Entrez Gene

Basic Information
Gene ID	9181
Name	ARHGEF2
Synonymous	Rho/Rac guanine nucleotide exchange factor (GEF) 2;ARHGEF2;Rho/Rac guanine nucleotide exchange factor (GEF) 2
Definition	Rho/Rac guanine nucleotide exchange factor 2\|guanine nucleotide exchange factor H1\|microtubule-regulated Rho-GEF\|proliferating cell nucleolar antigen p40\|rho guanine nucleotide exchange factor 2
Position	1q21-q22
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.1411G>T; p.V471L; 1:155958370-155958370	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.883A>G; p.I295V; 1:155962941-155962941	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1742G>A; p.R581Q; 1:155952786-155952786	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.228C>T; p.T76T; 1:155966447-155966447	bone; tibia	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2078C>G; p.S693C; 1:155951929-155951929	breast	carcinoma	Substitution - Missense
c.1779C>T; p.F593F; 1:155952749-155952749	breast	carcinoma	Substitution - coding silent
c.1947C>T; p.L649L; 1:155952189-155952189	breast	carcinoma	Substitution - coding silent
c.2230G>A; p.E744K; 1:155951218-155951218	breast	carcinoma	Substitution - Missense
c.2581G>A; p.A861T; 1:155950867-155950867	breast	carcinoma	Substitution - Missense
c.1282C>T; p.P428S; 1:155961763-155961763	breast	carcinoma	Substitution - Missense
c.2087G>C; p.R696T; 1:155951920-155951920	breast	carcinoma	Substitution - Missense
c.2401G>C; p.A801P; 1:155951047-155951047	breast	carcinoma	Substitution - Missense
c.1515C>T; p.N505N; 1:155957829-155957829	breast	carcinoma	Substitution - coding silent
c.2689C>A; p.R897R; 1:155950413-155950413	breast	carcinoma	Substitution - coding silent
c.741G>A; p.V247V; 1:155963083-155963083	breast	carcinoma	Substitution - coding silent
c.943_944delAG; p.S315fs*10; 1:155962666-155962667	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.1249A>G; p.I417V; 1:155961796-155961796	central_nervous_system; brain	glioma	Substitution - Missense
c.633C>T; p.V211V; 1:155964995-155964995	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.877C>G; p.L293V; 1:155962947-155962947	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1095G>A; p.K365K; 1:155962145-155962145	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.849G>T; p.R283R; 1:155962975-155962975	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.521T>C; p.M174T; 1:155965107-155965107	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.24C>T; p.R8R; 1:155969259-155969259	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.207G>A; p.A69A; 1:155966468-155966468	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.110A>G; p.E37G; 1:155969173-155969173	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1367C>T; p.A456V; 1:155961678-155961678	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.704C>T; p.T235M; 1:155963120-155963120	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2663G>A; p.R888H; 1:155950439-155950439	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.43T>G; p.F15V; 1:155969240-155969240	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.998G>A; p.R333H; 1:155962612-155962612	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.752T>C; p.L251P; 1:155963072-155963072	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2795G>A; p.S932N; 1:155950307-155950307	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2153A>G; p.Y718C; 1:155951505-155951505	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; polycythaemia_vera	Substitution - Missense
c.2089-1G>C; p.?; 1:155951777-155951777	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Unknown
c.1833C>A; p.G611G; 1:155952695-155952695	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1833C>A; p.G611G; 1:155952695-155952695	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1833C>A; p.G611G; 1:155952695-155952695	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.909G>C; p.A303A; 1:155962701-155962701	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1263G>A; p.M421I; 1:155961782-155961782	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.301G>T; p.D101Y; 1:155965719-155965719	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1055T>C; p.V352A; 1:155962185-155962185	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2190G>A; p.Q730Q; 1:155951258-155951258	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1175G>A; p.G392E; 1:155961870-155961870	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2569C>T; p.R857C; 1:155950879-155950879	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2569C>T; p.R857C; 1:155950879-155950879	large_intestine; colon	carcinoma	Substitution - Missense
c.2569C>T; p.R857C; 1:155950879-155950879	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.239C>T; p.S80F; 1:155966436-155966436	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2581G>A; p.A861T; 1:155950867-155950867	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.341G>A; p.R114H; 1:155965679-155965679	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1114C>T; p.R372C; 1:155962126-155962126	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2180C>A; p.A727D; 1:155951268-155951268	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1583G>A; p.R528Q; 1:155957761-155957761	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2299G>A; p.V767M; 1:155951149-155951149	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2626C>T; p.R876*; 1:155950476-155950476	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.556G>A; p.A186T; 1:155965072-155965072	large_intestine; colon	NS	Substitution - Missense
c.1749G>T; p.K583N; 1:155952779-155952779	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2615delC; p.P872fs*83; 1:155950833-155950833	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2716G>A; p.E906K; 1:155950386-155950386	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2476G>A; p.E826K; 1:155950972-155950972	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2753G>A; p.G918D; 1:155950349-155950349	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.251G>A; p.R84Q; 1:155966424-155966424	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1690C>T; p.R564*; 1:155954911-155954911	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1481C>T; p.S494L; 1:155957863-155957863	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.606A>G; p.K202K; 1:155965022-155965022	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1989C>T; p.S663S; 1:155952147-155952147	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1753G>A; p.G585R; 1:155952775-155952775	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2638C>T; p.R880C; 1:155950464-155950464	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3G>A; p.M1I; 1:155969280-155969280	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.804G>T; p.Q268H; 1:155963020-155963020	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.804G>T; p.Q268H; 1:155963020-155963020	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.940T>A; p.C314S; 1:155962670-155962670	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2092C>T; p.R698*; 1:155951773-155951773	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2520A>G; p.P840P; 1:155950928-155950928	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2520A>G; p.P840P; 1:155950928-155950928	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1528A>G; p.M510V; 1:155957816-155957816	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.467G>A; p.R156Q; 1:155965335-155965335	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.112G>A; p.A38T; 1:155969171-155969171	liver	carcinoma	Substitution - Missense
c.1385-8C>T; p.?; 1:155958404-155958404	liver	carcinoma	Unknown
c.1385-8C>T; p.?; 1:155958404-155958404	liver	carcinoma	Unknown
c.999C>T; p.R333R; 1:155962611-155962611	liver	carcinoma	Substitution - coding silent
c.999C>T; p.R333R; 1:155962611-155962611	liver	carcinoma	Substitution - coding silent
c.2673T>A; p.H891Q; 1:155950429-155950429	liver	carcinoma	Substitution - Missense
c.563C>G; p.S188C; 1:155965065-155965065	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.264C>T; p.T88T; 1:155965756-155965756	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.303C>A; p.D101E; 1:155965717-155965717	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.839G>T; p.G280V; 1:155962985-155962985	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2579C>T; p.P860L; 1:155950869-155950869	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2779C>G; p.L927V; 1:155950323-155950323	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2289G>C; p.G763G; 1:155951159-155951159	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1207G>T; p.E403*; 1:155961838-155961838	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.641-1G>A; p.?; 1:155963184-155963184	lung; right_lower_lobe	carcinoma; adenocarcinoma	Unknown
c.2125-1G>T; p.?; 1:155951534-155951534	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1522A>G; p.K508E; 1:155957822-155957822	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1149G>T; p.E383D; 1:155961896-155961896	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1585G>T; p.D529Y; 1:155957759-155957759	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2129C>T; p.A710V; 1:155951529-155951529	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2125-1G>A; p.?; 1:155951534-155951534	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.675A>T; p.T225T; 1:155963149-155963149	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.471C>T; p.T157T; 1:155965331-155965331	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2775C>A; p.S925R; 1:155950327-155950327	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1058A>T; p.Q353L; 1:155962182-155962182	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2627G>A; p.R876Q; 1:155950475-155950475	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1857G>A; p.E619E; 1:155952671-155952671	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.641-8C>A; p.?; 1:155963191-155963191	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.396C>T; p.F132F; 1:155965406-155965406	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1110C>T; p.I370I; 1:155962130-155962130	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.861C>T; p.I287I; 1:155962963-155962963	ovary	other; neoplasm	Substitution - coding silent
c.2042A>G; p.N681S; 1:155951965-155951965	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1810G>A; p.A604T; 1:155952718-155952718	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.1624G>A; p.V542M; 1:155957720-155957720	pituitary; craniopharyngeal_duct	craniopharyngioma; adamantinomatous	Substitution - Missense
c.1282C>T; p.P428S; 1:155961763-155961763	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.714delG; p.E239fs*32; 1:155963110-155963110	prostate	carcinoma; adenocarcinoma	Deletion - Frameshift
c.700C>T; p.R234C; 1:155963124-155963124	skin	malignant_melanoma	Substitution - Missense
c.1246G>A; p.E416K; 1:155961799-155961799	skin	malignant_melanoma	Substitution - Missense
c.2263C>T; p.R755W; 1:155951185-155951185	skin	malignant_melanoma	Substitution - Missense
c.2578C>T; p.P860S; 1:155950870-155950870	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.295C>T; p.P99S; 1:155965725-155965725	skin	malignant_melanoma	Substitution - Missense
c.2575C>T; p.L859F; 1:155950873-155950873	skin	malignant_melanoma	Substitution - Missense
c.2714C>T; p.P905L; 1:155950388-155950388	skin	malignant_melanoma	Substitution - Missense
c.2149C>T; p.L717F; 1:155951509-155951509	skin	malignant_melanoma	Substitution - Missense
c.440C>T; p.S147F; 1:155965362-155965362	skin	malignant_melanoma	Substitution - Missense
c.440C>T; p.S147F; 1:155965362-155965362	skin	malignant_melanoma	Substitution - Missense
c.440C>T; p.S147F; 1:155965362-155965362	skin	malignant_melanoma	Substitution - Missense
c.1257C>A; p.N419K; 1:155961788-155961788	skin	malignant_melanoma	Substitution - Missense
c.317C>T; p.S106F; 1:155965703-155965703	skin	malignant_melanoma	Substitution - Missense
c.1281C>T; p.T427T; 1:155961764-155961764	skin	malignant_melanoma	Substitution - coding silent
c.410C>T; p.P137L; 1:155965392-155965392	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.470C>T; p.T157I; 1:155965332-155965332	skin	malignant_melanoma	Substitution - Missense
c.1070T>C; p.L357P; 1:155962170-155962170	skin	malignant_melanoma	Substitution - Missense
c.865C>T; p.R289C; 1:155962959-155962959	skin	malignant_melanoma	Substitution - Missense
c.476C>T; p.S159F; 1:155965326-155965326	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2241G>A; p.E747E; 1:155951207-155951207	skin	malignant_melanoma	Substitution - coding silent
c.372T>C; p.S124S; 1:155965648-155965648	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2305C>T; p.P769S; 1:155951143-155951143	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - Missense
c.2742C>T; p.D914D; 1:155950360-155950360	skin	malignant_melanoma	Substitution - coding silent
c.552T>G; p.F184L; 1:155965076-155965076	skin; trunk	malignant_melanoma	Substitution - Missense
c.1130C>T; p.S377F; 1:155962110-155962110	skin	malignant_melanoma	Substitution - Missense
c.1549C>T; p.P517S; 1:155957795-155957795	skin	malignant_melanoma	Substitution - Missense
c.1741C>G; p.R581G; 1:155952787-155952787	skin	malignant_melanoma	Substitution - Missense
c.1741C>G; p.R581G; 1:155952787-155952787	skin	malignant_melanoma	Substitution - Missense
c.2777G>A; p.R926H; 1:155950325-155950325	skin	malignant_melanoma	Substitution - Missense
c.2485C>T; p.R829*; 1:155950963-155950963	skin	malignant_melanoma	Substitution - Nonsense
c.2852G>A; p.G951E; 1:155947967-155947967	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2776C>T; p.R926C; 1:155950326-155950326	skin	malignant_melanoma	Substitution - Missense
c.321C>T; p.L107L; 1:155965699-155965699	skin	malignant_melanoma	Substitution - coding silent
c.2042A>G; p.N681S; 1:155951965-155951965	small_intestine	carcinoid-endocrine_tumour	Substitution - Missense
c.1810G>A; p.A604T; 1:155952718-155952718	soft_tissue; striated_muscle	rhabdomyosarcoma; alveolar	Substitution - Missense
c.2264G>A; p.R755Q; 1:155951184-155951184	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2722C>T; p.R908W; 1:155950380-155950380	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2617C>T; p.Q873*; 1:155950831-155950831	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.23G>A; p.R8H; 1:155969260-155969260	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.312G>A; p.R104R; 1:155965708-155965708	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2330C>T; p.A777V; 1:155951118-155951118	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1687C>T; p.R563W; 1:155954914-155954914	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.836C>A; p.P279H; 1:155962988-155962988	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.954C>G; p.S318R; 1:155962656-155962656	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1237C>T; p.R413C; 1:155961808-155961808	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.767A>G; p.D256G; 1:155963057-155963057	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1327C>T; p.R443C; 1:155961718-155961718	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2024G>C; p.G675A; 1:155951983-155951983	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1628G>A; p.R543H; 1:155957716-155957716	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1212T>G; p.G404G; 1:155961833-155961833	thyroid	other; neoplasm	Substitution - coding silent
c.913C>A; p.Q305K; 1:155962697-155962697	thyroid	other; neoplasm	Substitution - Missense
c.984C>T; p.Y328Y; 1:155962626-155962626	thyroid	carcinoma	Substitution - coding silent
c.984C>T; p.Y328Y; 1:155962626-155962626	thyroid	carcinoma	Substitution - coding silent
c.1597A>G; p.T533A; 1:155957747-155957747	thyroid	carcinoma	Substitution - Missense
c.858C>T; p.V286V; 1:155962966-155962966	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.858C>T; p.V286V; 1:155962966-155962966	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.1742G>A; p.R581Q; 1:155952786-155952786	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.687G>T; p.M229I; 1:155963137-155963137	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1041C>T; p.L347L; 1:155962199-155962199	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1900+1G>T; p.?; 1:155952627-155952627	urinary_tract; bladder	carcinoma	Unknown
c.894C>G; p.F298L; 1:155962716-155962716	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1957C>T; p.R653*; 1:155952179-155952179	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.269G>A; p.R90Q; 1:155965751-155965751	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.269G>A; p.R90Q; 1:155965751-155965751	urinary_tract; bladder	carcinoma	Substitution - Missense

Oncogene database

COSMIC confirmed somatic mutation [Top]

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