| Gene information | Literature | Expression | lncRNA | Mutation | Homolog |
Basic Information | |
|---|---|
Gene ID | 10971 |
Name | YWHAQ |
Synonymous | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta;YWHAQ;tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta |
Definition | 14-3-3 protein T-cell|14-3-3 protein tau|14-3-3 protein theta|tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide |
Position | 2p25.1 |
Gene type | protein-coding |
Title | Abstract |
| The role of 14-3-3beta in transcriptional activation of estrogen receptor alpha and its involvement in proliferation of breast cancer cells. | The estrogen receptor (ER) functions as a transcription factor that mediates the effects of estrogen. ERalpha, which plays a crucial role in the development and progression of breast cancer, is activated by estrogen binding, leading to receptor phosphorylation, dimerization, and recruitment of co-activators and chaperons to the estrogen-bound receptor complex. The 14-3-3 proteins bind to target proteins via phosphorylation and influence many cellular events by altering their subcellular localization or acting as a chaperone. However, regulation of ERalpha expression and transactivation by the 14-3-3 proteins has not been reported. We demonstrate that 14-3-3beta functions as a positive regulator of ERalpha through a direct protein-protein interaction in an estrogen-dependent manner. Ectopic expression of 14-3-3beta stimulated ERalpha-mediated transcriptional activity in MCF-7 breast cancer cells. Enhanced ERalpha transcriptional activity due to 14-3-3beta increased the expressions of the endogenous ERalpha target genes, leading to proliferation of breast cancer cells. We suggest that 14-3-3beta has oncogenic potential in breast cancer via binding to ERalpha and activation of the transcriptional activity of ERalpha. |