| BARD1(h) + brca1(h) <==> BARD1(h):brca1(h) (binding)
|
brca1(h) + p53(h) <==> brca1(h):p53(h) (binding)
|
brca1(h) --/ Pin1(h) (inhibition)
|
brca1(h) --/ Bax(h) (inhibition)
|
brca1(h) + Rad51(h) <==> brca1(h):Rad51(h) (binding)
|
brca1(h) + Chk1(h) <==> brca1(h):Chk1(h) (binding)
|
brca1(h) + BRIP1(h) <==> brca1(h):BRIP1(h) (binding)
|
brca1(h) + CtIP(h) + Lmo4(h) <==> brca1(h):CtIP(h):Lmo4(h) (binding)
|
brca1(h) + Lmo4(h) <==> brca1(h):Lmo4(h) (binding)
|
brca1(h) + Aurora-A(h) <==> brca1(h):Aurora-A(h) (binding)
|
brca1(h) + ATP --Aurora-A(h)--> brca1(h){pS308} + ADP (phosphorylation)
|
HNF3A(h) + brca1(h) <==> brca1(h):HNF3A(h) (binding)
|
USF2(h) + brca1(h) <==> brca1(h):USF2(h) (binding)
|
c-Myc(h) + brca1(h) <==> brca1(h):c-Myc(h) (binding)
|
brca1(h) + ZBRK1(h) <==> ZBRK1(h):brca1(h) (binding)
|
brca1(h) --> CDKN1B(h) (DNA binding; transactivation).
|
brca1(h) --> CDKN1B(m) (DNA binding; transactivation).
|
brca1(h) + MSH2(h) <==> brca1(h):MSH2(h) (binding)
|
Slim-3(h) + brca1(h) <==> Slim-3(h):brca1(h) (binding)
|
brca1(h) + Claspin(m.s.) <==> brca1(h):Claspin(m.s.) (binding)
|
brca1(h) --> Chk1(h){pS345} (increase of phosphorylation)
|
brca1(h) + ATP --> brca1(h){pS1524} + ADP (phosphorylation)
|
brca1(h) + NF-YA(h) <==> brca1(h):NF-YA(h) (binding)
|
Oct-1(h) + brca1(h) <==> Oct-1(h):brca1(h) (binding)
|
RHA(h) + brca1(h) <==> RHA(h):brca1(h) (binding)
|
brca1(h) + Cdk1(h) <==> brca1(h):Cdk1(h) (binding)
|
Cdk2(h) + brca1(h) <==> Cdk2(h):brca1(h) (binding)
|
Cdk4(h) + brca1(h) <==> Cdk4(h):brca1(h) (binding)
|
cyclinA(h) + brca1(h) <==> cyclinA(h):brca1(h) (binding)
|
cyclinB1(h) + brca1(h) <==> cyclinB1(h):brca1(h) (binding)
|
cyclinD1(h) + brca1(h) <==> cyclinD1(h):brca1(h) (binding)
|
E2F-4(h) + brca1(h) <==> E2F-4(h):brca1(h) (binding)
|
cyclinA(m.s.) + brca1(h) <==> cyclinA(m.s.):brca1(h) (binding)
|
cyclinB1(m.s.) + brca1(h) <==> cyclinB1(m.s.):brca1(h) (binding)
|
cyclinD1(m.s.) + brca1(h) <==> cyclinD1(m.s.):brca1(h) (binding)
|
E2F-1(m.s.) + brca1(h) <==> E2F-1(m.s.):brca1(h) (binding)
|
E2F-4(m.s.) + brca1(h) <==> E2F-4(m.s.):brca1(h) (binding)
|
brca1(h) + E2F-1(h) <==> brca1(h):E2F-1(h) (binding)
|
Cdk1-isoform1(h) + brca1(h) <==> Cdk1-isoform1(h):brca1(h) (binding)
|
brca1(h) + Cdk2(h) <==> brca1(h):Cdk2(h) (binding)
|
brca1(h) + NUFIP(h) <==> brca1(h):NUFIP(h) (binding)
|
NUFIP(h) + brca1(h) <==> NUFIP(h):brca1(h) (binding)
|
c-Jun(m.s.) + brca1(h) <==> c-Jun(m.s.):brca1(h) (binding)
|
JunB(m.s.) + brca1(h) <==> JunB(m.s.):brca1(h) (binding)
|
JunD(m.s.) + brca1(h) <==> JunD(m.s.):brca1(h) (binding)
|
c-Jun(h) + brca1(h) <==> c-Jun(h):brca1(h) (binding)
|
JunB(h) + brca1(h) <==> JunB(h):brca1(h) (binding)
|
DRIP205(h) + brca1(h) <==> DRIP205(h):brca1(h) (binding)
|
RbAp46(h) + brca1(h) <==> RbAp46(h):brca1(h) (binding)
|
RbAp48(h) + brca1(h) <==> RbAp48(h):brca1(h) (binding)
|
p300(m.s.) + brca1(h) <==> p300(m.s.):brca1(h) (binding)
|
p300(h) + brca1(h) <==> p300(h):brca1(h) (binding)
|
ATF-1(h) + brca1(h) <==> ATF-1(h):brca1(h) (binding)
|
brca1(h) + n ATP --> brca1(h){pS1524}{p}n + n ADP (phosphorylation)
|
brca1(h) + n ATP --> brca1(h){pS1423}{p}n + n ADP (phosphorylation)
|
brca1(h) + STAT1alpha(h) <==> brca1(h):STAT1alpha(h) (binding)
|
brca1(h) + STAT1beta(h) <==> brca1(h):STAT1beta(h) (binding)
|
brca1(h) + MEKK3(m.s.) <==> brca1(h):MEKK3(m.s.) (binding)
|
MEKK3(h) + brca1(h) <==> MEKK3(h):brca1(h) (binding)
|
brca1(h) --> MBP(m.s.){p} (increase of phosphorylation)
|
brca1(h) --> p38alpha(h){p} (increase of phosphorylation)
|
brca1(h) --> Caspase-3-p17(h) (increase of cleavage)
|
brca1(h) + PabpC1(h) <==> brca1(h):PabpC1(h) (binding)
|
brca1(h) + HIF-1alpha(h) <==> brca1(h):HIF-1alpha(h) (binding)
|
brca1(h) --> VEGF-A(h) (increase of secretion)
|
brca1(h) + BAAT1(h) <==> brca1(h):BAAT1(h) (binding)
|
brca1(h) --> brca1(h) (translocation)
|
brca1(h) + FANCA(m.s.) <==> brca1(h):FANCA(m.s.) (binding)
|
brca1(h) + 2 ATP --> brca1(h){pS1423}{pS1524} + 2 ADP (phosphorylation)
|
brca1(h) --> Caspase-3(h) (increase of cleavage)
|
brca1(h) + 3 ATP --> brca1(h){pS1387}{pS1423}{pS1524} + 3 ADP (phosphorylation)
|
brca1(h) + 3 ATP --> brca1(h){pS1423}{pS1457}{pS1524} + 3 ADP (phosphorylation)
|
brca1(h) + 3 ATP --ATR(m.s.)--> brca1(h){pS1423}{pS1457}{pS1524} + 3 ADP (phosphorylation)
|
ATR(h) + brca1(h) <==> ATR(h):brca1(h) (binding)
|
BARD1(m.s.) + brca1(h) <==> BARD1(m.s.):brca1(h) (binding)
|
BRE(h) + BRCC36(h) + Rad51(h) + BRCA2(h) + brca1(h) + BARD1(m.s.) <==> BARD1(m.s.):brca1(h):BRCA2(h):BRCC36(h):BRE(h):Rad51(h) (binding)
|
BRCA2(h) + BARD1(h) + brca1(h) <==> BRCA2(h):BARD1(h):brca1(h) (binding)
|
BRE(h) + BRCA2(h) + brca1(h) + BARD1(m.s.) + BRCC36(m.s.) <==> BRE(h):BRCA2(h):brca1(h):BARD1(m.s.):BRCC36(m.s.) (binding)
|
Ubc5C(h) + brca1(h) <==> Ubc5C(h):brca1(h) (binding)
|
brca1(h) + ACCalpha(h) <==> brca1(h):ACCalpha(h) (binding)
|
brca1(h) + CCDC98(m.s.) <==> brca1(h):CCDC98(m.s.) (binding)
|
brca1(h) + RAP80(h) <==> brca1(h):RAP80(h) (binding)
|
brca1(h) + RAP80(h){p} <==> brca1(h):RAP80(h){p} (binding)
|
brca1(h) + CCDC98(h) <==> brca1(h):CCDC98(h) (binding)
|
brca1(h) + Bach1(h) <==> brca1(h):Bach1(h) (binding)
|
brca1(h) + CtIP(h) <==> brca1(h):CtIP(h) (binding)
|
BARD1(h) + BRCA2(h) + brca1(h) + Bach1(h) + MLH1(h) + tubulin(h) + CtIP(h) <==> BARD1(h):BRCA2(h):brca1(h):Bach1(h):MLH1(h):tubulin(h):CtIP(h) (binding)
|
Rad50(h) + TOP2BP1(h) + brca1(h) + BARD1(h) <==> Rad50(h):TOP2BP1(h):brca1(h):BARD1(h) (binding)
|
brca1(h) + ATP --> brca1(h){p} + ADP (phosphorylation)
|
BARD1(h) + NBS1(h) + TOP2BP1(h) + brca1(h) <==> BARD1(h):NBS1(h):TOP2BP1(h):brca1(h) (binding)
|
brca1(h) + TOP2BP1(h) <==> brca1(h):TOP2BP1(h) (binding)
|
brca1(h) + Mre11(h) <==> brca1(h):Mre11(h) (binding)
|
brca1(h) + ATP --> brca1(h){pS1423} + ADP (phosphorylation)
|
brca1(h) + BARD1(h) <==> brca1(h):BARD1(h) (binding)
|
Bach1(h) + TOP2BP1(h) + brca1(h) + BARD1(h) <==> Bach1(h):TOP2BP1(h):brca1(h):BARD1(h) (binding)
|
CtIP(h) + Rad50(h) + brca1(h) + BARD1(h) <==> CtIP(h):Rad50(h):brca1(h):BARD1(h) (binding)
|
BRCA2(h) + brca1(h) + BARD1(h) <==> BRCA2(h):brca1(h):BARD1(h) (binding)
|
Mre11(h) + NBS1(h) + CtIP(h) + Rad50(h) + brca1(h) <==> Mre11(h):NBS1(h):CtIP(h):Rad50(h):brca1(h) (binding)
|
MLH1(h) + TOP2BP1(h) + Bach1(h) + brca1(h) <==> MLH1(h):TOP2BP1(h):Bach1(h):brca1(h) (binding)
|
brca1(h) + RAP80(m.s.) <==> brca1(h):RAP80(m.s.) (binding)
|
BRE(h) + BRCC36(h) + brca1(h) + RAP80(m.s.) <==> BRE(h):BRCC36(h):brca1(h):RAP80(m.s.) (binding)
|
CtIP(h) + brca1(h) + ZBRK1(h) <==> CtIP(h):brca1(h):ZBRK1(h) (binding)
|
brca1(h) + CtIP(m.s.) <==> brca1(h):CtIP(m.s.) (binding)
|
brca1(h) + n ATP --> brca1(h){p}n + n ADP (phosphorylation)
|
brca1(h) + ATP --> brca1(h){pS988} + ADP (phosphorylation)
|
brca1(h) + ATP --Chk2(h)--> brca1(h){pS988} + ADP (phosphorylation)
|
BARD1(h) + Bach1(h) + brca1(h) + BRCA2(h) <==> BARD1(h):Bach1(h):brca1(h):BRCA2(h) (binding)
|
BRCC36(h) + BRE(h) + Bach1(h) + BRCA2(h) + brca1(h) + BARD1(m.s.) <==> BRCC36(h):BRE(h):Bach1(h):BRCA2(h):brca1(h):BARD1(m.s.) (binding)
|
BARD1(h) + BRCA2(h) + brca1(h) + BRCC36(m.s.) + BRE(h) <==> BARD1(h):BRCA2(h):brca1(h):BRCC36(m.s.):BRE(h) (binding)
|
brca1(h) + RelA-p65(h) <==> brca1(h):RelA-p65(h) (binding)
|
ER-alpha(h) + brca1(h) <==> ER-alpha(h):brca1(h) (binding)
|
brca1(h) + RECC1(h) <==> brca1(h):RECC1(h) (binding)
|
brca1(h) + GTBP(h) <==> brca1(h):GTBP(h) (binding)
|
BLM(h) + brca1(h) <==> BLM(h):brca1(h) (binding)
|
ATM(h) + brca1(h) <==> ATM(h):brca1(h) (binding)
|
Rad50(h) + brca1(h) <==> Rad50(h):brca1(h) (binding)
|
brca1(h) + NBS1(h) <==> brca1(h):NBS1(h) (binding)
|
BLM(h) + Rad50(h) + MSH2(h) + ATM(h) + brca1(h) + RECC1(h) <==> BLM(h):Rad50(h):MSH2(h):ATM(h):brca1(h):RECC1(h) (binding)
|
brca1(h) --> p53(h){pS15} (increase of phosphorylation)
|
arnt(h) + brca1(h) <==> arnt(h):brca1(h) (binding)
|
brca1(h) <==> protein remnants (cleavage)
|
brca1(h) + E2F-6(h) <==> brca1(h):E2F-6(h) (binding)
|
brca1(h) + CBP(h) <==> brca1(h):CBP(h) (binding)
|
brca1(h) --> Rad52(h) (increase of abundance)
|
brca1(h) --> RAD54A(h) (increase of abundance)
|
brca1(h) --> XRCC2(h) (increase of abundance)
|
brca1(h) --> XRCC3(h) (increase of abundance)
|
brca1(h) --> XRCC4(h) (increase of abundance)
|
brca1(h) + PR A(h) <==> brca1(h):PR A(h) (binding)
|
brca1(h) + PR B(h) <==> brca1(h):PR B(h) (binding)
|
brca1(h) + GCN5(h) <==> brca1(h):GCN5(h) (binding)
|
brca1(h) + trrap(h) <==> brca1(h):trrap(h) (binding)
|
brca1(h) + Bach1(h){p} <==> brca1(h):Bach1(h){p} (binding)
|
brca1(h) + pRb(m.s.) <==> brca1(h):pRb(m.s.) (binding)
|
brca1(h) + Smad3(h) <==> brca1(h):Smad3(h) (binding)
|
brca1(h) + BRIP1(m.s.){pS990} <==> brca1(h):BRIP1(m.s.){pS990} (binding)
|
brca1(h) + BRIP1(h){pS990} <==> brca1(h):BRIP1(h){pS990} (binding)
|
brca1(h) + 4 ATP --> brca1(h){pS988}{pS1423}{pS1497}{pS1524} + 4 ADP (phosphorylation)
|
brca1(h) + 3 ATP --> brca1(h){pS988}{pS1423}{pS1524} + 3 ADP (phosphorylation)
|
brca1(h) + ATP --AKT(m.s.)--> brca1(h){p} + ADP (phosphorylation)
|
brca1(h) --> protein remnants (degradation)
|
brca1(h) + n ubiquitin(h) --> brca1(h){ub}n (ubiquitination)
|
STAT5A(h) + brca1(h) <==> STAT5A(h):brca1(h) (binding)
|
brca1(h) + ACCalpha(m) <==> brca1(h):ACCalpha(m) (binding)
|
brca1(h) + sumo1(m.s.) --> brca1(h){sumo} (sumoylation)
|
brca1(h) + SUMO2(m.s.) --> brca1(h){sumo2} (sumoylation)
|
brca1(h) + Sp1(h) <==> brca1(h):Sp1(h) (binding)
|
Elk-1(h) + brca1(h) <==> Elk-1(h):brca1(h) (binding)
|
BRCA1(h) --> brca1(h) (expression).
|
brca1(h) --> brca1(h) (translocation)
|
NRG1(h) --> brca1(h) (increase of abundance)
|
Calmbp1(h) --> brca1(h) (increase of abundance)
|
PGE2 --/ brca1(h) (decrease of abundance)
|
DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide(h) + n ubiquitin(h) --brca1(h)--> DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide(h){ub}n (ubiquitination)
|
brca1(h) + Slim-3(h) <==> brca1(h):Slim-3(h) (binding)
|
p300(h) + TRAP80(h) + DRIP100(h) + DRIP130(h) + Bach1(h) + DRIP205(h) + TRAP240(h) + brca1(h) <==> p300(h):TRAP80(h):DRIP100(h):DRIP130(h):Bach1(h):DRIP205(h):TRAP240(h):brca1(h) (binding)
|
DRIP205(m.s.) + brca1(h) <==> DRIP205(m.s.):brca1(h) (binding)
|
RbAp46(h) + brca1(h) <==> RbAp46(h):brca1(h) (binding)
|
RbAp46(h) + brca1(h) <==> RbAp46(h):brca1(h) (binding)
|
RbAp48(h) + brca1(h) <==> RbAp48(h):brca1(h) (binding)
|
brca1(h) + pRb(m.s.) <==> brca1(h):pRb(m.s.) (binding)
|
HDAC1(h) + brca1(h) <==> HDAC1(h):brca1(h) (binding)
|
hdac2(h) + brca1(h) <==> hdac2(h):brca1(h) (binding)
|
CBP(m.s.) + brca1(h) <==> CBP(m.s.):brca1(h) (binding)
|
p300(m.s.) + brca1(h) <==> p300(m.s.):brca1(h) (binding)
|
brca1(h) + n ubiquitin(h) --> brca1(h){ub}n (ubiquitination; automodification)
|
brca1(h) --> STAT3(h){pY705} (increase of phosphorylation)
|
brca1(h) --> STAT3(h){pS727} (increase of phosphorylation)
|
brca1(h) + Jak1(h) <==> brca1(h):Jak1(h) (binding)
|
Jak2(h) + brca1(h) <==> Jak2(h):brca1(h) (binding)
|
brca1(h) + ATF-1(h) <==> brca1(h):ATF-1(h) (binding)
|
PP1-alpha(rb) + brca1(h) <==> PP1-alpha(rb):brca1(h) (binding)
|
brca1(h) + PP1-alpha(mo) <==> brca1(h):PP1-alpha(mo) (binding)
|
brca1(h) --> p21Cip1(m) (increase of abundance)
|
STAT1alpha(h) + brca1(h) <==> STAT1alpha(h):brca1(h) (binding)
|
brca1(h) + ACCalpha(h){pS80} <==> brca1(h):ACCalpha(h){pS80} (binding)
|
brca1(h) + MEKK3(m.s.) <==> brca1(h):MEKK3(m.s.) (binding)
|
brca1(h) + PabpC1(h) <==> brca1(h):PabpC1(h) (binding)
|
brca1(h) --> p53(h){pS15} (increase of phosphorylation)
|
brca1(h) --> c-Jun(h){pS63} (increase of phosphorylation)
|
brca1(h) --> NBS1(h){pS343} (increase of phosphorylation)
|
brca1(h) --> Chk2(h){pT68} (increase of phosphorylation)
|
brca1(h) --> CtIP(h){p} (increase of phosphorylation)
|
brca1(h) + ATRIP(h) <==> brca1(h):ATRIP(h) (binding)
|
ATRIP(h) + brca1(h) <==> ATRIP(h):brca1(h) (binding)
|
brca1(h) + XIAP(h) <==> brca1(h):XIAP(h) (binding)
|
brca1(h) + ATP --ATR(h)--> brca1(h){p} + ADP (phosphorylation)
|
brca1(h) + ATP --ATR(m.s.)--> brca1(h){p} + ADP (phosphorylation)
|
ACCalpha(h) + brca1(h) <==> ACCalpha(h):brca1(h) (binding)
|
brca1(h) + TOP2BP1(h) <==> brca1(h):TOP2BP1(h) (binding)
|
Bach1(h) + brca1(h) <==> Bach1(h):brca1(h) (binding)
|
BARD1(h) + brca1(h) <==> BARD1(h):brca1(h) (binding)
|
RAP80(h) + brca1(h) <==> RAP80(h):brca1(h) (binding)
|
brca1(h) + ER-alpha(m.s.) <==> brca1(h):ER-alpha(m.s.) (binding)
|
brca1(h) --/ VEGFA(h) (transrepression)
|
brca1(h) --> VEGF-A(h) (decrease of secretion)
|
ER-alpha(h) + brca1(h) <==> ER-alpha(h):brca1(h) (binding)
|
brca1(h) + ATP --Chk2-isoform1(h)--> brca1(h){pS988} + ADP (phosphorylation)
|
p53(h) + brca1(h) <==> p53(h):brca1(h) (binding)
|
RFC4(h) + RFC2(h) + MLH1(h) + MSH2(h) + RECC1(h) + BLM(h) + ATM(h) + brca1(h) + GTBP(h) <==> RFC4(h):RFC2(h):MLH1(h):MSH2(h):RECC1(h):BLM(h):ATM(h):brca1(h):GTBP(h) (binding)
|
brca1(h) + Rad50(h) + GTBP(h) <==> brca1(h):Rad50(h):GTBP(h) (binding)
|
brca1(h) + 3 ATP --> brca1(h){pS1387}{pS1423}{pS1524} + 3 ADP (phosphorylation)
|
BARD1(h) + brca1(h) <==> BARD1(h):brca1(h) (binding)
|
Ubc5A(h) + brca1(h) <==> Ubc5A(h):brca1(h) (binding)
|
brca1(h) + PR A(m.s.) <==> brca1(h):PR A(m.s.) (binding)
|
brca1(h) + CtIP(h){pS327} <==> brca1(h):CtIP(h){pS327} (binding)
|
brca1(h) + BRIP1(h){pS990} <==> brca1(h):BRIP1(h){pS990} (binding)
|
brca1(h) + Smad3(m.s.) <==> brca1(h):Smad3(m.s.) (binding)
|
brca1(h) + ATP --> brca1(h){p} + ADP (phosphorylation)
|
brca1(h) + 2 ATP --ATR(m.s.)--> brca1(h){pS1280}{pS1423} + 2 ADP (phosphorylation)
|
brca1(h) + ATP --> brca1(h){p}n + n ADP (phosphorylation)
|
brca1(h) + 3 ATP --ATM(m.s.)--> brca1(h){pS1298}{pS1387}{pS1466} + 3 ADP (phosphorylation)
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brca1(h) + 3 ATP --ATR(m.s.)--> brca1(h){pS1298}{pS1387}{pS1466} + 3 ADP (phosphorylation)
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brca1(h) + 3 ATP --DNA-PK(m.s.)--> brca1(h){pS1298}{pS1387}{pS1466} + 3 ADP (phosphorylation)
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brca1(h) + n ubiquitin(h) --> brca1(h){ub}n (ubiquitination)
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brca1(h) + ACCalpha-isoform1(h){pS1263} <==> brca1(h):ACCalpha-isoform1(h){pS1263} (binding)
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brca1(h) + ACCalpha(m) <==> brca1(h):ACCalpha(m) (binding)
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brca1(h) --> brca1(h) (expression).
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brca1(h){p} --PP1-alpha(rb)--> brca1(h) + p (dephosphorylation)
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brca1(h){p} --PP2ACalpha(m.s.)--> brca1(h) + ATP (dephosphorylation)
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brca1(h){p} --PP1(mo)--> brca1(h) + p (dephosphorylation)
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brca1(h){p} --PP1-alpha(mo)--> ATP + brca1(h) (dephosphorylation)
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brca1(h){pS988} --PP1-alpha(rb)--> brca1(h) + ATP (dephosphorylation)
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