| Gene ID | 5122 |
| Symbol | PCSK1 |
| Synonymous | BMIQ12|NEC1|PC1|PC3|SPC3 |
| Full name | proprotein convertase subtilisin/kexin type 1 |
| Gene description | neuroendocrine convertase 1|prohormone convertase 1|prohormone convertase 3 |
| Cytoband | 5q15-q21 |
| Gene type | protein-coding |
| Synonymous | MIM:162150; HGNC:HGNC:8743; Ensembl:ENSG00000175426; HPRD:01201; Vega:OTTHUMG00000122089 |
Pathways and Diseases | Detail |
|---|---|
Pathway | Integration of energy metabolism;Reactome;REACT:1505 |
Pathway | Diabetes pathways;Reactome;REACT:15380 |
Pathway | Alzheimer disease-presenilin pathway;PANTHER;P00004 |
Pathway | Diabetes pathways;PID Reactome;500127 |
Pathway | Endothelin signaling pathway;PANTHER;P00019 |
Pathway | Metabolism of amino acids and derivatives;Reactome;REACT:13 |
Pathway | Insulin Synthesis and Processing;PID Reactome;500128 |
Pathway | Synthesis, Secretion, and Deacylation of Ghrelin;PID Reactome;500141 |
Pathway | Hormone biosynthesis;Reactome;REACT:15314 |
Pathway | Alzheimer disease-amyloid secretase pathway;PANTHER;P00003 |
Pathway | Peptide hormone biosynthesis;PID Reactome;500768 |
Disease | Embryoma;FunDO |
Disease | Obesity, susceptibility to, BMIQ12;OMIM |
Disease | Obesity with impaired prohormone processing;OMIM |
Disease | nephropathy, diabetic;GAD |
Disease | Lymphoma;FunDO |
Disease | Obesity;FunDO |
Disease | METABOLIC;GAD |
Disease | obesity;GAD |
Disease | Liver metastases;FunDO |
Disease | Eating disorder;FunDO |
Disease | Sella turcica tumor;FunDO |
Disease | RENAL;GAD |
Sequence Information | |
|---|---|
Nucleotide Sequence | >5122 : length: 5166 ATTTCCATTCTGGCTGGGAAGGGCTGGGGCTCCACTCAGCCTGGAGACCGAAGCGCTTCACTGAGCGCTCGCCGCCGCCCAGCCTCTCCTCTCGCGCCTCCTAGCTCTTCGCAGAGCAAC CAGGAGCCAGGAGTGGTCTAGAGCCCGAGGGTGGGAAGGGGGAGTCTGTCTGGCTTTTCTCCTATCTTGCTTCTTTTTCCTCTTCCCTTCCCACTCTTGTTCAAGCGAGTGTGTGAGCTA TGGAGCGAAGAGCCTGGAGTCTGCAGTGCACTGCTTTCGTCCTCTTTTGCGCTTGGTGTGCACTGAACAGTGCAAAAGCGAAAAGGCAATTTGTCAATGAATGGGCAGCGGAGATCCCCG GGGGCCCGGAAGCAGCCTCGGCCATCGCCGAGGAGCTGGGCTATGACCTTTTGGGTCAGATTGGTTCACTTGAAAATCACTACTTATTCAAACATAAAAACCACCCCAGAAGGTCTCGAA GGAGTGCCTTTCATATCACTAAGAGATTATCTGATGATGATCGTGTGATATGGGCTGAACAACAGTATGAAAAAGAAAGAAGTAAACGTTCAGCTCTAAGGGACTCAGCACTAAATCTCT TCAATGATCCCATGTGGAATCAGCAATGGTACTTGCAAGATACCAGGATGACGGCAGCCCTGCCCAAGCTGGACCTTCATGTGATACCTGTTTGGCAAAAAGGCATTACGGGCAAAGGAG TTGTTATCACCGTACTGGATGATGGTTTGGAGTGGAATCACACGGACATTTATGCCAACTATGATCCAGAGGCTAGCTATGATTTTAATGATAATGACCATGATCCATTTCCCCGATATG ATCCCACAAACGAGAACAAACACGGGACCAGATGTGCAGGAGAAATTGCCATGCAAGCAAATAATCACAAATGCGGGGTTGGAGTTGCATACAATTCCAAAGTTGGAGGCATAAGAATGC TGGATGGCATTGTGACGGATGCTATTGAGGCCAGTTCAATTGGATTCAATCCTGGACACGTGGATATTTACAGTGCAAGCTGGGGCCCTAATGATGATGGGAAAACTGTGGAGGGGCCTG GCCGGCTAGCCCAGAAGGCTTTTGAATATGGTGTCAAACAGGGGAGACAGGGGAAGGGGTCCATCTTCGTCTGGGCTTCGGGAAACGGGGGGCGTCAGGGAGATAATTGTGACTGTGATG GCTACACAGACAGCATCTACACCATCTCCATCAGCAGTGCCTCCCAGCAAGGCCTATCCCCCTGGTACGCTGAGAAGTGCTCCTCCACACTGGCCACCTCTTACAGCAGCGGAGATTACA CCGACCAGAGAATCACGAGCGCTGACCTGCACAATGACTGCACGGAGACGCACACAGGCACCTCGGCCTCTGCACCTCTGGCTGCTGGCATCTTCGCTCTGGCCCTGGAAGCAAACCCAA ATCTCACCTGGCGAGATATGCAGCACCTGGTTGTCTGGACCTCTGAGTATGACCCGCTGGCCAATAACCCTGGATGGAAAAAGAATGGAGCAGGCTTGATGGTGAATAGTCGATTTGGAT TTGGCTTGCTAAATGCCAAAGCTCTGGTGGATTTAGCTGACCCCAGGACCTGGAGGAGCGTGCCTGAGAAGAAAGAGTGTGTTGTAAAGGACAATGACTTTGAGCCCAGAGCCCTGAAAG CTAATGGAGAAGTTATCATTGAAATTCCAACAAGAGCTTGTGAAGGACAAGAAAATGCTATCAAGTCCCTGGAGCATGTACAATTTGAAGCAACAATTGAATATTCCCGAAGAGGAGACC TTCATGTCACACTTACTTCTGCTGCTGGAACTAGCACTGTGCTCTTGGCTGAAAGAGAACGGGATACATCTCCTAATGGCTTTAAGAATTGGGACTTCATGTCTGTTCACACATGGGGAG AGAACCCTATAGGTACTTGGACTTTGAGAATTACAGACATGTCTGGAAGAATTCAAAATGAAGGAAGAATTGTGAACTGGAAGCTGATTTTGCACGGGACCTCTTCTCAGCCAGAGCATA TGAAGCAGCCTCGTGTGTACACGTCCTACAACACTGTTCAGAATGACAGAAGAGGGGTGGAGAAGATGGTGGATCCAGGGGAGGAGCAGCCCACACAAGAGAACCCTAAGGAGAACACCC TGGTGTCCAAAAGCCCCAGCAGCAGCAGCGTAGGGGGCCGGAGGGATGAGTTGGAGGAGGGAGCCCCTTCCCAGGCCATGCTGCGACTCCTGCAAAGTGCTTTCAGTAAAAACTCACCGC CAAAGCAATCACCAAAGAAGTCCCCAAGTGCAAAGCTCAACATCCCTTATGAAAACTTCTACGAAGCCCTGGAAAAGCTGAACAAACCTTCCCAGCTTAAAGACTCTGAAGACAGTCTGT ATAATGACTATGTTGATGTTTTTTATAACACTAAACCTTACAAGCACAGAGACGACCGGCTGCTTCAAGCTCTGGTGGACATTCTGAATGAGGAAAATTAAAATAAGTGTGTGGTCCCAA GTTGGAAATATTCATGCTTCTTCCTTACCCTGCGATTTTGCCTGTGTCTGAAGTGGTTGTTTTGTCATGAATTCTTATGCTTATAATATCCTTTGTGGCACCTTTTCTTTTTCTCCCTAA ACTGTACATGTGAAGGGGATGAGCTCAAGCAGGAAGTTCAACTTCCAGAATTGATCATAGGTATTTCAAAACACATCTTTCCTGTCTGCACAAGTGAAGTGTTTTGTTCTTTCTGGAGTC ACAGTTGACAAAAAGCTCTTACACTACATTAGAACACTGCATTAGAGCCCATTTCAATTCTCAAAAGAAAAGGCAAAACCTGGGATATCAATTAATTTGAAAACATAATCTGCAAAGAAT GAGAAGGAGTCAGAAACTGTTTCTGTAGCTTGTTCCCTGTCTTGTCCATGTGGTTCTTCAAATTTTGATGCCAAGAAAGTATTTGGTAGGCCTAATGAAGGAGTTCACTGTAAGACTCAT TCCCTAGATCTTTCTATTCCAAAGTGCCACTCATTCCTGTAGTCAAAATCTGGTCATGTTGGTCAAAAGCTGGATTATTTAGATCTAGAAACAGATCTTGAAATCTGAATGCTCTGGTTT GAGCAATTTTCGAACATTCTTTGCCTGGTGCACTGTGTCTGTGGTGCCAGAGGCGTCCGTGGATCCAGAGGTGGTTATGACTCGTGCTGCATGCCTGGTCTTTCCTCTGTTTCTCCTTCT GAAAGTTTTCTATACCTGTCTCCTTTCTCAGCCACAAAATAAATGTTGGGAGAAATGATATATACCACTTTCCCAGAAAAAAAAAAACTTACACTTGGGACTTGGCAAATTCCTAGTCAC AATTTTTTTCAGCAGTAACAGGAAACCACTTATCACATGGAGACCTAATGTAATAATAGAAAAATACTCATAATAGGGAGAAACCAAGAGAAGTTTTGTTTTTGTTTTTTTCCAACTGTG TTCATTAGAACAGCGTGTTCTAAGTATTTGAAACTGAATGTTTATTCCTTGATACTAAAAGTTCTTCTCCAATCCTATCACTGATAGTGTCCAAATTCTCACCAAATTGCTCCTAAGCTT CAAATCAGAAGCAGAAACTGGCAGGCCATGGACCTTAATTGTCCCTCAGGTAGATTTTGTTTGGTATGCAGAATGTTTTTAAAATATGAGTGGTTATTGAAAATATGATGTTTCACATAA AACCTCATTCTCGGACCCATCTTTGCTCATGGCAACAGTTAGCTGGAGCTGAGTAGCAGCTGCCTGATTAGATGACTCTCAGTCCCCATGGCACCCTGCTCCATGTTACCTAGAGCAGGC ACTTGATTCCTTGCTGGGCAGTATCCAATAGGCATTTGATTTTGCCCACTCCTACACTAAGCGAATGTGTACAAAGTGTAAATGCATTAGGAAAAACAAACTACCCGCATCTTCTGTTAG GCAGGATCTGTACAATAATAATTATGAGTTTGCTTATGTAATCTCACCTCACCTGGATGATCACTAATACTAATTCATTTATTACTAACCTTCTGGCTTCCTTCTCTCAATATGCTTACA AAGTCTCCAGTCACCTACAATGCTGGCTTTCTCCCACTGAGTTTGCTGTTTGCAATTTTTCCATGAAGTTTGAACTTCATAAGGTAATTCATGGCATTGAACTGGTTCATGAAAAGAACA CTAGAGTCTGTCATTTGCTTTGGCTTGAAGTATGGTTGGTAACACAAATTTTCACCTGCTCTTCTACCATTTGAATTTGTGTAGAGGGTGTTTGCAGAGCAATGCCCGTAATGCTTAGAG AATGTTCTCCTAAAAGACTTGCGGAATCACTCTGTCCTTGGAAGTTTCATATATTGTTTGATATGAAGTGTTAGATAGAATTTCCAATATTGGAGCATATCAAAAAGTATTAAAACTAAA AAGGACCAGAGAATTCTTAGATTGGCCCGGAAAGGCCAATAAAGAGTTAGAATGAAAACTCATTACTTTTCCATTCCCAATCTAGTGCTAGATGTATAAATCTTTCTTTTGATTCTTCCT AACAAAATATTTTCTGGGTTAAAACCCCAGCCAACTCATTGGGTTGTAGCCAAAGGTTCACTCTCAAGAAGCTTTAATATTTAAATAAAATCATATTGAATGTTTCCAACCTGGAGTATA ATATTCAGATATAAAACAGTTTTGTCAGTCTTTCTTAGTGCCTGTGTGGATTTTTGTGAAAATGTCAAAGAGAAAACTTATATACTATTTCCCTTGAAATTTTAAACTATATTTTCTTTA CAGGTATTTATAATATACCAATGCTTTTATCAAACAGAATTTTAAAGAGCATAATAAATTATATTAAAGAACCAAAAGTTTTCCTGAGAATAAGAAAGTTTCACCCAATAAAATATTTTT GAAAGGCATGTTCCTCTGTCAATGAAAAAAAGTACATGTATGTGTTGTGATATTAAAAGTGACATTTGTCTAATAGCCTAATACAACATGTAGCTGAGTTTAACATGTGTGGTCTTGGTA TTCTTAAGGGAACTTCCACATTATACATTTGATGTATTGACCAGAATATGTAAAATATGCTTATAAATCAGAAAAATAAATTGTTTCTCACTAAGTCAAAAGAAAAAAAGCTCATGTTTC CACCAC |
Protein Sequence | >5122 : length: 753 MERRAWSLQCTAFVLFCAWCALNSAKAKRQFVNEWAAEIPGGPEAASAIAEELGYDLLGQIGSLENHYLFKHKNHPRRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRDSALNL FNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRM LDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDY TDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALK ANGEVIIEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIVNWKLILHGTSSQPEH MKQPRVYTSYNTVQNDRRGVEKMVDPGEEQPTQENPKENTLVSKSPSSSSVGGRRDELEEGAPSQAMLRLLQSAFSKNSPPKQSPKKSPSAKLNIPYENFYEALEKLNKPSQLKDSEDSL YNDYVDVFYNTKPYKHRDDRLLQALVDILNEEN |