| Gene ID | 4085 |
| Symbol | MAD2L1 |
| Synonymous | HSMAD2|MAD2 |
| Full name | MAD2 mitotic arrest deficient-like 1 (yeast) |
| Gene description | MAD2 (mitotic arrest deficient, yeast, homolog)-like 1|MAD2-like protein 1|mitotic arrest deficient 2-like protein 1|mitotic arrest deficient, yeast, homolog-like 1|mitotic spindle assembly checkpoint protein MAD2A |
| Cytoband | 4q27 |
| Gene type | protein-coding |
| Synonymous | MIM:601467; HGNC:HGNC:6763; HPRD:03274 |
Pathways and Diseases | Detail |
|---|---|
Pathway | Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components;PID Reactome;500327 |
Pathway | DNA Replication;Reactome;REACT:383 |
Pathway | APC/C:Cdc20 mediated degradation of mitotic proteins;PID Reactome;500396 |
Pathway | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;PID Reactome;500325 |
Pathway | Progesterone-mediated oocyte maturation;KEGG PATHWAY;hsa04914 |
Pathway | APC-Cdc20 mediated degradation of Nek2A;Reactome;REACT:8017 |
Pathway | Cell Cycle Checkpoints;Reactome;REACT:1538 |
Pathway | Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Reactome;REACT:6850 |
Pathway | Oocyte meiosis;KEGG PATHWAY;hsa04114 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | Inactivation of APC/C via direct inhibition of the APC/C complex;PID Reactome;500328 |
Pathway | Cell Cycle, Mitotic;Reactome;REACT:152 |
Disease | Barrett's esophagus;FunDO |
Disease | Cancer;FunDO |
Sequence Information | |
|---|---|
Nucleotide Sequence | >4085 : length: 1453 CGCAAAGGACCTGACGACGTGCTGCGTCGTTACTTTTGAAACGCTTGGCGGGGAAGTGCTGTTGGAGCCGCTGTGGTTGCTGTCCGCGGAGTGGAAGCGCGTGCTTTTGTTTGTGTCCCT GGCCATGGCGCTGCAGCTCTCCCGGGAGCAGGGAATCACCCTGCGCGGGAGCGCCGAAATCGTGGCCGAGTTCTTCTCATTCGGCATCAACAGCATTTTATATCAGCGTGGCATATATCC ATCTGAAACCTTTACTCGAGTGCAGAAATACGGACTCACCTTGCTTGTAACTACTGATCTTGAGCTCATAAAATACCTAAATAATGTGGTGGAACAACTGAAAGATTGGTTATACAAGTG TTCAGTTCAGAAACTGGTTGTAGTTATCTCAAATATTGAAAGTGGTGAGGTCCTGGAAAGATGGCAGTTTGATATTGAGTGTGACAAGACTGCAAAAGATGACAGTGCACCCAGAGAAAA GTCTCAGAAAGCTATCCAGGATGAAATCCGTTCAGTGATCAGACAGATCACAGCTACGGTGACATTTCTGCCACTGTTGGAAGTTTCTTGTTCATTTGATCTGCTGATTTATACAGACAA AGATTTGGTTGTACCTGAAAAATGGGAAGAGTCGGGACCACAGTTTATTACCAATTCTGAGGAAGTCCGCCTTCGTTCATTTACTACTACAATCCACAAAGTAAATAGCATGGTGGCCTA CAAAATTCCTGTCAATGACTGAGGATGACATGAGGAAAATAATGTAATTGTAATTTTGAAATGTGGTTTTCCTGAAATCAAGTCATCTATAGTTGATATGTTTTATTTCATTGGTTAATT TTTACATGGAGAAAACCAAAATGATACTTACTGAACTGTGTGTAATTGTTCCTTTTATTTTTTTGGTACCTATTTGACTTACCATGGAGTTAACATCATGAATTTATTGCACATTGTTCA AAAGGAACCAGGAGGTTTTTTTGTCAACATTGTGATGTATATTCCTTTGAAGATAGTAACTGTAGATGGAAAAACTTGTGCTATAAAGCTAGATGCTTTCCTAAATCAGATGTTTTGGTC AAGTAGTTTGACTCAGTATAGGTAGGGAGATATTTAAGTATAAAATACAACAAAGGAAGTCTAAATATTCAGAATCTTTGTTAAGGTCCTGAAAGTAACTCATAATCTATAAACAATGAA ATATTGCTGTATAGCTCCTTTTGACCTTCATTTCATGTATAGTTTTCCCTATTGAATCAGTTTCCAATTATTTGACTTTAATTTATGTAACTTGAACCTATGAAGCAATGGATATTTGTA CTGTTTAATGTTCTGTGATACAGAACTCTTAAAAATGTTTTTTCATGTGTTTTATAAAATCAAGTTTTAAGTGAAAGTGAGGAAATAAAGTTAAGTTTGTTTTAAATTTGTCTTAAAAAA AAAAAAAAAAAAA |
Protein Sequence | >4085 : length: 205 MALQLSREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKDDSAPREKS QKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKIPVND |