Entrez Gene

Basic Information
Gene ID	8660
Name	IRS2
Synonymous	insulin receptor substrate 2;IRS2;insulin receptor substrate 2
Definition	-
Position	13q34
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.2492G>T; p.G831V; 13:109783562-109783562	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.2448T>C; p.C816C; 13:109783606-109783606	breast	carcinoma	Substitution - coding silent
c.2487C>T; p.P829P; 13:109783567-109783567	breast	carcinoma	Substitution - coding silent
c.609_610delGC; p.K203fs*102; 13:109785444-109785445	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.2283G>A; p.L761L; 13:109783771-109783771	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.518G>C; p.G173A; 13:109785536-109785536	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2818G>A; p.A940T; 13:109783236-109783236	kidney	carcinoma; renal_cell_carcinoma	Substitution - Missense
c.3481G>A; p.V1161M; 13:109782573-109782573	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.3099A>G; p.P1033P; 13:109782955-109782955	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.3263C>T; p.A1088V; 13:109782791-109782791	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3263C>T; p.A1088V; 13:109782791-109782791	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2411G>T; p.S804I; 13:109783643-109783643	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3688G>A; p.G1230S; 13:109782366-109782366	large_intestine; colon	carcinoma	Substitution - Missense
c.1908G>A; p.E636E; 13:109784146-109784146	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3742C>T; p.Q1248*; 13:109782312-109782312	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.3397G>A; p.A1133T; 13:109782657-109782657	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3027G>T; p.E1009D; 13:109783027-109783027	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3725A>T; p.E1242V; 13:109782329-109782329	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.3701G>A; p.S1234N; 13:109782353-109782353	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1534G>A; p.A512T; 13:109784520-109784520	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2518G>C; p.E840Q; 13:109783536-109783536	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3564C>T; p.G1188G; 13:109782490-109782490	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.878C>T; p.A293V; 13:109785176-109785176	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1602C>T; p.G534G; 13:109784452-109784452	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3523G>A; p.A1175T; 13:109782531-109782531	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3396C>T; p.G1132G; 13:109782658-109782658	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3396C>T; p.G1132G; 13:109782658-109782658	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3396C>T; p.G1132G; 13:109782658-109782658	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1966A>G; p.M656V; 13:109784088-109784088	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1966A>G; p.M656V; 13:109784088-109784088	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3170G>A; p.G1057D; 13:109782884-109782884	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3108_3109insCCG; p.P1036_A1037insP; 13:109782945-109782946	large_intestine; rectum	carcinoma; adenocarcinoma	Insertion - In frame
c.3108_3109insCCG; p.P1036_A1037insP; 13:109782945-109782946	large_intestine; rectum	carcinoma; adenocarcinoma	Insertion - In frame
c.2308T>C; p.S770P; 13:109783746-109783746	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1563C>T; p.P521P; 13:109784491-109784491	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1688C>T; p.A563V; 13:109784366-109784366	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1688C>T; p.A563V; 13:109784366-109784366	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3819G>A; p.P1273P; 13:109782235-109782235	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2370C>T; p.P790P; 13:109783684-109783684	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2902G>A; p.D968N; 13:109783152-109783152	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1575G>A; p.A525A; 13:109784479-109784479	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1617C>A; p.F539L; 13:109784437-109784437	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2995G>A; p.V999M; 13:109783059-109783059	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3261C>T; p.I1087I; 13:109782793-109782793	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3261C>T; p.I1087I; 13:109782793-109782793	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3261C>T; p.I1087I; 13:109782793-109782793	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3249G>T; p.P1083P; 13:109782805-109782805	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2826G>A; p.A942A; 13:109783228-109783228	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2826G>A; p.A942A; 13:109783228-109783228	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2448T>C; p.C816C; 13:109783606-109783606	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.3352G>A; p.E1118K; 13:109782702-109782702	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2494C>T; p.R832C; 13:109783560-109783560	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2392G>A; p.V798I; 13:109783662-109783662	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2392G>A; p.V798I; 13:109783662-109783662	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2392G>A; p.V798I; 13:109783662-109783662	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2392G>A; p.V798I; 13:109783662-109783662	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2487C>T; p.P829P; 13:109783567-109783567	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2487C>T; p.P829P; 13:109783567-109783567	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2169C>T; p.S723S; 13:109783885-109783885	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2169C>T; p.S723S; 13:109783885-109783885	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2162C>T; p.P721L; 13:109783892-109783892	liver	carcinoma	Substitution - Missense
c.3895G>T; p.V1299F; 13:109782159-109782159	liver	carcinoma	Substitution - Missense
c.3895G>T; p.V1299F; 13:109782159-109782159	liver	carcinoma	Substitution - Missense
c.2632G>C; p.E878Q; 13:109783422-109783422	liver	carcinoma	Substitution - Missense
c.2632G>C; p.E878Q; 13:109783422-109783422	liver	carcinoma	Substitution - Missense
c.1756C>A; p.P586T; 13:109784298-109784298	liver	carcinoma	Substitution - Missense
c.1756C>A; p.P586T; 13:109784298-109784298	liver	carcinoma	Substitution - Missense
c.1756C>A; p.P586T; 13:109784298-109784298	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2448T>C; p.C816C; 13:109783606-109783606	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.369C>G; p.A123A; 13:109785685-109785685	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.3531G>A; p.V1177V; 13:109782523-109782523	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.877G>T; p.A293S; 13:109785177-109785177	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.912T>A; p.S304R; 13:109785142-109785142	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.750C>A; p.H250Q; 13:109785304-109785304	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3523G>T; p.A1175S; 13:109782531-109782531	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3066C>T; p.S1022S; 13:109782988-109782988	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.554G>T; p.G185V; 13:109785500-109785500	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.652C>G; p.R218G; 13:109785402-109785402	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3970G>T; p.D1324Y; 13:109782084-109782084	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.739C>T; p.R247C; 13:109785315-109785315	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3244A>C; p.T1082P; 13:109782810-109782810	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.3753C>G; p.L1251L; 13:109782301-109782301	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3736G>T; p.G1246C; 13:109782318-109782318	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3212A>G; p.D1071G; 13:109782842-109782842	meninges	meningioma; haemangiopericytic	Substitution - Missense
c.307A>C; p.K103Q; 13:109785747-109785747	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.3632C>T; p.P1211L; 13:109782422-109782422	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.3273G>A; p.P1091P; 13:109782781-109782781	oesophagus	carcinoma	Substitution - coding silent
c.1842G>A; p.P614P; 13:109784212-109784212	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2591C>T; p.P864L; 13:109783463-109783463	ovary	other; neoplasm	Substitution - Missense
c.3857G>T; p.R1286L; 13:109782197-109782197	ovary	other; neoplasm	Substitution - Missense
c.710C>G; p.S237W; 13:109785344-109785344	ovary	other; neoplasm	Substitution - Missense
c.710C>G; p.S237W; 13:109785344-109785344	ovary	other; neoplasm	Substitution - Missense
c.3918C>G; p.C1306W; 13:109782136-109782136	pancreas	carcinoma	Substitution - Missense
c.3905C>A; p.T1302N; 13:109782149-109782149	pancreas	carcinoma	Substitution - Missense
c.3272C>T; p.P1091L; 13:109782782-109782782	pancreas	carcinoma	Substitution - Missense
c.2719T>A; p.Y907N; 13:109783335-109783335	pancreas	carcinoma	Substitution - Missense
c.3733G>T; p.A1245S; 13:109782321-109782321	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1973C>A; p.P658H; 13:109784081-109784081	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.3687C>T; p.V1229V; 13:109782367-109782367	prostate	carcinoma	Substitution - coding silent
c.2056C>T; p.P686S; 13:109783998-109783998	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2339C>T; p.P780L; 13:109783715-109783715	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3096G>A; p.P1032P; 13:109782958-109782958	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2810C>T; p.P937L; 13:109783244-109783244	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2375G>A; p.G792E; 13:109783679-109783679	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3162G>A; p.Q1054Q; 13:109782892-109782892	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.958C>T; p.P320S; 13:109785096-109785096	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3135C>T; p.P1045P; 13:109782919-109782919	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2210C>T; p.P737L; 13:109783844-109783844	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1891G>A; p.D631N; 13:109784163-109784163	skin	malignant_melanoma	Substitution - Missense
c.3988T>C; p.L1330L; 13:109782066-109782066	skin	malignant_melanoma	Substitution - coding silent
c.910A>C; p.S304R; 13:109785144-109785144	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4017+5C>T; p.?; 13:109756299-109756299	skin	malignant_melanoma	Unknown
c.3886G>A; p.A1296T; 13:109782168-109782168	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1661G>A; p.R554H; 13:109784393-109784393	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3790C>T; p.L1264L; 13:109782264-109782264	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.3676G>A; p.G1226R; 13:109782378-109782378	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2102_2104delCCG; p.A701delA; 13:109783950-109783952	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - In frame
c.1689G>A; p.A563A; 13:109784365-109784365	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.3895G>A; p.V1299I; 13:109782159-109782159	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3629C>T; p.A1210V; 13:109782425-109782425	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3984C>T; p.H1328H; 13:109782070-109782070	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1715G>A; p.R572H; 13:109784339-109784339	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3160C>A; p.Q1054K; 13:109782894-109782894	thyroid	other; neoplasm	Substitution - Missense
c.1397A>C; p.H466P; 13:109784657-109784657	thyroid	other; neoplasm	Substitution - Missense
c.3170G>A; p.G1057D; 13:109782884-109782884	thyroid	other; neoplasm	Substitution - Missense
c.341C>T; p.A114V; 13:109785713-109785713	thyroid	carcinoma	Substitution - Missense
c.2487C>T; p.P829P; 13:109783567-109783567	thyroid	other; neoplasm	Substitution - coding silent
c.2487C>T; p.P829P; 13:109783567-109783567	thyroid	other; neoplasm	Substitution - coding silent
c.2487C>T; p.P829P; 13:109783567-109783567	thyroid	other; neoplasm	Substitution - coding silent
c.3733G>T; p.A1245S; 13:109782321-109782321	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3733G>T; p.A1245S; 13:109782321-109782321	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3733G>T; p.A1245S; 13:109782321-109782321	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2788_2789insC; p.R930fs*61; 13:109783265-109783266	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1820G>A; p.G607D; 13:109784234-109784234	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.599T>G; p.V200G; 13:109785455-109785455	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.599T>G; p.V200G; 13:109785455-109785455	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.599T>G; p.V200G; 13:109785455-109785455	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.599T>G; p.V200G; 13:109785455-109785455	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.599T>G; p.V200G; 13:109785455-109785455	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.599T>G; p.V200G; 13:109785455-109785455	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.599T>G; p.V200G; 13:109785455-109785455	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.599T>G; p.V200G; 13:109785455-109785455	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.599T>G; p.V200G; 13:109785455-109785455	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.599T>G; p.V200G; 13:109785455-109785455	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.599T>G; p.V200G; 13:109785455-109785455	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.599T>G; p.V200G; 13:109785455-109785455	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.599T>G; p.V200G; 13:109785455-109785455	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.599T>G; p.V200G; 13:109785455-109785455	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.599T>G; p.V200G; 13:109785455-109785455	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.599T>G; p.V200G; 13:109785455-109785455	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.599T>G; p.V200G; 13:109785455-109785455	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.599T>G; p.V200G; 13:109785455-109785455	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.275T>G; p.V92G; 13:109785779-109785779	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.275T>G; p.V92G; 13:109785779-109785779	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.275T>G; p.V92G; 13:109785779-109785779	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.275T>G; p.V92G; 13:109785779-109785779	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.275T>G; p.V92G; 13:109785779-109785779	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.275T>G; p.V92G; 13:109785779-109785779	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.275T>G; p.V92G; 13:109785779-109785779	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.275T>G; p.V92G; 13:109785779-109785779	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.275T>G; p.V92G; 13:109785779-109785779	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3733G>T; p.A1245S; 13:109782321-109782321	urinary_tract; bladder	carcinoma	Substitution - Missense
c.855G>T; p.E285D; 13:109785199-109785199	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.855G>T; p.E285D; 13:109785199-109785199	urinary_tract; bladder	carcinoma	Substitution - Missense
c.3039G>A; p.P1013P; 13:109783015-109783015	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1897G>A; p.G633R; 13:109784157-109784157	urinary_tract; bladder	carcinoma	Substitution - Missense
c.3795A>C; p.P1265P; 13:109782259-109782259	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.3795A>C; p.P1265P; 13:109782259-109782259	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.3795A>C; p.P1265P; 13:109782259-109782259	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.3334G>T; p.E1112*; 13:109782720-109782720	urinary_tract; bladder	carcinoma	Substitution - Nonsense

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