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Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

8493

Name

PPM1D

Synonymous

protein phosphatase, Mg2+/Mn2+ dependent, 1D;PPM1D;protein phosphatase, Mg2+/Mn2+ dependent, 1D

Definition

protein phosphatase 1D|protein phosphatase 1D magnesium-dependent, delta isoform|protein phosphatase 2C delta isoform|protein phosphatase Wip1|wild-type p53-induced phosphatase 1

Position

17q23.2

Gene Type

protein-coding

COSMIC confirmed somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1434C>A; p.C478*; 17:60663168-60663168

 breastcarcinomaSubstitution - Nonsense

c.1669C>A; p.R557R; 17:60663403-60663403

 breastcarcinomaSubstitution - coding silent

c.865G>A; p.V289M; 17:60647930-60647930

 breastcarcinomaSubstitution - Missense

c.1179G>C; p.L393L; 17:60656760-60656760

 breastcarcinomaSubstitution - coding silent

c.1403C>A; p.S468*; 17:60663137-60663137

 central_nervous_system; brainstemglioma; astrocytoma_Grade_IVSubstitution - Nonsense

c.1286delG; p.V430fs*1; 17:60663020-60663020

 central_nervous_system; brainstemglioma; astrocytoma_Grade_IIDeletion - Frameshift

c.1618G>T; p.E540*; 17:60663352-60663352

 central_nervous_system; brainstemglioma; oligoastrocytoma_Grade_IIISubstitution - Nonsense

c.1414G>T; p.E472*; 17:60663148-60663148

 central_nervous_system; brainglioma; oligoastrocytoma_Grade_IIISubstitution - Nonsense

c.1547C>G; p.S516*; 17:60663281-60663281

 central_nervous_system; medullaglioma; oligodendroglioma_Grade_IIISubstitution - Nonsense

c.1538T>A; p.L513*; 17:60663272-60663272

 central_nervous_system; brainstemglioma; astrocytoma_Grade_IVSubstitution - Nonsense

c.1449delT; p.L484fs*1; 17:60663183-60663183

 central_nervous_system; brainstemglioma; astrocytoma_Grade_IVDeletion - Frameshift

c.1434C>A; p.C478*; 17:60663168-60663168

 central_nervous_system; brainstemglioma; astrocytoma_Grade_IIISubstitution - Nonsense

c.1344delT; p.L450fs*1; 17:60663078-60663078

 central_nervous_system; brainstemglioma; astrocytoma_Grade_IVDeletion - Frameshift

c.324C>T; p.G108G; 17:60600738-60600738

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.1282delC; p.P428fs*3; 17:60663016-60663016

 central_nervous_system; brainstemglioma; astrocytoma_Grade_IVDeletion - Frameshift

c.759C>T; p.H253H; 17:60633910-60633910

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.1573G>T; p.E525*; 17:60663307-60663307

 central_nervous_system; brainstemglioma; astrocytoma_Grade_IISubstitution - Nonsense

c.945A>T; p.G315G; 17:60648010-60648010

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.1286G>T; p.R429M; 17:60663020-60663020

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.539T>C; p.I180T; 17:60623587-60623587

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1715G>A; p.R572Q; 17:60663449-60663449

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.685G>A; p.E229K; 17:60623733-60623733

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1573G>T; p.E525*; 17:60663307-60663307

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1573G>T; p.E525*; 17:60663307-60663307

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1573G>T; p.E525*; 17:60663307-60663307

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1384C>T; p.Q462*; 17:60663118-60663118

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1614A>G; p.L538L; 17:60663348-60663348

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.14A>G; p.Y5C; 17:60600428-60600428

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1219T>C; p.C407R; 17:60656800-60656800

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1275T>C; p.D425D; 17:60663009-60663009

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1719G>A; p.K573K; 17:60663453-60663453

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.863T>G; p.F288C; 17:60647928-60647928

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1655G>A; p.R552Q; 17:60663389-60663389

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1654C>T; p.R552*; 17:60663388-60663388

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.460T>A; p.W154R; 17:60600874-60600874

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.460T>A; p.W154R; 17:60600874-60600874

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.40G>A; p.D14N; 17:60600454-60600454

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemiaSubstitution - Missense

c.262C>T; p.P88S; 17:60600676-60600676

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.1654C>T; p.R552*; 17:60663388-60663388

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; polycythaemia_veraSubstitution - Nonsense

c.555G>A; p.M185I; 17:60623603-60623603

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.532G>A; p.V178I; 17:60623580-60623580

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1351G>T; p.E451*; 17:60663085-60663085

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Nonsense

c.1672A>T; p.S558C; 17:60663406-60663406

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1742G>A; p.R581Q; 17:60663476-60663476

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.1684C>A; p.Q562K; 17:60663418-60663418

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1322G>A; p.R441H; 17:60663056-60663056

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1041_1042insA; p.M349fs*19; 17:60656622-60656623

 large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.743G>A; p.R248Q; 17:60633894-60633894

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.83T>C; p.V28A; 17:60600497-60600497

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1442C>T; p.A481V; 17:60663176-60663176

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.958A>C; p.I320L; 17:60648023-60648023

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1344delT; p.L450fs*1; 17:60663078-60663078

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.1344delT; p.L450fs*1; 17:60663078-60663078

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.1344delT; p.L450fs*1; 17:60663078-60663078

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.1536T>A; p.N512K; 17:60663270-60663270

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1373G>A; p.R458Q; 17:60663107-60663107

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.680G>A; p.R227Q; 17:60623728-60623728

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1583G>T; p.R528I; 17:60663317-60663317

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1528_1529insA; p.N512fs*16; 17:60663262-60663263

 large_intestinecarcinoma; adenocarcinomaInsertion - Frameshift

c.1255G>A; p.V419I; 17:60656836-60656836

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1529delA; p.N512fs*2; 17:60663263-60663263

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.1529delA; p.N512fs*2; 17:60663263-60663263

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.1529delA; p.N512fs*2; 17:60663263-60663263

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.1573G>T; p.E525*; 17:60663307-60663307

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1741C>T; p.R581*; 17:60663475-60663475

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.1578T>G; p.I526M; 17:60663312-60663312

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.378G>A; p.K126K; 17:60600792-60600792

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.568G>A; p.V190I; 17:60623616-60623616

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1321C>T; p.R441C; 17:60663055-60663055

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1321C>T; p.R441C; 17:60663055-60663055

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1343A>G; p.N448S; 17:60663077-60663077

 large_intestine; colonNSSubstitution - Missense

c.274T>C; p.C92R; 17:60600688-60600688

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.861A>C; p.E287D; 17:60647926-60647926

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.7G>A; p.G3R; 17:60600421-60600421

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1256T>G; p.V419G; 17:60656837-60656837

 livercarcinomaSubstitution - Missense

c.1256T>G; p.V419G; 17:60656837-60656837

 livercarcinomaSubstitution - Missense

c.901C>A; p.L301I; 17:60647966-60647966

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.727C>T; p.R243C; 17:60633878-60633878

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.538A>G; p.I180V; 17:60623586-60623586

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1318G>T; p.V440F; 17:60663052-60663052

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.923A>T; p.Y308F; 17:60647988-60647988

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.788T>C; p.I263T; 17:60633939-60633939

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.418G>T; p.A140S; 17:60600832-60600832

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1543A>G; p.M515V; 17:60663277-60663277

 oesophaguscarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1707C>G; p.T569T; 17:60663441-60663441

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.1741C>T; p.R581*; 17:60663475-60663475

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.1167T>C; p.D389D; 17:60656748-60656748

 pancreascarcinomaSubstitution - coding silent

c.1167T>C; p.D389D; 17:60656748-60656748

 pancreascarcinomaSubstitution - coding silent

c.1167T>C; p.D389D; 17:60656748-60656748

 pancreascarcinomaSubstitution - coding silent

c.191C>T; p.S64L; 17:60600605-60600605

 pancreascarcinomaSubstitution - Missense

c.1434C>T; p.C478C; 17:60663168-60663168

 prostatecarcinomaSubstitution - coding silent

c.767C>A; p.P256H; 17:60633918-60633918

 prostateadenomaSubstitution - Missense

c.474G>T; p.A158A; 17:60623522-60623522

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.1557C>T; p.G519G; 17:60663291-60663291

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1339G>A; p.E447K; 17:60663073-60663073

 skin; scalpcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1442C>T; p.A481V; 17:60663176-60663176

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1569C>T; p.A523A; 17:60663303-60663303

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.612G>A; p.K204K; 17:60623660-60623660

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.607C>T; p.P203S; 17:60623655-60623655

 skinmalignant_melanomaSubstitution - Missense

c.1000G>A; p.E334K; 17:60648065-60648065

 skinmalignant_melanomaSubstitution - Missense

c.411G>A; p.K137K; 17:60600825-60600825

 skinmalignant_melanomaSubstitution - coding silent

c.1232C>T; p.P411L; 17:60656813-60656813

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1528C>T; p.Q510*; 17:60663262-60663262

 skinmalignant_melanomaSubstitution - Nonsense

c.502C>T; p.P168S; 17:60623550-60623550

 skinmalignant_melanomaSubstitution - Missense

c.1199C>T; p.S400F; 17:60656780-60656780

 skinmalignant_melanomaSubstitution - Missense

c.515G>A; p.G172E; 17:60623563-60623563

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1337C>A; p.S446*; 17:60663071-60663071

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.1756G>A; p.G586S; 17:60663490-60663490

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1794C>T; p.H598H; 17:60663528-60663528

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.652A>G; p.K218E; 17:60623700-60623700

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1522A>G; p.M508V; 17:60663256-60663256

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1319T>C; p.V440A; 17:60663053-60663053

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1773A>G; p.G591G; 17:60663507-60663507

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1655G>A; p.R552Q; 17:60663389-60663389

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1109C>T; p.A370V; 17:60656690-60656690

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1408G>A; p.D470N; 17:60663142-60663142

 thyroidcarcinomaSubstitution - Missense

c.1434C>A; p.C478*; 17:60663168-60663168

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.1434C>A; p.C478*; 17:60663168-60663168

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.1528_1529insA; p.N512fs*16; 17:60663262-60663263

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaInsertion - Frameshift

c.1372C>T; p.R458*; 17:60663106-60663106

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.559G>C; p.V187L; 17:60623607-60623607

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1434C>A; p.C478*; 17:60663168-60663168

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Nonsense

c.1434C>A; p.C478*; 17:60663168-60663168

 urinary_tract; bladdercarcinomaSubstitution - Nonsense