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Cancer metastasis database

Annotation category 5

Gene information

Gene ID 4821
Symbol

NKX2-2

Synonymous

NKX2.2|NKX2B

Full name

NK2 homeobox 2

Gene description

NK-2 homolog B|NK2 transcription factor related, locus 2|NK2 transcription factor-like protein B|homeobox protein NK-2 homolog B|homeobox protein Nkx-2.2

Cytoband

20p11.22

Gene type

protein-coding

Synonymous

MIM:604612; HGNC:HGNC:7835; Ensembl:ENSG00000125820; HPRD:05213; Vega:OTTHUMG00000170524

Pathway and disease

Pathways and Diseases

Detail

Pathway

Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells;PID Reactome;500521

Pathway

Regulation of beta-cell development;PID Reactome;500518

Pathway

Maturity onset diabetes of the young;KEGG PATHWAY;hsa04950

Pathway

Insulin Synthesis and Processing;PID Reactome;500128

Pathway

Regulation of beta-cell development;Reactome;REACT:13698

Pathway

Regulation of gene expression in beta cells;PID Reactome;500522

Sequence Information

Nucleotide Sequence

>4821 : length: 9322
GTGAATCCCGGAGTCAGGCAGAAGTCTCCTTGGGGTTTTGTTGGGCCTGTCACTGGGTCCCTTTGTCATCCACGGGCTCCATGCTGGATTCCATATGGCCAGCTGGGCCGAGGGAGCGCG
AGGAGGGACCCGCACAAAACCTAAATTGTGTCCGGCTTTCAAACCCTGTATTGTTGTCTGTGAAAGGAAGACGCATTAAAAATTCGTGCTATATCTATTGGGGAGGAGGCTGGAGGAGGG
GAGAAAAAGCCACCCCTGTCTTTGATGGCTTCGGAGGGCGCTTGCCCCGCCTAGGCCCCGTGACACTGAAAGTTGGATCTCTCTCATTCTGTCTCTCTCTCTCAAAATCTCTCTTTTTCT
CTCTTCTCATAATCTCGCTCTCATAATCTCTTTCTCTACTTTCATAATCTCTTTTTCTCATAATCTCTCTCCCTTCCTCACTTCTCTCCTTCCTCTCTTCTGTCTCCTTGACTCTAACGC
TGGGATGGGAGTCCGCGAACCTGCGTCTTCAGGGTTTGGCTCACTTGTGCGCACTTTGCTCACTGCTGTGTGTGTATCAGGAAACTAACTTCTGCCTGGGAGCTCTGCACCATCGGACCG
TCCTGGGGCTCAGGAGGCAACTCAGGGTACCCAGGGCCTGGGTGATGCTCGGTCCCCTACGGGCTTAGCGGCTCCTGGGTAGATGAAAATCCACCCCCTGATTTCGCAACCGACCGGCCC
CGAAGCGCCCGCGCGCGGAGCCGCCCTTCCACTCACCGCGAGAAAGGTTCTGAGAGGCCAAGGGTGCCGCTCAGTCCCGGGCCCAGCTAGACTTGGGCTGCAGCCGGTTCCAAGGCGACT
TGCGCCCGGCCGGACCACTTGGTTACCAACCCCGAAGAGCTAAAGACGCGCGCGTTCCTTTGAATTATGCGCGGGGATCCATCCCACTGGCCTCTTGGTGCGATGGGAAACCACTTCAGA
AACTTCTTCCAACAGCGTCTCTCCCCATGTTGGAGGAGGGAGATACTTCCTCTTTAATTTTCAATGTCTCCTGTATCGCGTGCTTACAAAATTCAGTACCAGGGAGACACAGCAGGGCTT
CCAAGGAATTTGCCCATTTTTTGCCTCCTCTAAGCGGTCCAAATTGGCGCGAGGCAGTCGGAAATAATTTGGGTCATGCCTTCTCCCCTGCAATTGCCAGGTCAAAACTCCCATAAGCAG
TCCCCAAATAAACCATATGTACTAAACAAAAATAGTTTATGCTGAGCTCTGTGGAAATAAAAACTGGAACCCAGATATGTTCCCCACAAAGTCACTCGGCCCTTAATGAGCAGAACTGAG
CTGGTGGAAATTCCGACTAATGGGAAACTTGGATGCGCCCCCTTTCCTATTTAGTACAACGGTCATATTTAGTAGAATCAGATAATTTGGTAAGAGTGGAAGTCCCCCTTCCCAACATTC
CCCACCTCAGATGGGGAAATAACTTATTTCCTTACCTATTGACTGTTGGGCTTAGTTGAGACCTGGTGTGTATTTCTCGAGCCTTTTCAAGAGCCTGGTCATTGAAAAGCTAATCCAATA
TTTACCGAGCATAAGGACAGTTCTCAGACGTATTTATTAAGGCCCATCGCTAAGTGATTACTTGGACTGAAGACAAAGGCCAGGGGAGGGGGCGTCTAGGCATACCAGATCCTTCTCATT
TGGGCTCTCCCCACCCAGAACCAGGAAACCGGGAGCGCGCTTGTGCGCTGCTGAAGTTCCCCTCCCGGTGTTAAGTGGCGGGCGGATTAGATACTGTGCTGGGCGGTATTTCAGGAAATA
TGTACTTGTGGCTCCCTGAGAGGCCAAGCGCAGTGACACTCTAAACCGTGTCGATATATCATCTTTTATCCAGGATCTGCAAATAAACCCCTGATCCCCCCGGCGCATTATAGCCGCCGC
TATCTCGCCAAGGAAGCGATCTGAGTTTTATTGCTTTCACCAACGCCCCGAGACACACACACACACACACACACACACACACACACACACTCCTCTCTCGCACTCTGATTTTTAAAGGCT
CTATTTTTTCCCTCCCGAGGCATCGTTATTAATAAAGAGGCGAATAGGCCTCAGCGCCGCCATCCGAGCAAGCGGGGAAATGTGGGCCAGCAGCCCAGGCCCGCGCGCGGATCCCGCGTA
CGCTCCACGCGCCCCCTCGGGCCGGAGAACCGAGCGTGTGCCGCGTGCTGCCGCCGCCAGGAGGCGCCCGAGCCCAGCGTTCCCGAGCGTCTCTGCGCGCGGGTCCGGGCAGAGCCCGGG
AGCCGCCGGAGGCAGCTGCGCATCAGCGGACTCGCGGCCCGGGTCGGAGCCCGGTGAGTGGTGCCAAGAGGTGGCGGCGAGTCGGAACCTTGGGGAGAGCCGCGAGTCAGACGGCGGCGG
GTGCCTGGGAGGTGCGAGTCGACCTGTGTTCGGCTGTGGTTTTCCCGCCATGCCTCTTCTCCTCCACGTGCGTACCACCGCCCGTCCCAGCCCCGGTTTCCATCGTGTTTGGGCACAGAC
CACAGCCGACTGGTCCAGGAGCGCTCTGGCCACTGGGAGGGCCCCACCAGGCGCCAGGGCGCGCTGTCTCCGCGATCTCAGGGCCCCTGGCGGCGTCGGCCGCGCGGGTGGACGCGGAGA
GGGCGGTGCTGCGAGGGCCCGGAGAGTGGGTGCCCGCGTGGGGAGGCGGCCCGGGAGCGCGGGAGCGATGCGGAGGAGGGACCCGGTTTGGTTGCAGGTTTCCGGGGCGGGGGTTCCGGG
AAGGAGAGACCCTCGCCTTCCGCCCGCCCTGGATCCGGGTCCCGCCGGACCCCCGGCTCCTGCCGTTCGTCGCCTGGAAGCGGGGCAGGCGCACAGTCCAGACGCCAGGGAGAGACGCCT
CGCCGACCCAGACCGTGGGGTCAGGGCCCGGGAGGCAAGAACGCCCCACACACAGCAGGGCACCCCAGGCAACCCTCACTCCGTGCTGAGGCCTCGGCTAGGGTGCAAAGGTGTCCGGGA
ATGGAAGGGACACGAGGGTGTGGACGCCTCGCACTCTACTCACGCCTGGTGCCTTCTGAGAGGCTGGGCGTGGGGCAGAGGGTAGGGGACAAGGGGGTGACATTCCTTAAGGTCCTCCCC
CCAACAAAAGTAGGGCCTGCAGTTCCAGCTTGATTCGTTGATTGTTGGGTGGAACCGCCTCACATCAAAGGCATCGTGGCTCCAAACACTGTCCCCTTTACTTTTCTAAGCCCCCGCTTC
AAAACCAGCTGTCGGTGGGCCGGTGAGGGCGTCTGCAGTACCCAGGCTTTCCGCGGGGCGGCGCGGTTGGATAAGAAAAGGCTTCCCGGCTGGGGCGCGCAGCGCAGCTCAGACACCTGC
GGGACTCGAGATGTCTCCGCGAGGTGTCCTCTACACCAGGGCTGCATTCCCTAAATAATGAAAACTCCCTGCCCTTGCACTTGGTGCCTGGAGTGCGATGAAGAGGCTGAAGGTATCCAG
CCCGGCCCTTCTCCCCTCCCTCCTCAGACTGCTGATGTGACATGCGTGTAACTGTCACCCCACACAGGACGTGGAACACTTCCACCACCCCAAAATGTTCTCTTCTAATGGAATAACGTG
TTCTGTCCTAACAAAAGAATAGCTCAATACTTAAAGGTATCAATTCAAAGCTGCAGATGAAAAATCTCATCCGCCCTTTGCTGCTTGTTCTCGCCTGTGGTATTTTTACCTTTCTTCATA
AAATGATACAAAGAAAGCCCCAGGTCGCTGACCCCAGCCTCTCTCGCACCTGAAGACGATGACCATCACCGCTGCCACGTACTGAGCACCTTCTAGGCCAGGCTGCTTCTCCTCGTCGTC
TAATCAGATCATCATAGCCAATCTGTCCTTCTGCAGAGGAGCCTGTTTCAGAGAAGTTAAGCACCCGATCTTATAATCAAGCCAGTGTTCTGACAAAGAAAAGCATTCTGGGAGTGGAGG
TGGGATCTACCAGGGCGTCCTCTCCTATTCCAGAAGAGTGGGCAGGGGTGGGGGAGGACAAAGATGCCCTCCCACTCTGCAGAAGGCAGTTAGGTGACTTCTCCACAGGGCAGGGTTCTG
CCAGTTCTCCTCTGGCAGCCAGTGCCCAGGTCCCATCCTGGTTGGTGGGGGCTGGGCCAACCCCTTGTCATCCTCGGGGAAGCCTGTATGTACACCAGCACCTCCACTGGGTGCCAAGTG
GCCATCTCGGCCAGCGAGTGTCCCCTGAGAACTGAGGGGGAGTAGGCTGAGGGTGCACCTGAGGGGCACGCTCCGGAGCCTGTTCTCACTCCTGGGCCTGGGCCTGGGCCTTCCATGGTT
TCGATGACATGAGCAACTCCCCTCTCCCCCCAGGATGATAATGTGTACCAAAAAATAGATTTTTCAGTAGCCAATTGATCTTACTGCTTTAATTAAATGATTACTTTTTTGCCTAATGTG
GGGAAAAGGTAAAATAAGTTAACTTGTTCTTCTGTGCATAGTGTTGGGCTCCCTAATCTGAGAGATTTGCAACTTTTTGCTTTGTTTTGTTTCATTTTTTTTCTGAGACAGGATCTCGCT
CTGACACCCAGGATGTAGTTCATTGATGCTATCATAGCTCATTGCAGCCTTGAACTCCTGGGCTCAAAAGAGCCTCCTGTCTCAGCCTTCCCAAGAGCTGGGACCACGGGCAGGCACCAC
CGTGCCCAGCTATTTTTTATTTTTGTGTAGAGATGTGGTCTCACTGTGTTTCCAAGGTTGGTCTCAAACTCCTGGCCTCAAGCTATCCTCCCACCTTGGCCTCCCAAAGCACTGGGATTA
CAAATGTGAGCCACTGTGTCTAACCACAAGAATTATTAAAAGGAATTTTACTTAAGTATCTACTTCCAGATCTCTCCATGTTTCTTTACTAGCTACAAAATAAAAGAATTACCCCATCAG
CCTCTGTAGGGTAAGATGAATTGTGTGGAATGGGTATGAAATGAAGGATAGTTAGATGTAGAAGGTAAAACAAAAGGAATCAGCTTTTTGTGTCTGTGACAGAGGATCTGATACTTGATG
GTCTGACCACAAGGCATCGCTCAGAAATCAGCAGTCCTTTTCACCCAGTGAACAGCCAGCTGCTTTGAGCAGAGAGAGCTGTGGTTGGAACTCCTGCTCTGTGACTCAGGGGAGGAGGCA
GAGCTTGCCGCAGAATGCAGCCACTGCCCACAGCCCCTGTGCACTCCCTTTTCCCTTGTGCTGGCTTCCCGCTGCCAGCATCTGCAAGTCTCTGCCTGGAGGTGAGCAGGAGGGTGCTGG
GCCCATTAGACAGGTGGCTAGGGCTGGGGAGTTCATGGTCTTCACGCAGTTTCAGGTGGAGGTTGCAGGATATATGGCCCAGCTTCCTGGCCCCAGGTGGAACAACCCTGAGACATGTTC
GCCATTTCCCACAGGCCCCCAGTGGGACTGAGCCCTAGTTGTCTTCAGTGGCAATCTTCTCATTACCACCTCTCGTGTTGATTCTTTTTCCCTTCACTTTCTCATTTTTCCATTTCCTTG
TTGGTCCCCATTAACTACTTGCACATGAATCTTTGTCTCAGGGTCTGCATCTGGGGGACCCCAAAGACACAGACACTTGAGCTGTTACTCTGCCTTTATCTTAGACCTAGCATTGGTCTC
CAGAGGTCACTCATGACTTCAGGGCCTATTTTAATGGCCTCTTTCCCCATGTGTTCCTTGGGAATGTCCATTGTTGATGCGTCCTTCTGTACTAAGTAGAGTTTTTGGGCTGCAAGGAGG
CAGTTAGCACAGGGAACTACGTAGTGAGGGACATGGAGACTAAACAGCAGCTGGCCCATCTCTCTGGCTTCTCATGGCCAAGCCTGGGACACACAGCTGCCCTCGTGCAGGTCCAGAACT
ATGGCACTTGTTCCCTCAGGACCCATCCTCAAAGCCAGTGACTTGGTCTTTTCCTATGACAAAGGAGCTCCCAGAATGTGGCAGTCCCCCTTCCTAGAGGGAGAATCTGACTGGGTCAGG
GAGGCACCCCCGGTTTGCAGAGCCCCCATTGGTCAGGTTCAGTGTCCAAAACACCTGAGGGGCAAGTGGCTTCTCGAAGTCCAGCCCATATGGTTACTTTTGACTTGGACACTCAAGGCA
CAGGGACACATGACACAGGCACAGGGTGTGACAACTGCATGCAGAAAGAGCCACTCTCATTCCTCAGAAGAGGCTGTGGAGATGAGTGGCTGAGCCATGTGCCCCAAAATTCATGTTGAA
GTCCTAACCCCCAGTATCTTAAAATGTGACCATATTTAGAAATAGAACCTTTAAAGAGCTAACTGGGTTAAAATGAATTCATTAGGGTAGGCCCTACTTCAGTATGACCGGTGTCTTTAG
CAGAAGAAGAAATCGGTACAGACACGCAGAGGGGAGGGCATGTGAGGACATGGGAAGGAAATGCCACTTGCAAGCCAAGGAGAGAGGCCTCAGAAGAAACCAGCCCTCCTGACACCTTGA
TCCTAGACTTCCAGCCTCCAGAACTCCTAAATGCTATTGAAAAGAGCAGAGAAGATAGAGTGCAGGCCCCTAGAGACAGGATGGAACGAAACACGCAGTGTGCATCTGTGTCCTGCTCAG
CATACGCTCTTGGTCCCCACTGGGCCATCTCGCTGCTGACTGGCATCCCGAAGAACAGGCAGATTGCACAGGGGCAGCTCTTTCCTCCAAAGCTGCAATGTGGTGCATGAAGTCCTCAGA
TTTGGGAACTCATACAGGCACTTGAGCTCAAACATACAGTTCTGATCTAAGACATCACAGGTAAGAATATCCAAAAAGGTGAGCTTTCCCCCTGGAAACCATGACTTCCTCAGAAACAAG
GAGAAATGTTTCAGCTGCCCAGGTTGCAGTTCCGAGTATGGAGGCTTCCATGTTTCATGTCAGGGTCATGGTGGAGCTGTTTCAGCTGCAGGTGGTATTCCACCATTTGGTCCTCCCTGA
TGTCTCCTGGCACCTTTCCTTCTTCAGTCTCAGCACTCTGAAGAAGCGTGCTTGTGAGCGCCGCGGGACGATCCAGGATGTCCAGGATTGTGGACGATCCTGTTCTTCCCATCTGTGAGG
TAAGGCAGATTAGGAATGTCCACGTCTAGCTTGAATTTCACATCCAGCCATTGGCTGCCACCATGGCCAGGGGCTTCTGCAGATGGATCACCGTTTCCCTCCCAGGAGCAGGCAGGTGTC
CAGTATCAGCCCCAGAACATCCCGGTCACCCATCTCCATAGGGCTTGGATGACATGATGATGCTCTCTGTGCCTCTGAGGACGGCGCCTTGGGTCTTTGTACACTAAATCCCACCTTGTC
CTCTCCTCTATTTGAAACAGCCATTTCCCAAATCCCAATCTGATGAAATCCTGTTCTTCCTTCCCTCATGTTTCTCTAGGCCTCCTGTGGACTCCCAGAATGTAAAGTCAGCATTCCCTT
GAGCCTTTTGGGGACTTATAAGCACATGGCCCAAGGTCCACCTAACTCTAGGTGTATCCTGTAGAACCAGTATTCTAATCCTAACTTTAAAGATCTTACAGGACCATAGGGTGTGCGTAA
AAAGCCTGCTGCAAATCAGAGTGCTTCAACTGCGTATTAATGAGATGGAGGAAAGAGGCTGTGAGTGCAGACAATGAGTCCCTGAGTAAATAGACTCCAGAGCCAAAGGTGTTCTCCACA
CCGAAAGAATGACTGTACCCAGGGAAGGAGCTCAGACTCACCTGGACAAACCCTGAGGGGACAGCCATGTTCCAGTGTGGCTAGGAGGGTCTGGAGCTGGGCACGTCCCCCATGTCTGCT
TGATTCCCCTCTGGCCGAGTTCTACTCAGGTGAGTTGTGCTCATTCTTGCTTCCCCAGGGCCTGGATCACAGTTCCTCAAGCTTTGGGATACAAACGAATCACCTGGGATTTGGATAAAA
TGCAGATTCGTGTTCAGCAGCCCTGGCATTCTGCATTTCTCATGAGCTCCAGGGAGACGCTGGTGCTGCTGGGGCAGGACCACACTTTGGGTGGCAAGGGCTTGGCAGGCAATTCCAGGT
GTCACCCTAGAGATGGCCTGCTATTGCACTGTCAGTAGGTAGCTGCCACAGTGACGGCCGCTCCAGATCAAGGGGAGGACCTTTTGAAAAGGGTCCTTGAATCATTTGGGAAATAAATCA
AGCCATATGAGTAAAAAGTAATCAAAAAATATGTTGAATATTGGAACCAGAGGAAATCTTAGCATCATTTTGTAATGACTCCCTCCACGAATTTTCCAGATAAGGAAACTGACAAAGCCA
GGTGGCCTGTGGCTGAGGAGCGAGACGGTCAGCGAGGTCTCCCTGCTGCACTCTCGTGCACTTCCACAGTGAAACCCTGCTGAGAGACACAGGAAATGTTGAACATAGTGTCTTTAAAAT
TAAGACTATGACTGCCCTAAACATTTACAAAGCACAAACCATGAGAAAAAAGCCTGTACCAGAAATCAGAAGATGGCTTTTGTCCATGTGCAACCTTGGACAAGTTAATTACTTATCGCT
GCTCTCTGAGCCCGTTTCCCCACTGGTTACCGAAAAAATAGAAAAGGATATGCCTGCCCTTCCTAATTCACAGGGCATCGCAGGGAGGTAGGTAGTTAATATGCTGAACCACTTCAAAAC
GGTGGAGCTGAACTCACAGCAGGAACCCTGTCACACCTTTCCATGACAAGGATATCAGTGGGGTGAGGGAGGTGGGGAGAGGCATGAGGATGGGAGACAAAGGAGTGGGGTGGGGGGCGG
GGGAAGGAGGAAGCCAGAAGGACAGGCCCAGGCTAGGCTCTGAAGTCAGCAGGTGAGCGAGGTAGAGAACTAGCAGCACCACTGTCCATGGATATTTGCGGTGATGGAAATGTACTGTAT
CCATGTTCTCCAATATGGCAGCCACTAGCCACATGTGGCTATCAAGCGCTAGAAATGTAGCTAGTGTGATCGAGGAACTGATCTTTAATTTTTCTTTAATTGTTATTAATTTCCATTTAA
ATAGCCACATGTGGCCAGTGGCTTATGTAGCAAAGATCTAGATCATTTGTTTGAAGCAGTAAAAAGAGAAATGTGAATCCCCTCTTCTTACCTCCTATAACATGCTAATTAACATCACTG
CAATTAACCACCATTCACAGCTCTTCAGCTGCTCTGTGGAACCTCAGCCCACTCTGAAATGAACAGCCGCAGTGGCAGGGGTTACAGAATGGGCTGGGAGTGGCAATGTAGATTTATCTC
TTCACACACTCTATGCCCTCTATCAAAAATGCCTCAGGCTGTGTAAAATTCCACAAATAATAAAGAGATTTTAAAAATGTGA

Protein Sequence

>4821 : length: 273
MSLTNTKTGFSVKDILDLPDTNDEEGSVAEGPEEENEGPEPAKRAGPLGQGALDAVQSLPLKNPFYDSSDNPYTRWLASTEGLQYSLHGLAAGAPPQDSSSKSPEPSADESPDNDKETPG
GGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRVAVPVLVRDGKPCHALKAQDLAAATFQAGIPFSAYSAQ
SLQHMQYNAQYSSASTPQYPTAHPLVQAQQWTW