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Cancer metastasis database

Annotation category 5

Gene information

Gene ID 5551
Symbol

PRF1

Synonymous

FLH2|HPLH2|P1|PFN1|PFP

Full name

perforin 1 (pore forming protein)

Gene description

cytolysin|lymphocyte pore forming protein|lymphocyte pore-forming protein|perforin-1

Cytoband

10q22

Gene type

protein-coding

Synonymous

MIM:170280; HGNC:HGNC:9360; Ensembl:ENSG00000180644; HPRD:01362; Vega:OTTHUMG00000018412

Pathway and disease

Pathways and Diseases

Detail

Pathway

IL2 signaling events mediated by STAT5;PID Curated;200158

Pathway

Type I diabetes mellitus;KEGG PATHWAY;hsa04940

Pathway

Allograft rejection;KEGG PATHWAY;hsa05330

Pathway

Viral myocarditis;KEGG PATHWAY;hsa05416

Pathway

Caspase cascade in apoptosis;PID Curated;200148

Pathway

Downstream signaling in naive CD8+ T cells;PID Curated;200184

Pathway

Graft-versus-host disease;KEGG PATHWAY;hsa05332

Pathway

caspase cascade in apoptosis;PID BioCarta;100218

Pathway

granzyme a mediated apoptosis pathway;PID BioCarta;100035

Pathway

IL12 signaling mediated by STAT4;PID Curated;200197

Pathway

TCR signaling in naive CD8+ T cells;PID Curated;200062

Pathway

Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650

Pathway

Autoimmune thyroid disease;KEGG PATHWAY;hsa05320

Disease

Lymphoma, non-Hodgkin;OMIM

Disease

obesity (extreme);GAD

Disease

HTLV-1 infection;GAD

Disease

Immune system diseases;KEGG DISEASE

Disease

CANCER;GAD

Disease

Hemophagocytic lymphohistiocytosis, familial, 2;OMIM

Disease

METABOLIC;GAD

Disease

lymphoma;GAD

Disease

Familial hemophagocyic lymphohistiocytosis;KEGG DISEASE;H00109

Disease

INFECTION;GAD

Disease

Primary immunodeficiency;KEGG DISEASE

Disease

Obesity (extreme);NHGRI

Sequence Information

Nucleotide Sequence

>5551 : length: 2555
GAAGTGATGTGAGTGGTGGCTGGTGCAAGGAGCCACAGTGGGCTGCCTGGGGGGCTGATGCCACCATTCCAGGAGCCTCGGTGAAGAGAGGATATCCATCTGTGTAGCCGCTTCTCTATA
CGGGATTCCAGAGCCCAAGTGCCCCCTGTCTCTGCAGCTCCATGGCAGCCCGTCTGCTCCTCCTGGGCATCCTTCTCCTGCTGCTGCCCCTGCCCGTCCCTGCCCCGTGCCACACAGCCG
CACGCTCAGAGTGCAAGCGCAGCCACAAGTTCGTGCCTGGTGCATGGCTGGCCGGGGAGGGTGTGGACGTGACCAGCCTCCGCCGCTCGGGCTCCTTCCCAGTGGACACACAAAGGTTCC
TGCGGCCCGACGGCACCTGCACCCTCTGTGAAAATGCCCTACAGGAGGGCACCCTCCAGCGCCTGCCTCTGGCGCTCACCAACTGGCGGGCCCAGGGCTCTGGCTGCCAGCGCCATGTAA
CCAGGGCCAAAGTCAGCTCCACTGAAGCTGTGGCCCGGGATGCGGCTCGTAGCATCCGCAACGACTGGAAGGTCGGGCTGGACGTGACTCCTAAGCCCACCAGCAATGTGCATGTGTCTG
TGGCCGGCTCACACTCACAGGCAGCCAACTTTGCAGCCCAGAAGACCCACCAGGACCAGTACAGCTTCAGCACTGACACGGTGGAGTGCCGCTTCTACAGTTTCCATGTGGTACACACTC
CCCCGCTGCACCCTGACTTCAAGAGGGCCCTCGGGGACCTGCCCCACCACTTCAACGCCTCCACCCAGCCCGCCTACCTCAGGCTTATCTCCAACTACGGCACCCACTTCATCCGGGCTG
TGGAGCTGGGTGGCCGCATATCGGCCCTCACTGCCCTGCGCACCTGCGAGCTGGCCCTGGAAGGGCTCACGGACAACGAGGTGGAGGACTGCCTGACTGTCGAGGCCCAGGTCAACATAG
GCATCCACGGCAGCATCTCTGCCGAAGCCAAGGCCTGTGAGGAGAAGAAGAAGAAGCACAAGATGACGGCCTCCTTCCACCAAACCTACCGGGAGCGCCACTCGGAAGTGGTTGGCGGCC
ATCACACCTCCATTAACGACCTGCTGTTCGGGATCCAGGCCGGGCCCGAGCAGTACTCAGCCTGGGTAAACTCGCTGCCCGGCAGCCCTGGCCTGGTGGACTACACCCTGGAACCCCTGC
ACGTGCTGCTGGACAGCCAGGACCCGCGGCGGGAGGCACTGAGGAGGGCCCTGAGTCAGTACCTGACGGACAGGGCTCGCTGGAGGGACTGCAGCCGGCCGTGCCCACCAGGGCGGCAGA
AGAGCCCCCGAGACCCATGCCAGTGTGTGTGCCATGGCTCAGCGGTCACCACCCAGGACTGCTGCCCTCGGCAGAGGGGCCTGGCCCAGCTGGAGGTGACCTTCATCCAAGCATGGGGCC
TGTGGGGGGACTGGTTCACTGCCACGGATGCCTATGTGAAGCTCTTCTTTGGTGGCCAGGAGCTGAGGACGAGCACCGTGTGGGACAATAACAACCCCATCTGGTCAGTGCGGCTGGATT
TTGGGGATGTGCTCCTGGCCACAGGGGGGCCCCTGAGGTTGCAGGTCTGGGATCAGGACTCTGGCAGGGACGATGACCTCCTTGGCACCTGTGATCAGGCTCCCAAGTCTGGTTCCCATG
AGGTGAGATGCAACCTGAATCATGGCCACCTAAAATTCCGCTATCATGCCAGGTGCTTGCCCCACCTGGGAGGAGGCACCTGCCTGGACTATGTCCCCCAAATGCTTCTGGGGGAGCCTC
CAGGAAACCGGAGTGGGGCCGTGTGGTGAGAACAGTGAGCTTGGAAAGGACCAGTATGCTTGGACTGAAGGGGTTCTCACAGTGGGAGCCAGGGCTGTCTTCGTATTCCCATTAGACCAA
GCTTGTCCAACCCGAGGCCCGCATGCGGCCCAGGATGGCTTTGAATGCGGCCCAACGCAAATTCGCAAACTTTCTTAAAACATTATGAGTTTCTTTTTGCTATTTTTTTTTTTTTTTTAG
CTCATCGGCTATCGTTAGTGCTAGTGGATTTTACATGTGGCCCAACACAATTCTTCTTCCAACGTGGCCCAGAGAAGCCAAAAGATTGGATACGCATCAGACAGATGGAAAAGGGAGATT
CAGACTGTTTTTCAGGGAGGTGGCTGGGTTTACACGCTAATCCCGATTCACCCTGTCCAAACTGCCTAAGCCCTCCGCCATTCTCAAGCCCTGCAGTCACAGCTACACAGATCACAGCTT
CAGCCAGGAGCTGGGCAGAAGGCCAAGAGGCTGTTCCCACCAGGCTGCTCAGGGCTGGTCTTTTAGGACCCTTCCCTTGAGCCCTCTATGGTGTGGCAAAGCCTTCATTGCCTTAACTGG
AGCCCCATCAGCTCCAGCTGCTCTGTCTTCTTTGCCCACAATGCTTTGCCCCTGAGACAAATGGAGGCCTGTCCTGACCTGTCTCACCATGTACATAGCTTGATAAAGGGCCAATAAATA
TGATGTTATGGTGAAAAAAAAAAAAAAAAAAAAAA

Protein Sequence

>5551 : length: 555
MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFPVDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARD
AARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALR
TCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREAL
RRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRL
QVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQMLLGEPPGNRSGAVW