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Cancer metastasis database

Annotation category 5

Gene information

Gene ID 5244
Symbol

ABCB4

Synonymous

ABC21|GBD1|ICP3|MDR2|MDR2/3|MDR3|PFIC-3|PGY3

Full name

ATP-binding cassette, sub-family B (MDR/TAP), member 4

Gene description

ATP-binding cassette sub-family B member 4|P glycoprotein 3/multiple drug resistance 3|P-glycoprotein 3|P-glycoprotein-3/multiple drug resistance-3|multidrug resistance protein 3|multiple drug resistance 3

Cytoband

7q21.1

Gene type

protein-coding

Synonymous

MIM:171060; HGNC:HGNC:45; Ensembl:ENSG00000005471; HPRD:01371; Vega:OTTHUMG00000023396

Pathway and disease

Pathways and Diseases

Detail

Pathway

multi-drug resistance factors;PID BioCarta;100103

Pathway

ABC transporters;KEGG PATHWAY;hsa02010

Pathway

Metabolism of lipids and lipoproteins;Reactome;REACT:22258

Disease

cholelithiasis;GAD

Disease

REPRODUCTION;GAD

Disease

Cholestasis, familial intrahepatic, of pregnancy;OMIM

Disease

cholestasis, drug-induced hepatotoxicity;GAD

Disease

intrahepatic cholestatis of pregnancy;GAD

Disease

Gallbladder disease 1;OMIM

Disease

PHARMACOGENOMIC;GAD

Disease

METABOLIC;GAD

Disease

Cholestasis, progressive familial intrahepatic 3;OMIM

Sequence Information

Nucleotide Sequence

>5244 : length: 5310
TATGTGCTAATGAGTTTAATAATGTCCTCCAGTCACCACAAGCCTTCTTTCAAACTACACAATTCCAACTGCTTCCGTCTCAGAGTATCTTGAAATAATGATCTGACCGCCTGTTAGACC
AGTGAAGGGAAGGAATTTGGGTTGATTTAAGAAGAGAATCCTCATGGTCATGGTAGACTGATATGGAGAGAAAACATTTTGAGGAAAAATACTCAACTAAATTCATTTCTACTCCAGCAT
GCAGTTTCAAGTCAAGTTCCACCTTAGCTCCAGGTGGCAGGCAGAGCAGGATGCAGAGGCACAGCACAAGTAAGGGGTGAGTGCCGAAGCTGCTGGCTCCTGTTCCAGTCTTTCTTCCTT
GGCCTCGCCTGAACTTTTACTATAATAATAGTCACCATTTATTAGGTGTCTCCTACGTGCAGGACACTTTACACACAGTATCCCTAATCCTAATAACACCCTTATTTTATAGATCCAATG
ACTGAGTCAAGAATTACATAACCTGGCCAGACAGCTGGTACATGGGAAAGGTGAGATTCACACCAGGGTCCACCCAGCATCTCTACTTATACCATGCTCTGCTTTAAGGTTCTCTGAGAA
CTCAGACAAGCCTTGGGCTAACAATTGTGTTAACAGGACATAGCAGGTGCAAGGACCCACTGGTCATCCTGCTACCTGATCAGAAGGAAGGAAAGTTGTATTTGTTGCTCACCTACTATG
TTTTAGGCATAGTACTAGGTGCTTTTACCTAGTACTTAATTCCCTTATCCTCAACTCATTTATTCCTCGCAATAACCTGATAAGGGAGATGTTTTTATCCTCATTTTACATATAAGGAAA
CAGGCCTAGAGAAATGAGCACAGTGTCCAAAGTCACATAGTTAATAAGATGTGAAGCTCTGAGTTTGAAAGTCTCCGGTTTCAAAGCCATGAAACTTATGGCTCCCCGTTTTAGACACTT
CCTTTTGGGAAGAGTGTGGAGGAATTAATCAGAAAGAAGAAAGTCATACTCAAATAGGTGGTAGGAGCAGAGACAATTCAATACAGACAGAAGTCTTAGATGAGAGCAGTGAGCCAGGGC
ACTGGACTGGGACTCAGGAGGCTTCCCCTAGACTCTGGTTCCACCGATGCAGCCTCAGGCAGGACTTCACCTCTCTGGGCATCCGTTTCTTCATATGTTAAACATACGGGGTTTTAATTA
GATGATCGCTGAAGACCCCTCTAGCCCTAAAACTCTGTGTCTCTTAAGTGCTAAGAGGGCACCAACAGCGTTCCTCCTCCCCAAGGAGCATAATGTGATGGTTCCTGCCGGCCCTGGCTG
ACTCTCGCCGTCCTTGGAGATAATTGGGTTCAGTGCCACCTGGACCAGAACTGGGGATGCGGAAGCAAGAGGCTGAGATGGATCTTGAGGCGGCAAAGAACGGAACAGCCTGGCGCCCCA
CGAGCGCGGAGGGCGACTTTGAACTGGGCATCAGCAGCAAACAAAAAAGGAAAAAAACGAAGACAGTGAAAATGATTGGAGTATTAACATTGTTTCGATACTCCGATTGGCAGGATAAAT
TGTTTATGTCGCTGGGTACCATCATGGCCATAGCTCACGGATCAGGTCTCCCCCTCATGATGATAGTATTTGGAGAGATGACTGACAAATTTGTTGATACTGCAGGAAACTTCTCCTTTC
CAGTGAACTTTTCCTTGTCGCTGCTAAATCCAGGCAAAATTCTGGAAGAAGAAATGACTAGATATGCATATTACTACTCAGGATTGGGTGCTGGAGTTCTTGTTGCTGCCTATATACAAG
TTTCATTTTGGACTTTGGCAGCTGGTCGACAGATCAGGAAAATTAGGCAGAAGTTTTTTCATGCTATTCTACGACAGGAAATAGGATGGTTTGACATCAACGACACCACTGAACTCAATA
CGCGGCTAACAGATGACATCTCCAAAATCAGTGAAGGAATTGGTGACAAGGTTGGAATGTTCTTTCAAGCAGTAGCCACGTTTTTTGCAGGATTCATAGTGGGATTCATCAGAGGATGGA
AGCTCACCCTTGTGATAATGGCCATCAGCCCTATTCTAGGACTCTCTGCAGCCGTTTGGGCAAAGATACTCTCGGCATTTAGTGACAAAGAACTAGCTGCTTATGCAAAAGCAGGCGCCG
TGGCAGAAGAGGCTCTGGGGGCCATCAGGACTGTGATAGCTTTCGGGGGCCAGAACAAAGAGCTGGAAAGGTATCAGAAACATTTAGAAAATGCCAAAGAGATTGGAATTAAAAAAGCTA
TTTCAGCAAACATTTCCATGGGTATTGCCTTCCTGTTAATATATGCATCATATGCACTGGCCTTCTGGTATGGATCCACTCTAGTCATATCAAAAGAATATACTATTGGAAATGCAATGA
CAGTTTTTTTTTCAATCCTAATTGGAGCTTTCAGTGTTGGCCAGGCTGCCCCATGTATTGATGCTTTTGCCAATGCAAGAGGAGCAGCATATGTGATCTTTGATATTATTGATAATAATC
CTAAAATTGACAGTTTTTCAGAGAGAGGACACAAACCAGACAGCATCAAAGGGAATTTGGAGTTCAATGATGTTCACTTTTCTTACCCTTCTCGAGCTAACGTCAAGATCTTGAAGGGCC
TCAACCTGAAGGTGCAGAGTGGGCAGACGGTGGCCCTGGTTGGAAGTAGTGGCTGTGGGAAGAGCACAACGGTCCAGCTGATACAGAGGCTCTATGACCCTGATGAGGGCACAATTAACA
TTGATGGGCAGGATATTAGGAACTTTAATGTAAACTATCTGAGGGAAATCATTGGTGTGGTGAGTCAGGAGCCGGTGCTGTTTTCCACCACAATTGCTGAAAATATTTGTTATGGCCGTG
GAAATGTAACCATGGATGAGATAAAGAAAGCTGTCAAAGAGGCCAACGCCTATGAGTTTATCATGAAATTACCACAGAAATTTGACACCCTGGTTGGAGAGAGAGGGGCCCAGCTGAGTG
GTGGGCAGAAGCAGAGGATCGCCATTGCACGTGCCCTGGTTCGCAACCCCAAGATCCTTCTGCTGGATGAGGCCACGTCAGCATTGGACACAGAAAGTGAAGCTGAGGTACAGGCAGCTC
TGGATAAGGCCAGAGAAGGCCGGACCACCATTGTGATAGCACACCGACTGTCTACGGTCCGAAATGCAGATGTCATCGCTGGGTTTGAGGATGGAGTAATTGTGGAGCAAGGAAGCCACA
GCGAACTGATGAAGAAGGAAGGGGTGTACTTCAAACTTGTCAACATGCAGACATCAGGAAGCCAGATCCAGTCAGAAGAATTTGAACTAAATGATGAAAAGGCTGCCACTAGAATGGCCC
CAAATGGCTGGAAATCTCGCCTATTTAGGCATTCTACTCAGAAAAACCTTAAAAATTCACAAATGTGTCAGAAGAGCCTTGATGTGGAAACCGATGGACTTGAAGCAAATGTGCCACCAG
TGTCCTTTCTGAAGGTCCTGAAACTGAATAAAACAGAATGGCCCTACTTTGTCGTGGGAACAGTATGTGCCATTGCCAATGGGGGGCTTCAGCCGGCATTTTCAGTCATATTCTCAGAGA
TCATAGCGATTTTTGGACCAGGCGATGATGCAGTGAAGCAGCAGAAGTGCAACATATTCTCTTTGATTTTCTTATTTCTGGGAATTATTTCTTTTTTTACTTTCTTCCTTCAGGGTTTCA
CGTTTGGGAAAGCTGGCGAGATCCTCACCAGAAGACTGCGGTCAATGGCTTTTAAAGCAATGCTAAGACAGGACATGAGCTGGTTTGATGACCATAAAAACAGTACTGGTGCACTTTCTA
CAAGACTTGCCACAGATGCTGCCCAAGTCCAAGGAGCCACAGGAACCAGGTTGGCTTTAATTGCACAGAATATAGCTAACCTTGGAACTGGTATTATCATATCATTTATCTACGGTTGGC
AGTTAACCCTATTGCTATTAGCAGTTGTTCCAATTATTGCTGTGTCAGGAATTGTTGAAATGAAATTGTTGGCTGGAAATGCCAAAAGAGATAAAAAAGAACTGGAAGCTGCTGGAAAGA
TTGCAACAGAGGCAATAGAAAATATTAGGACAGTTGTGTCTTTGACCCAGGAAAGAAAATTTGAATCAATGTATGTTGAAAAATTGTATGGACCTTACAGGAATTCTGTGCAGAAGGCAC
ACATCTATGGAATTACTTTTAGTATCTCACAAGCATTTATGTATTTTTCCTATGCCGGTTGTTTTCGATTTGGTGCATATCTCATTGTGAATGGACATATGCGCTTCAGAGATGTTATTC
TGGTGTTTTCTGCAATTGTATTTGGTGCAGTGGCTCTAGGACATGCCAGTTCATTTGCTCCAGACTATGCTAAAGCTAAGCTGTCTGCAGCCCACTTATTCATGCTGTTTGAAAGACAAC
CTCTGATTGACAGCTACAGTGAAGAGGGGCTGAAGCCTGATAAATTTGAAGGAAATATAACATTTAATGAAGTCGTGTTCAACTATCCCACCCGAGCAAACGTGCCAGTGCTTCAGGGGC
TGAGCCTGGAGGTGAAGAAAGGCCAGACACTAGCCCTGGTGGGCAGCAGTGGCTGTGGGAAGAGCACGGTGGTCCAGCTCCTGGAGCGGTTCTACGACCCCTTGGCGGGGACAGTGTTTG
TGGACTTTGGTTTTCAGCTTCTCGATGGTCAAGAAGCAAAGAAACTCAATGTCCAGTGGCTCAGAGCTCAACTCGGAATCGTGTCTCAGGAGCCTATCCTATTTGACTGCAGCATTGCCG
AGAATATTGCCTATGGAGACAACAGCCGGGTTGTATCACAGGATGAAATTGTGAGTGCAGCCAAAGCTGCCAACATACATCCTTTCATCGAGACGTTACCCCACAAATATGAAACAAGAG
TGGGAGATAAGGGGACTCAGCTCTCAGGAGGTCAAAAACAGAGGATTGCTATTGCCCGAGCCCTCATCAGACAACCTCAAATCCTCCTGTTGGATGAAGCTACATCAGCTCTGGATACTG
AAAGTGAAAAGGTTGTCCAAGAAGCCCTGGACAAAGCCAGAGAAGGCCGCACCTGCATTGTGATTGCTCACCGCCTGTCCACCATCCAGAATGCAGACTTAATAGTGGTGTTTCAGAATG
GGAGAGTCAAGGAGCATGGCACGCATCAGCAGCTGCTGGCACAGAAAGGCATCTATTTTTCAATGGTCAGTGTCCAGGCTGGGACACAGAACTTATGAACTTTTGCTACAGTATATTTTA
AAAATAAATTCAAATTATTCTACCATTTTA

Protein Sequence

>5244 : length: 1293
MRKQEAEMDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEM
TRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAV
WAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPC
IDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIG
VVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLST
VRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVV
GTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLA
LIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYA
GCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGC
GKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIA
RALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQNL