignant_melanoma	Substitution - Missense
c.136C>T; p.R46W; 3:50092161-50092161	skin; mucosal	malignant_melanoma	Substitution - Missense
c.417C>T; p.S139S; 3:50100539-50100539	skin	malignant_melanoma	Substitution - coding silent
c.1653G>C; p.L551F; 3:50113985-50113985	breast	carcinoma	Substitution - Missense
c.1119+1G>A; p.?; 3:50108148-50108148	lung	carcinoma; adenocarcinoma	Unknown
c.443A>G; p.Y148C; 3:50100565-50100565	breast	carcinoma	Substitution - Missense
c.279C>T; p.D93D; 3:50093815-50093815	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2165G>A; p.R722H; 3:50117144-50117144	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.524A>G; p.Y175C; 3:50103123-50103123	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1242G>A; p.Q414Q; 3:50109652-50109652	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2332C>T; p.R778W; 3:50118340-50118340	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1295C>A; p.P432H; 3:50110395-50110395	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2409C>T; p.V803V; 3:50118417-50118417	skin	malignant_melanoma	Substitution - coding silent
c.1971G>A; p.P657P; 3:50115559-50115559	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.983T>C; p.V328A; 3:50107511-50107511	prostate	carcinoma	Substitution - Missense
c.2381C>T; p.S794L; 3:50118389-50118389	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1327G>A; p.A443T; 3:50110427-50110427	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.788G>A; p.R263H; 3:50105642-50105642	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1276C>T; p.P426S; 3:50109686-50109686	skin	malignant_melanoma	Substitution - Missense
c.788G>A; p.R263H; 3:50105642-50105642	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1903_1904delGA; p.S636fs*1; 3:50115491-50115492	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.533C>T; p.P178L; 3:50103132-50103132	skin	malignant_melanoma	Substitution - Missense
c.1027T>C; p.W343R; 3:50107555-50107555	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.268G>A; p.D90N; 3:50093804-50093804	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.316C>T; p.P106S; 3:50093852-50093852	skin	malignant_melanoma	Substitution - Missense
c.102G>A; p.R34R; 3:50092127-50092127	skin	malignant_melanoma	Substitution - coding silent
c.2399A>G; p.K800R; 3:50118407-50118407	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.616G>A; p.A206T; 3:50104296-50104296	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.968C>T; p.S323L; 3:50107496-50107496	urinary_tract; bladder	carcinoma	Substitution - Missense
c.968C>T; p.S323L; 3:50107496-50107496	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1982delC; p.L662fs*1; 3:50115570-50115570	liver	carcinoma	Deletion - Frameshift
c.1267C>T; p.P423S; 3:50109677-50109677	skin	malignant_melanoma	Substitution - Missense
c.2336T>G; p.L779R; 3:50118344-50118344	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1909G>A; p.E637K; 3:50115497-50115497	breast	carcinoma	Substitution - Missense
c.2376T>C; p.G792G; 3:50118384-50118384	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1110_1111insA; p.Y371fs*22; 3:50108138-50108139	breast	carcinoma; basal_(triple-negative)_carcinoma	Insertion - Frameshift
c.275G>A; p.S92N; 3:50093811-50093811	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2428C>T; p.R810W; 3:50118436-50118436	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation