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Cancer metastasis database

Annotation category 5

Gene information

Gene ID 3981
Symbol

LIG4

Synonymous

LIG4S

Full name

ligase IV, DNA, ATP-dependent

Gene description

DNA joinase|DNA ligase 4|DNA ligase IV|DNA repair enzyme|polydeoxyribonucleotide synthase [ATP] 4|polynucleotide ligase|sealase

Cytoband

13q33-q34

Gene type

protein-coding

Synonymous

MIM:601837; HGNC:HGNC:6601; Ensembl:ENSG00000174405; HPRD:03500; Vega:OTTHUMG00000017328

Pathway and disease

Pathways and Diseases

Detail

Pathway

2-LTR circle formation;PID Reactome;500732

Pathway

Nonhomologous End-joining (NHEJ);PID Reactome;500055

Pathway

Non-homologous end-joining;KEGG PATHWAY;hsa03450

Pathway

DNA Repair;Reactome;REACT:216

Pathway

HIV Infection;Reactome;REACT:6185

Disease

Multiple myeloma, resistance to;OMIM

Disease

PSYCH;GAD

Disease

prostate cancer;GAD

Disease

Immune system diseases;KEGG DISEASE

Disease

Attention deficit hyperactivity disorder and conduct disorder;GAD

Disease

Multiple myeloma;FunDO

Disease

CANCER;GAD

Disease

DNA repair defect;KEGG DISEASE;H00094

Disease

Leukemia;FunDO

Disease

Congenital abnormality;FunDO

Disease

breast cancer;GAD

Disease

lung cancer;GAD

Disease

Brain tumor;FunDO

Disease

Attention deficit hyperactivity disorder and conduct disorder;NHGRI

Disease

Primary immunodeficiency;KEGG DISEASE

Disease

Immunologic deficiency syndrome;FunDO

Disease

LIG4 syndrome;OMIM

Sequence Information

Nucleotide Sequence

>3981 : length: 5733
TGTCAAACTCCTGACCTCAAGTGATCCGCTCACCTCAGCCTCTTAAAGTGCTGGGATTACAGGCATTAGCCACTGGCCCGGCCTGTGGTGTTGTTGTTATTGAACATATGTGTCTTGCTA
CCAGATGGAGAGCTCCAGGTCAAAGCTGGGTTCTTGAATCATAGCTTCCTAATCTTGATCACGGAATAAGTGCCAAGCATATATAAAGTAGACCATTTACATAAATAAATTAATAATCAT
GGCAACTCTAGAAGATACTTAGTGAAAAAAACCCTTGATTGTCTTTGAACCAATCAACTAAAATAACATGATGAAATGGAGACTGGGCTTTGAATCAATTTGGAGTTTGCCTGGTTTCAT
AATTCATGGTTCTTCTCATGTAACTAATACAAAGTCCAGCTTCTGACATTGTAGGAGCTCAGTAGAGGTTGAACAAGCTACAAATGTACACGGATAGGTACCCTCTCCTAAGATGGGCAA
GTGGAGGCTCCTCTACCTTAACACTATTCATTTTTCCTCCAAAATAAATTGATAACTAAATTGAAGAGCAGATACTCACAAAACAATATCATGAGACTTTACAACATCACAGATGATTTT
AGATATTCAGGCATATTAGGTCAATTAGACATACGAAGTAAATAACTGAATGTTCTTGGGCTAGACGGAACCTCCGCTACAAACTAGCACTGAATGAAATGTGTCAGTTTTGAAAAAGGA
GGTTTTTATACATTACACAACCTCTAAGGGCACTTAACAGCTCTAATATGTTTTATCAGGGCCCACTGCAGCAAAATTTATTTTATTGTAAAGCAATATTTTATGCTAAAATAAAATAGT
TCTAAAAGTTGTTTCCACCCCTCTTTATGAATAACTTCTCACTTCTCCATGGCGAAAGAGGACTGACCACAGCAAAAATTCGGTGGAAACCAACAGCTCCTGGAACACAAAAACTGGGGT
TGTTTATAATCTCTCCACCCTGAATATCTAGCACCATTACTATATAATAATAGGTGCTCAATAAAGGTTTGTTAAATAACTTTATTTTTAAACCTTAAACAGATACTAGAAGAGTCCATA
GTTGATTTCTGGTCATGCAACGGTTTATTTCTATATTGTAAGTTATGTATTGTTATGTATTATTTCTGTATTAAGAGAACTGAGACCACAGTAGCAAACATCATTTAAAAAAAAAAACAG
CTCTATATAGTTTGCAAAAGCCTATTTTTTAAAAGTTTAAATGAAACAACCAACGTTTTGAGTTGGGAGGATGTCCTGTTCTCTCTTGGGAGTTTTCACAACCAGCGAAATCAGTATAGT
TACCACTGTTTTACGTACAGAGAACAAGAATTAGAGGCTATCACTAGCCAGAGCACAAAGTGATCTTAGGTCTCCCTCGAGACAAAATCCACTGGCGTGTGGATCAACTGCTTGCAGAGA
GCATCTGCTGCCGAGGCCAATAGGAGCCGTGTGTACTCAAGACCCTAACCAGGATCCTGCAGGTCCCGCCTCCGCAGCCCCACGGGGCTGCCGGCCCCCCCACCTCCCATCGCGAGCCTG
GCTGCGCCGGCGTGCTTGAGCCCGGTGACTGCAAGGCCCCGGGTCTCCCCTGCGCCTGCGCGGCGAGCAGCTGGCGGAACCGGCATCTTCTGGCGCCAGCTTCCGGCTTAGCGGCTGAGC
TTCAGGCTTGACGTCAGACCCAAGCCCCAGGTCGTGGGACGATTTCTCCCGTTTTTGACTCCCTGGAACTGTATTGCCTGCTTTACCTGCGTACATGTTGATTCTTTCTCATGGCAACCC
CGCAGGAAACCATCAAGATCTCATTTTACAGCTGGGATTCTCTGGTTCACAGAGGTAACGGAGCTTGCCCGAGGCCAGTTAAACGAGAAGATTCATCACCGCTTTGATGGCTGCCTCACA
AACTTCACAAACTGTTGCATCTCACGTTCCTTTTGCAGATTTGTGTTCAACTTTAGAACGAATACAGAAAAGTAAAGGACGTGCAGAAAAAATCAGACACTTCAGGGAATTTTTAGATTC
TTGGAGAAAATTTCATGATGCTCTTCATAAGAACCACAAAGATGTCACAGACTCTTTTTATCCAGCAATGAGACTAATTCTTCCTCAGCTAGAAAGAGAGAGAATGGCCTATGGAATTAA
AGAAACTATGCTTGCTAAGCTTTATATTGAGTTGCTTAATTTACCTAGAGATGGAAAAGATGCCCTCAAACTTTTAAACTACAGAACACCCACTGGAACTCATGGAGATGCTGGAGACTT
TGCAATGATTGCATATTTTGTGTTGAAGCCAAGATGTTTACAGAAAGGAAGTTTAACCATACAGCAAGTAAACGACCTTTTAGACTCAATTGCCAGCAATAATTCTGCTAAAAGAAAAGA
CCTAATAAAAAAGAGCCTTCTTCAACTTATAACTCAGAGTTCAGCACTTGAGCAAAAGTGGCTTATACGGATGATCATAAAGGATTTAAAGCTTGGTGTTAGTCAGCAAACTATCTTTTC
TGTTTTTCATAATGATGCTGCTGAGTTGCATAATGTCACTACAGATCTGGAAAAAGTCTGTAGGCAACTGCATGATCCTTCTGTAGGACTCAGTGATATTTCTATCACTTTATTTTCTGC
ATTTAAACCAATGCTAGCTGCTATTGCAGATATTGAGCACATTGAGAAGGATATGAAACATCAGAGTTTCTACATAGAAACCAAGCTAGATGGTGAACGTATGCAAATGCACAAAGATGG
AGATGTATATAAATACTTCTCTCGAAATGGATATAACTACACTGATCAGTTTGGTGCTTCTCCTACTGAAGGTTCTCTTACCCCATTCATTCATAATGCATTCAAAGCAGATATACAAAT
CTGTATTCTTGATGGTGAGATGATGGCCTATAATCCTAATACACAAACTTTCATGCAAAAGGGAACTAAGTTTGATATTAAAAGAATGGTAGAGGATTCTGATCTGCAAACTTGTTATTG
TGTTTTTGATGTATTGATGGTTAATAATAAAAAGCTAGGGCATGAGACTCTGAGAAAGAGGTATGAGATTCTTAGTAGTATTTTTACACCAATTCCAGGTAGAATAGAAATAGTGCAGAA
AACACAAGCTCATACTAAGAATGAAGTAATTGATGCATTGAATGAAGCAATAGATAAAAGAGAAGAGGGAATTATGGTAAAACAACCTCTATCCATCTACAAGCCAGACAAAAGAGGTGA
AGGGTGGTTAAAAATTAAACCAGAGTATGTCAGTGGACTAATGGATGAATTGGACATTTTAATTGTTGGAGGATATTGGGGTAAAGGATCACGGGGTGGAATGATGTCTCATTTTCTGTG
TGCAGTAGCAGAGAAGCCCCCTCCTGGTGAGAAGCCATCTGTGTTTCATACTCTCTCTCGTGTTGGGTCTGGCTGCACCATGAAAGAACTGTATGATCTGGGTTTGAAATTGGCCAAGTA
TTGGAAGCCTTTTCATAGAAAAGCTCCACCAAGCAGCATTTTATGTGGAACAGAGAAGCCAGAAGTATACATTGAACCTTGTAATTCTGTCATTGTTCAGATTAAAGCAGCAGAGATCGT
ACCCAGTGATATGTATAAAACTGGCTGCACCTTGCGTTTTCCACGAATTGAAAAGATAAGAGATGACAAGGAGTGGCATGAGTGCATGACCCTGGACGACCTAGAACAACTTAGGGGGAA
GGCATCTGGTAAGCTCGCATCTAAACACCTTTATATAGGTGGTGATGATGAACCACAAGAAAAAAAGCGGAAAGCTGCCCCAAAGATGAAGAAAGTTATTGGAATTATTGAGCACTTAAA
AGCACCTAACCTTACTAACGTTAACAAAATTTCTAATATATTTGAAGATGTAGAGTTTTGTGTTATGAGTGGAACAGATAGCCAGCCAAAGCCTGACCTGGAGAACAGAATTGCAGAATT
TGGTGGTTATATAGTACAAAATCCAGGCCCAGACACGTACTGTGTAATTGCAGGGTCTGAGAACATCAGAGTGAAAAACATAATTTTGTCAAATAAACATGATGTTGTCAAGCCTGCATG
GCTTTTAGAATGTTTTAAGACCAAAAGCTTTGTACCATGGCAGCCTCGCTTTATGATTCATATGTGCCCATCAACCAAAGAACATTTTGCCCGTGAATATGATTGCTATGGTGATAGTTA
TTTCATTGATACAGACTTGAACCAACTGAAGGAAGTATTCTCAGGAATTAAAAATTCTAACGAGCAGACTCCTGAAGAAATGGCTTCTCTGATTGCTGATTTAGAATATCGGTATTCCTG
GGATTGCTCTCCTCTCAGTATGTTTCGACGCCACACCGTTTATTTGGACTCGTATGCTGTTATTAATGACCTGAGTACCAAAAATGAGGGGACAAGGTTAGCTATTAAAGCCTTGGAGCT
TCGGTTTCATGGAGCAAAAGTAGTTTCTTGTTTAGCTGAGGGAGTGTCTCATGTAATAATTGGGGAAGATCATAGTCGTGTTGCAGATTTTAAAGCTTTTAGAAGAACTTTTAAGAGAAA
GTTTAAAATCCTAAAAGAAAGTTGGGTAACTGATTCAATAGACAAGTGTGAATTACAAGAAGAAAACCAGTATTTGATTTAAAGCTAGGTTTCCTAGTGAGGAAAGCCTCTGATCTGGCA
GACTCATTGCAGCAGGTGGTAATGATAAAATACTAAACTACATTTTATTTTTGTATCTTAAAAATCTATGCCTAAAAAGTATCATTACATATAGGAAAACAATAATTTTAACTTTTAAGG
TTGAAAAGACAATAGCCCAAAGCCAAGAAAGAAAAATTATCTTGAATGTAGTATTCAATGATTTTTTATGATCAAGGTGAAATAAACAGTCTAAAGAAGAGGTGTTTTTATAATATCCAT
ATAGAAATCTAGAATTTTTACTTAGATACTAATAAAATACATTTAGAAACTTTTAAAGTCATGAAAAAGCATTAACCTTCTAAACAGTATATTCTAAAAAGTCAAAACGTTAACAATAGT
TTTTATCTAATAAAAGCACTGCAAGAAAATAGGGTAGAATTGTTACAGCTGGACTTGTAAAAATATGTCTTTTTACTCAGGGTTTAAAATGTCCCATTTAAATATGAAATGTAAACAAAT
TTGTTTTTTAAGGTTAAGGCCAAATGTAACAATAAAACCCTGTCGATGGTTTTAGCTAAATTAGAGGAAGTTGTATGAGACTTAATGATCTAAAAACTTAAAATTGAATTGGTTTGATTA
AAAATAAAGCTTGCAATTTTAAAAGTAGCTCACATTTAATTTCTTGTGTGAAATAGAACATGCTTTAAAGGAAGTATTTTTATGTGAATTTGCATTCCAGTATAAATAGTATTCACAAAA
AAGATTTTCCTAGATTTTATCTATTGAATAGGTGTCAATATGGCATGCATATTGTAACTTTCATTAGAAATAAGTTGCTTTGACTTTTAAAAATGACATAGTTAGATTATTTAAAGTCAA
TGTATATAGTATATATTATGTATGGATTTATATACCAAATTTTGGAATACAGCCTATCTCATGACCATATTGAAATGTACGGAATTTGATCCATGCGATACTATGTGTGCATTATTTGAA
AGTTATTGGAAATTTTATTCAAACCGTGGAACAAATGTATGTGATTTTGTTATACTTCTTAATTTAAATAAAATATTTAATGCACTATTAAAA

Protein Sequence

>3981 : length: 911
MAASQTSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDVTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHG
DAGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGLSDISI
TLFSAFKPMLAAIADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTDQFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDL
QTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRGGMM
SHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILCGTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLE
QLRGKASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFEDVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDV
VKPAWLLECFKTKSFVPWQPRFMIHMCPSTKEHFAREYDCYGDSYFIDTDLNQLKEVFSGIKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAI
KALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDKCELQEENQYLI