| MVP(h) + PTEN(h) <==> MVP(h):PTEN(h) (binding)
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PTEN(h) + 2 ATP --CKII-alpha(h):CKII-alpha2(h):(CKII-beta(h))2--> PTEN(h){pS370}{pS385} + 2 ADP (phosphorylation)
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CKII-alpha(h) + PTEN(h) <==> CKII-alpha(h):PTEN(h) (binding)
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PTEN(h) + 5 ATP --CKII-alpha(h):CKII-alpha2(h):(CKII-beta(h))2--> PTEN(h){pS370}{pS380}{pT382}{pT383}{pS385} + 5 ADP (phosphorylation)
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PTEN(h) + 5 ATP --CKII(mo)--> PTEN(h){pS370}{pS380}{pT382}{pT383}{pS385} + 5 ADP (phosphorylation)
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p300(h) + PTEN(h) <==> p300(h):PTEN(h) (binding)
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p53(h) + PTEN(h) <==> p53(h):PTEN(h) (binding)
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PTEN(h) + 3 ATP --> PTEN(h){pS380}{pT381}{pT382} + 3 ADP (phosphorylation)
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PTEN(h) + ubiquitin(h) --> PTEN(h){ub} (ubiquitination)
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PTEN(h) --> AKT-1(h){pT308}{pS473} (decrease of phosphorylation)
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PTEN(h) --> p21Cip1(h) (increase of abundance)
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PTEN(h) --/ Skp2(h) (decrease of abundance)
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PTEN(h) --> AKT-1(h){pS473} (decrease of phosphorylation)
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HAUSP(h) + PTEN(h) <==> HAUSP(h):PTEN(h) (binding)
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PTEN(h) + HAUSP(m.s.) <==> PTEN(h):HAUSP(m.s.) (binding)
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PTEN(h) --> PTEN(h) (expression).
|
estradiol --/ PTEN(h) (decrease of abundance)
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p53(h) --> PTEN(h) (increase of abundance)
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p53(m.s.) --> PTEN(h) (increase of abundance)
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mdm2(m.s.) --/ PTEN(h) (decrease of abundance)
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p16INK4a(m.s.) --> PTEN(h) (increase of abundance)
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estradiol --> PTEN(h) (increase of abundance)
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Fzr(h) --/ PTEN(h) (decrease of abundance)
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PTEN(h){ub} --HAUSP(m.s.)--> PTEN(h) + ubiquitin(h) (deubiquitination)
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PIP3 --PTEN(h)--> PIP2 + p (dephosphorylation)
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PtdIns(3,4)P2 --PTEN(h)--> PtdIns(4)P + p (dephosphorylation)
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PtdIns(3)P --PTEN(h)--> PtdIns + p (dephosphorylation)
|
Ins(1,3,4,5)P4 --PTEN(h)--> IP3 + p (dephosphorylation)
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PTEN(h) --> p38(m.s.){p} (decrease of phosphorylation)
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PTEN(h) --> PTEN(h) (expression).
|
PTEN(h) --> PTEN(h) (expression).
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hsa-miR-19a --/ PTEN(h) (predicted)
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hsa-miR-19b --/ PTEN(h) (predicted)
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hsa-miR-214 --/ PTEN(h) (translational repression).
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