| Gene ID | 471 |
| Symbol | ATIC |
| Synonymous | AICAR|AICARFT|HEL-S-70p|IMPCHASE|PURH |
| Full name | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
| Gene description | 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase|AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme|AICARFT/IMPCHASE|bifunctional purine biosynthesis protein PURH|epididymis secretory sperm binding protein Li 7 |
| Cytoband | 2q35 |
| Gene type | protein-coding |
| Synonymous | MIM:601731; HGNC:HGNC:794; Ensembl:ENSG00000138363; HPRD:03434; Vega:OTTHUMG00000133023 |
Pathways and Diseases | Detail |
|---|---|
Pathway | De novo purine biosynthesis;PANTHER;P02738 |
Pathway | purine nucleotides de novo biosynthesis II;BioCyc;PWY-841 |
Pathway | One carbon pool by folate;KEGG PATHWAY;hsa00670 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Purine metabolism;KEGG PATHWAY;hsa00230 |
Pathway | Purine ribonucleoside monophosphate biosynthesis;PID Reactome;500226 |
Pathway | Metabolism of nucleotides;Reactome;REACT:1698 |
Pathway | inosine-5'-phosphate biosynthesis II;BioCyc;PWY-6124 |
Disease | methotrexate efficacy;GAD |
Disease | IMMUNE;GAD |
Disease | methotrexate toxicity;GAD |
Disease | PHARMACOGENOMIC;GAD |
Disease | Rheumatoid arthritis;FunDO |
Disease | rheumatoid arthritis;GAD |
Disease | AICA-ribosiduria due to ATIC deficiency;OMIM |
Sequence Information | |
|---|---|
Nucleotide Sequence | >471 : length: 2094 GCGCGGATCTTGCATCTGAAACTGAGCAGAGCAGGGCGCCGGGCAGGGCCGGCGGGCCACGTGATAAGCCCGGAAACAGCTCCGCCCCCTCGCTTCCTGAGCCGCCACATCCCGGCAGCC CTCCTACCTGCGCACGTGGTGCCGCCGCTGCTGCCTCCCGCTCGCCCTGAACCCAGTGCCTGCAGCCATGGCTCCCGGCCAGCTCGCCTTATTTAGTGTCTCTGACAAAACCGGCCTTGT GGAATTTGCAAGAAACCTGACCGCTCTTGGTTTGAATCTGGTCGCTTCCGGAGGGACTGCAAAAGCTCTCAGGGATGCTGGTCTGGCAGTCAGAGATGTCTCTGAGTTGACGGGATTTCC TGAAATGTTGGGGGGACGTGTGAAAACTTTGCATCCTGCAGTCCATGCTGGAATCCTAGCTCGTAATATTCCAGAAGATAATGCTGACATGGCCAGACTTGATTTCAATCTTATAAGAGT TGTTGCCTGCAATCTCTATCCCTTTGTAAAGACAGTGGCTTCTCCAGGTGTAACTGTTGAGGAGGCTGTGGAGCAAATTGACATTGGTGGAGTAACCTTACTGAGAGCTGCAGCCAAAAA CCACGCTCGAGTGACAGTGGTGTGTGAACCAGAGGACTATGTGGTGGTGTCCACGGAGATGCAGAGCTCCGAGAGTAAGGACACCTCCTTGGAGACTAGACGCCAGTTAGCCTTGAAGGC ATTCACTCATACGGCACAATATGATGAAGCAATTTCAGATTATTTCAGGAAACAGTACAGCAAAGGCGTATCTCAGATGCCCTTGAGATATGGAATGAACCCACATCAGACCCCTGCCCA GCTGTACACACTGCAGCCCAAGCTTCCCATCACAGTTCTAAATGGAGCCCCTGGATTTATAAACTTGTGCGATGCTTTGAACGCCTGGCAGCTGGTGAAGGAACTCAAGGAGGCTTTAGG TATTCCAGCCGCTGCCTCTTTCAAACATGTCAGCCCAGCAGGTGCTGCTGTTGGAATTCCACTCAGTGAAGATGAGGCCAAAGTCTGCATGGTTTATGATCTCTATAAAACCCTCACACC CATCTCAGCGGCATATGCAAGAGCAAGAGGGGCTGATAGGATGTCTTCATTTGGTGATTTTGTTGCATTGTCCGATGTTTGTGATGTACCAACTGCAAAAATTATTTCCAGAGAAGTATC TGATGGTATAATTGCCCCAGGATATGAAGAAGAAGCCTTGACAATACTTTCCAAAAAGAAAAATGGAAACTATTGTGTCCTTCAGATGGACCAATCTTACAAACCAGATGAAAATGAAGT TCGAACTCTCTTTGGTCTTCATTTAAGCCAGAAGAGAAATAATGGTGTCGTCGACAAGTCATTATTTAGCAATGTTGTTACCAAAAATAAAGATTTGCCAGAGTCTGCCCTCCGAGACCT CATCGTAGCCACCATTGCTGTCAAGTACACTCAGTCTAACTCTGTGTGCTACGCCAAGAACGGGCAGGTTATCGGCATTGGAGCAGGACAGCAGTCTCGTATACACTGCACTCGCCTTGC AGGAGATAAGGCAAACTATTGGTGGCTTAGACACCATCCACAAGTGCTTTCGATGAAGTTTAAAACAGGAGTGAAGAGAGCAGAAATCTCCAATGCCATCGATCAATATGTGACTGGAAC CATTGGCGAGGATGAAGATTTGATAAAGTGGAAGGCACTGTTTGAGGAAGTCCCTGAGTTACTCACTGAGGCAGAGAAGAAGGAATGGGTTGAGAAACTGACTGAAGTTTCTATCAGCTC TGATGCCTTCTTCCCTTTCCGAGATAACGTAGACAGAGCTAAAAGGAGTGGTGTGGCGTACATTGCGGCTCCCTCCGGTTCTGCTGCTGACAAAGTTGTGATTGAGGCCTGCGACGAACT GGGAATCATCCTCGCTCATACGAACCTTCGGCTCTTCCACCACTGATTTTACCACACACTGTTTTTTGGCTTGCTTATGTGTAGGTGAACAGTCACGCCTGAAACTTTGAGGATAACTTT TTAAAAAAATAAAACAGTATCTCTTAATCACTGGATCCATAGTTAAAAAAAAAA |
Protein Sequence | >471 : length: 592 MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEA VEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINL CDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNG NYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKT GVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDAFFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH |