| ErbB4(h) + NRG1(h) <==> ErbB4(h):NRG1(h) (binding)
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NRG1(h) + (ErbB4(m))2 <==> NRG1(h):(ErbB4(m))2 (binding)
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NRG1(h) + ErbB2(m.s.):ErbB4(m) <==> NRG1(h):ErbB2(m.s.):ErbB4(m) (binding)
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NRG1(h) + (ErbB3(m.s.))2 <==> NRG1(h):(ErbB3(m.s.))2 (binding)
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NRG1(h) + ErbB2(m.s.):ErbB3(m.s.) <==> NRG1(h):ErbB2(m.s.):ErbB3(m.s.) (binding)
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NRG1(h) --> ERK(h){pY} (increase of phosphorylation)
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NRG1(h) --> AKT-1(h){pS473} (increase of phosphorylation)
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NRG1(h) --/ ErbB4(h) (decrease of abundance)
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NRG1(h) --/ cyclinD1(h) (decrease of abundance)
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NRG1(h) --/ pRb(h){p} (decrease of abundance)
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NRG1(h) --> cyclinB1(h) (increase of abundance)
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NRG1(h) --> Cdk1(h){pY15} (decrease of phosphorylation)
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NRG1(h) --> cyclinB1(h):Cdk1(h) (increase of binding)
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NRG1(h) --> brca1(h) (increase of abundance)
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NRG1(h) --> ERK1(h){pY} (increase of phosphorylation)
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NRG1(h) --> ERK2(h){pY} (increase of phosphorylation)
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NRG1(h) --> JNK2(h){p} (increase of phosphorylation)
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NRG1(h) --> ErbB3(h){pY} (increase of phosphorylation)
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NRG1(h) --> ErbB3(h){pY1289} (increase of phosphorylation)
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NRG1(h) --> EGFR(h):ErbB3(h){pY1289} (increase of binding)
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NRG1(h) --> ErbB3(m){pY1286} (increase of phosphorylation)
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NRG1(h) --> NRG1(h) (expression).
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NRG1-beta1(h) + ErbB4(h) <==> NRG1-beta1(h):ErbB4(h) (binding)
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NRG1-beta1(h) --> ErbB2(h){pY} (increase of phosphorylation)
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NRG1-beta1(h) --> ErbB3(h){pY} (increase of phosphorylation)
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NRG1-beta1(h) --> ErbB2(h){pY}:PLCgamma1(h) (decrease of binding)
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NRG1-beta1(h) --> Shc-1-p52(h):ErbB2(h){pY} (increase of phosphorylation)
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NRG1-beta1(h) --> Shc-1-p52(h):ErbB3(h){pY} (increase of binding)
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NRG1-beta1(h) --> Grb-2(h):ErbB3(h){pY} (increase of binding)
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NRG1-beta1(h) --> p85(h):ErbB3(h){pY} (increase of binding)
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NRG1-beta1(h) --> ERK1(h){p} (increase of phosphorylation)
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NRG1-beta1(h) --> p38(h){p} (increase of phosphorylation)
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NRG1-beta1(h) --> JNK(h){p} (increase of phosphorylation)
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NRG1-beta1(h) --> c-Jun(m.s.){p} (increase of phosphorylation)
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NRG1-beta1(h) --> AKT(h){p} (increase of phosphorylation)
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NRG1-beta1(h) --> p70S6K(h){pS411} (increase of phosphorylation)
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NRG1-beta1(h) --> ErbB3(h){pY}:ErbB2(h){pY} (increase of binding)
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NRG1-beta1(h) --> Shc-1-p46(h):ErbB2(h){pY} (increase of binding)
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NRG1-beta1(h) + ErbB3(h):ErbB2(h) <==> NRG1-beta1(h):ErbB3(h):ErbB2(h) (binding)
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NRG1-beta1(h) + ErbB4(h):ErbB2(h) <==> NRG1-beta1(h):ErbB4(h):ErbB2(h) (binding)
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NRG1-beta1(h) + ErbB3-isoform1(h):ErbB2(ha) <==> NRG1-beta1(h):ErbB3-isoform1(h):ErbB2(ha) (binding)
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NRG1-beta1(h) + ErbB4(h):ErbB2(ha) <==> ErbB2(ha):ErbB4(h):NRG1-beta1(h) (binding)
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NRG1-beta1(h) --> AKT-1(r){pT308}{pS473} (increase of phosphorylation)
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NRG1-beta1(h) --> ERK(h){p} (increase of phosphorylation)
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NRG1-beta1(h) --> AKT-1(m){pS473} (increase of phosphorylation)
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NRG1-beta1(h) --> Src(h){pY216} (increase of phosphorylation)
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NRG1-beta1(h) --> FAK1(h){pY861} (increase of phosphorylation)
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NRG1-beta1(h) --> AKT-1(h){pS473} (increase of phosphorylation)
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NRG1-beta1(h) --> ErbB2(m){pY} (increase of phosphorylation)
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NRG1-beta1(h) --> ErbB3(m){pY} (increase of phosphorylation)
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NRG1-beta1(h) --> ErbB4(m){pY} (increase of phosphorylation)
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NRG1-beta1(h) --> ErbB4(h){pY} (increase of phosphorylation)
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NRG1-beta1(h) --> ErbB4(m.s.){pY} (increase of phosphorylation)
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NRG1-beta1(h) --> ERK2(h){p} (increase of phosphorylation)
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NRG1-beta1(h) --> ErbB4-JM-A(h){pY} (increase of phosphorylation)
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NRG1-beta1(h) --> ErbB4-JM-B(h){pY} (increase of phosphorylation)
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NRG1-beta1(h) --> Bmx(m.s.){pY} (increase of phosphorylation)
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NRG1(h) --> NRG1-beta1(h) (expression).
|
NRG1(h) --> NRG1-SMDF(h) (expression).
|
NRG1-alpha1A(h) --> ErbB4-JM-A(h){pY} (increase of phosphorylation)
|
NRG1-alpha1A(h) --> ErbB4-JM-B(h){pY} (increase of phosphorylation)
|
NRG1(h) --> NRG1-alpha1A(h) (expression).
|
NRG1(h) --> NRG1-alpha2B(h) (expression).
|
NRG1(h) --> NRG1-Alpha3(h) (expression).
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NRG1(h) --> NRG1-beta2(h) (expression).
|
NRG1-beta3(h) --> ERK1(h){pY} (increase of phosphorylation)
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NRG1-beta3(h) --> ERK2(h){pY} (increase of phosphorylation)
|
NRG1-beta3(h) --> Shc-1-p46(h){pY} (increase of phosphorylation)
|
NRG1-beta3(h) --> Shc-1-p52(h){pY} (increase of phosphorylation)
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NRG1-beta3(h) --> Shc-1(h):ErbB2(h) (increase of binding)
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NRG1-beta3(h) --> Shc-1(h):ErbB3(h) (increase of binding)
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NRG1-beta3(h) --> Shc-1(h):Grb-2(h) (increase of binding)
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NRG1-beta3(h) --> FOS(h) (transactivation)
|
NRG1(h) --> NRG1-beta3(h) (expression).
|
NRG1-GGF2(h) --> AKT(r){p} (increase of phosphorylation)
|
NRG1-GGF2(h) --> ERK1(r){p} (increase of phosphorylation)
|
NRG1-GGF2(h) --> ERK2(r){p} (increase of phosphorylation)
|
NRG1-GGF2(h) --> AKT-1(m.s.){p} (increase of phosphorylation)
|
NRG1-GGF2(h) --> bad(r){pS112} (increase of phosphorylation)
|
NRG1(h) --> NRG1-GGF2(h) (expression).
|
