| IkappaB-alpha(h) + Ubc9(h){sumo} + ATP --> IkappaB-alpha(h){sumo} + Ubc9(h) + AMP + p (conjugation; stabilization)
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IkappaB-alpha(h) + ATP --IKK-alpha(h):IKK-beta(h):(IKK-gamma(h))2--> IkappaB-alpha(h){p} + ADP (phosphorylation)
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IkappaB-alpha(h) + ATP --IKK-alpha(h)--> IkappaB-alpha(h){p} + ADP (phosphorylation)
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IkappaB-alpha(h) + NF-kappaB(m) <==> IkappaB-alpha(h):NF-kappaB(m) (binding)
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IkappaB-alpha(h) + ATP --IKK-alpha(h){p}--> IkappaB-alpha(h){p} + ADP (phosphorylation)
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IkappaB-alpha(h) + ATP --IKK-beta(h){p}--> IkappaB-alpha(h){p} + ADP (phosphorylation)
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RelA-p65(m) + IkappaB-alpha(h) <==> RelA-p65(m):IkappaB-alpha(h) (binding).
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v-Rel(REVT) + IkappaB-alpha(h) <==> v-Rel(REVT):IkappaB-alpha(h) (binding).
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NF-kappaB1(h) + IkappaB-alpha(h) <==> NF-kappaB1(h):IkappaB-alpha(h) (binding).
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NF-kappaB1-isoform1(m) + IkappaB-alpha(h) <==> NF-kappaB1-isoform1(m):IkappaB-alpha(h) (binding).
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IkappaB-alpha(h) + Raf-1(m) <==> IkappaB-alpha(h):Raf-1(m) (binding)
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NF-kappaB(r) + IkappaB-alpha(h) <==> NF-kappaB(r):IkappaB-alpha(h) (binding).
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NF-kappaB(h) + IkappaB-alpha(h) <==> NF-kappaB(h):IkappaB-alpha(h) (binding).
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IkappaB-alpha(h) + ATP --CSN(h)--> IkappaB-alpha(h){p} + ADP (phosphorylation)
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IKK-beta(h) + IkappaB-alpha(h) <==> IKK-beta(h):IkappaB-alpha(h) (binding)
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IkappaB-alpha(h) + ATP --IKK-beta(h)--> IkappaB-alpha(h){p} + ADP (phosphorylation)
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IkappaB-alpha(h) + ATP --IKK-i(h){p}--> IkappaB-alpha(h){p} + ADP (phosphorylation)
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IkappaB-alpha(h) + ATP --IKK-i(h)--> IkappaB-alpha(h){pS36} + ADP (phosphorylation)
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IkappaB-alpha(h) + ATP --IKK-i(h){pS172}--> IkappaB-alpha(h){pS36} + ADP (phosphorylation)
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IkappaB-alpha(h) + NTP --TBK1(h)--> IkappaB-alpha(h){pS36} + NDP (phosphorylation)
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IkappaB-alpha(h) + NTP --IKK-beta(v.s.)--> IkappaB-alpha(h){pS32} + NDP (phosphorylation)
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IkappaB-alpha(h) + ATP --PKR(h){p}--> IkappaB-alpha(h){p} + ADP (phosphorylation)
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IkappaB-alpha(h) + NF-kappaB1-p50(h) <==> IkappaB-alpha(h):NF-kappaB1-p50(h) (binding)
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RelA-p65(h) + IkappaB-alpha(h) <==> RelA-p65(h):IkappaB-alpha(h) (binding)
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IkappaB-alpha(h) + ATP --> IkappaB-alpha(h){pS32} + ADP (phosphorylation)
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IkappaB-alpha(h) + RelA-p65(h) <==> IkappaB-alpha(h):RelA-p65(h) (binding)
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RelA-p65(h) + c-Rel(h) + IkappaB-alpha(h) <==> IkappaB-alpha(h):RelA-p65(h):c-Rel(h) (binding)
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IkappaB-alpha(h) --> protein remnants (degradation)
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IkappaB-alpha(h) + ATP --> IkappaB-alpha(h){pY} + ADP (phosphorylation)
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IkappaB-alpha(h) + ATP --> IkappaB-alpha(h){p} + ADP (phosphorylation)
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IkappaB-alpha(h) --> IkappaB-alpha(h) (translocation)
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IkappaB-alpha(h) + 2 ATP --> IkappaB-alpha(h){pS32}{pS36} + 2 ADP (phosphorylation)
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IkappaB-alpha(h) + RelA-p65(h){pS468}{pS536} <==> IkappaB-alpha(h):RelA-p65(h){pS468}{pS536} (binding)
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HDAC1(h) + IkappaB-alpha(h) <==> HDAC1(h):IkappaB-alpha(h) (binding)
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HDAC3(h) + IkappaB-alpha(h) <==> HDAC3(h):IkappaB-alpha(h) (binding)
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IkappaB-alpha(h) --> IkappaB-alpha(h) (translocation)
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IkappaB-alpha(h) + NF-kappaB1(h) + RelA-p65(h) + rps3(h) <==> IkappaB-alpha(h):NF-kappaB1(h):RelA-p65(h):rps3(h) (binding)
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IkappaB-alpha(h) + ATP --> IkappaB-alpha(h){pS} + ADP (phosphorylation)
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IkappaB-alpha(h) + POM121(h) <==> IkappaB-alpha(h):POM121(h) (binding)
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IkappaB-alpha(h) + n ubiquitin(h) --> IkappaB-alpha(h){ub{K48}(n)} (ubiquitination)
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Trx1(h) --> IkappaB-alpha(h) (activation)
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NFKBIA(h) --> IkappaB-alpha(h) (expression).
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IL-1beta(h) --/ IkappaB-alpha(h) (decrease of abundance)
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TNF-alpha(h) --/ IkappaB-alpha(h) (decrease of abundance)
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TNF-alpha(m.s.) --/ IkappaB-alpha(h) (decrease of abundance)
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RelA-p65(m.s.) --> IkappaB-alpha(h) (increase of abundance)
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HCV-NS3-1A(HCV1A):HCV-NS4A-1A(HCV1A) --> IkappaB-alpha(h) (increase of abundance)
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IL-1(h) --> IkappaB-alpha(h) (increase of cleavage)
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TNF-alpha(h) --> IkappaB-alpha(h) (increase of cleavage)
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IkappaB-alpha(h) --> IkappaB-alpha(h) (translocation)
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IkappaB-alpha(h) --> IkappaB-alpha(h) (translocation)
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IFNalpha(m) --> IkappaB-alpha(h) (increase of abundance)
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IFNbeta(m) --> IkappaB-alpha(h) (increase of abundance)
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TNF(h) --/ IkappaB-alpha(h) (decrease of abundance)
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LIGHT(h) --/ IkappaB-alpha(h) (decrease of abundance)
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LT-betaR(h) --/ IkappaB-alpha(h) (decrease of abundance)
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TRAM(h) --> IkappaB-alpha(h) (increase of abundance)
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IL-17A(h) --/ IkappaB-alpha(h) (decrease of abundance)
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H2O2 --/ IkappaB-alpha(h) (decrease of abundance)
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LPS --/ IkappaB-alpha(h) (decrease of abundance)
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Jagged1(h) --/ IkappaB-alpha(h) (decrease of abundance)
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CKII-alpha(h):CKII-alpha2(h):(CKII-beta(h))2:RelA-p65(h) + ATP --> CKII-alpha(h):CKII-alpha2(h):(CKII-beta(h))2 + RelA-p65(h){pS529} + ADP (phosphorylation; dissociation)
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IkappaB-alpha(h) --/ SELE(h) (transrepression)
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LRF(h) + IkappaB-alpha(h) <==> LRF(h):IkappaB-alpha(h) (binding)
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IkappaB-alpha(h) --calpain(h)--> protein remnants (degradation)
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IkappaB-alpha(h) + ATP --IKK-beta(m)--> IkappaB-alpha(h){p} + ADP (phosphorylation)
|
IkappaB-alpha(h) + HDAC1(m.s.) <==> IkappaB-alpha(h):HDAC1(m.s.) (binding)
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RelA-p65(h) + IkappaB-alpha(h) <==> RelA-p65(h):IkappaB-alpha(h) (binding)
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IkappaB-alpha(h) + RelA-p65(h) + NF-kappaB1-p50(h) <==> IkappaB-alpha(h):RelA-p65(h):NF-kappaB1-p50(h) (binding)
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IkappaB-alpha(h) + HDAC3(m.s.) <==> HDAC3(m.s.):IkappaB-alpha(h) (binding)
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IkappaB-alpha(h) --> protein remnants (degradation)
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IkappaB-alpha(h) --> IkappaB-alpha(h) (translocation)
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IkappaB-alpha(h) --> IkappaB-alpha(h) (translocation)
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BARD1(h) + IkappaB-alpha(h) <==> BARD1(h):IkappaB-alpha(h) (binding)
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Pirin(h) + IkappaB-alpha(h) <==> Pirin(h):IkappaB-alpha(h) (binding)
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IkappaB-alpha(h) + ATP --IKK(h)--> IkappaB-alpha(h){pS32} + ADP (phosphorylation)
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IkappaB-alpha(h) --/ Beclin-1(h) (decrease of abundance)
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NFKBIA(h) --> IkappaB-alpha(h) (expression).
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HCV-NS5A-1B-Japanese(HCV1BJapan) --> IkappaB-alpha(h) (increase of cleavage)
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IkappaB-alpha(h) --> IkappaB-alpha(h) (translocation)
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IkappaB-alpha(h) --> IkappaB-alpha(h) (translocation)
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