Entrez Gene

Basic Information
Gene ID	92140
Name	MTDH
Synonymous	metadherin;MTDH;metadherin
Definition	3D3/LYRIC\|astrocyte elevated gene 1\|astrocyte elevated gene-1 protein\|lysine-rich CEACAM1 co-isolated protein\|metastasis adhesion protein\|protein LYRIC
Position	8q22.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.1439C>A; p.T480N; 8:97719107-97719107	breast	carcinoma	Substitution - Missense
c.1498G>A; p.E500K; 8:97719166-97719166	breast	carcinoma	Substitution - Missense
c.1663G>A; p.V555M; 8:97723020-97723020	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.1741G>A; p.E581K; 8:97724662-97724662	breast	carcinoma	Substitution - Missense
c.232G>T; p.A78S; 8:97644738-97644738	breast	carcinoma	Substitution - Missense
c.1440C>T; p.T480T; 8:97719108-97719108	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1442G>A; p.R481H; 8:97719110-97719110	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1658A>G; p.N553S; 8:97723015-97723015	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1658A>G; p.N553S; 8:97723015-97723015	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1216G>C; p.D406H; 8:97706694-97706694	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1623A>C; p.Q541H; 8:97722980-97722980	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.800C>A; p.S267Y; 8:97689092-97689092	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1096T>C; p.W366R; 8:97699801-97699801	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1027C>T; p.R343C; 8:97691167-97691167	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.914A>G; p.N305S; 8:97691054-97691054	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1460C>A; p.A487D; 8:97719128-97719128	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.542G>T; p.R181L; 8:97686726-97686726	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1558C>T; p.P520S; 8:97722915-97722915	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.56C>T; p.A19V; 8:97644562-97644562	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.839C>G; p.T280S; 8:97690979-97690979	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1032A>C; p.S344S; 8:97691172-97691172	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1071T>C; p.S357S; 8:97699776-97699776	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1181G>T; p.W394L; 8:97706659-97706659	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1148A>G; p.N383S; 8:97706626-97706626	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1510delA; p.N505fs*18; 8:97719178-97719178	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.391C>T; p.R131W; 8:97661081-97661081	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1070C>A; p.S357Y; 8:97699775-97699775	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1277C>G; p.S426*; 8:97713666-97713666	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1738C>T; p.R580*; 8:97724659-97724659	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1440C>T; p.T480T; 8:97719108-97719108	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.98G>A; p.R33H; 8:97644604-97644604	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1418T>G; p.L473R; 8:97719086-97719086	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1649C>T; p.T550I; 8:97723006-97723006	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1265A>G; p.D422G; 8:97706743-97706743	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1439C>T; p.T480I; 8:97719107-97719107	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1438A>G; p.T480A; 8:97719106-97719106	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1438A>G; p.T480A; 8:97719106-97719106	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1237C>A; p.L413I; 8:97706715-97706715	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.894T>C; p.S298S; 8:97691034-97691034	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.652G>C; p.D218H; 8:97687512-97687512	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.424C>T; p.R142*; 8:97661114-97661114	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1649C>G; p.T550S; 8:97723006-97723006	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.595_598delAGAG; p.E200fs*11; 8:97687455-97687458	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.671T>C; p.I224T; 8:97687531-97687531	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.598_601delGAGA; p.E200fs*11; 8:97687458-97687461	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.593A>G; p.H198R; 8:97687453-97687453	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.752C>A; p.S251Y; 8:97689044-97689044	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.232G>T; p.A78S; 8:97644738-97644738	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.232G>T; p.A78S; 8:97644738-97644738	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.232G>T; p.A78S; 8:97644738-97644738	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.232G>T; p.A78S; 8:97644738-97644738	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.232G>T; p.A78S; 8:97644738-97644738	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.232G>T; p.A78S; 8:97644738-97644738	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1342A>T; p.K448*; 8:97713731-97713731	liver	carcinoma	Substitution - Nonsense
c.1102G>T; p.V368F; 8:97699807-97699807	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1102G>T; p.V368F; 8:97699807-97699807	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1123A>G; p.I375V; 8:97699828-97699828	liver	carcinoma	Substitution - Missense
c.132G>C; p.P44P; 8:97644638-97644638	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.84C>T; p.G28G; 8:97644590-97644590	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.1006T>A; p.W336R; 8:97691146-97691146	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1530G>C; p.K510N; 8:97722887-97722887	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1387G>A; p.E463K; 8:97719055-97719055	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1282G>A; p.D428N; 8:97713671-97713671	oesophagus; upper_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.594C>A; p.H198Q; 8:97687454-97687454	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.448A>T; p.K150*; 8:97661138-97661138	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1438A>G; p.T480A; 8:97719106-97719106	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1020G>T; p.W340C; 8:97691160-97691160	ovary	other; neoplasm	Substitution - Missense
c.1020G>T; p.W340C; 8:97691160-97691160	ovary	other; neoplasm	Substitution - Missense
c.793G>T; p.G265*; 8:97689085-97689085	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.366G>A; p.L122L; 8:97644872-97644872	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1562C>T; p.S521F; 8:97722919-97722919	skin; hand	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.769G>A; p.V257I; 8:97689061-97689061	skin; trunk	malignant_melanoma	Substitution - Missense
c.918C>T; p.S306S; 8:97691058-97691058	skin	malignant_melanoma	Substitution - coding silent
c.1169C>T; p.P390L; 8:97706647-97706647	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1258C>T; p.P420S; 8:97706736-97706736	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.966G>A; p.W322*; 8:97691106-97691106	skin	malignant_melanoma	Substitution - Nonsense
c.1148-1G>T; p.?; 8:97706625-97706625	skin	malignant_melanoma	Unknown
c.296C>T; p.A99V; 8:97644802-97644802	skin	malignant_melanoma	Substitution - Missense
c.1133A>G; p.E378G; 8:97699838-97699838	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.917C>T; p.S306F; 8:97691057-97691057	skin	malignant_melanoma	Substitution - Missense
c.1466C>T; p.S489F; 8:97719134-97719134	skin	malignant_melanoma	Substitution - Missense
c.1601C>T; p.S534F; 8:97722958-97722958	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.1603C>T; p.Q535*; 8:97722960-97722960	skin	malignant_melanoma	Substitution - Nonsense
c.619C>T; p.R207C; 8:97687479-97687479	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1033A>G; p.I345V; 8:97691173-97691173	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.278C>T; p.A93V; 8:97644784-97644784	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.812-2A>C; p.?; 8:97690950-97690950	stomach	carcinoma; intestinal_adenocarcinoma	Unknown
c.605G>A; p.R202Q; 8:97687465-97687465	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.74T>G; p.L25R; 8:97644580-97644580	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1284T>A; p.D428E; 8:97713673-97713673	stomach	adenocarcinoma	Substitution - Missense
c.991A>G; p.T331A; 8:97691131-97691131	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1353G>A; p.K451K; 8:97713742-97713742	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1341G>A; p.K447K; 8:97713730-97713730	thyroid	other; neoplasm	Substitution - coding silent
c.1659T>C; p.N553N; 8:97723016-97723016	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1198G>T; p.E400*; 8:97706676-97706676	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.871G>C; p.V291L; 8:97691011-97691011	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1087G>C; p.D363H; 8:97699792-97699792	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1267C>T; p.Q423*; 8:97706745-97706745	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.754C>A; p.H252N; 8:97689046-97689046	urinary_tract; bladder	carcinoma	Substitution - Missense
c.754C>A; p.H252N; 8:97689046-97689046	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense

Oncogene database

COSMIC confirmed somatic mutation [Top]

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