| Gene information | Literature | Expression | lncRNA | Mutation | Homolog |
Basic Information | |
|---|---|
Gene ID | 4331 |
Name | MNAT1 |
Synonymous | MNAT CDK-activating kinase assembly factor 1;MNAT1;MNAT CDK-activating kinase assembly factor 1 |
Definition | CDK-activating kinase assembly factor MAT1|CDK7/cyclin-H assembly factor|RING finger protein 66|RING finger protein MAT1|cyclin G1 interacting protein|cyclin-G1-interacting protein|menage a trois 1 (CAK assembly factor)|menage a trois homolog 1, cyclin H |
Position | 14q23 |
Gene type | protein-coding |
Title | Abstract |
| Isolation of a cDNA for the human homolog of MAT-1 oncogene and its expression in human breast cancer cells. | Overexpression of mouse MAT-1 oncogene is associated with carcinogensis of mouse mammary epithelial cells. A human cDNA (hMAT) homologous to MAT-1 was isolated from normal human breast tissue. The hMAT cDNA is 1312 bp long and produces a 8.5 kDa peptide in vitro. The hMAT probe hybridized with 2.5 kb RNA in normal human breast epithelial cells from reduction mammoplasty specimens and in human breast cancer cell lines. The extent of hMAT gene expression in human breast cancer cell line was variable, with BT-20, T47-D, and MDA-MB-231 showing about a 10-fold overexpression compared to primary normal human breast epithelial cells, MCF-7, and ZR-75-1. |