Entrez Gene

Basic Information
Gene ID	9641
Name	IKBKE
Synonymous	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon;IKBKE;inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Definition	I-kappa-B kinase epsilon\|IKK-epsilon\|IKK-related kinase epsilon\|inducible I kappa-B kinase\|inducible IkappaB kinase\|inhibitor of nuclear factor kappa-B kinase subunit epsilon
Position	1q32.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.1574G>A; p.R525Q; 1:206485264-206485264	bone; rib	chondrosarcoma	Substitution - Missense
c.1230G>A; p.A410A; 1:206479916-206479916	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1587G>T; p.K529N; 1:206485277-206485277	breast	carcinoma	Substitution - Missense
c.297G>C; p.E99D; 1:206474933-206474933	breast	carcinoma	Substitution - Missense
c.717G>A; p.T239T; 1:206477764-206477764	breast	carcinoma	Substitution - coding silent
c.224A>G; p.E75G; 1:206474467-206474467	breast	carcinoma	Substitution - Missense
c.231C>T; p.G77G; 1:206474867-206474867	breast	carcinoma	Substitution - coding silent
c.1465C>T; p.L489L; 1:206485034-206485034	breast	carcinoma	Substitution - coding silent
c.440A>G; p.E147G; 1:206476262-206476262	breast	carcinoma	Substitution - Missense
c.485G>A; p.R162Q; 1:206476307-206476307	breast	carcinoma	Substitution - Missense
c.402C>T; p.R134R; 1:206476224-206476224	breast	carcinoma	Substitution - coding silent
c.682C>T; p.R228W; 1:206476819-206476819	breast	carcinoma	Substitution - Missense
c.1584G>A; p.V528V; 1:206485274-206485274	breast	carcinoma	Substitution - coding silent
c.1587G>A; p.K529K; 1:206485277-206485277	breast	carcinoma	Substitution - coding silent
c.401G>A; p.R134H; 1:206476223-206476223	central_nervous_system; brain	glioma	Substitution - Missense
c.1932+1G>A; p.?; 1:206493120-206493120	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Unknown
c.1366C>T; p.R456W; 1:206480472-206480472	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1093G>A; p.V365I; 1:206479043-206479043	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma; large_cell	Substitution - Missense
c.145C>T; p.R49C; 1:206474388-206474388	central_nervous_system; brain	glioma	Substitution - Missense
c.594C>T; p.F198F; 1:206476731-206476731	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.474C>T; p.F158F; 1:206476296-206476296	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1767G>A; p.L589L; 1:206491681-206491681	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2026C>T; p.R676*; 1:206493359-206493359	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.571C>T; p.R191*; 1:206476708-206476708	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1993C>T; p.P665S; 1:206493326-206493326	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2067G>A; p.G689G; 1:206493941-206493941	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.612C>A; p.L204L; 1:206476749-206476749	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1908G>T; p.Q636H; 1:206493095-206493095	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1151C>T; p.T384I; 1:206479101-206479101	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.629C>T; p.T210I; 1:206476766-206476766	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.650G>A; p.G217D; 1:206476787-206476787	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.1805C>T; p.A602V; 1:206491719-206491719	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2138C>T; p.P713L; 1:206496132-206496132	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.968A>G; p.H323R; 1:206478315-206478315	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1661A>T; p.Y554F; 1:206487958-206487958	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.365G>A; p.G122D; 1:206476187-206476187	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1574G>T; p.R525L; 1:206485264-206485264	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1321C>T; p.R441W; 1:206480094-206480094	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.947T>C; p.L316P; 1:206478294-206478294	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1001delT; p.F335fs*45; 1:206478951-206478951	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.583_584insA; p.A197fs*108; 1:206476720-206476721	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.583_584insA; p.A197fs*108; 1:206476720-206476721	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1284G>T; p.L428L; 1:206480057-206480057	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.622G>T; p.G208*; 1:206476759-206476759	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.622G>T; p.G208*; 1:206476759-206476759	large_intestine; colon	carcinoma	Substitution - Nonsense
c.80G>A; p.R27H; 1:206473307-206473307	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.162G>T; p.R54S; 1:206474405-206474405	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.311C>T; p.A104V; 1:206474947-206474947	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.349C>T; p.R117C; 1:206474985-206474985	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.516G>A; p.S172S; 1:206476338-206476338	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.414delG; p.N140fs*6; 1:206476236-206476236	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1299G>A; p.L433L; 1:206480072-206480072	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1920G>T; p.E640D; 1:206493107-206493107	large_intestine	adenoma	Substitution - Missense
c.963G>A; p.L321L; 1:206478310-206478310	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.139C>T; p.R47W; 1:206474382-206474382	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.139C>T; p.R47W; 1:206474382-206474382	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1300G>A; p.D434N; 1:206480073-206480073	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.844G>T; p.A282S; 1:206478191-206478191	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1574G>A; p.R525Q; 1:206485264-206485264	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.55G>A; p.A19T; 1:206473282-206473282	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.402C>T; p.R134R; 1:206476224-206476224	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1194C>T; p.D398D; 1:206479880-206479880	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1260C>T; p.G420G; 1:206480033-206480033	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.885C>T; p.F295F; 1:206478232-206478232	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.240G>A; p.R80R; 1:206474876-206474876	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.664A>G; p.I222V; 1:206476801-206476801	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.280C>A; p.L94M; 1:206474916-206474916	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1037delC; p.R348fs*32; 1:206478987-206478987	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1290G>T; p.R430R; 1:206480063-206480063	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.48G>A; p.G16G; 1:206473275-206473275	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1367G>A; p.R456Q; 1:206480473-206480473	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2138C>T; p.P713L; 1:206496132-206496132	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.319C>T; p.L107L; 1:206474955-206474955	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.585A>G; p.Q195Q; 1:206476722-206476722	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1118C>T; p.T373M; 1:206479068-206479068	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1498C>T; p.R500W; 1:206485067-206485067	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1545G>T; p.E515D; 1:206485235-206485235	liver	carcinoma	Substitution - Missense
c.1545G>T; p.E515D; 1:206485235-206485235	liver	carcinoma	Substitution - Missense
c.1594G>A; p.D532N; 1:206485284-206485284	liver	carcinoma	Substitution - Missense
c.364G>A; p.G122S; 1:206476186-206476186	liver	carcinoma	Substitution - Missense
c.1961T>C; p.L654P; 1:206493294-206493294	liver	carcinoma	Substitution - Missense
c.1334G>C; p.W445S; 1:206480107-206480107	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1215A>G; p.K405K; 1:206479901-206479901	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.596G>T; p.G199V; 1:206476733-206476733	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.359-2A>G; p.?; 1:206476179-206476179	lung	carcinoma; adenocarcinoma	Unknown
c.2117G>A; p.R706Q; 1:206493991-206493991	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1574G>C; p.R525P; 1:206485264-206485264	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.231C>T; p.G77G; 1:206474867-206474867	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.907A>T; p.S303C; 1:206478254-206478254	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1721A>G; p.H574R; 1:206490846-206490846	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2012A>C; p.Y671S; 1:206493345-206493345	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2104C>T; p.R702C; 1:206493978-206493978	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1150A>G; p.T384A; 1:206479100-206479100	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.124A>G; p.T42A; 1:206474367-206474367	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1250G>A; p.G417D; 1:206480023-206480023	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1859A>G; p.H620R; 1:206493046-206493046	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.906C>T; p.T302T; 1:206478253-206478253	NS	NS	Substitution - coding silent
c.1747C>A; p.H583N; 1:206491661-206491661	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1335G>T; p.W445C; 1:206480108-206480108	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1833G>A; p.M611I; 1:206491747-206491747	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.433G>A; p.V145I; 1:206476255-206476255	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1462G>T; p.E488*; 1:206485031-206485031	oesophagus	carcinoma	Substitution - Nonsense
c.1231G>T; p.D411Y; 1:206479917-206479917	oesophagus	carcinoma	Substitution - Missense
c.428G>A; p.R143H; 1:206476250-206476250	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1995G>A; p.P665P; 1:206493328-206493328	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1963C>T; p.Q655*; 1:206493296-206493296	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.1200C>T; p.P400P; 1:206479886-206479886	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1446A>G; p.G482G; 1:206485015-206485015	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1112C>T; p.A371V; 1:206479062-206479062	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1542G>A; p.T514T; 1:206485232-206485232	pancreas	carcinoma	Substitution - coding silent
c.2138C>T; p.P713L; 1:206496132-206496132	prostate	adenoma	Substitution - Missense
c.915C>T; p.I305I; 1:206478262-206478262	skin	malignant_melanoma	Substitution - coding silent
c.1743C>T; p.F581F; 1:206491657-206491657	skin	malignant_melanoma	Substitution - coding silent
c.461A>G; p.K154R; 1:206476283-206476283	skin	malignant_melanoma	Substitution - Missense
c.1915C>T; p.Q639*; 1:206493102-206493102	skin	malignant_melanoma	Substitution - Nonsense
c.1041_1042CC>TT; p.R348*; 1:206478991-206478992	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1635C>T; p.C545C; 1:206487932-206487932	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.985C>T; p.H329Y; 1:206478332-206478332	skin	malignant_melanoma	Substitution - Missense
c.1391C>T; p.S464F; 1:206480497-206480497	skin	malignant_melanoma	Substitution - Missense
c.1375G>A; p.E459K; 1:206480481-206480481	skin; mucosal	malignant_melanoma	Substitution - Missense
c.894C>T; p.F298F; 1:206478241-206478241	skin	malignant_melanoma	Substitution - coding silent
c.667C>T; p.P223S; 1:206476804-206476804	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.667C>T; p.P223S; 1:206476804-206476804	skin	malignant_melanoma	Substitution - Missense
c.2041C>T; p.L681F; 1:206493374-206493374	skin	malignant_melanoma	Substitution - Missense
c.1597C>T; p.Q533*; 1:206485287-206485287	skin	malignant_melanoma	Substitution - Nonsense
c.1597C>T; p.Q533*; 1:206485287-206485287	skin	malignant_melanoma	Substitution - Nonsense
c.579C>T; p.P193P; 1:206476716-206476716	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1353G>C; p.Q451H; 1:206480459-206480459	skin	malignant_melanoma	Substitution - Missense
c.993G>A; p.T331T; 1:206478943-206478943	skin	malignant_melanoma	Substitution - coding silent
c.523G>A; p.G175R; 1:206476345-206476345	skin; arm	malignant_melanoma	Substitution - Missense
c.400C>T; p.R134C; 1:206476222-206476222	skin	malignant_melanoma	Substitution - Missense
c.1965G>A; p.Q655Q; 1:206493298-206493298	skin	malignant_melanoma	Substitution - coding silent
c.1965G>A; p.Q655Q; 1:206493298-206493298	skin	malignant_melanoma	Substitution - coding silent
c.1395C>T; p.L465L; 1:206480501-206480501	skin	malignant_melanoma	Substitution - coding silent
c.1367G>A; p.R456Q; 1:206480473-206480473	skin	malignant_melanoma	Substitution - Missense
c.1180G>A; p.D394N; 1:206479130-206479130	skin	malignant_melanoma	Substitution - Missense
c.2131C>T; p.P711S; 1:206496125-206496125	skin	malignant_melanoma	Substitution - Missense
c.2131C>T; p.P711S; 1:206496125-206496125	skin	malignant_melanoma	Substitution - Missense
c.2131C>T; p.P711S; 1:206496125-206496125	skin	malignant_melanoma	Substitution - Missense
c.852C>T; p.I284I; 1:206478199-206478199	skin	malignant_melanoma	Substitution - coding silent
c.1159C>T; p.P387S; 1:206479109-206479109	skin	malignant_melanoma	Substitution - Missense
c.336C>T; p.F112F; 1:206474972-206474972	skin	malignant_melanoma	Substitution - coding silent
c.361G>A; p.A121T; 1:206476183-206476183	skin	malignant_melanoma	Substitution - Missense
c.686G>A; p.R229Q; 1:206476823-206476823	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2114A>G; p.E705G; 1:206493988-206493988	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.427C>T; p.R143C; 1:206476249-206476249	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.325G>A; p.E109K; 1:206474961-206474961	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1742T>A; p.F581Y; 1:206491656-206491656	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2133A>G; p.P711P; 1:206496127-206496127	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1037C>T; p.A346V; 1:206478987-206478987	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.176T>C; p.L59P; 1:206474419-206474419	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2050C>T; p.Q684*; 1:206493924-206493924	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Nonsense
c.560G>A; p.R187Q; 1:206476697-206476697	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1760G>T; p.R587I; 1:206491674-206491674	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1760G>T; p.R587I; 1:206491674-206491674	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.717G>A; p.T239T; 1:206477764-206477764	thyroid	other; neoplasm	Substitution - coding silent
c.2016C>A; p.P672P; 1:206493349-206493349	thyroid	other; neoplasm	Substitution - coding silent
c.442G>T; p.E148*; 1:206476264-206476264	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1207G>A; p.V403I; 1:206479893-206479893	urinary_tract; bladder	carcinoma	Substitution - Missense
c.973delT; p.Y325fs*8; 1:206478320-206478320	urinary_tract; bladder	carcinoma	Deletion - Frameshift
c.1143C>G; p.L381L; 1:206479093-206479093	urinary_tract; bladder	carcinoma	Substitution - coding silent

Oncogene database

COSMIC confirmed somatic mutation [Top]

Bioinformatics and cancer genomics links

Bioinformatics centers

Bioinformatics centers

Welcome to Bioinfo-MinZhao!