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Cancer metastasis database

Annotation category 5

Gene information

Gene ID 6464
Symbol

SHC1

Synonymous

SHC|SHCA

Full name

SHC (Src homology 2 domain containing) transforming protein 1

Gene description

SH2 domain protein C1|SHC (Src homology 2 domain-containing) transforming protein 1|SHC-transforming protein 1|SHC-transforming protein 3|SHC-transforming protein A

Cytoband

1q21

Gene type

protein-coding

Synonymous

MIM:600560; HGNC:HGNC:10840; Ensembl:ENSG00000160691; HPRD:02780; Vega:OTTHUMG00000037295

Pathway and disease

Pathways and Diseases

Detail

Pathway

il-2 receptor beta chain in t cell activation;PID BioCarta;100129

Pathway

role of erbb2 in signal transduction and oncology;PID BioCarta;100147

Pathway

Signaling by Insulin receptor;Reactome;REACT:498

Pathway

insulin signaling pathway;PID BioCarta;100124

Pathway

pdgf signaling pathway;PID BioCarta;100077

Pathway

PDGFR-beta signaling pathway;PID Curated;200127

Pathway

sprouty regulation of tyrosine kinase signals;PID BioCarta;100029

Pathway

FGF signaling pathway;PANTHER;P00021

Pathway

Bacterial invasion of epithelial cells;KEGG PATHWAY;hsa05100

Pathway

pten dependent cell cycle arrest and apoptosis;PID BioCarta;100058

Pathway

EPHB forward signaling;PID Curated;200041

Pathway

PDGF signaling pathway;PANTHER;P00047

Pathway

egf signaling pathway;PID BioCarta;100181

Pathway

EGF receptor signaling pathway;PANTHER;P00018

Pathway

EPHA2 forward signaling;PID Curated;200185

Pathway

nfat and hypertrophy of the heart ;PID BioCarta;100098

Pathway

the igf-1 receptor and longevity;PID BioCarta;100115

Pathway

bcr signaling pathway;PID BioCarta;100227

Pathway

erk1/erk2 mapk signaling pathway;PID BioCarta;100170

Pathway

Signaling events mediated by PTP1B;PID Curated;200033

Pathway

tpo signaling pathway;PID BioCarta;100012

Pathway

mcalpain and friends in cell motility;PID BioCarta;100111

Pathway

IL2 signaling events mediated by PI3K;PID Curated;200099

Pathway

ErbB4 signaling events;PID Curated;200009

Pathway

trka receptor signaling pathway;PID BioCarta;100011

Pathway

role of egf receptor transactivation by gpcrs in cardiac hypertrophy;PID BioCarta;100221

Pathway

Integrin alphaIIbbeta3 signaling;PID Reactome;500005

Pathway

Signaling events mediated by TCPTP;PID Curated;200065

Pathway

multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation;PID BioCarta;100135

Pathway

BCR signaling pathway;PID Curated;200005

Pathway

Insulin signaling pathway;KEGG PATHWAY;hsa04910

Pathway

IL2 signaling events mediated by STAT5;PID Curated;200158

Pathway

EGFR-dependent Endothelin signaling events;PID Curated;200095

Pathway

Integrin cell surface interactions;Reactome;REACT:13552

Pathway

Diabetes pathways;Reactome;REACT:15380

Pathway

growth hormone signaling pathway;PID BioCarta;100155

Pathway

IL2-mediated signaling events;PID Curated;200082

Pathway

epo signaling pathway;PID BioCarta;100175

Pathway

Signal attenuation;PID Reactome;500505

Pathway

TCR signaling in naive CD4+ T cells;PID Curated;200022

Pathway

phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway;PID BioCarta;100210

Pathway

Angiogenesis;PANTHER;P00005

Pathway

phospholipids as signalling intermediaries;PID BioCarta;100183

Pathway

IGF1 pathway;PID Curated;200084

Pathway

transcription factor creb and its extracellular signals;PID BioCarta;100198

Pathway

Signaling by EGFR;Reactome;REACT:9417

Pathway

Glioma;KEGG PATHWAY;hsa05214

Pathway

Interleukin signaling pathway;PANTHER;P00036

Pathway

Tie2 Signaling;PID Reactome;500306

Pathway

Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722

Pathway

trefoil factors initiate mucosal healing;PID BioCarta;100018

Pathway

p75(NTR)-mediated signaling;PID Curated;200103

Pathway

Trk receptor signaling mediated by PI3K and PLC-gamma;PID Curated;200183

Pathway

TGF-beta receptor signaling;PID Curated;200195

Pathway

igf-1 signaling pathway;PID BioCarta;100136

Pathway

Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031

Pathway

Signalling by NGF;Reactome;REACT:11061

Pathway

Insulin Pathway;PID Curated;200012

Pathway

bioactive peptide induced signaling pathway;PID BioCarta;100226

Pathway

keratinocyte differentiation;PID BioCarta;100119

Pathway

angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling;PID BioCarta;100236

Pathway

Integrin signalling pathway;PANTHER;P00034

Pathway

Ras Pathway;PANTHER;P04393

Pathway

nerve growth factor pathway (ngf);PID BioCarta;100096

Pathway

Hemostasis;Reactome;REACT:604

Pathway

Internalization of ErbB1;PID Curated;200146

Pathway

vegf hypoxia and angiogenesis;PID BioCarta;100006

Pathway

a6b1 and a6b4 Integrin signaling;PID Curated;200162

Pathway

Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156

Pathway

Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650

Pathway

GMCSF-mediated signaling events;PID Curated;200015

Pathway

Signaling in Immune system;Reactome;REACT:6900

Pathway

Signaling events regulated by Ret tyrosine kinase;PID Curated;200058

Pathway

il 4 signaling pathway;PID BioCarta;100127

Pathway

Fc-epsilon receptor I signaling in mast cells;PID Curated;200003

Pathway

VEGFR3 signaling in lymphatic endothelium;PID Curated;200188

Pathway

PDGFR-alpha signaling pathway;PID Curated;200140

Pathway

Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032

Pathway

calcium signaling by hbx of hepatitis b virus;PID BioCarta;100150

Pathway

IL4-mediated signaling events;PID Curated;200018

Pathway

Shc events in EGFR signaling;PID Reactome;500513

Pathway

il 3 signaling pathway;PID BioCarta;100128

Pathway

Focal adhesion;KEGG PATHWAY;hsa04510

Pathway

Chronic myeloid leukemia;KEGG PATHWAY;hsa05220

Pathway

EPO signaling pathway;PID Curated;200157

Pathway

EGF receptor (ErbB1) signaling pathway;PID Curated;200085

Pathway

Neurotrophic factor-mediated Trk receptor signaling;PID Curated;200128

Pathway

SHC-mediated cascade;PID Reactome;500250

Pathway

role of erk5 in neuronal survival pathway;PID BioCarta;100171

Pathway

map kinase inactivation of smrt corepressor;PID BioCarta;100032

Pathway

ErbB2/ErbB3 signaling events;PID Curated;200119

Pathway

Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161

Pathway

ErbB signaling pathway;KEGG PATHWAY;hsa04012

Pathway

Plasma membrane estrogen receptor signaling;PID Curated;200029

Pathway

links between pyk2 and map kinases;PID BioCarta;100057

Pathway

t cell receptor signaling pathway;PID BioCarta;100022

Pathway

il 2 signaling pathway;PID BioCarta;100130

Pathway

TCR signaling in naive CD8+ T cells;PID Curated;200062

Pathway

fc epsilon receptor i signaling in mast cells;PID BioCarta;100165

Pathway

Angiopoietin receptor Tie2-mediated signaling;PID Curated;200066

Pathway

SHC activation;PID Reactome;500495

Pathway

integrin signaling pathway;PID BioCarta;100123

Pathway

Chemokine signaling pathway;KEGG PATHWAY;hsa04062

Pathway

il 6 signaling pathway;PID BioCarta;100126

Pathway

Signaling by FGFR;Reactome;REACT:9470

Pathway

FGF signaling pathway;PID Curated;200189

Disease

Embryoma;FunDO

Disease

Diabetes mellitus;FunDO

Disease

Prostate cancer;FunDO

Disease

Hyperglycemia;FunDO

Disease

Kidney failure;FunDO

Disease

Breast cancer;FunDO

Disease

Colon cancer;FunDO

Disease

Liver cancer;FunDO

Disease

Atherosclerosis;FunDO

Sequence Information

Nucleotide Sequence

>6464 : length: 4717
ATCTTTGTTTTTTTTTTTTTGGTCACTTTCCAGCTTTGCCTGTGGCATTCTCCGGAAGAGCAGTGGCAGGAAGCCGTGGGTGGCAGGAATGGGTTTGGGACTGTTCCCTGTGTCCAGCTT
CAACCCATCTTCTCCTGACACCCCTTTCTCCTGTACTTATTTTTCTCCTGTCCTTATTGACGCAGATGTGTCTTCTGATCTCTCTGTCCCTTCCTGGCCTGTAGTTTCTACTTCTCTTGG
AGAACTGTTTCTTCCACCTCCTCCAGCCAGGCTCCTTCCCTGGTGTGAAGGATGCTGTGCTCTTTGGTGGGGCTTAGGGCCCTGTAAGAGGAGGGATGTGAATTGGGGTGGTTTGGAGTG
GGAGTGGGGACCTGATTGCCTCATTCTCACCCTTGACAGTGTGCTGTGTTAACAAGCCCTGTGGAAAGGGGAGACAGGACAGTGCTTGGCTATGAGCCATCGGTCTTGGTGTGGTAGATG
GCATACGTAGAGAACAAGCCGTGACCAGCATGTCCTCTTGTTCCCTTCTTGCCTGGTAGCTTCCTGATGTATCATCCAGGTTGAACTTTATTCCCCTTTTTTCACCAGCTTTGCTCTTCC
TCTTGGCCCTGCTCTGCATCCATTGGGACCACTTACTTCCCATCCCCACTTCGCTAGCTCCAGTCCACAGCTGCTGTAGCAGAGGATGCTAATGGCCCAGGCTTACTGTATGGGGTAGCG
GTTGGGGGTGGCCTGGGCTGGGGCCAGCCAGCTTTCGGGCATAGAGAGGGTGGGGGAATTCGAGTGTCCAACCAGGACAGGAAGGGAAATGCTGAGCTCTGAGATCTCCTCCCTTTTCCA
CCCCCAGCTGCCTCTGTTTCCTCCCTCATTCCCCTGTACTCCTGCCTGGCTTCCTGCCCCCTTTGGCCTGCGTGTGTCCGGTTTTGAGTGACCCAGACCTCCTATCTCCTTCCTTTCCGT
CCCACTCTTCCATCCTTCCCTCCCACCCCCACTTTACTTCTCCCCAGATTACTAGTTGTTTGTATAGGGCAGGGGAGAGGGGCTTGGATAGCCCTACCCCCTGCTCCAGTTCGAGGTTGG
GGCGGGGTGGGGGCTCAGCCCCTCTGAGCCTGTGAGTCAGCACTGTCCTCACGATTGGTCTCTCCCCTTAGCTCCCCGCCCCTGGGGAGGAGCCAGAAGCGCTGGGTCCAGCCTGTTCTC
TTCTCAGCCAGAGAAGAGGCTCCACGTTGGGCGGGGATGGGGCCTGAAACTGTCTGGGTCTGAGCTGGGGAGCGGAAGCCACTTGTCCCTCTCCCTCCCCAGGACTTCTGTGACTCCTGG
GCCACAGAGGTCCAACCAGGCTAAGGGCCTGGGGATACCCCCTGCCTGGCCCCCTTGCCCAAACTGGCAGGGGGGCCAGGCTGGGCAGCAGCCCCTCTTTCACCTCAACTATGGATCTCC
TGCCCCCCAAGCCCAAGTACAATCCACTCCGGAATGAGTCTCTGTCATCGCTGGAGGAAGGGGCTTCTGGGTCCACCCCCCCGGAGGAGCTGCCTTCCCCATCAGCTTCATCCCTGGGGC
CCATCCTGCCTCCTCTGCCTGGGGACGATAGTCCCACTACCCTGTGCTCCTTCTTCCCCCGGATGAGCAACCTGAGGCTGGCCAACCCGGCTGGGGGGCGCCCAGGGTCTAAGGGGGAGC
CAGGAAGGGCAGCTGATGATGGGGAGGGGATCGTAGGGGCAGCCATGCCAGACTCAGGCCCCCTACCCCTCCTCCAGGACATGAACAAGCTGAGTGGAGGCGGCGGGCGCAGGACTCGGG
TGGAAGGGGGCCAGCTTGGGGGCGAGGAGTGGACCCGCCACGGGAGCTTTGTCAATAAGCCCACGCGGGGCTGGCTGCATCCCAACGACAAAGTCATGGGACCCGGGGTTTCCTACTTGG
TTCGGTACATGGGTTGTGTGGAGGTCCTCCAGTCAATGCGTGCCCTGGACTTCAACACCCGGACTCAGGTCACCAGGGAGGCCATCAGTCTGGTGTGTGAGGCTGTGCCGGGTGCTAAGG
GGGCGACAAGGAGGAGAAAGCCCTGTAGCCGCCCGCTCAGCTCTATCCTGGGGAGGAGTAACCTGAAATTTGCTGGAATGCCAATCACTCTCACCGTCTCCACCAGCAGCCTCAACCTCA
TGGCCGCAGACTGCAAACAGATCATCGCCAACCACCACATGCAATCTATCTCATTTGCATCCGGCGGGGATCCGGACACAGCCGAGTATGTCGCCTATGTTGCCAAAGACCCTGTGAATC
AGAGAGCCTGCCACATTCTGGAGTGTCCCGAAGGGCTTGCCCAGGATGTCATCAGCACCATTGGCCAGGCCTTCGAGTTGCGCTTCAAACAATACCTCAGGAACCCACCCAAACTGGTCA
CCCCTCATGACAGCCACAGCTTCACTGTCCTGTCCCTCAGGATGGCTGGCTTTGATGGCTCAGCATGGGATGAGGAGGAGGAAGAGCCACCTGACCATCAGTACTATAATGACTTCCCGG
GGAAGGAACCCCCCTTGGGGGGGGTGGTAGACATGAGGCTTCGGGAAGGAGCCGCTCCAGGGGCTGCTCGACCCACTGCACCCAATGCCCAGACCCCCAGCCACTTGGGAGCTACATTGC
CTGTAGGACAGCCTGTTGGGGGAGATCCAGAAGTCCGCAAACAGATGCCACCTCCACCACCCTGTCCAGCAGGCAGAGAGCTTTTTGATGATCCCTCCTATGTCAACGTCCAGAACCTAG
ACAAGGCCCGGCAAGCAGTGGGTGGTGCTGGGCCCCCCAATCCTGCTATCAATGGCAGTGCACCCCGGGACCTGTTTGACATGAAGCCCTTCGAAGATGCTCTTCGCGTGCCTCCACCTC
CCCAGTCGGTGTCCATGGCTGAGCAGCTCCGAGGGGAGCCCTGGTTCCATGGGAAGCTGAGCCGGCGGGAGGCTGAGGCACTGCTGCAGCTCAATGGGGACTTCCTGGTACGGGAGAGCA
CGACCACACCTGGCCAGTATGTGCTCACTGGCTTGCAGAGTGGGCAGCCTAAGCATTTGCTACTGGTGGACCCTGAGGGTGTGGTTCGGACTAAGGATCACCGCTTTGAAAGTGTCAGTC
ACCTTATCAGCTACCACATGGACAATCACTTGCCCATCATCTCTGCGGGCAGCGAACTGTGTCTACAGCAACCTGTGGAGCGGAAACTGTGATCTGCCCTAGCGCTCTCTTCCAGAAGAT
GCCCTCCAATCCTTTCCACCCTATTCCCTAACTCTCGGGACCTCGTTTGGGAGTGTTCTGTGGGCTTGGCCTTGTGTCAGAGCTGGGAGTAGCATGGACTCTGGGTTTCATATCCAGCTG
AGTGAGAGGGTTTGAGTCAAAAGCCTGGGTGAGAATCCTGCCTCTCCCCAAACATTAATCACCAAAGTATTAATGTACAGAGTGGCCCCTCACCTGGGCCTTTCCTGTGCCAACCTGATG
CCCCTTCCCCAAGAAGGTGAGTGCTTGTCATGGAAAATGTCCTGTGGTGACAGGCCCAGTGGAACAGTCACCCTTCTGGGCAAGGGGGAACAAATCACACCTCTGGGCTTCAGGGTATCC
CAGACCCCTCTCAACACCCGCCCCCCCCATGTTTAAACTTTGTGCCTTTGACCATCTCTTAGGTCTAATGATATTTTATGCAAACAGTTCTTGGACCCCTGAATTCAATGACAGGGATGC
CAACACCTTCTTGGCTTCTGGGACCTGTGTTCTTGCTGAGCACCCTCTCCGGTTTGGGTTGGGATAACAGAGGCAGGAGTGGCAGCTGTCCCCTCTCCCTGGGGATATGCAACCCTTAGA
GATTGCCCCAGAGCCCCACTCCCGGCCAGGCGGGAGATGGACCCCTCCCTTGCTCAGTGCCTCCTGGCCGGGGCCCCTCACCCCAAGGGGTCTGTATATACATTTCATAAGGCCTGCCCT
CCCATGTTGCATGCCTATGTACTCTACGCCAAAGTGCAGCCCTTCCTCCTGAAGCCTCTGCCCTGCCTCCCTTTCTGGGAGGGCGGGGTGGGGGTGACTGAATTTGGGCCTCTTGTACAG
TTAACTCTCCCAGGTGGATTTTGTGGAGGTGAGAAAAGGGGCATTGAGACTATAAAGCAGTAGACAATCCCCACATACCATCTGTAGAGTTGGAACTGCATTCTTTTAAAGTTTTATATG
CATATATTTTAGGGCTGTAGACTTACTTTCCTATTTTCTTTTCCATTGCTTATTCTTGAGCACAAAATGATAATCAATTATTACATTTATACATCACCTTTTTGACTTTTCCAAGCCCTT
TTACAGCTCTTGGCATTTTCCTCGCCTAGGCCTGTGAGGTAACTGGGATCGCACCTTTTATACCAGAGACCTGAGGCAGATGAAATTTATTTCCATCTAGGACTAGAAAAACTTGGGTCT
CTTACCGCGAGACTGAGAGGCAGAAGTCAGCCCGAATGCCTGTCAGTTTCATGGAGGGGAAACGCAAAACCTGCAGTTCCTGAGTACCTTCTACAGGCCCGGCCCAGCCTAGGCCCGGGG
TGGCCACACCACAGCAAGCCGGCCCCCCCTCTTTTGGCCTTGTGGATAAGGGAGAGTTGACCGTTTTCATCCTGGCCTCCTTTTGCTGTTTGGATGTTTCCACGGGTCTCACTTATACCA
AAGGGAAAACTCTTCATTAAAGTCCGTATTTCTTCTA

Protein Sequence

>6464 : length: 598
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSMA
EQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVSVAEVWVRGGKKEGTVPYSVSLFLPSLLCRHSRWAAVYGPLLLFKVSGIFLQRLIP