lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	10
Symbol	NAT2
Synonymous	AAC2\|NAT-2\|PNAT
Full name	N-acetyltransferase 2 (arylamine N-acetyltransferase)
Gene description	N-acetyltransferase type 2\|arylamide acetylase 2\|arylamine N-acetyltransferase 2
Cytoband	8p22
Gene type	protein-coding
Synonymous	MIM:612182; HGNC:HGNC:7646; Ensembl:ENSG00000156006; HPRD:02000; Vega:OTTHUMG00000130826

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.493A>T; p.R165W; 8:18400496-18400496	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.317T>C; p.V106A; 8:18400320-18400320	skin	malignant_melanoma	Substitution - Missense
c.427C>T; p.Q143*; 8:18400430-18400430	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.854A>G; p.D285G; 8:18400857-18400857	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.63G>A; p.L21L; 8:18400066-18400066	skin	malignant_melanoma	Substitution - coding silent
c.199T>C; p.W67R; 8:18400202-18400202	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.457A>T; p.T153S; 8:18400460-18400460	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.633G>A; p.T211T; 8:18400636-18400636	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.386C>T; p.S129F; 8:18400389-18400389	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.87G>T; p.E29D; 8:18400090-18400090	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.792A>G; p.E264E; 8:18400795-18400795	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.197G>A; p.G66E; 8:18400200-18400200	skin	malignant_melanoma	Substitution - Missense
c.491T>C; p.I164T; 8:18400494-18400494	skin; extremity	malignant_melanoma	Substitution - Missense
c.287C>T; p.P96L; 8:18400290-18400290	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.730T>C; p.F244L; 8:18400733-18400733	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.843C>T; p.P281P; 8:18400846-18400846	skin	malignant_melanoma	Substitution - coding silent
c.760G>T; p.E254*; 8:18400763-18400763	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.790G>A; p.E264K; 8:18400793-18400793	skin	malignant_melanoma	Substitution - Missense
c.647C>T; p.S216L; 8:18400650-18400650	skin	malignant_melanoma	Substitution - Missense
c.269G>A; p.G90E; 8:18400272-18400272	skin	malignant_melanoma	Substitution - Missense
c.376G>A; p.G126R; 8:18400379-18400379	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.20T>A; p.F7Y; 8:18400023-18400023	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.200G>A; p.W67*; 8:18400203-18400203	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.540C>A; p.L180L; 8:18400543-18400543	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.345C>T; p.D115D; 8:18400348-18400348	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.345C>T; p.D115D; 8:18400348-18400348	prostate	carcinoma	Substitution - coding silent
c.345C>T; p.D115D; 8:18400348-18400348	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.406G>T; p.E136*; 8:18400409-18400409	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.481C>T; p.L161L; 8:18400484-18400484	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.481C>T; p.L161L; 8:18400484-18400484	thyroid	other; neoplasm	Substitution - coding silent
c.673T>C; p.L225L; 8:18400676-18400676	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.673T>C; p.L225L; 8:18400676-18400676	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.578C>T; p.T193M; 8:18400581-18400581	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.590G>A; p.R197Q; 8:18400593-18400593	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.342T>C; p.I114I; 8:18400345-18400345	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.4G>A; p.D2N; 8:18400007-18400007	skin	malignant_melanoma	Substitution - Missense
c.632C>T; p.T211M; 8:18400635-18400635	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.725G>T; p.R242I; 8:18400728-18400728	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.725G>T; p.R242I; 8:18400728-18400728	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.465G>A; p.E155E; 8:18400468-18400468	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.159G>T; p.E53D; 8:18400162-18400162	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.159G>T; p.E53D; 8:18400162-18400162	stomach	adenocarcinoma	Substitution - Missense
c.834T>C; p.N278N; 8:18400837-18400837	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.39G>A; p.K13K; 8:18400042-18400042	skin	malignant_melanoma	Substitution - coding silent
c.26G>T; p.R9I; 8:18400029-18400029	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.26G>T; p.R9I; 8:18400029-18400029	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.494G>A; p.R165K; 8:18400497-18400497	skin	malignant_melanoma	Substitution - Missense
c.838G>A; p.V280M; 8:18400841-18400841	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.627G>T; p.L209L; 8:18400630-18400630	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.598G>A; p.E200K; 8:18400601-18400601	skin	malignant_melanoma	Substitution - Missense
c.306C>T; p.S102S; 8:18400309-18400309	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.26G>A; p.R9K; 8:18400029-18400029	skin	malignant_melanoma	Substitution - Missense
c.282C>T; p.Y94Y; 8:18400285-18400285	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.523T>A; p.F175I; 8:18400526-18400526	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.351G>A; p.R117R; 8:18400354-18400354	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.351G>A; p.R117R; 8:18400354-18400354	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.551A>C; p.K184T; 8:18400554-18400554	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.98G>A; p.R33Q; 8:18400101-18400101	central_nervous_system; brain	glioma	Substitution - Missense
c.246C>T; p.I82I; 8:18400249-18400249	skin	malignant_melanoma	Substitution - coding silent
c.399G>C; p.Q133H; 8:18400402-18400402	central_nervous_system; brain	glioma	Substitution - Missense
c.821C>T; p.S274F; 8:18400824-18400824	skin	malignant_melanoma	Substitution - Missense
c.821C>T; p.S274F; 8:18400824-18400824	skin	malignant_melanoma	Substitution - Missense
c.821C>T; p.S274F; 8:18400824-18400824	skin	malignant_melanoma	Substitution - Missense
c.160G>A; p.A54T; 8:18400163-18400163	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.160G>A; p.A54T; 8:18400163-18400163	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.775A>G; p.T259A; 8:18400778-18400778	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.194G>A; p.G65D; 8:18400197-18400197	haematopoietic_and_lymphoid_tissue; spleen	lymphoid_neoplasm; marginal_zone_lymphoma	Substitution - Missense
c.48G>A; p.R16R; 8:18400051-18400051	skin	malignant_melanoma	Substitution - coding silent
c.48G>A; p.R16R; 8:18400051-18400051	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.837C>T; p.L279L; 8:18400840-18400840	skin	malignant_melanoma	Substitution - coding silent
c.400C>T; p.P134S; 8:18400403-18400403	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.760G>A; p.E254K; 8:18400763-18400763	skin	malignant_melanoma	Substitution - Missense
c.208C>T; p.Q70*; 8:18400211-18400211	skin	malignant_melanoma	Substitution - Nonsense
c.208C>T; p.Q70*; 8:18400211-18400211	skin	malignant_melanoma	Substitution - Nonsense
c.674T>C; p.L225S; 8:18400677-18400677	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.732C>G; p.F244L; 8:18400735-18400735	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.732C>G; p.F244L; 8:18400735-18400735	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.270A>T; p.G90G; 8:18400273-18400273	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.816G>T; p.K272N; 8:18400819-18400819	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation