| Gene ID | 4217 |
| Symbol | MAP3K5 |
| Synonymous | ASK1|MAPKKK5|MEKK5 |
| Full name | mitogen-activated protein kinase kinase kinase 5 |
| Gene description | ASK-1|MAP/ERK kinase kinase 5|MAPK/ERK kinase kinase 5|MEK kinase 5|MEKK 5|apoptosis signal regulating kinase 1|apoptosis signal-regulating kinase 1 |
| Cytoband | 6q22.33 |
| Gene type | protein-coding |
| Synonymous | MIM:602448; HGNC:HGNC:6857; Ensembl:ENSG00000197442; HPRD:03904; Vega:OTTHUMG00000015647 |
Pathways and Diseases | Detail |
|---|---|
Pathway | TNF receptor signaling pathway;PID Curated;200086 |
Pathway | Class I PI3K signaling events mediated by Akt;PID Curated;200169 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | the 41bb-dependent immune response;PID BioCarta;100257 |
Pathway | p38 MAPK signaling pathway;PID Curated;200014 |
Pathway | mapkinase signaling pathway;PID BioCarta;100113 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | keratinocyte differentiation;PID BioCarta;100119 |
Pathway | hiv-1 nef: negative effector of fas and tnf;PID BioCarta;100144 |
Pathway | Amyotrophic lateral sclerosis (ALS);KEGG PATHWAY;hsa05014 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | il-10 anti-inflammatory signaling pathway;PID BioCarta;100134 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | Protein processing in endoplasmic reticulum;KEGG PATHWAY;hsa04141 |
Pathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha;PID Curated;200133 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Pathway | p38 mapk signaling pathway;PID BioCarta;100085 |
Disease | Pancreas cancer;FunDO |
Disease | Leukemia;FunDO |
Disease | Parkinson disease;FunDO |
Sequence Information | |
|---|---|
Nucleotide Sequence | >4217 : length: 5734 GCTTGCGCTCCAGGTCTTCGTAGGTGGGGGCCGGGTGGGTGAAGACTGGGACCCTATGCCACGCGCAGCACTCAGAGGAGGGCTGGGGTCCCAGGGCCGCAGCGCGGTCAGTTCAGTCCG GGCTCGAGCTTCCTAGCAGCGCCCTCCTTGGGGGCTGGCCCTGACCCTCGGTGCCGCTACGAGTGGGTGGCCAGAAGCTGGTGGTGGAGAGGGAGAGCGTCTGCAAGGAACGACGAGGCT GGCGCCGGGACCACGCGGCGGAGGCGATCGAAAGAGAAACGAGGCCAGGCAAGGAGGAGGAAATCCACCCGATGAAGGCGAGCTGCCGCCTAAGAGGGAGGAGGGTCCTTTCGGCTGCCG CTGCTGCTGTTCCGGGACGCCGCCTGGGGAGCCAGCCCGCTCGTAAGGTGCGCGCCAGGTAGCTCCGCACCCAGGGGGCGCCCTTCCTGGCCCCTCCCAGAGCGGCCGGGACGGAAGGAG CTGCGCGGCGCGGCGCGGCGCGGCGCGGCGGGTGGCGAGGGCGGGCTGCACCCCGAGCGCGGCGCCCTTGAGCTGCACCGCGGCGCAGGTTTGCGAGCCGACTTGTCAGCCGGCCAAGAA AAGGAAGCTCCGTCCCTTCCCGCTCACCCGGCTTCCCCACCCCTTGTACTCTAAACTCTGCAGAGGGCGAGCGGCGCGGCCACGGAGGCGCCGAGGAGGAGCGAGCCGCCGCCGGGCAGC GGCGTGCCCTCGGGGGAGAGGGCGCCGGAGAGGAGGCGGCGGCGCGGCGGCGAGGGCGCGGCGCGCGATGGCAGCTGCTTAGCCCGGCGGGCGCGGAGCAGCCCCGAGCTGTGGCTGGCC AGGCGGTGCGGCTGGGCGGGGGACGCCGCCGCCGTTGCTGCCCGGCCCGGAGAGATGAGCACGGAGGCGGACGAGGGCATCACTTTCTCTGTGCCACCCTTCGCCCCCTCGGGCTTCTGC ACCATCCCCGAGGGCGGCATCTGCAGGAGGGGAGGAGCGGCGGCGGTGGGCGAGGGCGAGGAGCACCAGCTGCCACCGCCGCCGCCGGGCAGCTTCTGGAACGTGGAGAGCGCCGCTGCC CCTGGCATCGGTTGTCCGGCGGCCACCTCCTCGAGCAGTGCCACCCGAGGCCGGGGCAGCTCTGTTGGCGGGGGCAGCCGACGGACCACGGTGGCATATGTGATCAACGAAGCGAGCCAA GGGCAACTGGTGGTGGCCGAGAGCGAGGCCCTGCAGAGCTTGCGGGAGGCGTGCGAGACAGTGGGCGCCACCCTGGAAACCCTGCATTTTGGGAAACTCGACTTTGGAGAAACCACCGTG CTGGACCGCTTTTACAATGCAGATATTGCGGTGGTGGAGATGAGCGATGCCTTCCGGCAGCCGTCCTTGTTTTACCACCTTGGGGTGAGAGAAAGTTTCAGCATGGCCAACAACATCATC CTCTACTGTGATACTAACTCGGACTCTCTGCAGTCACTGAAGGAAATAATTTGCCAGAAGAATACTATGTGCACTGGGAACTACACCTTTGTTCCTTACATGATAACTCCACATAACAAA GTCTACTGCTGTGACAGCAGCTTCATGAAGGGGTTGACAGAGCTCATGCAACCGAACTTCGAGCTGCTTCTTGGACCCATCTGCTTACCTCTTGTGGATCGTTTTATTCAACTTTTGAAG GTGGCACAAGCAAGTTCTAGCCAGTACTTCCGGGAATCTATACTCAATGACATCAGGAAAGCTCGTAATTTATACACTGGTAAAGAATTGGCAGCTGAGTTGGCAAGAATTCGGCAGCGA GTAGATAATATCGAAGTCTTGACAGCAGATATTGTCATAAATCTGTTACTTTCCTACAGAGATATCCAGGACTATGATTCTATTGTGAAGCTGGTAGAGACTTTAGAAAAACTGCCAACC TTTGATTTGGCCTCCCATCACCATGTGAAGTTTCATTATGCATTTGCACTGAATAGGAGAAATCTCCCTGGTGACAGAGCAAAAGCTCTTGATATTATGATTCCCATGGTGCAAAGCGAA GGACAAGTTGCTTCAGATATGTATTGCCTAGTTGGTCGAATCTACAAAGATATGTTTTTGGACTCTAATTTCACGGACACTGAAAGCAGAGACCATGGAGCTTCTTGGTTCAAAAAGGCA TTTGAATCTGAGCCAACACTACAGTCAGGAATTAATTATGCGGTCCTCCTCCTGGCAGCTGGACACCAGTTTGAATCTTCCTTTGAGCTCCGGAAAGTTGGGGTGAAGCTAAGTAGTCTT CTTGGTAAAAAGGGAAACTTGGAAAAACTCCAGAGCTACTGGGAAGTTGGATTTTTTCTGGGGGCCAGCGTCCTAGCCAATGACCACATGAGAGTCATTCAAGCATCTGAAAAGCTTTTT AAACTGAAGACACCAGCATGGTACCTCAAGTCTATTGTAGAGACAATTTTAATATATAAGCATTTTGTGAAACTGACCACAGAACAGCCTGTGGCCAAGCAAGAACTTGTGGACTTTTGG ATGGATTTCCTGGTCGAGGCCACAAAGACAGATGTTACTGTGGTTAGGTTTCCAGTATTAATATTAGAACCAACCAAAATCTATCAACCTTCTTATTTGTCTATCAACAATGAAGTTGAG GAAAAGACAATCTCTATTTGGCACGTGCTTCCTGATGACAAGAAAGGTATACATGAGTGGAATTTTAGTGCCTCTTCTGTCAGGGGAGTGAGTATTTCTAAATTTGAAGAAAGATGCTGC TTTCTTTATGTGCTTCACAATTCTGATGATTTCCAAATCTATTTCTGTACAGAACTTCATTGTAAAAAGTTTTTTGAGATGGTGAACACCATTACCGAAGAGAAGGGGAGAAGCACAGAG GAAGGAGACTGTGAAAGTGACTTGCTGGAGTATGACTATGAATATGATGAAAATGGTGACAGAGTCGTTTTAGGAAAAGGCACTTATGGGATAGTCTACGCAGGTCGGGACTTGAGCAAC CAAGTCAGAATTGCTATTAAGGAAATCCCAGAGAGAGACAGCAGATACTCTCAGCCCCTGCATGAAGAAATAGCATTGCATAAACACCTGAAGCACAAAAATATTGTCCAGTATCTGGGC TCTTTCAGTGAGAATGGTTTCATTAAAATCTTCATGGAGCAGGTCCCTGGAGGAAGTCTTTCTGCTCTCCTTCGTTCCAAATGGGGTCCATTAAAAGACAATGAGCAAACAATTGGCTTT TATACAAAGCAAATACTGGAAGGATTAAAATATCTCCATGACAATCAGATAGTTCACCGGGACATAAAGGGTGACAATGTGTTGATTAATACCTACAGTGGTGTTCTCAAGATCTCTGAC TTCGGAACATCAAAGAGGCTTGCTGGCATAAACCCCTGTACTGAAACTTTTACTGGTACCCTCCAGTATATGGCACCAGAAATAATAGATAAAGGACCAAGAGGCTACGGAAAAGCAGCA GACATCTGGTCTCTGGGCTGTACAATCATTGAAATGGCCACAGGAAAACCCCCATTTTATGAACTGGGAGAACCACAAGCAGCTATGTTCAAGGTGGGAATGTTTAAAGTCCACCCTGAG ATCCCAGAGTCCATGTCTGCAGAGGCCAAGGCATTCATACTGAAATGTTTTGAACCAGATCCTGACAAGAGAGCCTGTGCTAACGACTTGCTTGTTGATGAGTTTTTAAAAGTTTCAAGC AAAAAGAAAAAGACACAACCTAAGCTTTCAGCTCTTTCAGCTGGATCAAATGCAGAATATCTCAGGAGTATATCCTTGCCGGTACCTGTGCTGGTGGAGGACACCAGCAGCAGCAGTGAG TACGGCTCAGTTTCACCCGACACGGAGTTGAAAGTGGACCCCTTCTCTTTCAAAACAAGAGCCAAGTCCTGCGGAGAAAGAGATGTCAAGGGAATTCGGACACTCTTTTTGGGCATTCCA GATGAGAATTTTGAAGATCACAGTGCTCCTCCTTCCCCTGAAGAAAAAGATTCTGGATTCTTCATGCTGAGGAAGGACAGTGAGAGGCGAGCTACCCTTCACAGGATCCTGACGGAAGAC CAAGACAAAATTGTGAGAAACCTAATGGAATCTTTAGCTCAGGGGGCTGAAGAACCGAAACTAAAATGGGAACACATCACAACCCTCATTGCAAGCCTCAGAGAATTTGTGAGATCCACT GACCGAAAAATCATAGCCACCACACTGTCAAAGCTGAAACTGGAGCTGGACTTCGACAGCCATGGCATTAGCCAAGTCCAGGTGGTACTCTTTGGTTTTCAAGATGCTGTCAATAAAGTT CTTCGGAATCATAACATCAAGCCGCACTGGATGTTTGCCTTAGACAGTATCATTCGGAAGGCGGTACAGACAGCCATTACCATCCTGGTTCCAGAACTAAGGCCACATTTCAGCCTTGCA TCTGAGAGTGATACTGCTGATCAAGAAGACTTGGATGTAGAAGATGACCATGAGGAACAGCCTTCAAATCAAACTGTCCGAAGACCTCAGGCTGTCATTGAAGATGCTGTGGCTACCTCA GGCGTGAGCACGCTCAGTTCTACTGTGTCTCATGATTCCCAGAGTGCTCACCGGTCACTGAATGTACAGCTTGGAAGGATGAAAATAGAAACCAATAGATTACTGGAAGAATTGGTTCGG AAAGAGAAAGAATTACAAGCACTCCTTCATCGAGCTATTGAAGAAAAAGACCAAGAAATTAAACACCTGAAGCTTAAGTCCCAACCCATAGAAATTCCTGAATTGCCTGTATTTCATCTA AATTCTTCTGGCACAAATACTGAAGATTCTGAACTTACCGACTGGCTGAGAGTGAATGGAGCTGATGAAGACACTATAAGCCGGTTTTTGGCTGAAGATTATACACTATTGGATGTTCTC TACTATGTTACACGTGATGACTTAAAATGCTTGAGACTAAGGGGAGGGATGCTGTGCACACTGTGGAAGGCTATCATTGACTTTCGAAACAAACAGACTTGACTGTTGCTCAATCTAATC TTCGATGGAAATTCTAAAAATTAATACAGAGCTGATCTTCTTGGGGGTGGGAAAATCGAAGGGAGAGGAGAAAGGCGCTGCACTTTAAATCCAGTATTTGTTTACTCATGTTAAAAAAAA AAAAAACAGACAAAACACACTGAAATTTCCTAACTACATCTATTTCTATAATTTTTAAGGACTCTTCATAAGGACTCTTAAAATAATCCTGAACATTAGAACCCTAATGTTCAGGAAGAT TTTAATCTAAGCATTTTTATGGAAATATTTTTAATGCAGCAGCTATTGCACTTCAGCCAAATGTTTATTTCACACAAAACGGATGTAACATTTCATGTGATCGTGCACCACTGGAACAAA ACCAAAATGTGACCATAACTGTTTAGGCTTCTGTGTGTTTGTAATATGCTCTAATAATCTGAGTAGAAATGCGTAATTTCAATTACTGTATAAAGTTTATGTTTTTTTAAGTGTGCAGAA TCTGAGAGCAATGGTTTTTACTTCTCTGTGTTAATTGTAATATTGACTCTATTTTGTAACTTAAGTTTCTGACCTGTCGTACATTTGTTTGAGTCGTTTATGTACTACTGAACTGTACCA GTTGCACATGCTTGAACTGTAGTAATGTTAGCTTGTTCTAAAGCTATCCATTGTGTCATATTTACTCTAAAAATTAAAGAGACTCTCAACATAC |
Protein Sequence | >4217 : length: 1375 MSTEADEGITFSVPPFAPSGFCTIPEGGICRRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQGQLVVAESEALQSLREAC ETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQP NFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALN RRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGF FLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIH EWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQ PLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT GTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNA EYLRSISLPVPVLVEDTSSSSEYGSVSPDTELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEE PKLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVEDDHE EQPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRV NGADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQT |