lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	10000
Symbol	AKT3
Synonymous	MPPH\|MPPH2\|PKB-GAMMA\|PKBG\|PRKBG\|RAC-PK-gamma\|RAC-gamma\|STK-2
Full name	v-akt murine thymoma viral oncogene homolog 3
Gene description	PKB gamma\|RAC-gamma serine/threonine protein kinase\|RAC-gamma serine/threonine-protein kinase\|v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Cytoband	1q44
Gene type	protein-coding
Synonymous	MIM:611223; HGNC:HGNC:393; Ensembl:ENSG00000117020; HPRD:06441; Vega:OTTHUMG00000039994

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1080G>A; p.M360I; 1:243552812-243552812	skin	malignant_melanoma	Substitution - Missense
c.820T>C; p.L274L; 1:243563848-243563848	breast	carcinoma	Substitution - coding silent
c.1080G>A; p.M360I; 1:243552812-243552812	skin	malignant_melanoma	Substitution - Missense
c.47-2A>C; p.?; 1:243695718-243695718	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.841A>G; p.K281E; 1:243563827-243563827	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1035T>A; p.P345P; 1:243552857-243552857	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.342G>A; p.E114E; 1:243645980-243645980	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.325C>A; p.L109M; 1:243645997-243645997	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.892A>G; p.T298A; 1:243563776-243563776	stomach	carcinoma	Substitution - Missense
c.1345C>T; p.P449S; 1:243512333-243512333	skin	malignant_melanoma	Substitution - Missense
c.819+7A>C; p.?; 1:243572919-243572919	pancreas	carcinoma	Unknown
c.323G>T; p.R108I; 1:243645999-243645999	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.120G>A; p.E40E; 1:243695643-243695643	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.196C>T; p.R66*; 1:243664860-243664860	breast	carcinoma	Substitution - Nonsense
c.250G>A; p.E84K; 1:243664806-243664806	breast	carcinoma	Substitution - Missense
c.496C>T; p.R166*; 1:243637676-243637676	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.496C>T; p.R166*; 1:243637676-243637676	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.92C>T; p.T31I; 1:243695671-243695671	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.496C>T; p.R166*; 1:243637676-243637676	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.856A>C; p.K286Q; 1:243563812-243563812	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.687T>G; p.N229K; 1:243613680-243613680	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.825G>A; p.E275E; 1:243563843-243563843	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.825G>A; p.E275E; 1:243563843-243563843	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.433A>C; p.M145L; 1:243637739-243637739	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.834G>A; p.M278I; 1:243563834-243563834	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.180G>T; p.Q60H; 1:243664876-243664876	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.524C>A; p.A175D; 1:243637648-243637648	genital_tract; extragonadal	germ_cell_tumour; yolk_sac_tumour	Substitution - Missense
c.621T>G; p.F207L; 1:243615102-243615102	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1334C>G; p.T445R; 1:243512344-243512344	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1324C>T; p.Q442*; 1:243512354-243512354	oesophagus	carcinoma	Substitution - Nonsense
c.94G>A; p.D32N; 1:243695669-243695669	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.447C>T; p.D149D; 1:243637725-243637725	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1061T>G; p.L354R; 1:243552831-243552831	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.113A>T; p.Y38F; 1:243695650-243695650	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.928C>G; p.P310A; 1:243563740-243563740	breast	carcinoma	Substitution - Missense
c.44G>T; p.R15M; 1:243843127-243843127	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.109G>T; p.G37*; 1:243695654-243695654	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; chronic_myeloid_leukaemia	Substitution - Nonsense
c.825G>T; p.E275D; 1:243563843-243563843	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1355-1G>T; p.?; 1:243505335-243505335	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1348G>A; p.E450K; 1:243512330-243512330	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.642C>A; p.S214S; 1:243613725-243613725	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.765T>C; p.I255I; 1:243572980-243572980	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.573A>T; p.A191A; 1:243615150-243615150	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.430-5T>A; p.?; 1:243637747-243637747	oesophagus	carcinoma; adenocarcinoma	Unknown
c.1056G>T; p.E352D; 1:243552836-243552836	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1394G>A; p.R465Q; 1:243505295-243505295	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.511G>A; p.G171R; 1:243637661-243637661	central_nervous_system; brain	glioma	Substitution - Missense
c.511G>A; p.G171R; 1:243637661-243637661	central_nervous_system; brain	glioma	Substitution - Missense
c.1100G>A; p.R367Q; 1:243552792-243552792	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.285-1G>A; p.?; 1:243646038-243646038	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.516delA; p.K172fs*5; 1:243637656-243637656	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1100G>A; p.R367Q; 1:243552792-243552792	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.425G>T; p.R142I; 1:243645897-243645897	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.929C>G; p.P310R; 1:243563739-243563739	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1256T>C; p.V419A; 1:243512422-243512422	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1256T>C; p.V419A; 1:243512422-243512422	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.398T>C; p.M133T; 1:243645924-243645924	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.224G>T; p.R75I; 1:243664832-243664832	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1175G>A; p.G392E; 1:243545586-243545586	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1335A>C; p.T445T; 1:243512343-243512343	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.136G>C; p.D46H; 1:243695627-243695627	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.433A>G; p.M145V; 1:243637739-243637739	liver	carcinoma	Substitution - Missense
c.1188A>G; p.A396A; 1:243545573-243545573	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.232C>A; p.Q78K; 1:243664824-243664824	prostate	carcinoma	Substitution - Missense
c.232C>A; p.Q78K; 1:243664824-243664824	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.433A>G; p.M145V; 1:243637739-243637739	liver	carcinoma	Substitution - Missense
c.1397C>T; p.P466L; 1:243505292-243505292	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.469G>T; p.G157C; 1:243637703-243637703	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1163+1G>A; p.?; 1:243552728-243552728	skin	malignant_melanoma	Unknown
c.49G>A; p.E17K; 1:243695714-243695714	skin; extremity	malignant_melanoma	Substitution - Missense
c.49G>A; p.E17K; 1:243695714-243695714	skin	malignant_melanoma	Substitution - Missense
c.49G>A; p.E17K; 1:243695714-243695714	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1183G>T; p.D395Y; 1:243545578-243545578	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1096C>T; p.P366S; 1:243552796-243552796	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1124C>A; p.S375*; 1:243552768-243552768	breast	carcinoma	Substitution - Nonsense
c.109G>A; p.G37R; 1:243695654-243695654	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.797A>G; p.K266R; 1:243572948-243572948	pancreas	carcinoma	Substitution - Missense
c.66G>T; p.W22C; 1:243695697-243695697	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.289G>T; p.E97*; 1:243646033-243646033	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.902C>A; p.A301D; 1:243563766-243563766	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1118C>G; p.A373G; 1:243552774-243552774	breast	carcinoma	Substitution - Missense
c.808C>T; p.R270C; 1:243572937-243572937	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.415C>T; p.H139Y; 1:243645907-243645907	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1433G>A; p.R478Q; 1:243505256-243505256	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1355-6C>T; p.?; 1:243505340-243505340	stomach	adenocarcinoma	Unknown
c.793G>A; p.G265R; 1:243572952-243572952	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.420T>C; p.H140H; 1:243645902-243645902	liver	carcinoma	Substitution - coding silent
c.420T>C; p.H140H; 1:243645902-243645902	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.993C>T; p.G331G; 1:243552899-243552899	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1425A>T; p.A475A; 1:243505264-243505264	kidney	other; neoplasm	Substitution - coding silent
c.116A>T; p.K39I; 1:243695647-243695647	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.262C>A; p.H88N; 1:243664794-243664794	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.723G>T; p.R241R; 1:243573022-243573022	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - coding silent
c.699G>C; p.L233L; 1:243573046-243573046	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1134A>G; p.S378S; 1:243552758-243552758	breast	carcinoma; ER-PR-positive_carcinoma	Substitution - coding silent
c.371A>T; p.Q124L; 1:243645951-243645951	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.197G>T; p.R66L; 1:243664859-243664859	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.630C>A; p.S210S; 1:243613737-243613737	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1192G>T; p.E398*; 1:243545569-243545569	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1192G>T; p.E398*; 1:243545569-243545569	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.514A>C; p.K172Q; 1:243637658-243637658	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.791C>T; p.S264F; 1:243572954-243572954	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.514A>C; p.K172Q; 1:243637658-243637658	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.514A>C; p.K172Q; 1:243637658-243637658	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.152T>G; p.L51R; 1:243695611-243695611	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.567A>G; p.E189E; 1:243615156-243615156	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.386G>A; p.G129E; 1:243645936-243645936	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1062T>G; p.L354L; 1:243552830-243552830	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.178C>G; p.Q60E; 1:243664878-243664878	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.898G>A; p.A300T; 1:243563770-243563770	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.838G>C; p.D280H; 1:243563830-243563830	urinary_tract; bladder	carcinoma	Substitution - Missense
c.899C>T; p.A300V; 1:243563769-243563769	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.561G>A; p.K187K; 1:243637611-243637611	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.148C>T; p.P50S; 1:243695615-243695615	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.61A>C; p.N21H; 1:243695702-243695702	pancreas	carcinoma	Substitution - Missense
c.1185T>G; p.D395E; 1:243545576-243545576	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.860T>G; p.I287S; 1:243563808-243563808	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1383C>T; p.D461D; 1:243505306-243505306	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1212C>G; p.F404L; 1:243545549-243545549	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.391G>A; p.E131K; 1:243645931-243645931	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.567A>C; p.E189D; 1:243615156-243615156	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation