| Gene information | Literature | Expression | lncRNA | Mutation | Homolog |
Basic Information | |
|---|---|
Gene ID | 2117 |
Name | ETV3 |
Synonymous | ets variant 3;ETV3;ets variant 3 |
Definition | ETS domain transcriptional repressor PE1|ETS translocation variant 3|ets variant gene 3, ETS family transcriptional repressor|mitogenic Ets transcriptional suppressor |
Position | 1q21-q23 |
Gene type | protein-coding |
Title | Abstract |
| PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23. | The v-ets oncogene family shares a conserved peptide motif called the ETS domain that mediates sequence-specific DNA binding. This motif is unique among transcription factor families. Using partially degenerate oligonucleotides from conserved regions of the ETS domain and the polymerase chain reaction, we isolated a new member of the v-ets family designated PE-1 from HL60 cells. PE-1 was expressed as an approximately 7.5-kb transcript in most cell lines tested. In the hairy cell leukemia line Eskol, there was an additional 1.8-kb transcript observed. PE-1 was the most common ETS domain gene found in CD34+HLA-DR- hematopoietic progenitors. PE-1 was localized to human chromosome 1q21-q23 using both in situ chromosomal hybridization and human-hamster hybrids. |