Entrez Gene

Basic Information
Gene ID	990
Name	CDC6
Synonymous	cell division cycle 6;CDC6;cell division cycle 6
Definition	CDC6 cell division cycle 6 homolog\|CDC6-related protein\|cdc18-related protein\|cell division control protein 6 homolog\|cell division cycle 6 homolog\|p62(cdc6)
Position	17q21.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.633C>T; p.C211C; 17:40291641-40291641	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.206A>G; p.H69R; 17:40291085-40291085	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.809_810delAT; p.M271fs*31; 17:40293604-40293605	breast	carcinoma	Deletion - Frameshift
c.855G>A; p.E285E; 17:40293968-40293968	breast	carcinoma	Substitution - coding silent
c.1324G>C; p.D442H; 17:40300902-40300902	breast	carcinoma	Substitution - Missense
c.1413G>A; p.L471L; 17:40300991-40300991	breast	carcinoma	Substitution - coding silent
c.457G>A; p.E153K; 17:40291336-40291336	breast	carcinoma; lobular_carcinoma	Substitution - Missense
c.1658A>T; p.N553I; 17:40301976-40301976	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.979C>T; p.L327L; 17:40294399-40294399	breast	carcinoma	Substitution - coding silent
c.1639G>C; p.D547H; 17:40301957-40301957	breast	carcinoma	Substitution - Missense
c.1435G>T; p.E479*; 17:40301013-40301013	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1475T>C; p.V492A; 17:40301490-40301490	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1085T>C; p.V362A; 17:40295357-40295357	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.205C>T; p.H69Y; 17:40291084-40291084	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.582_583insA; p.A195fs*33; 17:40291590-40291591	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Insertion - Frameshift
c.1204G>C; p.E402Q; 17:40296722-40296722	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.314A>G; p.K105R; 17:40291193-40291193	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1473A>G; p.K491K; 17:40301488-40301488	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1068A>G; p.Q356Q; 17:40294488-40294488	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.349C>T; p.Q117*; 17:40291228-40291228	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.529A>T; p.R177W; 17:40291537-40291537	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.511C>T; p.R171W; 17:40291519-40291519	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1221C>T; p.S407S; 17:40296739-40296739	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.386A>G; p.E129G; 17:40291265-40291265	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.281G>A; p.R94Q; 17:40291160-40291160	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1333A>G; p.R445G; 17:40300911-40300911	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1333A>G; p.R445G; 17:40300911-40300911	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.335T>C; p.L112P; 17:40291214-40291214	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1447G>T; p.G483W; 17:40301025-40301025	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1560A>T; p.G520G; 17:40301575-40301575	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1560A>T; p.G520G; 17:40301575-40301575	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1350A>G; p.Q450Q; 17:40300928-40300928	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1047T>A; p.N349K; 17:40294467-40294467	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1404G>T; p.L468F; 17:40300982-40300982	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.458A>G; p.E153G; 17:40291337-40291337	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.458A>G; p.E153G; 17:40291337-40291337	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.458A>G; p.E153G; 17:40291337-40291337	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.685A>G; p.I229V; 17:40293480-40293480	liver	carcinoma	Substitution - Missense
c.685A>G; p.I229V; 17:40293480-40293480	liver	carcinoma	Substitution - Missense
c.548G>A; p.R183K; 17:40291556-40291556	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1537T>A; p.L513M; 17:40301552-40301552	liver	carcinoma	Substitution - Missense
c.1537T>A; p.L513M; 17:40301552-40301552	liver	carcinoma	Substitution - Missense
c.240G>T; p.K80N; 17:40291119-40291119	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.410G>C; p.R137T; 17:40291289-40291289	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.760G>A; p.E254K; 17:40293555-40293555	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1181G>T; p.C394F; 17:40295453-40295453	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1181G>T; p.C394F; 17:40295453-40295453	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.880C>T; p.Q294*; 17:40293993-40293993	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1081C>G; p.Q361E; 17:40294501-40294501	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1181G>A; p.C394Y; 17:40295453-40295453	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1246G>A; p.E416K; 17:40296764-40296764	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.661-1G>A; p.?; 17:40293455-40293455	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.881A>T; p.Q294L; 17:40293994-40293994	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.546C>T; p.I182I; 17:40291554-40291554	meninges	meningioma	Substitution - coding silent
c.939G>C; p.L313L; 17:40294052-40294052	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1335G>T; p.R445S; 17:40300913-40300913	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.336A>C; p.L112L; 17:40291215-40291215	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1409T>G; p.L470R; 17:40300987-40300987	prostate	carcinoma	Substitution - Missense
c.637A>G; p.S213G; 17:40291645-40291645	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1582C>A; p.R528S; 17:40301597-40301597	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1367_1368CC>TT; p.S456F; 17:40300945-40300946	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.551A>C; p.N184T; 17:40291559-40291559	skin	malignant_melanoma	Substitution - Missense
c.1277C>T; p.P426L; 17:40300855-40300855	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1096C>T; p.Q366*; 17:40295368-40295368	skin; acral	malignant_melanoma	Substitution - Nonsense
c.573T>A; p.C191*; 17:40291581-40291581	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1400C>G; p.S467C; 17:40300978-40300978	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.700A>C; p.M234L; 17:40293495-40293495	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.716C>T; p.A239V; 17:40293511-40293511	stomach	adenocarcinoma	Substitution - Missense
c.954T>A; p.N318K; 17:40294374-40294374	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1027T>C; p.F343L; 17:40294447-40294447	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1012C>T; p.P338S; 17:40294432-40294432	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1446G>A; p.L482L; 17:40301024-40301024	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.963T>A; p.D321E; 17:40294383-40294383	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1662C>G; p.I554M; 17:40301980-40301980	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1662C>G; p.I554M; 17:40301980-40301980	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.469T>A; p.Y157N; 17:40291477-40291477	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.818C>T; p.A273V; 17:40293613-40293613	urinary_tract; bladder	carcinoma	Substitution - Missense
c.25C>T; p.Q9*; 17:40289445-40289445	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.652G>C; p.D218H; 17:40291660-40291660	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1453-2A>G; p.?; 17:40301466-40301466	urinary_tract; bladder	carcinoma	Unknown
c.1151C>T; p.S384L; 17:40295423-40295423	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1151C>T; p.S384L; 17:40295423-40295423	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1657A>G; p.N553D; 17:40301975-40301975	urinary_tract; bladder	carcinoma	Substitution - Missense

Oncogene database

COSMIC confirmed somatic mutation [Top]

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