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Cancer metastasis database

Annotation category 5

Gene information

Gene ID 5045
Symbol

FURIN

Synonymous

FUR|PACE|PCSK3|SPC1

Full name

furin (paired basic amino acid cleaving enzyme)

Gene description

FES upstream region|dibasic processing enzyme|furin|furin, membrane associated receptor protein|paired basic amino acid residue-cleaving enzyme|proprotein convertase subtilisin/kexin type 3

Cytoband

15q26.1

Gene type

protein-coding

Synonymous

MIM:136950; HGNC:HGNC:8568; Ensembl:ENSG00000140564; HPRD:00653; Vega:OTTHUMG00000149831

Pathway and disease

Pathways and Diseases

Detail

Pathway

Signaling by PDGF;Reactome;REACT:16888

Pathway

Signalling by NGF;Reactome;REACT:11061

Pathway

Signaling by TGF beta;PID Reactome;500590

Pathway

p75(NTR)-mediated signaling;PID Curated;200103

Pathway

Removal of aminoterminal propeptides from gamma-carboxylated proteins;PID Reactome;500543

Pathway

Alzheimer disease-presenilin pathway;PANTHER;P00004

Pathway

HIF-1-alpha transcription factor network;PID Curated;200172

Pathway

Signaling by TGF beta;Reactome;REACT:6844

Pathway

Endothelin signaling pathway;PANTHER;P00019

Pathway

Signaling by Notch;Reactome;REACT:299

Pathway

Metabolism of proteins;Reactome;REACT:17015

Pathway

Notch signaling pathway;PID Curated;200013

Pathway

Maturation of Notch precursor via proteolytic cleavage;PID Reactome;500112

Pathway

Signaling by PDGF;PID Reactome;500508

Pathway

Glypican 3 network;PID Curated;200193

Pathway

Alzheimer disease-amyloid secretase pathway;PANTHER;P00003

Pathway

proteolysis and signaling pathway of notch;PID BioCarta;100091

Disease

Cystic fibrosis;FunDO

Disease

Vitiligo;FunDO

Disease

Rabies;FunDO

Disease

Ovary cancer;FunDO

Disease

Cardiovascular disease;FunDO

Disease

Breast cancer;FunDO

Disease

Malignant glioma;FunDO

Disease

Larynx cancer;FunDO

Disease

Neoplasm metastasis;FunDO

Sequence Information

Nucleotide Sequence

>5045 : length: 4352
AAACAGCAGTCGGTCCTGGGGTGAGGCGCAATTTGAGTGGCCCAGAGTGGCTCTCTGTGTCAGGAGGTTCTGGTGCTGGAGAAAAGGGCTTTGCCCAAGAACACAGCCAGGAAGAGCACC
CACAGCTCTCTCTGGCCACAGCCTGGAACAGAGTCCCATGTGAAACAAGACCATGAGAAATACAGCAAGCCTCCAGGTTTGAGACAAACTGGGACTAGAGGGGTCGGCACTCTTCACCCT
CCCGAGCCCTGCCCGTCTCGGCCCCATGCCCCCACCAGTCAGCCCCGGGCCACAGGCAGTGAGCAGGCACCTGGGAGCCGAGGCCCTGTGACCAGGCCAAGGAGACGGGCGCTCCAGGGT
CCCAGCCACCTGTCCCCCCCATGGAGCTGAGGCCCTGGTTGCTATGGGTGGTAGCAGCAACAGGAACCTTGGTCCTGCTAGCAGCTGATGCTCAGGGCCAGAAGGTCTTCACCAACACGT
GGGCTGTGCGCATCCCTGGAGGCCCAGCGGTGGCCAACAGTGTGGCACGGAAGCATGGGTTCCTCAACCTGGGCCAGATCTTCGGGGACTATTACCACTTCTGGCATCGAGGAGTGACGA
AGCGGTCCCTGTCGCCTCACCGCCCGCGGCACAGCCGGCTGCAGAGGGAGCCTCAAGTACAGTGGCTGGAACAGCAGGTGGCAAAGCGACGGACTAAACGGGACGTGTACCAGGAGCCCA
CAGACCCCAAGTTTCCTCAGCAGTGGTACCTGTCTGGTGTCACTCAGCGGGACCTGAATGTGAAGGCGGCCTGGGCGCAGGGCTACACAGGGCACGGCATTGTGGTCTCCATTCTGGACG
ATGGCATCGAGAAGAACCACCCGGACTTGGCAGGCAATTATGATCCTGGGGCCAGTTTTGATGTCAATGACCAGGACCCTGACCCCCAGCCTCGGTACACACAGATGAATGACAACAGGC
ACGGCACACGGTGTGCGGGGGAAGTGGCTGCGGTGGCCAACAACGGTGTCTGTGGTGTAGGTGTGGCCTACAACGCCCGCATTGGAGGGGTGCGCATGCTGGATGGCGAGGTGACAGATG
CAGTGGAGGCACGCTCGCTGGGCCTGAACCCCAACCACATCCACATCTACAGTGCCAGCTGGGGCCCCGAGGATGACGGCAAGACAGTGGATGGGCCAGCCCGCCTCGCCGAGGAGGCCT
TCTTCCGTGGGGTTAGCCAGGGCCGAGGGGGGCTGGGCTCCATCTTTGTCTGGGCCTCGGGGAACGGGGGCCGGGAACATGACAGCTGCAACTGCGACGGCTACACCAACAGTATCTACA
CGCTGTCCATCAGCAGCGCCACGCAGTTTGGCAACGTGCCGTGGTACAGCGAGGCCTGCTCGTCCACACTGGCCACGACCTACAGCAGTGGCAACCAGAATGAGAAGCAGATCGTGACGA
CTGACTTGCGGCAGAAGTGCACGGAGTCTCACACGGGCACCTCAGCCTCTGCCCCCTTAGCAGCCGGCATCATTGCTCTCACCCTGGAGGCCAATAAGAACCTCACATGGCGGGACATGC
AACACCTGGTGGTACAGACCTCGAAGCCAGCCCACCTCAATGCCAACGACTGGGCCACCAATGGTGTGGGCCGGAAAGTGAGCCACTCATATGGCTACGGGCTTTTGGACGCAGGCGCCA
TGGTGGCCCTGGCCCAGAATTGGACCACAGTGGCCCCCCAGCGGAAGTGCATCATCGACATCCTCACCGAGCCCAAAGACATCGGGAAACGGCTCGAGGTGCGGAAGACCGTGACCGCGT
GCCTGGGCGAGCCCAACCACATCACTCGGCTGGAGCACGCTCAGGCGCGGCTCACCCTGTCCTATAATCGCCGTGGCGACCTGGCCATCCACCTGGTCAGCCCCATGGGCACCCGCTCCA
CCCTGCTGGCAGCCAGGCCACATGACTACTCCGCAGATGGGTTTAATGACTGGGCCTTCATGACAACTCATTCCTGGGATGAGGATCCCTCTGGCGAGTGGGTCCTAGAGATTGAAAACA
CCAGCGAAGCCAACAACTATGGGACGCTGACCAAGTTCACCCTCGTACTCTATGGCACCGCCCCTGAGGGGCTGCCCGTACCTCCAGAAAGCAGTGGCTGCAAGACCCTCACGTCCAGTC
AGGCCTGTGTGGTGTGCGAGGAAGGCTTCTCCCTGCACCAGAAGAGCTGTGTCCAGCACTGCCCTCCAGGGTTCGCCCCCCAAGTCCTCGATACGCACTATAGCACCGAGAATGACGTGG
AGACCATCCGGGCCAGCGTCTGCGCCCCCTGCCACGCCTCATGTGCCACATGCCAGGGGCCGGCCCTGACAGACTGCCTCAGCTGCCCCAGCCACGCCTCCTTGGACCCTGTGGAGCAGA
CTTGCTCCCGGCAAAGCCAGAGCAGCCGAGAGTCCCCGCCACAGCAGCAGCCACCTCGGCTGCCCCCGGAGGTGGAGGCGGGGCAACGGCTGCGGGCAGGGCTGCTGCCCTCACACCTGC
CTGAGGTGGTGGCCGGCCTCAGCTGCGCCTTCATCGTGCTGGTCTTCGTCACTGTCTTCCTGGTCCTGCAGCTGCGCTCTGGCTTTAGTTTTCGGGGGGTGAAGGTGTACACCATGGACC
GTGGCCTCATCTCCTACAAGGGGCTGCCCCCTGAAGCCTGGCAGGAGGAGTGCCCGTCTGACTCAGAAGAGGACGAGGGCCGGGGCGAGAGGACCGCCTTTATCAAAGACCAGAGCGCCC
TCTGATGAGCCCACTGCCCACCCCCTCAAGCCAATCCCCTCCTTGGGCACTTTTTAATTCACCAAAGTATTTTTTTATCTTGGGACTGGGTTTGGACCCCAGCTGGGAGGCAAGAGGGGT
GGAGACTGCTTCCCATCCTACCCTCGGGCCCACCTGGCCACCTGAGGTGGGCCCAGGACCAGCTGGGGCGTGGGGAGGGCCGTACCCCACCCTCAGCACCCCTTCCATGTGGAGAAAGGA
GTGAAACCTTTAGGGCAGCTTGCCCCGGCCCCGGCCCCAGCCAGAGTTCCTGCGGAGTGAAGAGGGGCAGCCCTTGCTTGTTGGGATTCCTGACCCAGGCCGCAGCTCTTGCCCTTCCCT
GTCCCTCTAAAGCAATAATGGTCCCATCCAGGCAGTCGGGGGCTGGCCTAGGAGATATCTGAGGGAGGAGGCCACCTCTCCAAGGGCTTCTGCACCCTCCACCCTGTCCCCCAGCTCTGG
TGAGTCTTGGCGGCAGCAGCCATCATAGGAAGGGACCAAGGCAAGGCAGGTGCCTCCAGGTGTGCACGTGGCATGTGGCCTGTGGCCTGTGTCCCATGACCCACCCCTGTGCTCCGTGCC
TCCACCACCACTGGCCACCAGGCTGGCGCAGCCAAGGCCGAAGCTCTGGCTGAACCCTGTGCTGGTGTCCTGACCACCCTCCCCTCTCTTGCACCCGCCTCTCCCGTCAGGGCCCAAGTC
CCTGTTTTCTGAGCCCGGGCTGCCTGGGCTGTTGGCACTCACAGACCTGGAGCCCCTGGGTGGGTGGTGGGGAGGGGCGCTGGCCCAGCCGGCCTCTCTGGCCTCCCACCCGATGCTGCT
TTCCCCTGTGGGGATCTCAGGGGCTGTTTGAGGATATATTTTCACTTTGTGATTATTTCACTTTAGATGCTGATGATTTGTTTTTGTATTTTTAATGGGGGTAGCAGCTGGACTACCCAC
GTTCTCACACCCACCGTCCGCCCTGCTCCTCCCTGGCTGCCCTGGCCCTGAGGTGTGGGGGCTGCAGCATGTTGCTGAGGAGTGAGGAATAGTTGAGCCCCAAGTCCTGAAGAGGCGGGC
CAGCCAGGCGGGCTCAAGGAAAGGGGGTCCCAGTGGGAGGGGCAGGCTGACATCTGTGTTTCAAGTGGGGCTCGCCATGCCGGGGGTTCATAGGTCACTGGCTCTCCAAGTGCCAGAGGT
GGGCAGGTGGTGGCACTGAGCCCCCCCAACACTGTGCCCTGGTGGAGAAAGCACTGACCTGTCATGCCCCCCTCAAACCTCCTCTTCTGACGTGCCTTTTGCACCCCTCCCATTAGGACA
ATCAGTCCCCTCCCATCTGGGAGTCCCCTTTTCTTTTCTACCCTAGCCATTCCTGGTACCCAGCCATCTGCCCAGGGGTGCCCCCTCCTCTCCCATCCCCCTGCCCTCGTGGCCAGCCCG
GCTGGTTTTGTAAGATGCTGGGTTGGTGCACAGTGATTTTTTTCTTGTAATTTAAACAGGCCCAGCATTGCTGGTTCTATTTAATGGACATGAGATAATGTTAGAGGTTTTAAAGTGATT
AAACGTGCAGACTATGCAAACCAGGAAAAAAA

Protein Sequence

>5045 : length: 794
MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQ
QWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSL
GLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKC
TESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNH
ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCE
EGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGL
SCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL