Entrez Gene

Basic Information
Gene ID	688
Name	KLF5
Synonymous	Kruppel-like factor 5 (intestinal);KLF5;Kruppel-like factor 5 (intestinal)
Definition	BTE-binding protein 2\|GC box binding protein 2\|Klf5C isoform\|Krueppel-like factor 5\|basic transcription element binding protein 2\|colon krueppel-like factor\|colon kruppel-like factor\|intestinal-enriched krueppel-like factor\|intestinal-enriched kruppel-lik
Position	13q22.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.1053A>T; p.S351S; 13:73062652-73062652	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - coding silent
c.896_897insA; p.Y299fs*1; 13:73062495-73062496	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Insertion - Frameshift
c.486_487insAC; p.E164fs*41; 13:73062085-73062086	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Insertion - Frameshift
c.655C>T; p.L219F; 13:73062254-73062254	breast	carcinoma	Substitution - Missense
c.812C>T; p.P271L; 13:73062411-73062411	breast	carcinoma	Substitution - Missense
c.595G>A; p.A199T; 13:73062194-73062194	central_nervous_system; brain	glioma	Substitution - Missense
c.864G>A; p.M288I; 13:73062463-73062463	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.462G>T; p.Q154H; 13:73062061-73062061	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.781G>A; p.A261T; 13:73062380-73062380	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.764C>T; p.S255F; 13:73062363-73062363	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.443C>A; p.T148N; 13:73062042-73062042	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1230C>T; p.C410C; 13:73075742-73075742	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.725C>A; p.S242Y; 13:73062324-73062324	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.853A>G; p.T285A; 13:73062452-73062452	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; Burkitt_lymphoma	Substitution - Missense
c.539C>T; p.P180L; 13:73062138-73062138	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1288G>A; p.A430T; 13:73075800-73075800	kidney	other; neoplasm	Substitution - Missense
c.307G>A; p.V103I; 13:73061906-73061906	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.903C>T; p.P301P; 13:73062502-73062502	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1210A>G; p.K404E; 13:73075722-73075722	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.901C>T; p.P301S; 13:73062500-73062500	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.902C>A; p.P301H; 13:73062501-73062501	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1253A>G; p.D418G; 13:73075765-73075765	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.369C>T; p.F123F; 13:73061968-73061968	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.897C>T; p.Y299Y; 13:73062496-73062496	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.499G>A; p.A167T; 13:73062098-73062098	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.841A>G; p.M281V; 13:73062440-73062440	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.932G>T; p.S311I; 13:73062531-73062531	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.932G>T; p.S311I; 13:73062531-73062531	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.929_931delGAA; p.S311delS; 13:73062528-73062530	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.1192A>G; p.T398A; 13:73063880-73063880	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.350C>T; p.A117V; 13:73061949-73061949	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.492A>C; p.E164D; 13:73062091-73062091	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.907T>C; p.S303P; 13:73062506-73062506	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.911C>T; p.P304L; 13:73062510-73062510	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.725C>G; p.S242C; 13:73062324-73062324	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.420C>T; p.L140L; 13:73062019-73062019	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.919T>G; p.S307A; 13:73062518-73062518	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1024A>T; p.N342Y; 13:73062623-73062623	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.843G>A; p.M281I; 13:73062442-73062442	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1163_1165delCTC; p.S388_H389>Y; 13:73063851-73063853	large_intestine	carcinoma; adenocarcinoma	Complex - deletion inframe
c.28G>A; p.A10T; 13:73059355-73059355	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.28G>A; p.A10T; 13:73059355-73059355	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.905C>A; p.P302Q; 13:73062504-73062504	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.902C>T; p.P301L; 13:73062501-73062501	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1165C>A; p.H389N; 13:73063853-73063853	large_intestine; colon	carcinoma	Substitution - Missense
c.1165C>A; p.H389N; 13:73063853-73063853	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1165C>A; p.H389N; 13:73063853-73063853	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.447C>T; p.G149G; 13:73062046-73062046	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1317C>T; p.N439N; 13:73075829-73075829	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.293C>G; p.P98R; 13:73061892-73061892	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.421C>T; p.P141S; 13:73062020-73062020	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.910C>A; p.P304T; 13:73062509-73062509	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.953T>G; p.M318R; 13:73062552-73062552	liver	carcinoma	Substitution - Missense
c.953T>G; p.M318R; 13:73062552-73062552	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.846C>T; p.P282P; 13:73062445-73062445	liver	carcinoma	Substitution - coding silent
c.1255G>C; p.E419Q; 13:73075767-73075767	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1255G>C; p.E419Q; 13:73075767-73075767	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1255G>C; p.E419Q; 13:73075767-73075767	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1255G>C; p.E419Q; 13:73075767-73075767	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1255G>C; p.E419Q; 13:73075767-73075767	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1242C>T; p.F414F; 13:73075754-73075754	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1255G>A; p.E419K; 13:73075767-73075767	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.586C>A; p.H196N; 13:73062185-73062185	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1185G>T; p.R395S; 13:73063873-73063873	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.901C>T; p.P301S; 13:73062500-73062500	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.483C>G; p.I161M; 13:73062082-73062082	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.545C>T; p.P182L; 13:73062144-73062144	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1250C>T; p.S417L; 13:73075762-73075762	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.941G>C; p.R314T; 13:73062540-73062540	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1252G>T; p.D418Y; 13:73075764-73075764	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.375T>G; p.T125T; 13:73061974-73061974	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.672G>C; p.Q224H; 13:73062271-73062271	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.324G>A; p.E108E; 13:73061923-73061923	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.317T>G; p.I106S; 13:73061916-73061916	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.261+3A>C; p.?; 13:73059591-73059591	oesophagus	carcinoma; adenocarcinoma	Unknown
c.398G>T; p.S133I; 13:73061997-73061997	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.843G>T; p.M281I; 13:73062442-73062442	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1165C>A; p.H389N; 13:73063853-73063853	pancreas	carcinoma	Substitution - Missense
c.1165C>A; p.H389N; 13:73063853-73063853	pancreas	NS	Substitution - Missense
c.842_843insAT; p.M281fs*43; 13:73062441-73062442	prostate	carcinoma	Insertion - Frameshift
c.1253A>T; p.D418V; 13:73075765-73075765	salivary_gland; parotid	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.1190A>C; p.H397P; 13:73063878-73063878	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.593C>T; p.T198I; 13:73062192-73062192	skin	malignant_melanoma	Substitution - Missense
c.941G>A; p.R314K; 13:73062540-73062540	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.958C>T; p.Q320*; 13:73062557-73062557	skin	malignant_melanoma	Substitution - Nonsense
c.845C>T; p.P282L; 13:73062444-73062444	skin	malignant_melanoma	Substitution - Missense
c.443C>A; p.T148N; 13:73062042-73062042	skin	malignant_melanoma	Substitution - Missense
c.902C>T; p.P301L; 13:73062501-73062501	skin; neck	malignant_melanoma	Substitution - Missense
c.811C>T; p.P271S; 13:73062410-73062410	skin	malignant_melanoma	Substitution - Missense
c.523A>G; p.T175A; 13:73062122-73062122	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1081_1083delAGA; p.R362delR; 13:73062680-73062682	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - In frame
c.914C>G; p.P305R; 13:73062513-73062513	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.914C>G; p.P305R; 13:73062513-73062513	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1261A>C; p.T421P; 13:73075773-73075773	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1261A>C; p.T421P; 13:73075773-73075773	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1261A>C; p.T421P; 13:73075773-73075773	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1261A>C; p.T421P; 13:73075773-73075773	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.341G>A; p.R114Q; 13:73061940-73061940	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1158G>C; p.K386N; 13:73063846-73063846	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1158G>C; p.K386N; 13:73063846-73063846	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1242C>T; p.F414F; 13:73075754-73075754	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1085_1100del16; p.S363fs*23; 13:73062684-73062699	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Deletion - Frameshift
c.1198G>A; p.E400K; 13:73075710-73075710	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1198G>A; p.E400K; 13:73075710-73075710	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.816G>A; p.Q272Q; 13:73062415-73062415	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.353C>T; p.S118L; 13:73061952-73061952	urinary_tract; bladder	carcinoma	Substitution - Missense

Oncogene database

COSMIC confirmed somatic mutation [Top]

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