| Gene ID | 2778 |
| Symbol | GNAS |
| Synonymous | AHO|C20orf45|GNAS1|GPSA|GSA|GSP|NESP|PHP1A|PHP1B|PHP1C|POH|SgVI |
| Full name | GNAS complex locus |
| Gene description | adenylate cyclase-stimulating G alpha protein|alternative gene product encoded by XL-exon|extra large alphas protein|guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1|guanine nucleotide regulatory protein|guanine nuc |
| Cytoband | 20q13.3 |
| Gene type | protein-coding |
| Synonymous | MIM:139320; HGNC:HGNC:4392; Ensembl:ENSG00000087460; HPRD:00761; Vega:OTTHUMG00000033069 |
Pathways and Diseases | Detail |
|---|---|
Pathway | Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270 |
Pathway | role of beta-arrestins in the activation and targeting of map kinases;PID BioCarta;100229 |
Pathway | Vibrio cholerae infection;KEGG PATHWAY;hsa05110 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | signaling pathway from g-protein families;PID BioCarta;100153 |
Pathway | phospholipase c-epsilon pathway;PID BioCarta;100070 |
Pathway | ion channels and their functional role in vascular endothelium;PID BioCarta;100055 |
Pathway | Transmembrane transport of small molecules;Reactome;REACT:15518 |
Pathway | Salivary secretion;KEGG PATHWAY;hsa04970 |
Pathway | Vasopressin-regulated water reabsorption;KEGG PATHWAY;hsa04962 |
Pathway | Amoebiasis;KEGG PATHWAY;hsa05146 |
Pathway | Melanogenesis;KEGG PATHWAY;hsa04916 |
Pathway | Glucagon signaling in metabolic regulation;PID Reactome;500715 |
Pathway | Regulation of Insulin Secretion by Glucagon-like Peptide-1;PID Reactome;500139 |
Pathway | gata3 participate in activating the th2 cytokine genes expression;PID BioCarta;100157 |
Pathway | beta-arrestins in gpcr desensitization;PID BioCarta;100231 |
Pathway | corticosteroids and cardioprotection;PID BioCarta;100156 |
Pathway | LPA4-mediated signaling events;PID Curated;200036 |
Pathway | Diabetes pathways;Reactome;REACT:15380 |
Pathway | roles of beta arrestin dependent recruitment of src kinases in gpcr signaling;PID BioCarta;100230 |
Pathway | Taste transduction;KEGG PATHWAY;hsa04742 |
Pathway | activation of camp-dependent protein kinase pka;PID BioCarta;100151 |
Pathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor;PID BioCarta;100196 |
Pathway | how progesterone initiates the oocyte maturation;PID BioCarta;100104 |
Pathway | Calcium signaling pathway;KEGG PATHWAY;hsa04020 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | transcription factor creb and its extracellular signals;PID BioCarta;100198 |
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Pancreatic secretion;KEGG PATHWAY;hsa04972 |
Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | ccr3 signaling in eosinophils;PID BioCarta;100215 |
Pathway | Integration of energy metabolism;Reactome;REACT:1505 |
Pathway | chrebp regulation by carbohydrates and camp;PID BioCarta;100203 |
Pathway | regulation of spermatogenesis by crem;PID BioCarta;100197 |
Pathway | attenuation of gpcr signaling;PID BioCarta;100253 |
Pathway | Dilated cardiomyopathy;KEGG PATHWAY;hsa05414 |
Pathway | Long-term depression;KEGG PATHWAY;hsa04730 |
Pathway | regulation of ck1/cdk5 by type 1 glutamate receptors;PID BioCarta;100201 |
Pathway | G alpha (s) signalling events;PID Reactome;500433 |
Pathway | Gastric acid secretion;KEGG PATHWAY;hsa04971 |
Pathway | cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway;PID BioCarta;100205 |
Disease | Osseous heteroplasia, progressive;OMIM |
Disease | Pseudohypoparathyroidism Ic;OMIM |
Disease | Prolonged bleeding time, brachydactyly and mental retardation;OMIM |
Disease | PSYCH;GAD |
Disease | Acromegaly;OMIM |
Disease | leukemia;GAD |
Disease | Pseudohypoparathyroidism Ia;OMIM |
Disease | breast cancer;GAD |
Disease | liver cancer;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | schizophrenia;GAD |
Disease | kidney cancer;GAD |
Disease | CANCER;GAD |
Disease | hypertension;GAD |
Disease | NEUROLOGICAL;GAD |
Disease | autonomic nervous system dysfunction;GAD |
Disease | Pseudohypoparathyroidism Ib;OMIM |
Disease | bladder cancer;GAD |
Disease | esophageal cancer;GAD |
Disease | McCune-Albright syndrome;OMIM |
Disease | migraine migraine with aura;GAD |
Sequence Information | |
|---|---|
Nucleotide Sequence | >2778 : length: 3784 AGGATAGACCAAGGAAGAGGGGCTGGGGGGCAGCCTGGGGGCATGAAAAGTGGCCAGGAAGGAGCCAAGACTCCACCAGCAACAATTGAGTTGCTTCAGCCTCAGTCTAGGGTTCCTTCC AGGCCTTGAACCCCCCAACCTCACAAGGGTTGGAAAGTGAGGCCGGTGAACTTTCCAGCTGGTACTTTGATTTTAAAATAATAATAATAATTTTTTCACCCTAGTTCGGTTGGGTGCTCC ATCTTACGGAGCCCCAAACTTATTTTGAGAGGCCGCCACCGTGTTATGGGCGTGCGCAACTGCCTCTACGGCAATAATATGTCAGGACAACGCGATATCCCCCCTGAAATCGGGGAACAG CCCGAGCAACCACCTTTGGAGGCCCCAGGGGCAGCTGCCCCCGGTGCTGGGCCTAGCCCAGCCGAAGAGATGGAGACCGAACCGCCTCACAACGAGCCCATCCCCGTCGAGAATGATGGC GAGGCCTGTGGACCCCCAGAGGTCTCCAGACCCAACTTTCAGGTCCTCAACCCGGCATTCAGGGAAGCTGGAGCCCATGGAAGCTACAGCCCACCTCCTGAGGAAGCAATGCCCTTCGAG GCTGAACAGCCCAGCTTGGGAGGCTTCTGGCCTACACTGGAGCAGCCTGGATTCCCCAGTGGGGTCCATGCAGGCCTTGAGGCCTTCGGCCCAGCACTCATGGAGCCCGGAGCCTTCAGT GGTGCCAGACCAGGCCTGGGAGGATACAGCCCTCCACCAGAAGAAGCTATGCCCTTTGAGTTTGACCAGCCTGCCCAGAGAGGCTGCAGTCAACTTCTCTTACAGGTCCCAGACCTTGCT CCAGGAGGCCCAGGTGCTGCAGGGGTCCCCGGAGCTCCTCCCGAGGAGCCCCAAGCCCTCAGGCCTGCAAAGGCTGGCTCCAGAGGAGGCTACAGCCCTCCCCCTGAGGAGACTATGCCA TTTGAGCTTGATGGAGAAGGATTTGGGGACGACAGCCCACCCCCGGGGCTTTCCCGAGTTATCGCACAAGTCGACGGCAGCAGCCAGTTCGCGGCAGTCGCGGCCTCGAGTGCGGTCCGC CTCACTCCCGCCGCGAACGCGCCTCCCCTCTGGGTCCCAGGCGCCATCGGCAGCCCATCCCAAGAGGCTGTCAGACCTCCTTCTAACTTCACGGGCAGCAGCCCCTGGATGGAGATCTCC GGACCCCCGTTCGAGATTGGCAGCGCCCCCGCTGGGGTCGACGACACTCCCGTCAACATGGACAGCCCCCCAATCGCGCTTGACGGCCCGCCCATCAAGGTCTCCGGAGCCCCAGATAAG AGAGAGCGAGCAGAGAGACCCCCAGTTGAGGAGGAAGCAGCAGAGATGGAAGGAGCCGCTGATGCCGCGGAGGGAGGAAAAGTACCCTCTCCGGGGTACGGATCCCCTGCCGCCGGGGCA GCCTCAGCGGATACCGCTGCCAGGGCAGCCCCTGCAGCCCCAGCCGATCCTGACTCCGGGGCAACCCCAGAAGATCCCGACTCCGGGACAGCACCAGCCGATCCTGACTCCGGGGCATTC GCAGCCGATCCCGACTCCGGGGCAGCCCCTGCCGCCCCAGCCGATCCCGACTCCGGGGCGGCCCCTGACGCCCCAGCCGATCCCGACTCCGGGGCGGCCCCTGACGCCCCAGCCGATCCA GATGCCGGGGCGGCCCCTGAGGCTCCCGCCGCCCCTGCGGCTGCTGAGACCCGGGCAGCCCATGTCGCCCCAGCTGCGCCAGACGCAGGGGCTCCCACTGCCCCAGCCGCTTCTGCCACC CGGGCAGCCCAAGTCCGCCGGGCGGCCTCTGCAGCCCCTGCCTCCGGGGCCAGACGCAAGATCCATCTCAGACCCCCCAGCCCCGAGATCCAGGCTGCCGATCCGCCTACTCCGCGGCCT ACTCGCGCGTCTGCCTGGCGGGGCAAGTCCGAGAGCAGCCGCGGCCGCCGCGTGTACTACGATGAAGGGGTGGCCAGCAGCGACGATGACTCCAGCGGAGACGAGTCCGACGATGGGACC TCCGGATGCCTCCGCTGGTTTCAGCATCGGCGAAATCGCCGCCGCCGAAAGCCCCAGCGCAACTTACTCCGCAACTTTCTCGTGCAAGCCTTCGGGGGCTGCTTCGGTCGATCTGAGAGT CCCCAGCCCAAAGCCTCGCGCTCTCTCAAGGTCAAGAAGGTACCCCTGGCGGAGAAGCGCAGACAGATGCGCAAAGAAGCCCTGGAGAAGCGGGCCCAGAAGCGCGCAGAGAAGAAACGC AGTAAGCTCATCGACAAACAACTCCAGGACGAAAAGATGGGCTACATGTGTACGCACCGCCTGCTGCTTCTAGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATC CTGCATGTTAATGGGTTTAATGGAGAGGGCGGCGAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGTGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAACCTGAAAGAGGCG ATTGAAACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCCCGTGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGACTACATCCTGAGTGTGATGAACGTGCCTGACTTTGACTTC CCTCCCGAATTCTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCTGCTACGAACGCTCCAACGAGTACCAGCTGATTGACTGTGCCCAGTACTTCCTGGACAAGATC GACGTGATCAAGCAGGCTGACTATGTGCCGAGCGATCAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTGGAATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCACATGTTT GACGTGGGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCAGTGCTTCAACGATGTGACTGCCATCATCTTCGTGGTGGCCAGCAGCAGCTACAACATGGTCATCCGGGAGGACAACCAG ACCAACCGCCTGCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAACAGATGGCTGCGCACCATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCTGCTCGCTGAGAAAGTCCTT GCTGGGAAATCGAAGATTGAGGACTACTTTCCAGAATTTGCTCGCTACACTACTCCTGAGGATGCTACTCCCGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTCATTCGA GATGAGTTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCGTCACTACTGCTACCCTCATTTCACCTGCGCTGTGGACACTGAGAACATCCGCCGTGTGTTCAACGACTGCCGTGACATC ATTCAGCGCATGCACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCCCCAAATTTAATTAAAGCCTTAAGCACAATTAATTAAAAGTGAAACGTAATTGTACAAGCAGTTAATCACC CACCATAGGGCATGATTAACAAAGCAACCTTTCCCTTCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCCTTCAGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTACAG AAAAAGGAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCAGTAAAAATAAATAAAACAGCAGCAGCAAACAAATAAAATGAAATAAAAGAAACAAATGAAATAAATATTGTGTTGTGCAG CATTAAAAAAAATCAAAATAAAAATTAAATGTGAGCAAAGAATGAAAAAAAAAAAAAAAAAAAA |
Protein Sequence | >2778 : length: 1037 MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNPAFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQ PGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPP GLSRVIAQVDGSSQFAAVAASSAVRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAE MEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAA ETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADPPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRR RKPQRNLLRNFLVQAFGGCFGRSESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDP QAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDL LRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFAR YTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL |