| MKK4(h) --> Trx1(h){reC}2 (activation)
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MKK4(h) + AKT(h){pT308}{pS473} <==> MKK4(h):AKT(h){pT308}{pS473} (binding)
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MKK4(h) + 2 ATP --MEKK2(v.s.)--> MKK4(h){pS221}{pT225} + 2 ADP (phosphorylation)
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MKK4(h) + 2 ATP --MEKK3(v.s.)--> MKK4(h){pS221}{pT225} + 2 ADP (phosphorylation)
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MKK4(h) + POSH(m) <==> MKK4(h):POSH(m) (binding)
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MKK4(h) --/ KLK3(h) (transrepression)
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MKK4(h) --> Cyp24a1(r) (transactivation).
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MKK4(h) + ATP --> MKK4(h){p} + ADP (phosphorylation)
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AKT-1(h) + MKK4(h) <==> AKT-1(h):MKK4(h) (binding)
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TRIB1(m.s.) + MKK4(h) <==> TRIB1(m.s.):MKK4(h) (binding)
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MKK4(h) + ATP --> MKK4(h){pT261} + ADP (phosphorylation)
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MAP2K4(h) --> MKK4(h) (expression).
|
MKK4(h){p} --PP2Calpha2(h)--> MKK4(h) + p (dephosphorylation)
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JNK2(h) + ATP --MKK4(h)--> JNK2(h){p} + ADP (phosphorylation)
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MKK4beta(h) + JNK2(h) <==> MKK4beta(h):JNK2(h) (binding)
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MAP2K4(h) --> MKK4beta(h) (expression).
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MAP2K4(h) --> MAP2K4(h) (expression).
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hsa-miR-25 --/ MAP2K4(h) (predicted)
|
hsa-miR-92 --/ MAP2K4(h) (predicted)
|
