| Gene information | Literature | Expression | lncRNA | Mutation | Homolog |
Basic Information | |
|---|---|
Gene ID | 10879 |
Name | SMR3B |
Synonymous | submaxillary gland androgen regulated protein 3B;SMR3B;submaxillary gland androgen regulated protein 3B |
Definition | proline rich 3|proline-rich peptide P-B|proline-rich protein 3|salivary proline-rich protein|submaxillary gland androgen regulated protein 3 homolog B|submaxillary gland androgen-regulated protein 3B |
Position | 4q13.3 |
Gene type | protein-coding |
Title | Abstract |
| Engineering the first chimeric antibody in targeting intracellular PRL-3 oncoprotein for cancer therapy in mice. | Antibodies are considered as magic bullets because of their high specificity. It is believed that antibodies are too large to routinely enter the cytosol, thus antibody therapeutic approach has been limited to extracellular or secreted proteins expressed by cancer cells. However, many oncogenic proteins are localized within the cell. To explore the possibility of antibody therapies against intracellular targets, we generated a chimeric antibody targeting the intracellular PRL-3 oncoprotein to assess its antitumor activities in mice. Remarkably, we observed that the PRL-3 chimeric antibody could efficiently and specifically reduce the formation of PRL-3 expressing metastatic tumors. We further found that natural killer (NK) cells were important in mediating the therapeutic effect, which was only observed in a nude mouse model (T-cell deficient), but not in a Severe Combined Immunodeficiency (scid ) mouse model (B- and T-cell deficient), indicating the anticancer effect also depends on host B-cell activity. Our study involving 377 nude and scid mice suggest that antibodies targeting intracellular proteins can be developed to treat cancer. |