Entrez Gene

Basic Information
Gene ID	6850
Name	SYK
Synonymous	spleen tyrosine kinase;SYK;spleen tyrosine kinase
Definition	tyrosine-protein kinase SYK
Position	9q22
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC confirmed somatic mutation [Top]

c.82T>G; p.Y28D; 9:90843980-90843980	breast	carcinoma	Substitution - Missense
c.437C>G; p.A146G; 9:90845453-90845453	breast	carcinoma	Substitution - Missense
c.971T>G; p.V324G; 9:90874708-90874708	breast	carcinoma	Substitution - Missense
c.1799A>G; p.E600G; 9:90895560-90895560	breast	carcinoma	Substitution - Missense
c.66G>A; p.R22R; 9:90843964-90843964	central_nervous_system; brain	glioma	Substitution - coding silent
c.702C>A; p.F234L; 9:90862329-90862329	central_nervous_system; frontal_lobe	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1811G>A; p.R604H; 9:90895572-90895572	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.702C>T; p.F234F; 9:90862329-90862329	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.897G>A; p.P299P; 9:90874254-90874254	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1512G>T; p.K504N; 9:90878953-90878953	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1706G>T; p.G569V; 9:90888567-90888567	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1206G>T; p.Q402H; 9:90877664-90877664	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1546T>A; p.Y516N; 9:90887782-90887782	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; follicular_lymphoma	Substitution - Missense
c.1407C>G; p.H469Q; 9:90878848-90878848	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; polycythaemia_vera	Substitution - Missense
c.1233G>C; p.R411R; 9:90877691-90877691	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1452C>T; p.Y484Y; 9:90878893-90878893	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1476T>C; p.L492L; 9:90878917-90878917	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1269G>A; p.L423L; 9:90877727-90877727	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.973T>C; p.Y325H; 9:90874710-90874710	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.1596C>G; p.V532V; 9:90887832-90887832	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.996C>T; p.P332P; 9:90874733-90874733	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.717+1G>A; p.?; 9:90862345-90862345	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.897G>A; p.P299P; 9:90874254-90874254	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.108T>C; p.D36D; 9:90844006-90844006	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.534T>C; p.S178S; 9:90845550-90845550	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.988G>A; p.A330T; 9:90874725-90874725	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.988G>A; p.A330T; 9:90874725-90874725	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.988G>A; p.A330T; 9:90874725-90874725	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.988G>A; p.A330T; 9:90874725-90874725	large_intestine; colon	carcinoma	Substitution - Missense
c.988G>A; p.A330T; 9:90874725-90874725	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1828G>A; p.V610M; 9:90895589-90895589	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1367C>T; p.S456F; 9:90878808-90878808	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.702C>T; p.F234F; 9:90862329-90862329	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.702C>T; p.F234F; 9:90862329-90862329	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1470C>T; p.F490F; 9:90878911-90878911	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1584C>T; p.S528S; 9:90887820-90887820	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1233G>C; p.R411R; 9:90877691-90877691	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.965C>G; p.T322R; 9:90874702-90874702	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1120A>G; p.K374E; 9:90877578-90877578	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1092G>T; p.K364N; 9:90874829-90874829	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.154G>A; p.A52T; 9:90844052-90844052	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.832G>A; p.G278S; 9:90865083-90865083	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.254C>T; p.P85L; 9:90844152-90844152	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1452C>T; p.Y484Y; 9:90878893-90878893	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.92_93insG; p.M34fs*3; 9:90843990-90843991	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.92_93insG; p.M34fs*3; 9:90843990-90843991	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1269G>A; p.L423L; 9:90877727-90877727	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1651C>T; p.R551*; 9:90887887-90887887	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1651C>T; p.R551*; 9:90887887-90887887	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1144delA; p.N383fs*13; 9:90877602-90877602	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.490_491insA; p.M166fs*14; 9:90845506-90845507	large_intestine; rectum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1810C>T; p.R604C; 9:90895571-90895571	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.962A>G; p.D321G; 9:90874699-90874699	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1469T>G; p.F490C; 9:90878910-90878910	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.921G>T; p.W307C; 9:90874278-90874278	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.176G>A; p.R59K; 9:90844074-90844074	large_intestine; colon	adenoma	Substitution - Missense
c.272A>G; p.Y91C; 9:90844170-90844170	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.173G>A; p.G58E; 9:90844071-90844071	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1772A>G; p.E591G; 9:90895533-90895533	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1220C>T; p.P407L; 9:90877678-90877678	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.988G>A; p.A330T; 9:90874725-90874725	liver	carcinoma	Substitution - Missense
c.988G>A; p.A330T; 9:90874725-90874725	liver	carcinoma	Substitution - Missense
c.1432T>C; p.L478L; 9:90878873-90878873	liver	carcinoma	Substitution - coding silent
c.1432T>C; p.L478L; 9:90878873-90878873	liver	carcinoma	Substitution - coding silent
c.131G>T; p.S44I; 9:90844029-90844029	liver	carcinoma	Substitution - Missense
c.602G>A; p.G201D; 9:90862229-90862229	liver	carcinoma	Substitution - Missense
c.1121A>C; p.K374T; 9:90877579-90877579	liver	carcinoma	Substitution - Missense
c.1105A>C; p.M369L; 9:90874842-90874842	liver	carcinoma	Substitution - Missense
c.1105A>C; p.M369L; 9:90874842-90874842	liver	carcinoma	Substitution - Missense
c.1428T>C; p.N476N; 9:90878869-90878869	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.958A>T; p.M320L; 9:90874695-90874695	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1113-7C>G; p.?; 9:90877564-90877564	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.76G>A; p.E26K; 9:90843974-90843974	liver	carcinoma	Substitution - Missense
c.76G>A; p.E26K; 9:90843974-90843974	liver	carcinoma	Substitution - Missense
c.76G>A; p.E26K; 9:90843974-90843974	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1097A>G; p.Y366C; 9:90874834-90874834	liver	carcinoma	Substitution - Missense
c.1097A>G; p.Y366C; 9:90874834-90874834	liver	carcinoma	Substitution - Missense
c.1637G>T; p.G546V; 9:90887873-90887873	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1014G>T; p.K338N; 9:90874751-90874751	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.313A>G; p.K105E; 9:90844211-90844211	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.922G>T; p.A308S; 9:90874279-90874279	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.583C>T; p.R195*; 9:90862210-90862210	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1738G>C; p.D580H; 9:90888599-90888599	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.877A>T; p.S293C; 9:90874234-90874234	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1635T>G; p.Y545*; 9:90887871-90887871	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1635T>G; p.Y545*; 9:90887871-90887871	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.315G>T; p.K105N; 9:90844213-90844213	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.936C>A; p.G312G; 9:90874673-90874673	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.647A>G; p.Y216C; 9:90862274-90862274	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.311A>G; p.K104R; 9:90844209-90844209	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1048G>T; p.E350*; 9:90874785-90874785	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.854C>A; p.P285H; 9:90874211-90874211	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1239C>T; p.I413I; 9:90877697-90877697	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1548C>T; p.Y516Y; 9:90887784-90887784	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1548C>T; p.Y516Y; 9:90887784-90887784	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1809G>A; p.L603L; 9:90895570-90895570	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1255G>A; p.E419K; 9:90877713-90877713	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.851C>T; p.S284F; 9:90874208-90874208	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.259G>T; p.D87Y; 9:90844157-90844157	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1213G>A; p.D405N; 9:90877671-90877671	ovary	other; neoplasm	Substitution - Missense
c.1113-1G>C; p.?; 9:90877570-90877570	ovary	carcinoma; serous_carcinoma	Unknown
c.1031G>A; p.R344Q; 9:90874768-90874768	pancreas	carcinoma	Substitution - Missense
c.1675A>G; p.T559A; 9:90888536-90888536	pancreas	carcinoma	Substitution - Missense
c.1675A>G; p.T559A; 9:90888536-90888536	pancreas	carcinoma	Substitution - Missense
c.988G>A; p.A330T; 9:90874725-90874725	prostate	carcinoma	Substitution - Missense
c.1043C>T; p.T348M; 9:90874780-90874780	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1796T>C; p.V599A; 9:90895557-90895557	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.125G>A; p.R42H; 9:90844023-90844023	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1738G>A; p.D580N; 9:90888599-90888599	skin	malignant_melanoma	Substitution - Missense
c.1738G>A; p.D580N; 9:90888599-90888599	skin	malignant_melanoma	Substitution - Missense
c.1368C>T; p.S456S; 9:90878809-90878809	skin	malignant_melanoma	Substitution - coding silent
c.1368C>T; p.S456S; 9:90878809-90878809	skin	malignant_melanoma	Substitution - coding silent
c.1241G>A; p.G414E; 9:90877699-90877699	skin	malignant_melanoma	Substitution - Missense
c.1465G>A; p.D489N; 9:90878906-90878906	skin	malignant_melanoma	Substitution - Missense
c.1372G>A; p.G458S; 9:90878813-90878813	skin	malignant_melanoma	Substitution - Missense
c.960G>A; p.M320I; 9:90874697-90874697	skin	malignant_melanoma	Substitution - Missense
c.913G>A; p.A305T; 9:90874270-90874270	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1664G>A; p.G555E; 9:90888525-90888525	skin	malignant_melanoma	Substitution - Missense
c.1664G>A; p.G555E; 9:90888525-90888525	skin	malignant_melanoma	Substitution - Missense
c.1664G>A; p.G555E; 9:90888525-90888525	skin	malignant_melanoma	Substitution - Missense
c.1213G>A; p.D405N; 9:90877671-90877671	skin	malignant_melanoma	Substitution - Missense
c.1655G>A; p.G552E; 9:90888516-90888516	skin	malignant_melanoma	Substitution - Missense
c.852C>T; p.S284S; 9:90874209-90874209	skin	malignant_melanoma	Substitution - coding silent
c.685C>T; p.P229S; 9:90862312-90862312	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.778C>T; p.Q260*; 9:90864649-90864649	skin	malignant_melanoma	Substitution - Nonsense
c.1535C>T; p.P512L; 9:90887771-90887771	skin	malignant_melanoma	Substitution - Missense
c.1443C>T; p.T481T; 9:90878884-90878884	skin	malignant_melanoma	Substitution - coding silent
c.1750C>T; p.L584L; 9:90888611-90888611	skin	malignant_melanoma	Substitution - coding silent
c.1314G>A; p.Q438Q; 9:90877772-90877772	skin	malignant_melanoma	Substitution - coding silent
c.649C>T; p.R217C; 9:90862276-90862276	skin	malignant_melanoma	Substitution - Missense
c.1669G>A; p.E557K; 9:90888530-90888530	skin	malignant_melanoma	Substitution - Missense
c.215G>A; p.G72D; 9:90844113-90844113	skin	malignant_melanoma	Substitution - Missense
c.153C>T; p.F51F; 9:90844051-90844051	skin	malignant_melanoma	Substitution - coding silent
c.810T>G; p.F270L; 9:90865061-90865061	skin	malignant_melanoma	Substitution - Missense
c.810T>G; p.F270L; 9:90865061-90865061	skin	malignant_melanoma	Substitution - Missense
c.944G>A; p.R315K; 9:90874681-90874681	skin	malignant_melanoma	Substitution - Missense
c.1142T>C; p.L381P; 9:90877600-90877600	skin	malignant_melanoma	Substitution - Missense
c.1700_1701GG>AC; p.R567H; 9:90888561-90888562	skin	malignant_melanoma	Substitution - Missense
c.1625C>T; p.A542V; 9:90887861-90887861	skin	malignant_melanoma	Substitution - Missense
c.1625C>T; p.A542V; 9:90887861-90887861	skin	malignant_melanoma	Substitution - Missense
c.1015G>A; p.E339K; 9:90874752-90874752	skin	malignant_melanoma	Substitution - Missense
c.975C>T; p.Y325Y; 9:90874712-90874712	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1737C>T; p.Y579Y; 9:90888598-90888598	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.655G>A; p.D219N; 9:90862282-90862282	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1428T>C; p.N476N; 9:90878869-90878869	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.93delG; p.G33fs*2; 9:90843991-90843991	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.457C>T; p.Q153*; 9:90845473-90845473	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.525G>T; p.R175R; 9:90845541-90845541	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.274C>T; p.H92Y; 9:90844172-90844172	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.862G>A; p.G288R; 9:90874219-90874219	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.737A>G; p.Y246C; 9:90864608-90864608	stomach	carcinoma	Substitution - Missense
c.1273A>T; p.M425L; 9:90877731-90877731	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.134G>A; p.R45H; 9:90844032-90844032	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1283C>T; p.A428V; 9:90877741-90877741	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.298G>T; p.V100F; 9:90844196-90844196	thyroid	other; neoplasm	Substitution - Missense
c.1700G>A; p.R567Q; 9:90888561-90888561	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.297G>T; p.L99L; 9:90844195-90844195	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.297G>T; p.L99L; 9:90844195-90844195	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.465G>A; p.E155E; 9:90845481-90845481	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.465G>A; p.E155E; 9:90845481-90845481	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.1248C>G; p.C416W; 9:90877706-90877706	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.267C>T; p.C89C; 9:90844165-90844165	urinary_tract; bladder	carcinoma	Substitution - coding silent

Oncogene database

COSMIC confirmed somatic mutation [Top]

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