| Gene information | Literature | Expression | lncRNA | Mutation | Homolog |
Basic Information | |
|---|---|
Gene ID | 868 |
Name | CBLB |
Synonymous | Cbl proto-oncogene B, E3 ubiquitin protein ligase;CBLB;Cbl proto-oncogene B, E3 ubiquitin protein ligase |
Definition | Cas-Br-M (murine) ecotropic retroviral transforming sequence b|Cas-Br-M (murine) ectropic retroviral transforming sequence b|Cbl proto-oncogene, E3 ubiquitin protein ligase B|E3 ubiquitin-protein ligase CBL-B|RING finger protein 56|SH3-binding protein CBL |
Position | 3q13.11 |
Gene type | protein-coding |
Title | Abstract |
| Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene. | We have cloned a new gene, cbl-b, with homology to the c-cbl proto-oncogene. A large protein is predicted (approx. MW 108,000) that has a proline rich domain, a nuclear localization signal, a C3HC4 zinc finger and a putative leucine zipper. There is striking nucleotide and amino acid homology to the c-cbl proto-oncogene most notably in the structural motifs described above. Cbl-b is expressed in normal and malignant mammary epithelial cells, in a variety of normal tissues, and in hematopoietic tissue and cell lines. Cbl-b expressions is up-regulated with macrophage/monocyte differentiation of the HL60 and U937 cell lines. There is direct association of the cbl-b protein with the Src Homology 3 domains of several proteins including signaling, cytoskeletal and adaptor proteins. Our data suggest that cbl-b encodes a protein which can interact with signal transduction proteins to regulate their function or to be regulated by them. Together, cbl-b and c-cbl are members of a novel family of proto-oncogenes involved in signal transduction. |