Entrez Gene

Basic Information
Gene ID	6885
Name	MAP3K7
Synonymous	mitogen-activated protein kinase kinase kinase 7;MAP3K7;mitogen-activated protein kinase kinase kinase 7
Definition	TGF-beta activated kinase 1\|TGF-beta-activated kinase 1\|transforming growth factor-beta-activated kinase 1
Position	6q15
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.607+8G>A; p.?; 6:90556492-90556492	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Unknown
c.919G>A; p.E307K; 6:90550498-90550498	breast	carcinoma	Substitution - Missense
c.742C>T; p.R248*; 6:90552174-90552174	breast	carcinoma	Substitution - Nonsense
c.975A>C; p.T325T; 6:90548152-90548152	breast	carcinoma	Substitution - coding silent
c.821G>A; p.R274H; 6:90552095-90552095	breast	carcinoma	Substitution - Missense
c.868-1G>T; p.?; 6:90550550-90550550	central_nervous_system; temporal_lobe	glioma; ependymoma	Unknown
c.592C>T; p.P198S; 6:90556515-90556515	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.194T>C; p.I65T; 6:90571734-90571734	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.194T>C; p.I65T; 6:90571734-90571734	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.269T>C; p.V90A; 6:90568586-90568586	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.535G>A; p.A179T; 6:90556572-90556572	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.794G>A; p.R265H; 6:90552122-90552122	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.675T>C; p.R225R; 6:90553519-90553519	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1216G>A; p.G406R; 6:90536396-90536396	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1177T>C; p.S393P; 6:90547291-90547291	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.235C>T; p.R79W; 6:90568620-90568620	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.673C>T; p.R225C; 6:90553521-90553521	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.808G>T; p.D270Y; 6:90552108-90552108	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.557T>C; p.M186T; 6:90556550-90556550	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.981G>A; p.T327T; 6:90548146-90548146	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1455G>A; p.P485P; 6:90518551-90518551	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1175T>A; p.M392K; 6:90547293-90547293	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.78C>T; p.L26L; 6:90586806-90586806	kidney	other; neoplasm	Substitution - coding silent
c.1444-1G>T; p.?; 6:90518563-90518563	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.848T>A; p.I283K; 6:90552068-90552068	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1117G>T; p.G373W; 6:90547351-90547351	kidney	other; neoplasm	Substitution - Missense
c.1673A>G; p.Y558C; 6:90516568-90516568	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1199C>T; p.A400V; 6:90547269-90547269	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1673A>G; p.Y558C; 6:90516568-90516568	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.135A>G; p.G45G; 6:90571793-90571793	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1617C>T; p.R539R; 6:90516624-90516624	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.672G>A; p.T224T; 6:90553522-90553522	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.672G>A; p.T224T; 6:90553522-90553522	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.218C>T; p.A73V; 6:90571710-90571710	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.860T>C; p.L287S; 6:90552056-90552056	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1615C>T; p.R539C; 6:90516626-90516626	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.741T>C; p.T247T; 6:90552175-90552175	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.571G>A; p.G191R; 6:90556536-90556536	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.571G>A; p.G191R; 6:90556536-90556536	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.757A>C; p.K253Q; 6:90552159-90552159	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.33_35delCTC; p.S14delS; 6:90586849-90586851	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.33_35delCTC; p.S14delS; 6:90586849-90586851	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.1528C>T; p.Q510*; 6:90518478-90518478	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1197C>T; p.I399I; 6:90547271-90547271	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.19G>T; p.A7S; 6:90586865-90586865	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.247C>T; p.R83C; 6:90568608-90568608	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.247C>T; p.R83C; 6:90568608-90568608	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.995A>G; p.D332G; 6:90548132-90548132	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.217G>T; p.A73S; 6:90571711-90571711	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.49G>A; p.E17K; 6:90586835-90586835	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.504_505insG; p.T169fs*7; 6:90556602-90556603	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.389C>T; p.A130V; 6:90560169-90560169	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1045G>T; p.E349*; 6:90548082-90548082	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.24C>T; p.S8S; 6:90586860-90586860	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.712C>T; p.R238*; 6:90553482-90553482	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.181G>T; p.A61S; 6:90571747-90571747	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.197A>G; p.E66G; 6:90571731-90571731	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1291T>A; p.S431T; 6:90523768-90523768	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.68C>T; p.S23F; 6:90586816-90586816	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.985A>G; p.N329D; 6:90548142-90548142	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1428G>A; p.L476L; 6:90519273-90519273	liver	carcinoma	Substitution - coding silent
c.1428G>A; p.L476L; 6:90519273-90519273	liver	carcinoma	Substitution - coding silent
c.617A>G; p.Y206C; 6:90553577-90553577	liver	carcinoma	Substitution - Missense
c.832G>T; p.E278*; 6:90552084-90552084	liver	carcinoma	Substitution - Nonsense
c.832G>T; p.E278*; 6:90552084-90552084	liver	carcinoma	Substitution - Nonsense
c.1000A>G; p.N334D; 6:90548127-90548127	liver	carcinoma	Substitution - Missense
c.1000A>G; p.N334D; 6:90548127-90548127	liver	carcinoma	Substitution - Missense
c.811C>T; p.P271S; 6:90552105-90552105	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1033A>G; p.I345V; 6:90548094-90548094	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1076A>C; p.Q359P; 6:90548051-90548051	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1106G>C; p.G369A; 6:90547362-90547362	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.501G>T; p.G167G; 6:90556606-90556606	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1209_1210AG>CC; p.T403>?; 6:90547258-90547259	lung	carcinoma; adenocarcinoma	Complex
c.800G>A; p.W267*; 6:90552116-90552116	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.634G>T; p.V212F; 6:90553560-90553560	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1388A>G; p.N463S; 6:90519313-90519313	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1118_1119GG>TT; p.G373V; 6:90547349-90547350	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1189G>A; p.A397T; 6:90547279-90547279	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1696G>A; p.E566K; 6:90516545-90516545	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.196G>C; p.E66Q; 6:90571732-90571732	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.608-1G>T; p.?; 6:90553587-90553587	lung	carcinoma; adenocarcinoma	Unknown
c.869A>G; p.Y290C; 6:90550548-90550548	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1232G>T; p.R411I; 6:90536380-90536380	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.608-5delT; p.?; 6:90553591-90553591	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.505A>G; p.T169A; 6:90556602-90556602	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.134G>T; p.G45V; 6:90571794-90571794	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.278A>G; p.Y93C; 6:90568577-90568577	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.994G>A; p.D332N; 6:90548133-90548133	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1323A>T; p.S441S; 6:90523736-90523736	prostate	adenoma	Substitution - coding silent
c.247C>T; p.R83C; 6:90568608-90568608	salivary_gland; maxilla	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.1166G>A; p.S389N; 6:90547302-90547302	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1113C>T; p.S371S; 6:90547355-90547355	skin	malignant_melanoma	Substitution - coding silent
c.1471G>A; p.E491K; 6:90518535-90518535	skin	malignant_melanoma	Substitution - Missense
c.1293C>T; p.S431S; 6:90523766-90523766	skin	malignant_melanoma	Substitution - coding silent
c.1564G>A; p.E522K; 6:90516677-90516677	skin	malignant_melanoma	Substitution - Missense
c.1382-1G>C; p.?; 6:90519320-90519320	skin; leg	malignant_melanoma	Unknown
c.1696G>A; p.E566K; 6:90516545-90516545	skin	malignant_melanoma	Substitution - Missense
c.1382-1G>C; p.?; 6:90519320-90519320	skin; leg	malignant_melanoma	Unknown
c.1719G>C; p.Q573H; 6:90516522-90516522	skin	malignant_melanoma	Substitution - Missense
c.712C>T; p.R238*; 6:90553482-90553482	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1593A>G; p.E531E; 6:90516648-90516648	skin	malignant_melanoma	Substitution - coding silent
c.946A>G; p.T316A; 6:90550471-90550471	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.1353T>A; p.S451R; 6:90523706-90523706	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1595A>G; p.K532R; 6:90516646-90516646	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.949+2T>A; p.?; 6:90550466-90550466	stomach	carcinoma; adenocarcinoma	Unknown
c.995A>C; p.D332A; 6:90548132-90548132	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.584G>A; p.W195*; 6:90556523-90556523	stomach	adenocarcinoma	Substitution - Nonsense
c.673C>T; p.R225C; 6:90553521-90553521	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.968C>T; p.A323V; 6:90548159-90548159	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.360A>G; p.E120E; 6:90560198-90560198	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.410G>A; p.C137Y; 6:90560148-90560148	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.865C>T; p.R289W; 6:90552051-90552051	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.1384A>G; p.T462A; 6:90519317-90519317	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.949G>T; p.G317C; 6:90550468-90550468	stomach	carcinoma	Substitution - Missense
c.1489G>C; p.E497Q; 6:90518517-90518517	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.247C>T; p.R83C; 6:90568608-90568608	upper_aerodigestive_tract; mouth	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.953C>T; p.S318L; 6:90548174-90548174	urinary_tract; bladder	carcinoma	Substitution - Missense

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COSMIC confirmed somatic mutation [Top]

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