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Cancer metastasis database

Annotation category 5

Gene information

Gene ID 5126
Symbol

PCSK2

Synonymous

NEC 2|NEC-2|NEC2|PC2|SPC2

Full name

proprotein convertase subtilisin/kexin type 2

Gene description

KEX2-like endoprotease 2|neuroendocrine convertase 2|prohormone convertase 2

Cytoband

20p11.2

Gene type

protein-coding

Synonymous

MIM:162151; HGNC:HGNC:8744; Ensembl:ENSG00000125851; HPRD:01202; Vega:OTTHUMG00000031941

Pathway and disease

Pathways and Diseases

Detail

Pathway

Diabetes pathways;Reactome;REACT:15380

Pathway

Insulin Synthesis and Processing;PID Reactome;500128

Pathway

Alzheimer disease-presenilin pathway;PANTHER;P00004

Pathway

Alzheimer disease-amyloid secretase pathway;PANTHER;P00003

Disease

Embryoma;FunDO

Disease

diabetes, type 2;GAD

Disease

Diabetes mellitus;FunDO

Disease

CHEMDEPENDENCY;GAD

Disease

smoking cessation;GAD

Disease

Lymphoma;FunDO

Disease

Biochemical measures;GAD

Disease

METABOLIC;GAD

Disease

Liver metastases;FunDO

Disease

Biochemical measures;NHGRI

Sequence Information

Nucleotide Sequence

>5126 : length: 4792
GAGCTGGTGCTCTCCCCCAGCCCCTAGGGAATTGGAGCTGAGGAGGAGCTGAAAATGCAGATTTAGCATCAAGCACAGACCTACACTCGCTCTTTCTCTCCGGTACACACAGCTCCCCAC
ATTCGCACCCCTGCCCGCGCGCCGGGCCGCCTGACTGCACGGCTTCCCCTCCAGCCAGATGCTGGAGAACACACACTGATTCGCTGCTTTCCAAGACCCTGTTCAGTCTCTTTCTCTATA
CAAAGATTTTTTTAAAAACTATATATAAGAATTCTTTATTTGCACCCTCCCTCCGAGTCCCCTGCTCCGCCAGCCTGCGCGCCTCCTAGCACCACTTTTCACTCCCAAAGAAGGATGAAG
GGTGGTTGTGTCTCCCAGTGGAAGGCGGCCGCCGGGTTCCTCTTCTGTGTCATGGTTTTTGCATCTGCTGAGCGACCGGTCTTCACGAATCATTTTCTTGTGGAGTTGCATAAAGGGGGA
GAGGACAAAGCTCGCCAAGTTGCAGCAGAACACGGCTTTGGAGTCCGAAAGCTTCCCTTTGCTGAAGGTCTGTACCACTTTTATCACAATGGCCTTGCAAAGGCCAAGAGAAGACGCAGC
CTACACCACAAGCAGCAGCTGGAGAGAGACCCCAGGGTAAAGATGGCTTTGCAGCAGGAAGGATTTGACCGAAAAAAGCGAGGTTACAGAGACATCAATGAGATCGACATCAACATGAAC
GATCCTCTTTTTACAAAGCAGTGGTATCTGATCAATACTGGGCAAGCTGATGGCACTCCTGGCCTTGATTTGAATGTGGCTGAAGCCTGGGAGCTGGGATACACAGGGAAAGGTGTTACC
ATTGGAATTATGGATGATGGGATTGACTATCTCCACCCGGACCTGGCCTCCAACTATAATGCCGAAGCAAGTTACGACTTCAGCAGCAACGACCCCTATCCTTACCCTCGGTACACAGAT
GACTGGTTTAACAGCCACGGGACCCGATGTGCAGGAGAAGTTTCTGCTGCCGCCAACAACAATATCTGTGGAGTTGGAGTAGCATACAACTCCAAGGTTGCAGGCATCCGGATGCTGGAC
CAGCCATTCATGACAGACATCATCGAGGCCTCCTCCATCAGTCATATGCCACAGCTGATTGACATCTACAGCGCCAGCTGGGGCCCCACAGACAACGGCAAGACAGTGGATGGGCCCCGG
GAGCTCACGCTGCAGGCCATGGCCGATGGCGTGAACAAGGGCCGCGGCGGCAAAGGCAGCATCTACGTGTGGGCCTCCGGGGACGGCGGCAGCTATGACGACTGCAACTGCGACGGCTAC
GCCTCCAGCATGTGGACCATCTCCATCAACTCAGCCATCAACGACGGCAGGACTGCCCTGTACGACGAGAGCTGCTCTTCCACCTTGGCTTCCACCTTCAGCAACGGGAGGAAAAGGAAC
CCCGAGGCCGGTGTGGCAACCACAGATTTGTACGGCAACTGCACTCTGAGGCATTCTGGGACATCTGCAGCTGCCCCCGAGGCAGCTGGTGTGTTTGCACTGGCTCTGGAGGCTAACCTG
GGTCTGACCTGGCGGGACATGCAGCATCTGACTGTGCTCACCTCCAAACGGAACCAGCTTCACGACGAGGTCCATCAGTGGCGGCGCAATGGGGTCGGCCTGGAATTTAATCACCTCTTT
GGCTACGGGGTCCTTGATGCAGGTGCCATGGTGAAAATGGCTAAAGACTGGAAAACCGTGCCTGAGAGATTCCACTGTGTGGGAGGCTCCGTGCAGGACCCTGAGAAAATACCATCCACT
GGCAAGTTGGTGCTGACACTCACAACCGACGCCTGTGAGGGGAAGGAAAATTTTGTCCGCTACCTGGAGCATGTCCAGGCTGTCATCACGGTCAACGCAACCAGAAGAGGAGACCTGAAC
ATCAACATGACTTCCCCTATGGGCACCAAGTCCATTTTGCTGAGCCGGCGTCCAAGGGATGACGACTCCAAGGTGGGCTTTGACAAGTGGCCTTTCATGACCACTCACACGTGGGGGGAA
GACGCCCGAGGCACCTGGACCCTGGAGCTGGGATTTGTCGGCAGCGCCCCGCAGAAGGGGGTGCTGAAGGAGTGGACCCTGATGCTGCATGGCACTCAGAGTGCCCCGTACATCGACCAG
GTGGTGCGGGATTACCAGTCCAAGTTGGCCATGTCCAAGAAAGAGGAGCTGGAGGAAGAGCTGGACGAAGCCGTGGAGAGAAGCCTGAAAAGCATCCTTAACAAGAACTAGCGCTGCACA
TCCGCCTTTCCCACCGCCCTCCCTCCCCAGCTCCGCCTCTGTCCTCGCTCCACGTTTCAGGCAGGCACCTAGCAATTCCATCACCCGTACAGGCAATTCCGTCTTCTTAATCTGAAGCTT
CACTCACTGTCAATGATTATTTTCATTACAATGGAAACAATCTTTTTTACTCTATGCCCCAAATATAGCGTTCCCAACAACATCCATGTCCTATGTGTGACTCTAAATTCTTTATTTCTG
TCATTCAAATGGGTGATATCCTGAAAAAAAAAAAAAAAAAAAAACTGGGACAGCTTTCCCCTCATTTTTTTTTTTGTTTCTGAGAAAAGAACGTATTTTAAAAGCCACATAGAGTGACTC
CAAGAACAATTGTCCATGGTCTCAAACAAGGGGCTGTTACATAACAAGAAAATCAAAGCTGAGGACAGGGTGTGAGCGCCACATCTCTGAAAGCACAGGAGACACTGTGCTATAAATCCT
TTGGGGAGCGATGTTTTGAATTTAGTGAGATTTACCAGGGATGTAGATTAAGGTGATGTGATTCAAAAGATGCCATTCATAGAGAGCCCTAGTTACTGCATGGGGAAAGAGATCCAGGAA
GCATGAGTGCTGGATATTTTACTACCAATGCCAAGATAATTCACTCTACTCAGCCGGCGTGGCAAATATAAAACTTACAGAGCGTGGCTGTGCTCTCACCAGCTGCTGCTCTGAGTTATG
TTAAAATCCGCTAGAGCAGCCCAAATTTTTCTCAGTTTGTATAGAGTTCATCCCAGCCCCAATTTTCTGGGGCTCCTCACATAGCTACCCAAAAGAGAAAAAAAATTAAGACAAGCCTGG
CAACACACCTGGTGAAGAGTAGTTTACTAGCTTTTCAAACAAGAATGTCCCTTTTCCTAAGTCACTTTGAGGTGTCTCAATCTGATCTGAGTGAGAGGCGACAGGAGTATTTTTTTTTTT
TTACAGCTTTACACACACAGATGTGGGCTTTGATTTCCAAGTAATATAATGGAAGAGAAATCTCATACTCCCCCACAGTTTGATGTCATTAATGTGTTGGGAAAAAGGCCTCTGTCCCGG
AAGAGTCATGGGAGGTGAAAGGGGCACGTTTGAAGATGCGAGCGCTATCTTCACATAGTTCTCCAGTTGTATGGAGCCTCTTCTGCCAAGAGAGGGCCATGCAATTCATCCCAGAGGAAC
CTGAGGCCTGAAGGAGGTGAGAGAAGACCTCTGTGAGGAAAGCACACAGTCACCTTCTCGGCAACTAAGCAGTCCCTGAGACCATTTAACATGCAACCCGAAGGTTATGGTCAATCCCAA
AAGTCACCACTCCATTCCCAACTAGACATTACCAAAGTGACCTACCCAGAGATTGCTTCTCATCCCCAGTCCCAATGCACATCCATTCCCAAGAAATGCTTTGTCTTCAGCCTCTCCAGG
CACCATCTCCCTTCCTGTGGGAGCAGAGAGCTTAGCCTGGAGCACCTTTCCTTCAAGCCAGCAACACAGAGCACTAGGTTCAATTCCCTGAAGGTGGCCACTTTAAGAGAGAAATCTGAA
AACCCCATTTGCTTTCTTTTCTCCCATATTGGCATGGATTTCTGTCTTCTCTAACACCTTGTGACCTTCTCTATATCATGCTTTAAAGTGTAATAATATGATTTTTTAAAAGAAATTTAT
TACTTGTTGCAAAGGTCTTTTTAAACCAGTTTAGATTTCAAGAAAAAATAAATGGAAATCATCGAAAATTCATTTCACATTAATGGTCTAAAAATAAACCAAAGGACATTATGTGTGCAT
GTGTGTATAAGTGCACACAGAAATATATATACATATGTAGACTATATACATGTGTGTATATATGTGTATATATACATACACTTGTATAAATGTATATACACATATACCTATAATGTGTGT
ATGTGTATTTATTGAAGAAACAGATACCATACTCATTTCTAAAAGAATATTCAGAGAATATCAAGATGATTCTGGCTGAAAAAGGCCAGTGGAAATTCAGGTGAAAATGTTCATCAATTC
CCATTGCATCACCTCTGTAATTTTTCAGCTCTCTGTATAAACATTAAATGTCTTATATAGCAGCAAAAATATAAAATAGTTGTCCATATTTTCACAGGTGTGGTGTAATTTATAAAATTA
GAAAGCAACTTATCAGCTACTTAAGAGAAATGGCAAGTTTTGATATGAGTATACAATATATAAAAATATATATAGTGCTATATATATAAATATTTGGTCTCTATTTCATTTTTTGCATCA
GTATTAATACTAAAATATGTCTCGCTAGTGATGTTTTTATGATATCCCTGATCCTAACTGAAGAGACAGTTATTTATAGTCATTTATTTTAAAAAATGAAAATAAGTGAATAATAATTAG
GTTAACATTGTTGCTCCCTGTGACAAAATTTTATAAGCAAATTTCAAAAGACATGTTGTAAATTAGGAGGCTCAACAATAAAACATTATGCTCCAGAAAAAAAAAAAAAAAA

Protein Sequence

>5126 : length: 638
MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDIN
MNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRM
LDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK
RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIP
STGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYI
DQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN