| IKK-gamma(h) + EAC(h) <==> IKK-gamma(h):EAC(h) (binding)
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EAC(h) + TRAF2(h) <==> EAC(h):TRAF2(h) (binding)
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EAC(h) + NTP --IKK-gamma(h)--> EAC(h){p} + NDP (phosphorylation)
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EAC(h) --> IkappaB-alpha(h){p} (decrease of phosphorylation)
|
EAC(h) --> MKK3(h){p} (decrease of phosphorylation)
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EAC(h) --> MKK6(h){p} (decrease of phosphorylation)
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EAC(h) --> p38(h){p} (decrease of phosphorylation)
|
CYLD(h) --> EAC(h) (expression).
|
(ubiquitin(v.s.))4 --EAC(h)--> 4 ubiquitin(v.s.) (processing)
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TRAF6(m){ub{K63}(n)} --EAC(h)--> TRAF6(m) + ubiquitin(v.s.) (deubiquitination)
|
TRAF2(h){ub{K63}(n)} --EAC(h)--> TRAF2(h) + n ubiquitin(v.s.) (deubiquitination)
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TRAF2(v.s.){ub{K63}(n)} --EAC(h)--> TRAF2(v.s.) + n ubiquitin(h) (deubiquitination)
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TRAF6(v.s.){ub{K63}(n)} --EAC(h)--> TRAF6(v.s.) + n ubiquitin(h) (deubiquitination)
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IKK-gamma(h){ub{K63}(n)} --EAC(h)--> IKK-gamma(h) + n ubiquitin(h) (deubiquitination)
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IKK-gamma(m.s.){ub{K63}(n)} --EAC(h)--> IKK-gamma(m.s.) + n ubiquitin(m.s.) (deubiquitination)
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CYLD(h) --> EAC-isoform2(h) (expression).
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CYLD(h) --> EAC-isoform1(h) (expression).
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