| Gene ID | 328 |
| Symbol | APEX1 |
| Synonymous | APE|APE1|APEN|APEX|APX|HAP1|REF1 |
| Full name | APEX nuclease (multifunctional DNA repair enzyme) 1 |
| Gene description | AP endonuclease class I|AP lyase|DNA-(apurinic or apyrimidinic site) lyase|apurinic-apyrimidinic endonuclease 1|apurinic/apyrimidinic (abasic) endonuclease|deoxyribonuclease (apurinic or apyrimidinic)|protein REF-1|redox factor-1 |
| Cytoband | 14q11.2 |
| Gene type | protein-coding |
| Synonymous | MIM:107748; HGNC:HGNC:587; Ensembl:ENSG00000100823; HPRD:00136; Vega:OTTHUMG00000029544 |
Pathways and Diseases | Detail |
|---|---|
Pathway | granzyme a mediated apoptosis pathway;PID BioCarta;100035 |
Pathway | Resolution of AP sites via the multiple-nucleotide patch replacement pathway;PID Reactome;500033 |
Pathway | Base excision repair;KEGG PATHWAY;hsa03410 |
Pathway | Base-free sugar-phosphate removal via the single-nucleotide replacement pathway;PID Reactome;500984 |
Pathway | DNA Repair;Reactome;REACT:216 |
Pathway | HIF-2-alpha transcription factor network;PID Curated;200030 |
Pathway | Removal of DNA patch containing abasic residue;PID Reactome;500945 |
Pathway | Displacement of DNA glycosylase by APE1;PID Reactome;501000 |
Disease | Amyotrophic lateral sclerosis;FunDO |
Disease | radiotherapy;GAD |
Disease | DNA repair;GAD |
Disease | lung cancer;GAD |
Disease | radiotherapy response;GAD |
Disease | prostate cancer;GAD |
Disease | CANCER;GAD |
Disease | Cockayne syndrome;FunDO |
Disease | Cancer;FunDO |
Disease | radiotherapy sensitivity;GAD |
Disease | Stroke;FunDO |
Disease | melanoma;GAD |
Disease | upper aerodigestive tract cancer;GAD |
Sequence Information | |
|---|---|
Nucleotide Sequence | >328 : length: 1563 CAGACAGACCAATCACGCGCATTCTTCGGCCACGACAAGCGCGCCTCTGATCACGTGACCAGGTCCGCTACCCACGTGGGGGCTCAGCGTGCACCCTTCTTTGTGCTCGGGTTAGGAGGA GCTAGGCTGCCATCGGGCCGGTGCAGATACGGGGTTGCTCTTTTGCTCATAAGAGGGGCTTCGCTGGCAGTCTGAACGGCAAGCTTGAGTCAGGACCCTTAATTAAGATCCTCAATTGGC TGGAGGGCAGATCTCGCGAGTAGGGCAACGCGGTAAAAATATTGCTTCGGTGGGTGACGCGGTACAGCTGCCCAAGGGCGTTCGTAACGGGAATGCCGAAGCGTGGGAAAAAGGGAGCGG TGGCGGAAGACGGGGATGAGCTCAGGACAGAGCCAGAGGCCAAGAAGAGTAAGACGGCCGCAAAGAAAAATGACAAAGAGGCAGCAGGAGAGGGCCCAGCCCTGTATGAGGACCCCCCAG ATCAGAAAACCTCACCCAGTGGCAAACCTGCCACACTCAAGATCTGCTCTTGGAATGTGGATGGGCTTCGAGCCTGGATTAAGAAGAAAGGATTAGATTGGGTAAAGGAAGAAGCCCCAG ATATACTGTGCCTTCAAGAGACCAAATGTTCAGAGAACAAACTACCAGCTGAACTTCAGGAGCTGCCTGGACTCTCTCATCAATACTGGTCAGCTCCTTCGGACAAGGAAGGGTACAGTG GCGTGGGCCTGCTTTCCCGCCAGTGCCCACTCAAAGTTTCTTACGGCATAGGCGATGAGGAGCATGATCAGGAAGGCCGGGTGATTGTGGCTGAATTTGACTCGTTTGTGCTGGTAACAG CATATGTACCTAATGCAGGCCGAGGTCTGGTACGACTGGAGTACCGGCAGCGCTGGGATGAAGCCTTTCGCAAGTTCCTGAAGGGCCTGGCTTCCCGAAAGCCCCTTGTGCTGTGTGGAG ACCTCAATGTGGCACATGAAGAAATTGACCTTCGCAACCCCAAGGGGAACAAAAAGAATGCTGGCTTCACGCCACAAGAGCGCCAAGGCTTCGGGGAATTACTGCAGGCTGTGCCACTGG CTGACAGCTTTAGGCACCTCTACCCCAACACACCCTATGCCTACACCTTTTGGACTTATATGATGAATGCTCGATCCAAGAATGTTGGTTGGCGCCTTGATTACTTTTTGTTGTCCCACT CTCTGTTACCTGCATTGTGTGACAGCAAGATCCGTTCCAAGGCCCTCGGCAGTGATCACTGTCCTATCACCCTATACCTAGCACTGTGACACCACCCCTAAATCACTTTGAGCCTGGGAA ATAAGCCCCCTCAACTACCATTCCTTCTTTAAACACTCTTCAGAGAAATCTGCATTCTATTTCTCATGTATAAAACTAGGAATCCTCCAACCAGGCTCCTGTGATAGAGTTCTTTTAAGC CCAAGATTTTTTATTTGAGGGTTTTTTGTTTTTTAAAAAAAAATTGAACAAAGACTACTAATGACTTTGTTTGAATTATCCACATGAAAATAAAGAGCCATAGTTTCAGCCTTAAAAAAA AAA |
Protein Sequence | >328 : length: 318 MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS APSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL |