| Gene information | Literature | Expression | lncRNA | Mutation | Homolog |
Basic Information | |
|---|---|
Gene ID | 1501 |
Name | CTNND2 |
Synonymous | catenin (cadherin-associated protein), delta 2;CTNND2;catenin (cadherin-associated protein), delta 2 |
Definition | T-cell delta-catenin|catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)|catenin delta-2|neurojungin |
Position | 5p15.2 |
Gene type | protein-coding |
Title | Abstract |
| The expression of delta-catenin in esophageal squamous cell carcinoma and its correlations with prognosis of patients. | As a member of the catenin family, expression of delta-catenin and its clinical implication in numerous tumors remain unclear. In the present study, expression of delta-catenin in esophageal squamous cell carcinoma (ESCC) and its correlations with patient prognosis were explored. We detected the expression of delta-catenin, by immunohistochemistry, in ESCC tissues from 299 cases and analyzed the correlation between delta-catenin expression and patient clinicopathological features. Compared with a lack of expression in adjacent normal esophageal epithelium (0%, 0/47), the frequency of delta-catenin protein was increased in ESCC tissues to 41.5% (124/299, P < .001) and expression correlated with TNM stage and lymph node metastasis (P = .025 and .019, respectively). Furthermore, Kaplan-Meier survival analysis revealed that patients with high delta-catenin expression had shorter survival than patients with low expression (P = .010), and multivariate Cox analysis revealed that high delta-catenin expression was also an independent prognostic factor (P = .001). In transwell assays, migration of ESCC cells was enhanced by delta-catenin overexpression, whereas proliferation of ESCC cells was unchanged. Together, our results suggest that delta-catenin acts as an oncoprotein when overexpressed in ESCC, and its expression is associated with poor prognosis and malignant cell behavior. |