lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1001
Symbol	CDH3
Synonymous	CDHP\|HJMD\|PCAD
Full name	cadherin 3, type 1, P-cadherin (placental)
Gene description	cadherin-3\|calcium-dependent adhesion protein, placental
Cytoband	16q22.1
Gene type	protein-coding
Synonymous	MIM:114021; HGNC:HGNC:1762; Ensembl:ENSG00000062038; HPRD:00227; Vega:OTTHUMG00000137560

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1984G>A; p.A662T; 16:68691908-68691908	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.292T>C; p.S98P; 16:68678179-68678179	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1031A>G; p.H344R; 16:68682336-68682336	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.803T>C; p.L268P; 16:68679910-68679910	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.495C>T; p.G165G; 16:68678605-68678605	liver	carcinoma	Substitution - coding silent
c.1093A>G; p.T365A; 16:68682398-68682398	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1914C>T; p.C638C; 16:68691838-68691838	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.613G>A; p.V205M; 16:68678828-68678828	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1827_1828CC>TT; p.(=); 16:68691751-68691752	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.613G>A; p.V205M; 16:68678828-68678828	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.619G>A; p.D207N; 16:68678834-68678834	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1120G>A; p.G374R; 16:68682425-68682425	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.45+1G>C; p.?; 16:68645425-68645425	ovary	other; neoplasm	Unknown
c.1104C>A; p.I368I; 16:68682409-68682409	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2470G>A; p.G824S; 16:68698380-68698380	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2464A>G; p.M822V; 16:68698374-68698374	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1201A>T; p.K401*; 16:68684601-68684601	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2469C>T; p.Y823Y; 16:68698379-68698379	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1541A>G; p.Y514C; 16:68685321-68685321	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1504G>A; p.D502N; 16:68685284-68685284	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1111G>A; p.G371S; 16:68682416-68682416	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1111G>A; p.G371S; 16:68682416-68682416	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2084G>A; p.R695H; 16:68695336-68695336	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2192G>A; p.R731H; 16:68695835-68695835	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2337G>T; p.V779V; 16:68698247-68698247	skin	malignant_melanoma	Substitution - coding silent
c.1182G>T; p.K394N; 16:68682487-68682487	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.444G>A; p.P148P; 16:68678554-68678554	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1499C>T; p.T500I; 16:68685279-68685279	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2331C>A; p.L777L; 16:68698241-68698241	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1621G>A; p.V541I; 16:68687562-68687562	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1775C>T; p.T592M; 16:68687716-68687716	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.417C>A; p.T139T; 16:68678527-68678527	skin	malignant_melanoma	Substitution - coding silent
c.543T>A; p.Y181*; 16:68678653-68678653	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1659C>T; p.I553I; 16:68687600-68687600	skin	malignant_melanoma	Substitution - coding silent
c.1651C>T; p.R551C; 16:68687592-68687592	skin	malignant_melanoma	Substitution - Missense
c.2068C>T; p.P690S; 16:68695320-68695320	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1788C>T; p.N596N; 16:68687729-68687729	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2461G>A; p.D821N; 16:68698371-68698371	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1956G>A; p.K652K; 16:68691880-68691880	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1956G>A; p.K652K; 16:68691880-68691880	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2092G>A; p.V698I; 16:68695344-68695344	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.559G>A; p.A187T; 16:68678774-68678774	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.900C>T; p.A300A; 16:68681000-68681000	breast	carcinoma	Substitution - coding silent
c.1785C>T; p.V595V; 16:68687726-68687726	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.218T>A; p.F73Y; 16:68676442-68676442	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.650A>G; p.Q217R; 16:68678865-68678865	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1207C>T; p.Q403*; 16:68684607-68684607	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.605C>T; p.S202F; 16:68678820-68678820	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1076C>T; p.S359L; 16:68682381-68682381	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1003G>A; p.A335T; 16:68682308-68682308	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.235G>A; p.E79K; 16:68676459-68676459	prostate	adenoma	Substitution - Missense
c.1505A>G; p.D502G; 16:68685285-68685285	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1592C>A; p.T531K; 16:68687533-68687533	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1536C>T; p.N512N; 16:68685316-68685316	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2106C>T; p.G702G; 16:68695358-68695358	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1113T>C; p.G371G; 16:68682418-68682418	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.431G>A; p.S144N; 16:68678541-68678541	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1932C>T; p.V644V; 16:68691856-68691856	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.935C>T; p.A312V; 16:68681035-68681035	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.853G>T; p.G285C; 16:68679960-68679960	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2476G>T; p.G826W; 16:68698386-68698386	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.891C>T; p.T297T; 16:68680991-68680991	skin	malignant_melanoma	Substitution - coding silent
c.1191T>A; p.D397E; 16:68684591-68684591	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.518T>C; p.L173P; 16:68678628-68678628	pancreas	carcinoma	Substitution - Missense
c.502T>A; p.L168M; 16:68678612-68678612	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1981G>T; p.G661W; 16:68691905-68691905	breast	carcinoma	Substitution - Missense
c.2420A>T; p.D807V; 16:68698330-68698330	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1756G>T; p.D586Y; 16:68687697-68687697	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.311G>A; p.R104K; 16:68678198-68678198	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.949G>T; p.E317*; 16:68681049-68681049	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1237G>A; p.E413K; 16:68684637-68684637	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1237G>A; p.E413K; 16:68684637-68684637	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1689G>C; p.Q563H; 16:68687630-68687630	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1689G>C; p.Q563H; 16:68687630-68687630	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1689G>C; p.Q563H; 16:68687630-68687630	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1403A>G; p.D468G; 16:68684803-68684803	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1689G>C; p.Q563H; 16:68687630-68687630	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.491C>T; p.T164I; 16:68678601-68678601	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.720G>A; p.T240T; 16:68679827-68679827	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.862C>T; p.R288W; 16:68679969-68679969	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2213T>C; p.I738T; 16:68695856-68695856	NS	NS	Substitution - Missense
c.2360C>G; p.S787C; 16:68698270-68698270	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.932C>T; p.T311M; 16:68681032-68681032	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.437C>T; p.T146M; 16:68678547-68678547	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1065C>T; p.D355D; 16:68682370-68682370	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1065C>T; p.D355D; 16:68682370-68682370	breast	carcinoma	Substitution - coding silent
c.1626T>C; p.N542N; 16:68687567-68687567	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.680G>T; p.G227V; 16:68678895-68678895	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.1626T>C; p.N542N; 16:68687567-68687567	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2418C>T; p.Y806Y; 16:68698328-68698328	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1196A>G; p.E399G; 16:68684596-68684596	skin; arm	malignant_melanoma	Substitution - Missense
c.1118A>G; p.D373G; 16:68682423-68682423	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1118A>G; p.D373G; 16:68682423-68682423	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1290C>T; p.H430H; 16:68684690-68684690	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1904C>T; p.A635V; 16:68691828-68691828	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2380T>C; p.S794P; 16:68698290-68698290	liver	carcinoma	Substitution - Missense
c.1725C>T; p.H575H; 16:68687666-68687666	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2011C>T; p.L671L; 16:68695263-68695263	stomach	adenocarcinoma	Substitution - coding silent
c.644T>G; p.F215C; 16:68678859-68678859	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1114G>A; p.D372N; 16:68682419-68682419	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.31_33delCTC; p.L11delL; 16:68645410-68645412	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - In frame
c.288C>T; p.F96F; 16:68678175-68678175	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.705G>T; p.M235I; 16:68679812-68679812	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1364C>T; p.T455I; 16:68684764-68684764	urinary_tract; bladder	carcinoma	Substitution - Missense
c.370T>C; p.F124L; 16:68678257-68678257	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2484C>T; p.D828D; 16:68698394-68698394	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2059C>T; p.L687F; 16:68695311-68695311	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.612C>A; p.I204I; 16:68678827-68678827	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1648C>A; p.P550T; 16:68687589-68687589	skin	malignant_melanoma	Substitution - Missense
c.781G>C; p.E261Q; 16:68679888-68679888	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2355C>T; p.S785S; 16:68698265-68698265	pancreas	carcinoma	Substitution - coding silent
c.474C>T; p.F158F; 16:68678584-68678584	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.474C>T; p.F158F; 16:68678584-68678584	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.820C>T; p.R274W; 16:68679927-68679927	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2239C>A; p.R747R; 16:68695882-68695882	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2239C>A; p.R747R; 16:68695882-68695882	thyroid	other; neoplasm	Substitution - coding silent
c.1996C>T; p.L666L; 16:68691920-68691920	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2459C>T; p.A820V; 16:68698369-68698369	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.226C>T; p.R76W; 16:68676450-68676450	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.308G>A; p.R103Q; 16:68678195-68678195	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2262C>T; p.I754I; 16:68695905-68695905	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2262C>T; p.I754I; 16:68695905-68695905	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2169G>T; p.E723D; 16:68695812-68695812	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2395G>A; p.A799T; 16:68698305-68698305	breast	carcinoma	Substitution - Missense
c.813C>A; p.T271T; 16:68679920-68679920	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.813C>A; p.T271T; 16:68679920-68679920	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1790A>C; p.E597A; 16:68687731-68687731	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1339G>A; p.V447I; 16:68684739-68684739	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1726A>C; p.T576P; 16:68687667-68687667	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1844A>G; p.Y615C; 16:68691768-68691768	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.525_526GG>TT; p.R175>?; 16:68678635-68678636	lung	carcinoma; adenocarcinoma	Complex
c.1115A>G; p.D372G; 16:68682420-68682420	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.524G>A; p.R175Q; 16:68678634-68678634	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.426C>A; p.F142L; 16:68678536-68678536	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1116C>T; p.D372D; 16:68682421-68682421	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.245A>G; p.Q82R; 16:68676469-68676469	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.245A>G; p.Q82R; 16:68676469-68676469	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1116C>T; p.D372D; 16:68682421-68682421	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.245A>G; p.Q82R; 16:68676469-68676469	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1087C>T; p.R363C; 16:68682392-68682392	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2368G>A; p.A790T; 16:68698278-68698278	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation