| Separin(h) + ATP --> Separin(h){pS1126} + ADP (phosphorylation)
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cyclinB1(h) + Separin(h) <==> cyclinB1(h):Separin(h) (binding)
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securin(h) + Separin(h) <==> securin(h):Separin(h) (binding)
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securin(h) + Separin(h) <==> securin(h):Separin(h) (binding)
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Separin(h) --> Separin-p170(h) + protein remnants (cleavage; automodification)
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Separin(h) + Cdk1(h) <==> Separin(h):Cdk1(h) (binding)
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Separin(h) + 8 ATP --> Separin(h){pS1073}{pS1126}{pS1305}{pS1501}{pS1508}{pS1545}{pS1552}{pT1346} + 8 ADP (phosphorylation)
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Separin(h) + B56alpha(h) <==> Separin(h):B56alpha(h) (binding)
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Separin(h) + PR65(h) <==> Separin(h):PR65(h) (binding)
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Separin(h) + PP2AC(h) <==> Separin(h):PP2AC(h) (binding)
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Separin(h) + B56alpha(m.s.) <==> Separin(h):B56alpha(m.s.) (binding)
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Separin(h) + securin(m.s.) + PP2AC(h) + B56alpha(m.s.) <==> Separin(h):securin(m.s.):PP2AC(h):B56alpha(m.s.) (binding)
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Separin(h) + cyclinB1(m.s.) <==> Separin(h):cyclinB1(m.s.) (binding)
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Separin(h) + 3 ATP --> Separin(h){pT1346}{pT1363}{pS1399} + 3 ADP (phosphorylation)
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ESPL1(h) --> Separin(h) (expression).
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Rad21(h) --Separin(h)--> protein remnants (cleavage)
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Separin(h) --> Separin-p150(h) + Separin-p65(h) + protein remnants (cleavage; automodification)
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securin(h) + PR65-alpha(h) + B56gamma(h) + Separin(h) <==> securin(h):PR65-alpha(h):B56gamma(h):Separin(h) (binding)
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Separin(h) + cyclinB1(h) <==> Separin(h):cyclinB1(h) (binding)
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PR65(h) + Separin(h) <==> PR65(h):Separin(h) (binding)
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Separin(h) + PP2AC(h) <==> Separin(h):PP2AC(h) (binding)
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securin(h) + Separin(h) <==> securin(h):Separin(h) (binding)
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Separin(h) + B56alpha(h) <==> Separin(h):B56alpha(h) (binding)
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Separin(h) + B56beta(h) <==> Separin(h):B56beta(h) (binding)
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Separin(h) + B56gamma1(h) <==> Separin(h):B56gamma1(h) (binding)
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Separin(h) + B56gamma3(h) <==> Separin(h):B56gamma3(h) (binding)
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Separin(h) + B56delta(h) <==> Separin(h):B56delta(h) (binding)
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Separin(h) + B56epsilon(h) <==> Separin(h):B56epsilon(h) (binding)
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Separin(h) + B56alpha(m.s.) <==> Separin(h):B56alpha(m.s.) (binding)
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Separin(h) + ATP --ATM(m.s.)--> Separin(h){pS1940} + ADP (phosphorylation)
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Separin(h) + ATP --ATR(m.s.)--> Separin(h){pS1940} + ADP (phosphorylation)
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Separin(h) + ATP --DNA-PK(m.s.)--> Separin(h){pS1940} + ADP (phosphorylation)
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Separin(h) + ATP --plk1(x)--> Separin(h){pS1399} + ADP (phosphorylation)
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ESPL1(h) --> Separin(h) (expression).
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