| Gene ID | 2729 |
| Symbol | GCLC |
| Synonymous | GCL|GCS|GLCL|GLCLC |
| Full name | glutamate-cysteine ligase, catalytic subunit |
| Gene description | GCS heavy chain|gamma-ECS|gamma-glutamylcysteine synthetase|glutamate--cysteine ligase catalytic subunit |
| Cytoband | 6p12 |
| Gene type | protein-coding |
| Synonymous | MIM:606857; HGNC:HGNC:4311; Ensembl:ENSG00000001084; HPRD:06032; Vega:OTTHUMG00000160220 |
Pathways and Diseases | Detail |
|---|---|
Pathway | glutathione biosynthesis;BioCyc;GLUTATHIONESYN-PWY |
Pathway | Biological oxidations;Reactome;REACT:13433 |
Pathway | Glutathione metabolism;KEGG PATHWAY;hsa00480 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | gamma-glutamyl cycle;BioCyc;PWY-4041 |
Disease | Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency;OMIM |
Disease | Hypertension;FunDO |
Disease | Lung disease;FunDO |
Disease | Posttransplantation diabetes mellitus (PTDM);GAD |
Disease | cystic fibrosis;GAD |
Disease | Myocardial infarction, susceptibility to;OMIM |
Disease | METABOLIC;GAD |
Disease | Colon cancer;FunDO |
Disease | Chronic obstructive airway disease;FunDO |
Disease | Bronchial disease;FunDO |
Sequence Information | |
|---|---|
Nucleotide Sequence | >2729 : length: 3823 ATAAAACCTGGAGCGCAGGATCGCGCCCAGGAGCGGCGAGCTAGCGGACGCAAAGACTGGGCATGCTCCGCGGCGGCGCAGGTTTTGGTCACAAGTAGGAAGAAGCCAGTGCACCAGACC GGCAAAGAGAAGCGGGAGCCGCCGCGGCAGCGCGGCCGTGGGGTCCGCCGCCGCCGCATCGGAGCGGGAGGAGGAGCAGCGGGGAGGGCGAGGCCGCCGGGCCGAGAGCCGTCCCGCCTG CTCTCGGTCTTCTGCCTTCGCCTCCGCGCGGTGCGTCGGACCCAGGGTCTGTCACCTGGGCGCCAGGGGCCGCCGCCGGGGAGCCGGAGCGGGCAGGACCCTCCCTCCGCCGACTGCGGC CCGAGAGCGCCCCCGCGGGGTGGAGCGGCAGCCGCCTTCTGCGGGCGGCTGAGTGTCCGTCTCGCGCCCGGAGCGGGCGACCGCCGTCAGCCCGGAGGAGGAGGAGGAGGAGGAGGGGGC GGCCATGGGGCTGCTGTCCCAGGGCTCGCCGCTGAGCTGGGAGGAAACCAAGCGCCATGCCGACCACGTGCGGCGGCACGGGATCCTCCAGTTCCTGCACATCTACCACGCCGTCAAGGA CCGGCACAAGGACGTTCTCAAGTGGGGCGATGAGGTGGAATACATGTTGGTATCTTTTGATCATGAAAATAAAAAAGTCCGGTTGGTCCTGTCTGGGGAGAAAGTTCTTGAAACTCTGCA AGAGAAGGGGGAAAGGACAAACCCAAACCATCCTACCCTTTGGAGACCAGAGTATGGGAGTTACATGATTGAAGGGACACCAGGACAGCCCTACGGAGGAACAATGTCCGAGTTCAATAC AGTTGAGGCCAACATGCGAAAACGCCGGAAGGAGGCTACTTCTATATTAGAAGAAAATCAGGCTCTTTGCACAATAACTTCATTTCCCAGATTAGGCTGTCCTGGGTTCACACTGCCCGA GGTCAAACCCAACCCAGTGGAAGGAGGAGCTTCCAAGTCCCTCTTCTTTCCAGATGAAGCAATAAACAAGCACCCTCGCTTCAGTACCTTAACAAGAAATATCCGACATAGGAGAGGAGA AAAGGTTGTCATCAATGTACCAATATTTAAGGACAAGAATACACCATCTCCATTTATAGAAACATTTACTGAGGATGATGAAGCTTCAAGGGCTTCTAAGCCGGATCATATTTACATGGA TGCCATGGGATTTGGAATGGGCAATTGCTGTCTCCAGGTGACATTCCAAGCCTGCAGTATATCTGAGGCCAGATACCTTTATGATCAGTTGGCTACTATCTGTCCAATTGTTATGGCTTT GAGTGCTGCATCTCCCTTTTACCGAGGCTATGTGTCAGACATTGATTGTCGCTGGGGAGTGATTTCTGCATCTGTAGATGATAGAACTCGGGAGGAGCGAGGACTGGAGCCATTGAAGAA CAATAACTATAGGATCAGTAAATCCCGATATGACTCAATAGACAGCTATTTATCTAAGTGTGGTGAGAAATATAATGACATCGACTTGACGATAGATAAAGAGATCTACGAACAGCTGTT GCAGGAAGGCATTGATCATCTCCTGGCCCAGCATGTTGCTCATCTCTTTATTAGAGACCCACTGACACTGTTTGAAGAGAAAATACACCTGGATGATGCTAATGAGTCTGACCATTTTGA GAATATTCAGTCCACAAATTGGCAGACAATGAGATTTAAGCCCCCTCCTCCAAACTCAGACATTGGATGGAGAGTAGAATTTCGACCCATGGAGGTGCAATTAACAGACTTTGAGAACTC TGCCTATGTGGTGTTTGTGGTACTGCTCACCAGAGTGATCCTTTCCTACAAATTGGATTTTCTCATTCCACTGTCAAAGGTTGATGAGAACATGAAGGTAGCACAGAAAAGAGATGCTGT CTTGCAGGGAATGTTTTATTTCAGGAAAGATATTTGCAAAGGTGGCAATGCAGTGGTGGATGGTTGTGGCAAGGCCCAGAACAGCACGGAGCTCGCTGCAGAGGAGTACACCCTCATGAG CATAGACACCATCATCAATGGGAAGGAAGGTGTGTTTCCTGGACTGATCCCAATTCTGAACTCTTACCTTGAAAACATGGAAGTGGATGTGGACACCAGATGTAGTATTCTGAACTACCT AAAGCTAATTAAGAAGAGAGCATCTGGAGAACTAATGACAGTTGCCAGATGGATGAGGGAGTTTATCGCAAACCATCCTGACTACAAGCAAGACAGTGTCATAACTGATGAAATGAATTA TAGCCTTATTTTGAAGTGTAACCAAATTGCAAATGAATTATGTGAATGCCCAGAGTTACTTGGATCAGCATTTAGGAAAGTAAAATATAGTGGAAGTAAAACTGACTCATCCAACTAGAC ATTCTACAGAAAGAAAAATGCATTATTGACGAACTGGCTACAGTACCATGCCTCTCAGCCAGCCCGTGTGTATAATATGAAGACCAAATGATAGAACTGTACTGTTTTCTGGGCCAGTGA GCCAGAAATTGATTAAGGCTTTCTTTGGTAGGTAAATCTAGAGTTTATACAGTGTACATGTACATAGTAAAGTATTTTTGATTAACAATGTATTTTAATAACATATCTAAAGTCATCATG AACTGGCTTGTACATTTTTAAATTCTTACTCTGGAGCAACCTACTGTCTAAGCAGTTTTGTAAATGTACTGGTAATTGTACAATACTTGCATTCCAGAGTTAAAATGTTTACTGTAAATT TTTGTTCTTTTAAAGACTACCTGGGACCTGATTTATTGAAATTTTTCTCTTTAAAAACATTTTCTCTCGTTAATTTTCCTTTGTCATTTCCTTTGTTGTCTACATTAAATCACTTGAATC CATTGAAAGTGCTTCAAGGGTAATCTTGGGTTTCTAGCACCTTATCTATGATGTTTCTTTTGCAATTGGAATAATCACTTGGTCACCTTGCCCCAAGCTTTCCCCTCTGAATAAATACCC ATTGAACTCTGATGGCTGTTATCAAAGGAACTTTTCTTTGTTTAAATTTGCTGATGCAGGAATTAAGTTTAAACACAACTCTATAGAAAGAAAGGAGATTATTACCCAGAATTCACATGT AGTGATTATTAAGGACAATTTTTTTTTTTAACTAAAAAAGTTGGCGGCAGGGGTGGGGGGTGGCAATCATTTTTCTTCCTATACATACAAAGGATATTGTCAAAAATGGCGTTCTTCTCT TGTGGCCTGTTATTCTGATTGCTGCTGTATACAGTTTTGTCACTCTTTAGTTTTTAGTTAAGCATACTGATAGACTTTCCTCTAAAAGCCATTCACTCCAGATTTTACCTGGGGAATATT CTACATACTGCTTACTTTCTCTATAAAACTCATCAATAAATCATGAAAGGCACTGAGTTTTGTAAATCAGGACCCTAAATGTTTAATTGTAAATAAGTTTCAGATAATTATTATAGCTTT GCGTTGAAGTTTGTTGTTTTTTTTCTCAACTAGTTAAGTCAACTGCTTCTGAAATAACTCTGTATTGTAGATTATGCAGATCTTTACAGGCATAAATATTTAAACTGTAATATGCTAACT TGAAGAGATTGCAATAAAGCTGCTTCAGCTAACCCTGTTTATGTTTAAATACTAGGGTTTGTTCTATATTTTATACATGCATTTTGGATGATTAAAGAATGCCTGGTTTTCGTTTGCAAT TTGCTTGTGTAAATCAGGTTGTAAAAAGGCAGATAAATTGAAATGTTTGTGGTATGAGGAAATAAAAGAATGGAATTAGCTTTCATTCAGAAAAAAAAAAAAA |
Protein Sequence | >2729 : length: 637 MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV EANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDA MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQ EGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL QGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYS LILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN |