| HB-EGF(h) + ErbB4(h) <==> HB-EGF(h):ErbB4(h) (binding)
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HB-EGF(h) + ErbB1(h) <==> HB-EGF(h):ErbB1(h) (binding)
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HB-EGF(h) --stromelysin1(h)--> HB-EGF-ECD(h) + protein remnants (processing; cleavage)
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HB-EGF(h) --TACE(m)--> HB-EGF-ECD(h) + protein remnants (processing; cleavage)
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HB-EGF(h) + ErbB2(m.s.):ErbB4(m) <==> HB-EGF(h):ErbB2(m.s.):ErbB4(m) (binding)
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HB-EGF(h) + (ErbB1(m.s.))2 <==> (ErbB1(m.s.))2:HB-EGF(h) (binding)
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HB-EGF(h) + ErbB1(m.s.):ErbB2(m.s.) <==> HB-EGF(h):ErbB1(m.s.):ErbB2(m.s.) (binding)
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HB-EGF(h) --> RSK1(r){p} (increase of phosphorylation)
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HB-EGF(h) --> ERK1(r){pT203}{pY205} (increase of phosphorylation)
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HB-EGF(h) --> ERK2(r){pT183}{pY185} (increase of phosphorylation)
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HB-EGF(h) --> Shc(r){p} (increase of phosphorylation)
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HB-EGF(h) --TACE(h)--> HB-EGF-p17(h) + protein remnants (cleavage)
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HB-EGF(h) --adam10(h)--> HB-EGF-p16.4(h) + protein remnants (cleavage)
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HB-EGF(h) --TACE(h)--> HB-EGF-p16(h) + protein remnants (cleavage)
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HB-EGF(h) --adam10(h)--> HB-EGF-p15(h) + protein remnants (cleavage)
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HB-EGF(h) --> ERK1(h){p} (increase of phosphorylation)
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HB-EGF(h) --> ERK2(h){p} (increase of phosphorylation)
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HBEGF(h) --> HB-EGF(h) (expression).
|
adiponectin(m) + HB-EGF(h) <==> adiponectin(m):HB-EGF(h) (binding)
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HB-EGF(h) --> p38alpha(h){pT180}{pY182} (increase of phosphorylation)
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HB-EGF(h) --> HB-EGF-ECD(h) + protein remnants (processing)
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HB-EGF(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation)
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HB-EGF(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation)
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HBEGF(h) --> HB-EGF(h) (expression).
|
