| p53(h) + mdm2(h) <==> p53(h):mdm2(h) (binding)
|
mdm2(h) + p16INK4a-p14(h) <==> mdm2(h):p16INK4a-p14(h) (binding)
|
p53(h) + mdm2(h) + p16INK4a-p14(h) <==> p53(h):mdm2(h):p16INK4a-p14(h) (binding)
|
mdm2(h) + ubiquitin(h) --E1(m),Ubc5A(h)--> mdm2(h){ub} (ubiquitination)
|
p53(m) + mdm2(h) <==> p53(m):mdm2(h) (binding)
|
mdm2(h) + p16INK4a-p19(m) <==> mdm2(h):p16INK4a-p19(m) (binding)
|
p300(h) + p53(h) + mdm2(h) <==> p300(h):p53(h):mdm2(h) (binding)
|
mdm2(h) + p300(h) <==> mdm2(h):p300(h) (binding)
|
mdm2(h) + ATM(h) <==> mdm2(h):ATM(h) (binding)
|
mdm2(h) + ATP --CKII-alpha(h):CKII-alpha2(h):(CKII-beta(h))2--> mdm2(h){p} + ADP (phosphorylation)
|
HIF-1alpha(h) + mdm2(h) <==> HIF-1alpha(h):mdm2(h) (binding)
|
p73alpha(mo) + mdm2(h) <==> p73alpha(mo):mdm2(h) (binding)
|
p73beta(mo) + mdm2(h) <==> p73beta(mo):mdm2(h) (binding)
|
mdm2(h) + p63alpha(h) <==> mdm2(h):p63alpha(h) (binding)
|
mdm2(h) + p63gamma(h) <==> mdm2(h):p63gamma(h) (binding)
|
p53(h){pS315} + mdm2(h) <==> p53(h){pS315}:mdm2(h) (binding)
|
mdm2(h) + Tip60(h) <==> mdm2(h):Tip60(h) (binding)
|
Rad23A(h) + mdm2(h) + p53(h) <==> Rad23A(h):mdm2(h):p53(h) (binding)
|
Rad23A(h) + mdm2(h) <==> Rad23A(h):mdm2(h) (binding)
|
Rad23B(h) + mdm2(h) <==> Rad23B(h):mdm2(h) (binding)
|
mdm2(h) + p73alpha(v.s.) <==> mdm2(h):p73alpha(v.s.) (binding)
|
AKT(h) + mdm2(h) <==> AKT(h):mdm2(h) (binding)
|
mdm2(h) + 2 ATP --AKT-1(h)--> mdm2(h){pS166}{pS188} + 2 ADP (phosphorylation)
|
mdm2(h) + n ubiquitin(v.s.) --> mdm2(h){ub(n)} (ubiquitination)
|
mdm2(h) <==> mdm2(h) (translocation)
|
mdm2(h) + 2 ATP --AKT-1(v.s.)--> mdm2(h){pS166}{pS188} + 2 ADP (phosphorylation)
|
mdm2(h) + 3 ATP --Chk1(v.s.)--> mdm2(h){pS166}{pS186}{pS188} + 3 ADP (phosphorylation)
|
PML(h) + mdm2(h) <==> PML(h):mdm2(h) (binding)
|
PML-X(h) + mdm2(h) <==> PML-X(h):mdm2(h) (binding)
|
rpl5(h) + mdm2(h) <==> rpl5(h):mdm2(h) (binding)
|
rpl23(h) + rpl11(h) + rpl5(h) + mdm2(h) <==> rpl23(h):rpl11(h):rpl5(h):mdm2(h) (binding)
|
rpl11(h) + mdm2(h) <==> rpl11(h):mdm2(h) (binding)
|
mdm2(h) + ATP --ATM(h)--> mdm2(h){p} + ADP (phosphorylation)
|
Abl(m) + mdm2(h) <==> Abl(m):mdm2(h) (binding)
|
mdm2(h) + NTP --Abl(m)--> mdm2(h){p} + NDP (phosphorylation)
|
mdm2(h) + ATP --Abl(m)--> mdm2(h){pY394} + ADP (phosphorylation)
|
mdm2(h) + TSG101(h) <==> mdm2(h):TSG101(h) (binding)
|
AKT(v.s.) + mdm2(h) <==> AKT(v.s.):mdm2(h) (binding)
|
mdm2(h) + ATP --AKT(v.s.)--> mdm2(h){pS166}{pS186} + ADP (phosphorylation)
|
mdm2(h) + ATP --ATM(h)--> mdm2(h){pS395} + ADP (phosphorylation)
|
CtBP2(h) + mdm2(h) <==> CtBP2(h):mdm2(h) (binding)
|
CtBP2(h) + mdm2(h) + p53(h) <==> CtBP2(h):mdm2(h):p53(h) (binding)
|
CtBP1(h) + mdm2(h) <==> CtBP1(h):mdm2(h) (binding)
|
Sel-1(h) + mdm2(h) <==> Sel-1(h):mdm2(h) (binding)
|
mdm2(h) --> RELA(h) (transactivation)
|
CUL4A(m.s.) + mdm2(h) <==> CUL4A(m.s.):mdm2(h) (binding)
|
mdm2(h) + POLE1(h) <==> mdm2(h):POLE1(h) (binding)
|
AR(h) + mdm2(h) <==> AR(h):mdm2(h) (binding)
|
mdm2(h) --> mdm2-p68(h) + mdm2-p32(h) + protein remnants (cleavage)
|
mdm2(h) --Caspase-3(m)--> mdm2-p68(h) + mdm2-p32(h) + protein remnants (cleavage)
|
mdm2(h) --caspase-3beta(h)--> mdm2-p68(h) + mdm2-p32(h) + protein remnants (cleavage)
|
p53(m.s.) + mdm2(h) <==> p53(m.s.):mdm2(h) (binding)
|
mdm2(h) + sumo1(h) --> mdm2(h){sumo} (sumoylation)
|
mdm2(h) + sumo1(m.s.) --> mdm2(h){sumoK446} (sumoylation)
|
mdm2(h) + ubiquitin(h) --E1(m.s.),Ubc5B(m.s.)--> mdm2(h){ubK446} (ubiquitination)
|
mdm2(h) + HAUSP(h) <==> mdm2(h):HAUSP(h) (binding)
|
mdm2(h) --/ p53-isoform1(h) (decrease of abundance)
|
mdm2(h) + Hsp90(h) <==> mdm2(h):Hsp90(h) (binding)
|
n mdm2(h) <==> (mdm2(h))n (oligomerization)
|
p/CAF(h) + mdm2(h) <==> p/CAF(h):mdm2(h) (binding)
|
p/CAF(h) + mdm2(h) <==> p/CAF(h):mdm2(h) (binding)
|
mdm2(h) + HDAC1(h) <==> mdm2(h):HDAC1(h) (binding)
|
mdm2(h) + Mre11(h):NBS1(h):Rad50(h) <==> mdm2(h):Mre11(h):NBS1(h):Rad50(h) (binding)
|
mdm2(h) + NBS1(h) <==> mdm2(h):NBS1(h) (binding)
|
mdm2(h) + NBS1(h) <==> mdm2(h):NBS1(h) (binding)
|
mdm2(h) + Mre11(h):NBS1(h):Rad50(h) <==> mdm2(h):Mre11(h):NBS1(h):Rad50(h) (binding)
|
AR(h) + mdm2(h) + AKT-1(h) <==> AR(h):mdm2(h):AKT-1(h) (binding)
|
AR(h) + mdm2(h) + HDAC1(h) <==> AR(h):mdm2(h):HDAC1(h) (binding)
|
mdm2(h) + sumo1(m.s.) --> mdm2(h){sumo} (sumoylation)
|
mdm2(h) + ATP --> mdm2(h){p} + ADP (phosphorylation)
|
mdm2(h) + ubiquitin(h) --> mdm2(h){ub} (ubiquitination)
|
p16INK4a(h) + mdm2(h) <==> p16INK4a(h):mdm2(h) (binding)
|
mdm2(h) + nucleophosmin(h) <==> mdm2(h):nucleophosmin(h) (binding)
|
RNF96(h) + mdm2(h) <==> RNF96(h):mdm2(h) (binding)
|
YY1(m.s.) + mdm2(h) <==> YY1(m.s.):mdm2(h) (binding)
|
p16INK4a-p19(m) + mdm2(h) <==> p16INK4a-p19(m):mdm2(h) (binding)
|
mdm2(h) --/ p21Cip1(h) (decrease of abundance)
|
mdm2(h) --/ Bax(h) (decrease of abundance)
|
mdm2(h) --/ p53(h) (decrease of abundance)
|
mdm2(h) + p16INK4a-xbb1(h) <==> mdm2(h):p16INK4a-xbb1(h) (binding)
|
mdm2(h) + ATP --Abl(h)--> mdm2(h){pY276} + ADP (phosphorylation)
|
mdm2(h) + Nedd8(h) --> mdm2(h){nedd} (neddylation)
|
p53(h){pS15} + mdm2(h) <==> p53(h){pS15}:mdm2(h) (binding)
|
p53(h){pS20} + mdm2(h) <==> p53(h){pS20}:mdm2(h) (binding)
|
p53(h){pT18} + mdm2(h) <==> p53(h){pT18}:mdm2(h) (binding)
|
p53(h){pS15}{pS20} + mdm2(h) <==> p53(h){pS15}{pS20}:mdm2(h) (binding)
|
p53(h){pS15}{pT18} + mdm2(h) <==> p53(h){pS15}{pT18}:mdm2(h) (binding)
|
p53(h){pS20}{pT18} + mdm2(h) <==> p53(h){pS20}{pT18}:mdm2(h) (binding)
|
p53(h){pS15}{pT18}{pS20} + mdm2(h) <==> p53(h){pS15}{pT18}{pS20}:mdm2(h) (binding)
|
mdm2(h) + Mdm4(h) <==> mdm2(h):Mdm4(h) (binding)
|
Mdm4(h) + mdm2(h) <==> Mdm4(h):mdm2(h) (binding)
|
mdm2(h) + n ubiquitin(h) --> mdm2(h){ub}n (ubiquitination; automodification)
|
mdm2(h) + n ubiquitin(h) --E1(m.s.),Ubc5B(m.s.),p/CAF(h)--> mdm2(h){ub}n (ubiquitination)
|
mdm2(h) + p/CAF(h) <==> mdm2(h):p/CAF(h) (binding)
|
Fbx11-isoform1(h) + mdm2(h) + p53(h) <==> Fbx11-isoform1(h):mdm2(h):p53(h) (binding)
|
mdm2(h) + Daxx(h) <==> mdm2(h):Daxx(h) (binding)
|
mdm2(h) + Daxx(h) + HAUSP(h) <==> mdm2(h):Daxx(h):HAUSP(h) (binding)
|
FOXO3a(h) + mdm2(h) <==> FOXO3a(h):mdm2(h) (binding)
|
AATF(h) + mdm2(h) <==> AATF(h):mdm2(h) (binding)
|
mdm2(h) + p16-INK4a-p14(m.s.) + LZAP(h) <==> mdm2(h):p16-INK4a-p14(m.s.):LZAP(h) (binding)
|
rad6(h) + mdm2(h) <==> rad6(h):mdm2(h) (binding)
|
mdm2(h) + sumo1(h) --> mdm2(h){sumo} (sumoylation)
|
mdm2(h) + (p16INK4a-p14(h))n <==> mdm2(h):(p16INK4a-p14(h))n (binding)
|
mdm2(h) + ATP --> mdm2(h){pY} + ADP (phosphorylation)
|
RPL26(h) + mdm2(h) <==> RPL26(h):mdm2(h) (binding)
|
RPL26(h) + mdm2(h) <==> RPL26(h):mdm2(h) (binding)
|
mdm2(h) + p53(h) <==> mdm2(h):p53(h) (binding)
|
GIF(h) + mdm2(h) + p53(h) <==> GIF(h):mdm2(h):p53(h) (binding)
|
mdm2(h) + HAUSP(h) <==> mdm2(h):HAUSP(h) (binding)
|
slug(h) + mdm2(h) <==> slug(h):mdm2(h) (binding)
|
mdm2(h) --/ slug(h) (decrease of abundance)
|
mdm2(h) + p53(h) + slug(h) <==> mdm2(h):p53(h):slug(h) (binding)
|
mdm2(h) + slug(h) + p53(h) <==> mdm2(h):slug(h):p53(h) (binding)
|
mdm2(h) + n ubiquitin(h) --> mdm2(h){ub(n)} (ubiquitination; automodification)
|
mdm2(h) + RASSF1-A(h) <==> mdm2(h):RASSF1-A(h) (binding)
|
HAUSP(h) + p53(h) + Daxx(h) + mdm2(h) <==> HAUSP(h):p53(h):Daxx(h):mdm2(h) (binding)
|
UBP41(h) + mdm2(h) <==> UBP41(h):mdm2(h) (binding)
|
mdm2(h) + n ubiquitin(h) --> mdm2(h){ub(n)} (ubiquitination)
|
psmc4(h) + mdm2(h) <==> psmc4(h):mdm2(h) (binding)
|
mdm2(h) + mdm2-isoform1(m) <==> mdm2(h):mdm2-isoform1(m) (binding)
|
mdm2(h) + plk1(h) <==> mdm2(h):plk1(h) (binding)
|
gamma radiation --> mdm2(h) (activation)
|
MDM2(h) --> mdm2(h) (expression).
|
mdm2(h) <==> mdm2(h) (translocation)
|
SMAR1-isoform1(m) --> mdm2(h) (increase of abundance)
|
OSR1(h) --> mdm2(h) (decrease of abundance; decrease of promoter activity)
|
mdm2(h){ub} --HAUSP(h)--> mdm2(h) + ubiquitin(h) (deubiquitination; stabilization)
|
p53-isoform1(h) --> mdm2(h) (increase of abundance)
|
RNF96(h) --/ mdm2(h) (decrease of abundance)
|
MULE(h) --/ mdm2(h) (decrease of abundance)
|
p16INK4a-xbb1(h) --> mdm2(h) (increase of abundance)
|
p16-INK4a-p14(m.s.) --> mdm2(h) (increase of abundance)
|
p16INK4a-p19(m) --> mdm2(h) (increase of abundance)
|
p16INK4a-p14(h) --> mdm2(h) (increase of abundance)
|
HAUSP(h) --> mdm2(h) (increase of abundance)
|
mdm2(h){ub} --HAUSP(h)--> mdm2(h) + ubiquitin(h) (deubiquitination)
|
mdm2(h){ub}n --HAUSP(h)--> mdm2(h) + n ubiquitin(h) (deubiquitination)
|
mdm2(h){ub} --HAUSP(m.s.)--> mdm2(h) + ubiquitin(h) (deubiquitination)
|
mdm2(h):Daxx(h) <==> mdm2(h) + Daxx(h) (dissociation)
|
mdm2(h):Daxx(h):HAUSP(h) <==> mdm2(h) + Daxx(h) + HAUSP(h) (dissociation)
|
estradiol --> mdm2(h) (increase of abundance)
|
GIF(h) --/ mdm2(h) (decrease of abundance)
|
Skp2(m.s.) --/ mdm2(h) (decrease of abundance)
|
p53(h) --> mdm2(h) (increase of abundance)
|
HAUSP(m.s.) --> mdm2(h) (activation; increase of abundance)
|
RASSF1-A(m.s.) --/ mdm2(h) (inhibition; decrease of abundance)
|
rps6(h) --/ mdm2(h) (decrease of abundance)
|
rpl7a(h) --/ mdm2(h) (decrease of abundance)
|
chd8-isoform2(m) --/ mdm2(h) (decrease of abundance)
|
EIF5A1-isoform1(h) --> mdm2(h) (increase of abundance)
|
p53(h) + n ubiquitin(h) --E1(m),Ubc5A(h),mdm2(h)--> p53(h){ub(n)} (ubiquitination)
|
p53(h) + n ubiquitin(h) --mdm2(h)--> p53(h){ub(n)} (ubiquitination)
|
p53(h) + n ubiquitin(v.s.) --E1(v.s.),Ubc5(h),mdm2(h)--> p53(h){ub(n)} (ubiquitination)
|
p/CAF(h) + n ubiquitin(m.s.) --mdm2(h)--> p/CAF(h){ub(n)} (ubiquitination)
|
AR-isoform1(h) + n ubiquitin(h) --mdm2(h)--> AR-isoform1(h){ub(n)} (ubiquitination)
|
Mdm4(h) + ubiquitin(h) --mdm2(h)--> Mdm4(h){ub} (ubiquitination)
|
p53(h) + n ubiquitin(h) --mdm2(h)--> p53(h){ub}n (ubiquitination)
|
Mdm4(h) + n ubiquitin(h) --mdm2(h)--> Mdm4(h){ub}n (ubiquitination)
|
p73beta(m.s.) + Nedd8(m.s.) --mdm2(h)--> p73beta(m.s.){nedd} (neddylation)
|
p53(m.s.) + n ubiquitin(m.s.) --mdm2(h)--> p53(m.s.){ub}n (ubiquitination)
|
p53(m.s.) + ubiquitin(m.s.) --E1(m.s.),Ubc5A(h),mdm2(h)--> p53(m.s.){ub} (ubiquitination)
|
p53(m.s.){ub} + n ubiquitin(m.s.) --E1(m.s.),Ubc5A(h),mdm2(h),p300(m.s.)--> p53(m.s.){ub(n)} (ubiquitination)
|
p53(m.s.) --E1(m.s.),mdm2(h)--> p53(m.s.){ub}n (ubiquitination)
|
RPL26(h) + n ubiquitin(h) --mdm2(h)--> RPL26(h){ub}n (ubiquitination)
|
RPL26(h) + n ubiquitin(h) --mdm2(h)--> RPL26(h){ub}n (ubiquitination)
|
p53(h) + n ubiquitin(h) --E1(m.s.),Ubc5A(m.s.),mdm2(h)--> p53(h){ub}n (ubiquitination)
|
slug(h) + n ubiquitin(h) --mdm2(h)--> slug(h){ub(n)} (ubiquitination)
|
p53(h) + ubiquitin(h) --E1(rb),Ubc5A(h),mdm2(h)--> p53(h){ub} (ubiquitination)
|
p53(h) + n ubiquitin(h) --E1(rb),mdm2(h),Ubc5A(h)--> p53(h){ub(n)} (ubiquitination)
|
p53(h) + ubiquitin(h) --mdm2(h)--> p53(h){ub} (ubiquitination)
|
mdm2-isoform1(h) + p53(h) <==> mdm2-isoform1(h):p53(h) (binding)
|
mdm2-isoform1(h) + ATP --CKII(m.s.)--> mdm2-isoform1(h){pS269} + ADP (phosphorylation)
|
mdm2-isoform1(h) + p/CAF(h) <==> mdm2-isoform1(h):p/CAF(h) (binding)
|
HDAC1(m.s.) + mdm2-isoform1(h) <==> HDAC1(m.s.):mdm2-isoform1(h) (binding)
|
mdm2-isoform1(h) --/ p21Cip1(h) (decrease of abundance)
|
mdm2-isoform1(h) --> p53(m.s.){ace} (decrease of acetylation)
|
mdm2-isoform1(h) + HDAC1(m.s.) + p53(h) <==> mdm2-isoform1(h):HDAC1(m.s.):p53(h) (binding)
|
Hsp90-beta(h) + CHIP(m.s.) + mdm2-isoform1(h) <==> Hsp90-beta(h):CHIP(m.s.):mdm2-isoform1(h) (binding)
|
Hsp90-beta(h) + mdm2-isoform1(h) <==> Hsp90-beta(h):mdm2-isoform1(h) (binding)
|
AR-isoform1(h) + mdm2-isoform1(h) <==> AR-isoform1(h):mdm2-isoform1(h) (binding)
|
AR-isoform1(h){pS213}{pS791} + mdm2-isoform1(h) <==> AR-isoform1(h){pS213}{pS791}:mdm2-isoform1(h) (binding)
|
AR-isoform1(h) + mdm2-isoform1(h) --26S proteasome(h)--> mdm2-isoform1(h) + protein remnants (degradation)
|
RNF96(h) + mdm2-isoform1(h) <==> RNF96(h):mdm2-isoform1(h) (binding)
|
mdm2-isoform1(h) + RNF96-isoform1(h) <==> mdm2-isoform1(h):RNF96-isoform1(h) (binding)
|
RNF96(h) + mdm2-isoform1(h) + p53(h) <==> RNF96(h):mdm2-isoform1(h):p53(h) (binding)
|
mdm2-isoform1(h) --> p53(h){aceK373}{aceK382} (decrease of acetylation)
|
p16INK4a(h) + mdm2-isoform1(h) <==> p16INK4a(h):mdm2-isoform1(h) (binding)
|
NIAM(m.s.) + mdm2-isoform1(h) <==> NIAM(m.s.):mdm2-isoform1(h) (binding)
|
mdm2-isoform1(h) + 3 ATP --Abl(m.s.)--> mdm2-isoform1(h){pY276}{pY394}{pY405} + 3 ADP (phosphorylation)
|
mdm2-isoform1(h) + ATP --Abl-xbb1(m)--> mdm2-isoform1(h){pY276} + ADP (phosphorylation)
|
mdm2-isoform1(h) + 3 ATP --Abl-xbb1(m)--> mdm2-isoform1(h){pY276}{pY394}{pY405} + 3 ADP (phosphorylation)
|
mdm2-isoform1(h) + Mdm4(h) <==> mdm2-isoform1(h):Mdm4(h) (binding)
|
mdm2-isoform1(h) + ATP --DNA-PK(h)--> mdm2-isoform1(h){pS17} + ADP (phosphorylation)
|
mdm2-isoform1(h) + sumo1(h) --Aos1(m.s.):SAE2(m.s.),Ubc9(h),RanBP2(m.s.)--> mdm2-isoform1(h){sumo} (sumoylation)
|
mdm2-isoform1(h) + sumo1(h) --Aos1(m.s.):SAE2(m.s.),Ubc9(h),PIAS2-beta(m.s.)--> mdm2-isoform1(h){sumo} (sumoylation)
|
mdm2-isoform1(h) + 2 ATP --AKT-1(h)--> mdm2-isoform1(h){pS166}{pS188} + 2 ADP (phosphorylation)
|
mdm2-isoform1(h) + 2 ATP --pim1(h)--> mdm2-isoform1(h){pS166}{pS186} + 2 ADP (phosphorylation)
|
mdm2-isoform1(h) + 2 ATP --Pim-2(h)--> mdm2-isoform1(h){pS166}{pS186} + 2 ADP (phosphorylation)
|
mdm2-isoform1(h) + 3 ATP --pim3(h)--> mdm2-isoform1(h){pS166}{pS186}{pS188} + 3 ADP (phosphorylation)
|
mdm2-isoform1(h) + ATP --plk1(h)--> mdm2-isoform1(h){pS260} + ADP (phosphorylation)
|
plk1(h) + mdm2-isoform1(h) <==> plk1(h):mdm2-isoform1(h) (binding)
|
MDM2(h) --> mdm2-isoform1(h) (expression).
|
AR-isoform1(h) + mdm2-isoform1(h) --26S proteasome(h)--> mdm2-isoform1(h) + protein remnants (degradation)
|
p53(h) + n ubiquitin(h) --mdm2-isoform1(h)--> p53(h){ub(n)} (ubiquitination)
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AR-isoform1(h){pS213}{pS791} + n ubiquitin(h) --mdm2-isoform1(h)--> AR-isoform1(h){pS213}{pS791}{ub(n)} (ubiquitination)
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p53(h) + ubiquitin(h) --mdm2-isoform1(h)--> p53(h){ub} (ubiquitination)
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NIAM(m.s.) + ubiquitin(m.s.) --mdm2-isoform1(h)--> NIAM(m.s.){ub} (ubiquitination)
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p53(m.s.) + ubiquitin(m.s.) --Ubc5A(m.s.),mdm2-isoform1(h)--> p53(m.s.){ub} (ubiquitination)
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Mdm4(h) + n ubiquitin(h) --E1(rb),Ubc5B(h),mdm2-isoform1(h)--> Mdm4(h){ub}n (ubiquitination)
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Mdm4(h) + n ubiquitin(h) --mdm2-isoform1(h)--> Mdm4(h){ub}n (ubiquitination)
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p53-isoform1(h) + n ubiquitin(h) --E1(h),Ubc5A(h),mdm2-isoform1(h)--> p53-isoform1(h){ub}n (ubiquitination)
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MDM2(h) --> mdm2-isoform2(h) (expression).
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MDM2(h) --> mdm2-isoform3(h) (expression).
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MDM2(h) --> mdm2-isoform4(h) (expression).
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MDM2(h) --> mdm2-isoform5(h) (expression).
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MDM2(h) --> mdm2-isoform6(h) (expression).
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MDM2(h) --> mdm2-isoform7(h) (expression).
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MDM2(h) --> mdm2-isoform8(h) (expression).
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MDM2(h) --> mdm2-isoform9(h) (expression).
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MDM2(h) --> mdm2-isoform10(h) (expression).
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