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Cancer metastasis database

Annotation category 5

Expression and regulation

Regulation From TransFac database

Mcl-1(h) + ATP --JNK3alpha1(m){p}--> Mcl-1(h){p} + ADP (phosphorylation)
Mcl-1(h) + PCNA(h) <==> Mcl-1(h):PCNA(h) (binding)
Bax(h){pS} + Mcl-1(h) <==> Bax(h){pS}:Mcl-1(h) (binding)
Bax(m){pS184} + Mcl-1(h) <==> Bax(m){pS184}:Mcl-1(h) (binding)
Mcl-1(h) --> Mcl-1-p27(h) + protein remnants (cleavage)
Mcl-1(h) --26S proteasome(h)--> protein remnants (degradation)
Mcl-1(h) --Caspase-3(m.s.)--> protein remnants (degradation)
Mcl-1(h) --Caspase-8(m.s.)--> protein remnants (degradation)
Mcl-1(h) + Bim(h) <==> Mcl-1(h):Bim(h) (binding)
Mcl-1(h) --> Mcl-1-p24(h) + protein remnants (cleavage)
Bak(h) + Mcl-1(h) <==> Bak(h):Mcl-1(h) (binding)
Mcl-1(h) + Bak(m.s.) <==> Mcl-1(h):Bak(m.s.) (binding)
Mcl-1(h) + Noxa(m.s.) <==> Mcl-1(h):Noxa(m.s.) (binding)
Mcl-1(h) + BimS(m) <==> Mcl-1(h):BimS(m) (binding)
Mcl-1(h) + Bax(h) <==> Mcl-1(h):Bax(h) (binding)
Mcl-1(h) --Caspase(h)--> Mcl-1-p24(h) + protein remnants (cleavage)
Mcl-1(h) + tBid(h) <==> Mcl-1(h):tBid(h) (binding)
Mcl-1(h) --> PARP-p85(h) (decrease of cleavage)
Mcl-1(h) + 2 ATP --ERK1(m.s.)--> Mcl-1(h){pT92}{pT163} + 2 ADP (phosphorylation)
Mcl-1(h) + Pin1(m.s.) <==> Mcl-1(h):Pin1(m.s.) (binding)
Mcl-1(h) + Pin1(h) <==> Mcl-1(h):Pin1(h) (binding)
Mcl-1(h) + ATP --> Mcl-1(h){pS64} + ADP (phosphorylation)
Mcl-1(h) --> protein remnants (degradation)
MULE(h) + Mcl-1(h) <==> MULE(h):Mcl-1(h) (binding)
Fam(h) + Mcl-1(h) <==> Fam(h):Mcl-1(h) (binding)
Mcl-1(h) + n ubiquitin(h) --> Mcl-1(h){ub{K48}(n)} (ubiquitination)
Mcl-1(h) + n ubiquitin(h) --> Mcl-1(h){ub}n (ubiquitination)
Mcl-1(h) + ubiquitin(h) --> Mcl-1(h){ub} (ubiquitination)
Mcl-1(h) + IEX1(h) <==> Mcl-1(h):IEX1(h) (binding)
Mcl-1(h) + IEX1(h) <==> Mcl-1(h):IEX1(h) (binding)
MCL1(h) --> Mcl-1(h) (expression).
Apo2L(m.s.) --/ Mcl-1(h) (decrease of abundance)
YB-1(h) --> Mcl-1(h) (increase of abundance)
IL-3(m.s.) --> Mcl-1(h) (increase of abundance)
IL-5(m.s.) --> Mcl-1(h) (increase of abundance)
Mcl-1(h){ub} --26S proteasome(h)--> Mcl-1(h) + ubiquitin(h) (degradation)
Mcl-1L(h) + BimEL(h) <==> Mcl-1L(h):BimEL(h) (binding)
Mcl-1L(h) + BimL(h) <==> Mcl-1L(h):BimL(h) (binding)
Mcl-1L(h) + BimS(h) <==> Mcl-1L(h):BimS(h) (binding)
Mcl-1L(h) --Caspase-3(v.s.)--> protein remnants (processing)
Mcl-1L(h) --granzymeB(v.s.)--> protein remnants (processing)
Mcl-1L(h) --Caspase-3(h)--> Mcl-1L-p27(h) + protein remnants (cleavage)
Mcl-1L(h) --Caspase-3(h)--> Mcl-1L-p19(h) + protein remnants (cleavage)
Mcl-1L(h) + tBid(h) <==> Mcl-1L(h):tBid(h) (binding)
Mcl-1L(h) + Bak(m.s.) <==> Mcl-1L(h):Bak(m.s.) (binding)
Mcl-1L(h) --Caspase-3(m.s.)--> protein remnants (degradation)
Mcl-1L(h) --Caspase-8(m.s.)--> protein remnants (degradation)
MULE(h) + Mcl-1L(h) <==> MULE(h):Mcl-1L(h) (binding)
Fam(h) + Mcl-1L(h) <==> Fam(h):Mcl-1L(h) (binding)
Mcl-1L(h) + n ubiquitin(h) --> Mcl-1L(h){ub}n (ubiquitination)
Mcl-1L(h) + n ubiquitin(h) --> Mcl-1L(h){ub{k48}(n)} (ubiquitination)
Mcl-1L(h) + ubiquitin(h) --> Mcl-1L(h){ub} (ubiquitination)
Mcl-1L(h) + IEX1(h) <==> Mcl-1L(h):IEX1(h) (binding)
MCL1(h) --> Mcl-1L(h) (expression).
Mcl-1L(h){ub} --26S proteasome(h)--> Mcl-1L(h) + ubiquitin(h) (degradation)
Mcl-1S(h) + BimEL(h) <==> Mcl-1S(h):BimEL(h) (binding)
Mcl-1S(h) --Caspase-3(v.s.)--> protein remnants (processing)
Mcl-1S(h) --granzymeB(v.s.)--> protein remnants (processing)
MCL1(h) --> Mcl-1S(h) (expression).
MCL1(h) --> Mcl-1(h) (expression).
hsa-miR-29b --/ Mcl-1(h) (translational repression).
hsa-miR-512-5p --/ Mcl-1(h) (increase of mRNA decay).

Human Primary Tumor Samples (U95)  | Top

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Human U133A/GNF1H Gene Atlas  | Top