Entrez Gene

Basic Information
Gene ID	9314
Name	KLF4
Synonymous	Kruppel-like factor 4 (gut);KLF4;Kruppel-like factor 4 (gut)
Definition	Krueppel-like factor 4\|endothelial Kruppel-like zinc finger protein\|epithelial zinc finger protein EZF\|gut-enriched krueppel-like factor
Position	9q31
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.1237C>T; p.L413F; 9:107487055-107487055	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1343G>C; p.R448P; 9:107485848-107485848	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.341C>T; p.T114I; 9:107488053-107488053	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	breast	carcinoma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	breast	carcinoma	Substitution - Missense
c.1148G>C; p.R383T; 9:107487144-107487144	breast	carcinoma	Substitution - Missense
c.1168C>T; p.R390W; 9:107487124-107487124	central_nervous_system; brain	glioma	Substitution - Missense
c.249C>T; p.C83C; 9:107488145-107488145	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.1211G>A; p.G404D; 9:107487081-107487081	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1129G>T; p.E377*; 9:107487163-107487163	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1086G>A; p.P362P; 9:107487308-107487308	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1086G>A; p.P362P; 9:107487308-107487308	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.109G>T; p.A37S; 9:107488947-107488947	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.109G>T; p.A37S; 9:107488947-107488947	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1243G>A; p.A415T; 9:107487049-107487049	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.843G>A; p.A281A; 9:107487551-107487551	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1065G>C; p.Q355H; 9:107487329-107487329	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.9G>A; p.Q3Q; 9:107489047-107489047	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1360C>T; p.R454C; 9:107485831-107485831	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.109G>A; p.A37T; 9:107488947-107488947	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.708C>A; p.S236R; 9:107487686-107487686	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.712C>T; p.P238S; 9:107487682-107487682	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.242C>T; p.A81V; 9:107488152-107488152	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1255A>G; p.T419A; 9:107487037-107487037	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.385T>C; p.S129P; 9:107488009-107488009	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.489G>T; p.A163A; 9:107487905-107487905	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.38G>A; p.S13N; 9:107489018-107489018	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.288C>T; p.T96T; 9:107488106-107488106	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1286A>T; p.D429V; 9:107485905-107485905	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.614G>A; p.R205Q; 9:107487780-107487780	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.919_920insC; p.L307fs*16; 9:107487474-107487475	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.504C>T; p.G168G; 9:107487890-107487890	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.504C>T; p.G168G; 9:107487890-107487890	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.191A>T; p.D64V; 9:107488203-107488203	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1321G>A; p.D441N; 9:107485870-107485870	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1321G>A; p.D441N; 9:107485870-107485870	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1246C>T; p.H416Y; 9:107487046-107487046	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.685T>C; p.F229L; 9:107487709-107487709	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.685T>C; p.F229L; 9:107487709-107487709	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1040A>G; p.N347S; 9:107487354-107487354	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.185C>A; p.P62H; 9:107488209-107488209	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.395C>G; p.S132C; 9:107487999-107487999	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1318T>G; p.S440A; 9:107485873-107485873	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.901G>T; p.A301S; 9:107487493-107487493	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1312G>T; p.A438S; 9:107485879-107485879	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1204G>T; p.G402C; 9:107487088-107487088	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.288C>A; p.T96T; 9:107488106-107488106	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.1188C>T; p.H396H; 9:107487104-107487104	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	meninges	meningioma; secretory	Substitution - Missense
c.1265G>A; p.G422D; 9:107485926-107485926	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1294G>A; p.G432S; 9:107485897-107485897	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1252C>T; p.R418*; 9:107487040-107487040	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1203G>T; p.A401A; 9:107487089-107487089	oesophagus	carcinoma	Substitution - coding silent
c.188A>G; p.Y63C; 9:107488206-107488206	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1364C>T; p.P455L; 9:107485827-107485827	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1232C>T; p.S411F; 9:107487060-107487060	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.648G>T; p.Q216H; 9:107487746-107487746	pancreas	carcinoma	Substitution - Missense
c.946A>C; p.T316P; 9:107487448-107487448	pancreas	carcinoma	Substitution - Missense
c.1225A>C; p.K409Q; 9:107487067-107487067	pancreas	other; adenoma	Substitution - Missense
c.1232C>A; p.S411Y; 9:107487060-107487060	pancreas	carcinoma	Substitution - Missense
c.1322A>G; p.D441G; 9:107485869-107485869	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Missense
c.433C>A; p.P145T; 9:107487961-107487961	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1320A>G; p.S440S; 9:107485871-107485871	prostate	carcinoma	Substitution - coding silent
c.1227G>C; p.K409N; 9:107487065-107487065	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1099+7_1099+8CC>TT; p.?; 9:107487287-107487288	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.1178C>T; p.T393I; 9:107487114-107487114	skin	malignant_melanoma	Substitution - Missense
c.1353G>A; p.T451T; 9:107485838-107485838	skin	malignant_melanoma	Substitution - coding silent
c.663A>T; p.P221P; 9:107487731-107487731	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1001T>C; p.L334P; 9:107487393-107487393	skin	malignant_melanoma	Substitution - Missense
c.877C>T; p.P293S; 9:107487517-107487517	skin	malignant_melanoma	Substitution - Missense
c.1100-8A>G; p.?; 9:107487200-107487200	skin	malignant_melanoma	Unknown
c.1027C>A; p.H343N; 9:107487367-107487367	skin	malignant_melanoma	Substitution - Missense
c.916C>T; p.P306S; 9:107487478-107487478	skin	malignant_melanoma	Substitution - Missense
c.335C>T; p.S112L; 9:107488059-107488059	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.411G>A; p.S137S; 9:107487983-107487983	skin	malignant_melanoma	Substitution - coding silent
c.1253G>A; p.R418Q; 9:107487039-107487039	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.202G>A; p.A68T; 9:107488192-107488192	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1186C>A; p.H396N; 9:107487106-107487106	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.469G>A; p.G157R; 9:107487925-107487925	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.271C>T; p.L91L; 9:107488123-107488123	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.436T>G; p.S146A; 9:107487958-107487958	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1180G>A; p.A394T; 9:107487112-107487112	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1403C>T; p.S468L; 9:107485788-107485788	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.48G>T; p.L16L; 9:107489008-107489008	thyroid	other; neoplasm	Substitution - coding silent
c.272T>C; p.L91P; 9:107488122-107488122	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272T>C; p.L91P; 9:107488122-107488122	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272T>C; p.L91P; 9:107488122-107488122	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272T>C; p.L91P; 9:107488122-107488122	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.217G>A; p.D73N; 9:107488177-107488177	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1137C>G; p.P379P; 9:107487155-107487155	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1137C>G; p.P379P; 9:107487155-107487155	urinary_tract; bladder	carcinoma	Substitution - coding silent

Oncogene database

COSMIC confirmed somatic mutation [Top]

Bioinformatics and cancer genomics links

Bioinformatics centers

Bioinformatics centers

Welcome to Bioinfo-MinZhao!