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Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

7306

Name

TYRP1

Synonymous

tyrosinase-related protein 1;TYRP1;tyrosinase-related protein 1

Definition

5,6-dihydroxyindole-2-carboxylic acid oxidase|DHICA oxidase|catalase B|glycoprotein 75|melanoma antigen gp75

Position

9p23

Gene Type

protein-coding

COSMIC confirmed somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.125G>A; p.C42Y; 9:12694121-12694121

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.858G>A; p.W286*; 9:12698600-12698600

 breastcarcinomaSubstitution - Nonsense

c.1245G>A; p.L415L; 9:12704689-12704689

 breastcarcinomaSubstitution - coding silent

c.680A>C; p.H227P; 9:12695809-12695809

 breastcarcinomaSubstitution - Missense

c.1054_1057delACAA; p.N353fs*31; 9:12702411-12702414

 breastcarcinomaDeletion - Frameshift

c.1015G>A; p.V339I; 9:12702372-12702372

 breastcarcinomaSubstitution - Missense

c.1308A>G; p.R436R; 9:12708043-12708043

 breastcarcinomaSubstitution - coding silent

c.1017T>G; p.V339V; 9:12702374-12702374

 breastcarcinomaSubstitution - coding silent

c.607G>C; p.V203L; 9:12695736-12695736

 breastcarcinomaSubstitution - Missense

c.1550A>T; p.D517V; 9:12709118-12709118

 breastcarcinomaSubstitution - Missense

c.1294A>G; p.I432V; 9:12708029-12708029

 central_nervous_system; braingliomaSubstitution - Missense

c.1054_1057delACAA; p.N353fs*31; 9:12702411-12702414

 central_nervous_system; brainglioma; astrocytoma_Grade_IVDeletion - Frameshift

c.489C>T; p.T163T; 9:12695618-12695618

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1054_1057delACAA; p.N353fs*31; 9:12702411-12702414

 endometriumcarcinoma; endometrioid_carcinomaDeletion - Frameshift

c.1455C>T; p.G485G; 9:12709023-12709023

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1399C>A; p.Q467K; 9:12708134-12708134

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1289C>T; p.A430V; 9:12708024-12708024

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.771C>A; p.V257V; 9:12698513-12698513

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1567G>A; p.A523T; 9:12709135-12709135

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.898G>T; p.G300*; 9:12698640-12698640

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.819T>C; p.D273D; 9:12698561-12698561

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1037C>A; p.P346H; 9:12702394-12702394

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1425A>G; p.V475V; 9:12708993-12708993

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.758C>G; p.T253R; 9:12698500-12698500

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.205A>G; p.T69A; 9:12694201-12694201

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1098G>T; p.T366T; 9:12704542-12704542

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - coding silent

c.1067G>C; p.R356P; 9:12702424-12702424

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.1409-4A>C; p.?; 9:12708973-12708973

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaUnknown

c.1043A>T; p.Y348F; 9:12702400-12702400

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - Missense

c.1043A>T; p.Y348F; 9:12702400-12702400

 haematopoietic_and_lymphoid_tissue; lymph_nodelymphoid_neoplasm; follicular_lymphomaSubstitution - Missense

c.727T>A; p.S243T; 9:12698469-12698469

 haematopoietic_and_lymphoid_tissue; small_intestinelymphoid_neoplasm; enteropathy_type_T_cell_lymphomaSubstitution - Missense

c.6T>A; p.S2R; 9:12694002-12694002

 kidneyother; neoplasmSubstitution - Missense

c.1348A>G; p.T450A; 9:12708083-12708083

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.343C>G; p.P115A; 9:12694339-12694339

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.771C>T; p.V257V; 9:12698513-12698513

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.1230C>A; p.V410V; 9:12704674-12704674

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.259C>A; p.R87R; 9:12694255-12694255

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1167A>G; p.G389G; 9:12704611-12704611

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.315C>A; p.F105L; 9:12694311-12694311

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.282C>A; p.F94L; 9:12694278-12694278

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.293C>T; p.T98I; 9:12694289-12694289

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1504C>T; p.R502C; 9:12709072-12709072

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.125G>A; p.C42Y; 9:12694121-12694121

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1449_1450insGTT; p.V484_G485insV; 9:12709017-12709018

 large_intestinecarcinoma; adenocarcinomaInsertion - In frame

c.1066C>T; p.R356*; 9:12702423-12702423

 large_intestinecarcinoma; adenocarcinomaSubstitution - Nonsense

c.659T>C; p.F220S; 9:12695788-12695788

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1120C>T; p.R374*; 9:12704564-12704564

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1477A>G; p.I493V; 9:12709045-12709045

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1121G>A; p.R374Q; 9:12704565-12704565

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.446A>G; p.D149G; 9:12695575-12695575

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1430A>C; p.E477A; 9:12708998-12708998

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.567T>G; p.V189V; 9:12695696-12695696

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.891T>C; p.D297D; 9:12698633-12698633

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.565G>T; p.V189F; 9:12695694-12695694

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.227G>T; p.S76I; 9:12694223-12694223

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.227G>T; p.S76I; 9:12694223-12694223

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.227G>T; p.S76I; 9:12694223-12694223

 large_intestine; coloncarcinomaSubstitution - Missense

c.227G>T; p.S76I; 9:12694223-12694223

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.218G>A; p.R73Q; 9:12694214-12694214

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1456G>A; p.A486T; 9:12709024-12709024

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.28G>T; p.G10C; 9:12694024-12694024

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.729T>C; p.S243S; 9:12698471-12698471

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.397C>A; p.L133I; 9:12695526-12695526

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.688C>A; p.R230S; 9:12695817-12695817

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.688C>A; p.R230S; 9:12695817-12695817

 livercarcinomaSubstitution - Missense

c.214T>A; p.S72T; 9:12694210-12694210

 livercarcinomaSubstitution - Missense

c.61C>T; p.Q21*; 9:12694057-12694057

 livercarcinomaSubstitution - Nonsense

c.61C>T; p.Q21*; 9:12694057-12694057

 livercarcinomaSubstitution - Nonsense

c.61C>T; p.Q21*; 9:12694057-12694057

 livercarcinomaSubstitution - Nonsense

c.903A>G; p.T301T; 9:12698645-12698645

 livercarcinomaSubstitution - coding silent

c.903A>G; p.T301T; 9:12698645-12698645

 livercarcinomaSubstitution - coding silent

c.1033C>A; p.P345T; 9:12702390-12702390

 livercarcinomaSubstitution - Missense

c.1153A>G; p.N385D; 9:12704597-12704597

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.18C>T; p.L6L; 9:12694014-12694014

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.70G>T; p.A24S; 9:12694066-12694066

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.70G>T; p.A24S; 9:12694066-12694066

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.1393G>A; p.E465K; 9:12708128-12708128

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.363C>G; p.A121A; 9:12694359-12694359

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1381G>T; p.G461*; 9:12708116-12708116

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.585A>C; p.S195S; 9:12695714-12695714

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.625G>T; p.G209C; 9:12695754-12695754

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1162G>T; p.G388W; 9:12704606-12704606

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1054_1057delACAA; p.N353fs*31; 9:12702411-12702414

 lungcarcinoma; small_cell_carcinomaDeletion - Frameshift

c.306C>T; p.N102N; 9:12694302-12694302

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1550A>G; p.D517G; 9:12709118-12709118

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.92delC; p.T32fs*5; 9:12694088-12694088

 lungcarcinoma; adenocarcinomaDeletion - Frameshift

c.1438G>T; p.A480S; 9:12709006-12709006

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1609G>T; p.V537F; 9:12709177-12709177

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.527C>A; p.T176K; 9:12695656-12695656

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.389G>T; p.R130M; 9:12695518-12695518

 lung; middle_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.389G>T; p.R130M; 9:12695518-12695518

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.135G>T; p.L45L; 9:12694131-12694131

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.925G>C; p.G309R; 9:12702282-12702282

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1054_1057delACAA; p.N353fs*31; 9:12702411-12702414

 NSNSDeletion - Frameshift

c.1594C>T; p.P532S; 9:12709162-12709162

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.1358T>C; p.F453S; 9:12708093-12708093

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.231T>C; p.P77P; 9:12694227-12694227

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.164G>A; p.R55H; 9:12694160-12694160

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.760G>T; p.G254W; 9:12698502-12698502

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.601C>T; p.L201F; 9:12695730-12695730

 skinmalignant_melanomaSubstitution - Missense

c.392G>A; p.R131K; 9:12695521-12695521

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.455A>G; p.K152R; 9:12695584-12695584

 skinmalignant_melanomaSubstitution - Missense

c.1397T>C; p.I466T; 9:12708132-12708132

 skinmalignant_melanomaSubstitution - Missense

c.420A>C; p.E140D; 9:12695549-12695549

 skinmalignant_melanomaSubstitution - Missense

c.238C>T; p.P80S; 9:12694234-12694234

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.410G>A; p.S137N; 9:12695539-12695539

 skinmalignant_melanomaSubstitution - Missense

c.251G>A; p.R84K; 9:12694247-12694247

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.875C>T; p.S292F; 9:12698617-12698617

 skinmalignant_melanomaSubstitution - Missense

c.244G>A; p.D82N; 9:12694240-12694240

 skinmalignant_melanomaSubstitution - Missense

c.21C>T; p.L7L; 9:12694017-12694017

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.886T>G; p.Y296D; 9:12698628-12698628

 skinmalignant_melanomaSubstitution - Missense

c.10C>G; p.P4A; 9:12694006-12694006

 soft_tissue; striated_musclerhabdomyosarcoma; embryonalSubstitution - Missense

c.786G>A; p.T262T; 9:12698528-12698528

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.408A>G; p.L136L; 9:12695537-12695537

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.164G>A; p.R55H; 9:12694160-12694160

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.17T>A; p.L6H; 9:12694013-12694013

 stomachcarcinoma; adenocarcinomaSubstitution - Missense