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Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

7088

Name

TLE1

Synonymous

transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila);TLE1;transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)

Definition

enhancer of split groucho-like protein 1|transducin-like enhancer protein 1

Position

9q21.32

Gene Type

protein-coding

COSMIC confirmed somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.225G>T; p.M75I; 9:81685685-81685685

 adrenal_gland; adrenal_glandadrenal_cortical_carcinoma; functioningSubstitution - Missense

c.1464C>G; p.C488W; 9:81593142-81593142

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.2230_2234delAGCTG; p.S744fs*1; 9:81584277-81584281

 biliary_tract; bile_ductcarcinoma; adenocarcinomaDeletion - Frameshift

c.1212A>G; p.A404A; 9:81611811-81611811

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.1830G>T; p.R610S; 9:81587828-81587828

 breastcarcinomaSubstitution - Missense

c.1846A>G; p.T616A; 9:81587812-81587812

 breastcarcinomaSubstitution - Missense

c.1852G>C; p.G618R; 9:81587806-81587806

 breastcarcinomaSubstitution - Missense

c.686T>G; p.V229G; 9:81620466-81620466

 breastcarcinomaSubstitution - Missense

c.2004C>T; p.T668T; 9:81585629-81585629

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.2004C>T; p.T668T; 9:81585629-81585629

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.1980C>A; p.I660I; 9:81585653-81585653

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.579_582delCAGA; p.D193fs*15; 9:81633360-81633363

 endometriumcarcinoma; endometrioid_carcinomaDeletion - Frameshift

c.2176C>T; p.R726W; 9:81584477-81584477

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1917_1937del21; p.V640_R646delVRSWDLR; 9:81587721-81587741

 endometriumcarcinoma; endometrioid_carcinomaDeletion - In frame

c.1707G>T; p.E569D; 9:81590927-81590927

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1852G>A; p.G618R; 9:81587806-81587806

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1898C>T; p.T633M; 9:81587760-81587760

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.907G>T; p.E303*; 9:81615993-81615993

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.907G>T; p.E303*; 9:81615993-81615993

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.2299G>T; p.E767*; 9:81584212-81584212

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.623_624insTT; p.R209fs*1; 9:81620528-81620529

 endometriumcarcinoma; endometrioid_carcinomaInsertion - Frameshift

c.2164_2166delCTC; p.L722delL; 9:81584487-81584489

 endometriumcarcinoma; endometrioid_carcinomaDeletion - In frame

c.1938C>T; p.R646R; 9:81587720-81587720

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.829C>T; p.R277C; 9:81616071-81616071

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1225G>A; p.A409T; 9:81611798-81611798

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1600C>T; p.R534C; 9:81591034-81591034

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1899G>T; p.T633T; 9:81587759-81587759

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1117G>T; p.G373W; 9:81611906-81611906

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.2183_2184insT; p.Y729fs*16; 9:81584469-81584470

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaInsertion - Frameshift

c.1062G>A; p.A354A; 9:81613378-81613378

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemiaSubstitution - coding silent

c.63T>C; p.T21T; 9:81687396-81687396

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.2119G>A; p.A707T; 9:81585514-81585514

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1726G>A; p.A576T; 9:81590908-81590908

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.304C>G; p.Q102E; 9:81652282-81652282

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.357G>C; p.L119F; 9:81652229-81652229

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2100C>T; p.C700C; 9:81585533-81585533

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.468G>A; p.P156P; 9:81634206-81634206

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1660T>G; p.L554V; 9:81590974-81590974

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1326G>A; p.G442G; 9:81610225-81610225

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1679C>T; p.A560V; 9:81590955-81590955

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.119A>G; p.Y40C; 9:81687340-81687340

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1324G>A; p.G442R; 9:81610227-81610227

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1852G>C; p.G618R; 9:81587806-81587806

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1274delC; p.P425fs*3; 9:81610277-81610277

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.1215C>A; p.A405A; 9:81611808-81611808

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1465G>A; p.A489T; 9:81593141-81593141

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1741G>A; p.A581T; 9:81590893-81590893

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1741G>A; p.A581T; 9:81590893-81590893

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1741G>A; p.A581T; 9:81590893-81590893

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1407C>T; p.P469P; 9:81593199-81593199

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.109C>A; p.Q37K; 9:81687350-81687350

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1690C>T; p.P564S; 9:81590944-81590944

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.997G>A; p.A333T; 9:81613443-81613443

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1593T>C; p.N531N; 9:81591041-81591041

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1165G>A; p.A389T; 9:81611858-81611858

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.234+2T>C; p.?; 9:81685674-81685674

 large_intestine; caecumcarcinoma; adenocarcinomaUnknown

c.1680G>A; p.A560A; 9:81590954-81590954

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1852G>T; p.G618*; 9:81587806-81587806

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.1693C>T; p.R565C; 9:81590941-81590941

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1693C>T; p.R565C; 9:81590941-81590941

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.195T>C; p.Y65Y; 9:81685715-81685715

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.2085C>T; p.H695H; 9:81585548-81585548

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1291A>G; p.T431A; 9:81610260-81610260

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1595A>C; p.Y532S; 9:81591039-81591039

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.1239C>T; p.Y413Y; 9:81611784-81611784

 livercarcinomaSubstitution - coding silent

c.1854A>T; p.G618G; 9:81587804-81587804

 livercarcinomaSubstitution - coding silent

c.1854A>T; p.G618G; 9:81587804-81587804

 livercarcinomaSubstitution - coding silent

c.1527C>G; p.V509V; 9:81593079-81593079

 livercarcinomaSubstitution - coding silent

c.1402G>T; p.G468*; 9:81593204-81593204

 livercarcinomaSubstitution - Nonsense

c.1390G>A; p.D464N; 9:81593216-81593216

 livercarcinomaSubstitution - Missense

c.1390G>A; p.D464N; 9:81593216-81593216

 livercarcinomaSubstitution - Missense

c.1857_1860delCAGC; p.S620fs*66; 9:81587798-81587801

 livercarcinomaDeletion - Frameshift

c.1561G>T; p.V521F; 9:81593045-81593045

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.665A>G; p.N222S; 9:81620487-81620487

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1534A>T; p.I512F; 9:81593072-81593072

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1848A>G; p.T616T; 9:81587810-81587810

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1459G>A; p.V487M; 9:81593147-81593147

 lung; middle_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.664A>G; p.N222D; 9:81620488-81620488

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.294G>A; p.Q98Q; 9:81653977-81653977

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.526C>T; p.H176Y; 9:81634148-81634148

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2260A>G; p.I754V; 9:81584251-81584251

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1852G>C; p.G618R; 9:81587806-81587806

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1427G>T; p.R476L; 9:81593179-81593179

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.1402G>T; p.G468*; 9:81593204-81593204

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Nonsense

c.975C>T; p.D325D; 9:81613465-81613465

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.2110C>T; p.L704L; 9:81585523-81585523

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1796C>A; p.A599D; 9:81590838-81590838

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.712G>T; p.D238Y; 9:81616699-81616699

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2207C>G; p.S736C; 9:81584304-81584304

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.347T>A; p.M116K; 9:81652239-81652239

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.581G>C; p.R194T; 9:81633361-81633361

 NSNSSubstitution - Missense

c.203C>T; p.S68L; 9:81685707-81685707

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.657A>G; p.E219E; 9:81620495-81620495

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.1558C>G; p.P520A; 9:81593048-81593048

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.1829+4A>G; p.?; 9:81590801-81590801

 oesophagus; lower_thirdcarcinoma; adenocarcinomaUnknown

c.1713G>A; p.T571T; 9:81590921-81590921

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.1427G>A; p.R476H; 9:81593179-81593179

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.2057T>A; p.V686E; 9:81585576-81585576

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1243C>T; p.R415C; 9:81611780-81611780

 pancreascarcinomaSubstitution - Missense

c.764A>C; p.E255A; 9:81616647-81616647

 pancreascarcinomaSubstitution - Missense

c.764A>C; p.E255A; 9:81616647-81616647

 pancreascarcinoma; ductal_carcinomaSubstitution - Missense

c.1359C>G; p.D453E; 9:81593247-81593247

 pleurapulmonary_blastomaSubstitution - Missense

c.1896G>C; p.W632C; 9:81587762-81587762

 prostatecarcinomaSubstitution - Missense

c.1017A>G; p.P339P; 9:81613423-81613423

 prostatecarcinomaSubstitution - coding silent

c.2258A>G; p.Y753C; 9:81584253-81584253

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.2108C>T; p.S703F; 9:81585525-81585525

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.121C>T; p.H41Y; 9:81687338-81687338

 skinmalignant_melanomaSubstitution - Missense

c.2188G>A; p.G730R; 9:81584465-81584465

 skin; handmalignant_melanomaSubstitution - Missense

c.603C>T; p.S201S; 9:81620549-81620549

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.741C>T; p.N247N; 9:81616670-81616670

 skinmalignant_melanomaSubstitution - coding silent

c.242T>A; p.I81N; 9:81654029-81654029

 skinmalignant_melanomaSubstitution - Missense

c.1012C>T; p.R338C; 9:81613428-81613428

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.662C>T; p.S221F; 9:81620490-81620490

 skinmalignant_melanomaSubstitution - Missense

c.1119delG; p.M374fs*7; 9:81611904-81611904

 skin; head_neckcarcinoma; squamous_cell_carcinomaDeletion - Frameshift

c.427C>T; p.L143F; 9:81634247-81634247

 skinmalignant_melanomaSubstitution - Missense

c.1203G>A; p.M401I; 9:81611820-81611820

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1129delC; p.H377fs*4; 9:81611894-81611894

 skinmalignant_melanomaDeletion - Frameshift

c.493C>T; p.L165F; 9:81634181-81634181

 skinmalignant_melanomaSubstitution - Missense

c.2182C>T; p.P728S; 9:81584471-81584471

 skin; facecarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1646G>A; p.G549E; 9:81590988-81590988

 skin; scalpcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1386C>T; p.P462P; 9:81593220-81593220

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1407C>T; p.P469P; 9:81593199-81593199

 skinmalignant_melanomaSubstitution - coding silent

c.1250C>T; p.P417L; 9:81611773-81611773

 skinmalignant_melanomaSubstitution - Missense

c.829C>T; p.R277C; 9:81616071-81616071

 skinmalignant_melanomaSubstitution - Missense

c.1276C>T; p.H426Y; 9:81610275-81610275

 skinmalignant_melanomaSubstitution - Missense

c.1112C>T; p.P371L; 9:81611911-81611911

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1112_1113delCT; p.P371fs*51; 9:81611910-81611911

 skin; head_neckcarcinoma; squamous_cell_carcinomaDeletion - Frameshift

c.467C>T; p.P156L; 9:81634207-81634207

 soft_tissue; blood_vesselangiosarcomaSubstitution - Missense

c.1501A>G; p.T501A; 9:81593105-81593105

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1326G>A; p.G442G; 9:81610225-81610225

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.908A>G; p.E303G; 9:81615992-81615992

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1159C>A; p.P387T; 9:81611864-81611864

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.144G>C; p.E48D; 9:81685878-81685878

 stomachcarcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiableSubstitution - Missense

c.1131C>T; p.H377H; 9:81611892-81611892

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.2231G>A; p.S744N; 9:81584280-81584280

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.2219C>T; p.S740L; 9:81584292-81584292

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.1734C>T; p.Y578Y; 9:81590900-81590900

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1165G>A; p.A389T; 9:81611858-81611858

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.590G>A; p.G197D; 9:81633352-81633352

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.2170G>C; p.A724P; 9:81584483-81584483

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.957A>T; p.T319T; 9:81613483-81613483

 upper_aerodigestive_tract; larynxcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.2212G>C; p.E738Q; 9:81584299-81584299

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.2212G>C; p.E738Q; 9:81584299-81584299

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.201G>T; p.M67I; 9:81685709-81685709

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1874C>G; p.S625C; 9:81587784-81587784

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.859C>G; p.P287A; 9:81616041-81616041

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.871G>A; p.A291T; 9:81616029-81616029

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.622C>T; p.L208L; 9:81620530-81620530

 urinary_tract; bladdercarcinomaSubstitution - coding silent